{"entity": "researcher", "timestamp": "2026-08-26T06:11:54.721Z", "family": "Wray", "given": "Naomi R", "initials": "NR", "orcid": "0000-0001-7421-3357", "affiliations": ["Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/58962e389d9645f694e1a9e23d820acd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/58962e389d9645f694e1a9e23d820acd"}}, "publications": [{"entity": "publication", "iuid": "bee5ac73046042688e3e3c43444545e4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bee5ac73046042688e3e3c43444545e4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bee5ac73046042688e3e3c43444545e4"}}, "title": "Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index.", "authors": [{"family": "Yang", "given": "Jian", "initials": "J", "orcid": "0000-0003-2001-2474", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/86905621292e4ef38d32bc2f0dc09525.json"}}, {"family": "Bakshi", "given": "Andrew", "initials": "A"}, {"family": "Zhu", "given": "Zhihong", "initials": "Z"}, {"family": "Hemani", "given": "Gibran", "initials": "G"}, {"family": "Vinkhuyzen", "given": "Anna A E", "initials": "AA"}, {"family": "Lee", "given": "Sang Hong", "initials": "SH"}, {"family": "Robinson", "given": "Matthew R", "initials": "MR"}, {"family": "Perry", "given": "John R B", "initials": "JR"}, {"family": "Nolte", "given": "Ilja M", "initials": "IM"}, {"family": "van Vliet-Ostaptchouk", "given": "Jana V", "initials": "JV"}, {"family": "Snieder", "given": "Harold", "initials": "H"}, {"family": "LifeLines Cohort Study", "given": "", "initials": ""}, {"family": "Esko", "given": "Tonu", "initials": "T", "orcid": "0000-0003-1982-6569", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/45dd48f2bc61400db209bc5543f86e0b.json"}}, {"family": "Milani", "given": "Lili", "initials": "L"}, {"family": "M\u00e4gi", "given": "Reedik", "initials": "R"}, {"family": "Metspalu", "given": "Andres", "initials": "A"}, {"family": "Hamsten", "given": "Anders", "initials": "A"}, {"family": "Magnusson", "given": "Patrik K E", "initials": "PK"}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL"}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "Soranzo", "given": "Nicole", "initials": "N", "orcid": "0000-0003-1095-3852", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/751b4656807c42f9a668ebb98e8da987.json"}}, {"family": "Keller", "given": "Matthew C", "initials": "MC"}, {"family": "Wray", "given": "Naomi R", "initials": "NR", "orcid": "0000-0001-7421-3357", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/58962e389d9645f694e1a9e23d820acd.json"}}, {"family": "Goddard", "given": "Michael E", "initials": "ME"}, {"family": "Visscher", "given": "Peter M", "initials": "PM", "orcid": "0000-0002-2143-8760", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9232be0ea244fb7ab43593e04265c2e.json"}}], "type": "journal article", "published": "2015-10-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "47", "issue": "10", "pages": "1114-1120", "issn-l": "1061-4036"}, "abstract": "We propose a method (GREML-LDMS) to estimate heritability for human complex traits in unrelated individuals using whole-genome sequencing data. We demonstrate using simulations based on whole-genome sequencing data that \u223c97% and \u223c68% of variation at common and rare variants, respectively, can be captured by imputation. Using the GREML-LDMS method, we estimate from 44,126 unrelated individuals that all \u223c17 million imputed variants explain 56% (standard error (s.e.) = 2.3%) of variance for height and 27% (s.e. = 2.5%) of variance for body mass index (BMI), and we find evidence that height- and BMI-associated variants have been under natural selection. Considering the imperfect tagging of imputation and potential overestimation of heritability from previous family-based studies, heritability is likely to be 60-70% for height and 30-40% for BMI. Therefore, the missing heritability is small for both traits. For further discovery of genes associated with complex traits, a study design with SNP arrays followed by imputation is more cost-effective than whole-genome sequencing at current prices.", "doi": "10.1038/ng.3390", "pmid": "26323059", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS712807"}, {"db": "pmc", "key": "PMC4589513"}, {"db": "pii", "key": "ng.3390"}, {"db": "dbGaP", "key": "PHS000090"}, {"db": "dbGaP", "key": "PHS000091"}, {"db": "dbGaP", "key": "PHS000428"}], "notes": [], "created": "2018-12-05T08:35:02.967Z", "modified": "2026-08-21T11:45:42.717Z"}]}