{"entity": "researcher", "timestamp": "2026-08-20T21:01:39.267Z", "family": "Mauro", "given": "Francesca R", "initials": "FR", "orcid": "0000-0003-2425-9474", "affiliations": ["Hematology Unit, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/588b17f8a7544766bdfcd763978dad5d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/588b17f8a7544766bdfcd763978dad5d"}}, "publications": [{"entity": "publication", "iuid": "048922da2a384daa953047cd1a0fa998", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/048922da2a384daa953047cd1a0fa998.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/048922da2a384daa953047cd1a0fa998"}}, "title": "Clinical and transcriptomic characterization of patients with chronic lymphocytic leukemia harboring t(14;19): an ERIC study.", "authors": [{"family": "Visentin", "given": "Andrea", "initials": "A", "orcid": "0000-0003-0271-7200", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10a25bb174034d55a6a2f0fccb036f02.json"}}, {"family": "Gaffo", "given": "Enrico", "initials": "E", "orcid": "0000-0001-6338-7677", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a30412a5d86429d99d9ab62bf7be0b2.json"}}, {"family": "F\u00fcrstenau", "given": "Moritz", "initials": "M", "orcid": "0000-0002-6593-0140", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f3c1950a80040ada1cda908470910c9.json"}}, {"family": "Rogers", "given": "Kerry A", "initials": "KA"}, {"family": "Panagiotis", "given": "Baliakas", "initials": "B", "orcid": "0000-0002-5634-7156", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a31997db1ee4ef1aaff75e423b8ccfb.json"}}, {"family": "Cui", "given": "Chenghua", "initials": "C"}, {"family": "Miller", "given": "Cecelia", "initials": "C", "orcid": "0000-0001-6110-6069", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a1123529d141447bafd9b556d5990544.json"}}, {"family": "Haferlach", "given": "Claudia", "initials": "C", "orcid": "0000-0002-6333-5049", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b317dae860d040cfa971ea54ed81558a.json"}}, {"family": "Plevova", "given": "Karla", "initials": "K", "orcid": "0000-0002-6148-8877", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a4174bc21ce468a90d6f7cba6688179.json"}}, {"family": "Oscier", "given": "David", "initials": "D", "orcid": "0000-0001-8486-2051", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/220096a970af4fcc99a358e4f0d6f239.json"}}, {"family": "Davis", "given": "Zadie", "initials": "Z", "orcid": "0000-0001-6959-4853", "researcher": {"href": 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{"href": "https://publications-affiliated.scilifelab.se/researcher/f223eed5e0dc4decad48346341db0f6b.json"}}, {"family": "Cuneo", "given": "Antonio", "initials": "A"}, {"family": "Ghia", "given": "Paolo", "initials": "P", "orcid": "0000-0003-3750-7342", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/475d35f1a3c446819b2f24be819c2dee.json"}}, {"family": "Stamatopoulos", "given": "Kostas", "initials": "K", "orcid": "0000-0001-8529-640X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06f6107d6f774ee6acb2c66ecfcb90cc.json"}}, {"family": "Trentin", "given": "Livio", "initials": "L", "orcid": "0000-0003-1222-6149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/820ab4c1a5534ada88d9c318fa8aa2e1.json"}}, {"family": "Bortoluzzi", "given": "Stefania", "initials": "S", "orcid": "0000-0001-8240-3070", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0831daa98b3b4ea980ccd20da78a22fb.json"}}], "type": "journal article", "published": "2025-12-00", "journal": {"title": "Leukemia", "issn": "1476-5551", "volume": "39", "issue": "12", "pages": "2957-2967", "issn-l": "0887-6924"}, "abstract": "In chronic lymphocytic leukemia (CLL), the role of complex karyotype (CK) for prognostic stratification remains a topic of debate, and the impact of specific cytogenetic abnormalities is still unclear. This study aims to investigate the clinical and biological features of CLL with t(14;19)(q32;q13) (tCLL) involving the BCL3 gene. Patients with tCLL were younger and more commonly presented unmutated IGHV gene, subset #8 stereotypy, trisomy of chromosome 12, and complex karyotype than other patients without t(14;19) (oCLL). The presence of t(14;19) was associated with a shorter time to treatment and overall survival compared to oCLL. Gene expression analysis revealed a unique transcriptome profile in tCLL, characterized by the upregulation of BCL3 and the activation of B-cell receptor, PI3K-Akt. Conversely, apoptosis-related pathways were suppressed in tCLL. While the BTK gene was upregulated, the BCL2L11 gene, coding for the pro-apoptotic protein BIM, was downregulated. Notably, patients with tCLL were characterized by a trend (p = 0.058) for a longer time to the next treatment with BTK inhibitors (BTKi) compared to those treated with a venetoclax-based (Ven-based) regimen. We underscore the adverse outcomes of tCLL, its distinct molecular features and gene expression patterns. Therefore, our data suggest that identifying tCLL could help tailor therapeutic approaches.", "doi": "10.1038/s41375-025-02755-8", "pmid": "40973766", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12634426"}, {"db": "pii", "key": "10.1038/s41375-025-02755-8"}], "notes": [], "created": "2026-08-20T08:47:27.388Z", "modified": "2026-08-20T08:47:52.757Z"}, {"entity": "publication", "iuid": "4dcc7aa2e98e41e5924199166195f148", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4dcc7aa2e98e41e5924199166195f148.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4dcc7aa2e98e41e5924199166195f148"}}, "title": "The evolving landscape of COVID-19 and post-COVID condition in patients with chronic lymphocytic leukemia: A study by ERIC, the European research initiative on CLL.", "authors": [{"family": "Visentin", "given": "Andrea", "initials": "A", "orcid": "0000-0003-0271-7200", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10a25bb174034d55a6a2f0fccb036f02.json"}}, {"family": "Chatzikonstantinou", "given": "Thomas", "initials": "T", "orcid": "0000-0003-4105-1253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a205228c1594457fbd55004721eb19c3.json"}}, {"family": "Scarf\u00f2", "given": "Lydia", "initials": "L", "orcid": "0000-0002-0844-0989", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7697d7b279ae48a387843c617f30fa3c.json"}}, {"family": "Kapetanakis", "given": "Anargyros", "initials": "A", "orcid": "0000-0002-5770-8654", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6dabcfc8a904913a5f44441b30fb9cc.json"}}, {"family": "Demosthenous", "given": "Christos", "initials": "C", "orcid": "0000-0002-2008-7954", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/147aee2210fa4325bf08d88d92054a51.json"}}, {"family": "Karakatsoulis", "given": "Georgios", "initials": "G"}, {"family": "Minga", "given": "Eva", "initials": "E"}, {"family": "Chamou", "given": "Dimitra", "initials": "D"}, {"family": "Allsup", "given": "David", "initials": "D"}, {"family": "Cabrero", "given": "Alejandro Alonso", "initials": "AA"}, {"family": "Andres", "given": "Martin", "initials": "M"}, {"family": "Antic", "given": "Darko", "initials": "D", "orcid": "0000-0002-2608-1342", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/568b2b24d1d34de78087067a3472d972.json"}}, {"family": "Baile", "given": "M\u00f3nica", "initials": "M"}, {"family": "Baliakas", "given": "Panagiotis", "initials": "P", "orcid": "0000-0002-5634-7156", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a31997db1ee4ef1aaff75e423b8ccfb.json"}}, {"family": "Besikli-Dimou", "given": "Sotiria", "initials": "S"}, {"family": "Bron", "given": "Dominique", "initials": "D"}, {"family": "Chatzileontiadou", 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"J"}, {"family": "Orsucci", "given": "Lorella", "initials": "L"}, {"family": "Papaioannou", "given": "Maria", "initials": "M"}, {"family": "Pavlovsky", "given": "Miguel Arturo", "initials": "MA"}, {"family": "Piskunova", "given": "Inga", "initials": "I"}, {"family": "Popov", "given": "Viola Maria", "initials": "VM"}, {"family": "Quaglia", "given": "Francesca Maria", "initials": "FM"}, {"family": "Quaresmini", "given": "Giulia", "initials": "G"}, {"family": "Qvist", "given": "Kristian", "initials": "K"}, {"family": "Rigolin", "given": "Gian Matteo", "initials": "GM", "orcid": "0000-0002-8370-5190", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f66f2d62db5d49d2a7443f5e0b5d3eed.json"}}, {"family": "Ruchlemer", "given": "Rosa", "initials": "R", "orcid": "0000-0001-8349-0794", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7080290ab374d69a3c85484bb71bd11.json"}}, {"family": "\u0160imkovi\u010d", "given": "Martin", "initials": "M"}, {"family": "\u0160pa\u010dek", "given": "Martin", "initials": "M"}, {"family": "Sportoletti", "given": "Paolo", "initials": "P", "orcid": "0000-0002-5630-9862", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c6ab8837a35443f0a3ef319ca9b4f683.json"}}, {"family": "Stanca", "given": "Oana", "initials": "O"}, {"family": "Tadmor", "given": "Tamar", "initials": "T", "orcid": "0000-0002-3435-8612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ce4288f837e475e8ad1ea911d78fa4c.json"}}, {"family": "Capasso", "given": "Antonella", "initials": "A"}, {"family": "Del Poeta", "given": "Giovanni", "initials": "G"}, {"family": "Gutwein", "given": "Odit", "initials": "O"}, {"family": "Karlsson", "given": "Linda Katharina", "initials": "LK"}, {"family": "Milosevic", "given": "Ivana", "initials": "I"}, {"family": "Mir\u00e1s", "given": "Fatima", "initials": "F"}, {"family": "Reda", "given": "Gianluigi", "initials": "G", "orcid": "0000-0003-4687-7089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc2be38bcf024aa4a06c571c1ed7ffcf.json"}}, {"family": "Saghumyan", "given": "Gevorg", "initials": "G"}, {"family": "Shrestha", "given": "Amit", "initials": "A"}, {"family": "Te Raa", "given": "Doreen", "initials": "D"}, {"family": "Tonino", "given": "Sanne H", "initials": "SH"}, {"family": "Van Der Spek", "given": "Ellen", "initials": "E"}, {"family": "van Gelder", "given": "Michel", "initials": "M"}, {"family": "van Kampen", "given": "Roel", "initials": "R"}, {"family": "Wasik-Szczepanek", "given": "Ewa", "initials": "E"}, {"family": "Wr\u00f3bel", "given": "Tomasz", "initials": "T"}, {"family": "Segundo", "given": "Lucrecia Y\u00e1\u00f1ez San", "initials": "LYS"}, {"family": "Yassin", "given": "Mohamed", "initials": "M", "orcid": "0000-0002-1144-8076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40a808948be848ed8c749a1d3b842b56.json"}}, {"family": "Pocali", "given": "Barbara", "initials": "B"}, {"family": "Vandenberghe", "given": "Elisabeth", "initials": "E"}, {"family": "Iyengar", "given": "Sunil", "initials": "S"}, {"family": "Varettoni", "given": "Marzia", "initials": "M", "orcid": "0000-0001-7304-1629", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/399b2772fab646c38c128e7d14eca17b.json"}}, {"family": "Vitale", "given": "Candida", "initials": "C"}, {"family": "Coscia", "given": "Marta", "initials": "M"}, {"family": "Rambaldi", "given": "Alessandro", "initials": "A"}, {"family": "Montserrat", "given": "Emili", "initials": "E"}, {"family": "Cuneo", "given": "Antonio", "initials": "A"}, {"family": "Stavroyianni", "given": "Niki", "initials": "N"}, {"family": "Trentin", "given": "Livio", "initials": "L", "orcid": "0000-0003-1222-6149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/820ab4c1a5534ada88d9c318fa8aa2e1.json"}}, {"family": "Stamatopoulos", "given": "Kostas", "initials": "K", "orcid": "0000-0001-8529-640X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06f6107d6f774ee6acb2c66ecfcb90cc.json"}}, {"family": "Ghia", "given": "Paolo", "initials": "P", "orcid": "0000-0003-3750-7342", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/475d35f1a3c446819b2f24be819c2dee.json"}}], "type": "multicenter study", "published": "2023-12-00", "journal": {"title": "Am. J. Hematol.", "issn": "1096-8652", "volume": "98", "issue": "12", "pages": "1856-1868", "issn-l": "0361-8609"}, "abstract": "In this retrospective international multicenter study, we describe the clinical characteristics and outcomes of patients with chronic lymphocytic leukemia (CLL) and related disorders (small lymphocytic lymphoma and high-count monoclonal B lymphocytosis) infected by SARS-CoV-2, including the development of post-COVID condition. Data from 1540 patients with CLL infected by SARS-CoV-2 from January 2020 to May 2022 were included in the analysis and assigned to four phases based on cases disposition and SARS-CoV-2 variants emergence. Post-COVID condition was defined according to the WHO criteria. Patients infected during the most recent phases of the pandemic, though carrying a higher comorbidity burden, were less often hospitalized, rarely needed intensive care unit admission, or died compared to patients infected during the initial phases. The 4-month overall survival (OS) improved through the phases, from 68% to 83%, p = .0015. Age, comorbidity, CLL-directed treatment, but not vaccination status, emerged as risk factors for mortality. Among survivors, 6.65% patients had a reinfection, usually milder than the initial one, and 16.5% developed post-COVID condition. The latter was characterized by fatigue, dyspnea, lasting cough, and impaired concentration. Infection severity was the only risk factor for developing post-COVID. The median time to resolution of the post-COVID condition was 4.7 months. OS in patients with CLL improved during the different phases of the pandemic, likely due to the improvement of prophylactic and therapeutic measures against SARS-CoV-2 as well as the emergence of milder variants. However, mortality remained relevant and a significant number of patients developed post-COVID conditions, warranting further investigations.", "doi": "10.1002/ajh.27093", "pmid": "37772428", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T06:28:29.653Z", "modified": "2026-08-20T06:28:31.016Z"}]}