{"entity": "researcher", "timestamp": "2026-05-12T21:19:29.570Z", "family": "Malvestutto", "given": "Carlos", "initials": "C", "orcid": "0000-0003-3156-2965", "affiliations": ["Wexner Medical Center, Ohio State University, Columbus, OH."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/579e40a069684a539bd8a9aaeeb9f88b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/579e40a069684a539bd8a9aaeeb9f88b"}}, "publications": [{"entity": "publication", "iuid": "bf6df9e11dba43d98d3f283fdc3302a4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bf6df9e11dba43d98d3f283fdc3302a4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bf6df9e11dba43d98d3f283fdc3302a4"}}, "title": "Clonal Hematopoiesis and Major Adverse Cardiac Events in People With HIV: Insights From the REPRIEVE Trial.", "authors": [{"family": "Xue", "given": "Liying", "initials": "L"}, {"family": "Bhattacharya", "given": "Romit", "initials": "R", "orcid": "0000-0002-0782-4753", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/adea681afe7c431c91b30900a92baf8f.json"}}, {"family": "Uddin", "given": "Md Mesbah", "initials": "MM", "orcid": "0000-0003-1846-0411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/42f1ac7010c34ba997a3fd9e56c6a56a.json"}}, {"family": "Nakao", "given": "Tetsushi", "initials": "T", "orcid": "0000-0001-9979-2682", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7e818cd4544c41c2a7fa91dbce13429e.json"}}, {"family": "Zou", "given": "Roger", "initials": "R", "orcid": "0000-0003-1338-6398", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c4cddede9054c1585a557247cd2c32d.json"}}, {"family": "Patel", "given": "Aniruddh", "initials": "A", "orcid": "0000-0001-7871-9638", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7bf68d8799f4946814bc4e6ea80ef2f.json"}}, {"family": "Haidermota", "given": "Sara", "initials": "S", "orcid": "0000-0002-8588-3388", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/78ed21c17b99495790f19b85531c29b3.json"}}, {"family": "Niroula", "given": "Abhishek", "initials": "A"}, {"family": "Viscosi", "given": "Victoria", "initials": "V"}, {"family": "Postupaka", "given": "Darina", "initials": "D", "orcid": "0000-0003-4893-6265", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d77a6443167d49de834411434e1d0b5f.json"}}, {"family": "Bhatnagar", "given": "Aarushi", "initials": "A", "orcid": "0009-0004-4699-6779", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca127e06c66d48e9bd4be7cb2b2238a4.json"}}, {"family": "Finneran", "given": "Phoebe", "initials": "P", "orcid": "0000-0001-8201-733X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/113e6ea36d2d4a9d8a7f90377acc31f6.json"}}, {"family": "Bernardo", "given": "Rachel", "initials": "R", "orcid": "0000-0001-7139-6899", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c5a8588e727e4bfb80b622375ccd5d89.json"}}, {"family": "Diggs", "given": "Marissa R", "initials": "MR"}, {"family": "Fitch", "given": "Kathleen V", "initials": "KV", "orcid": "0000-0002-0541-3707", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9925de23fac74c2bb76faaa538e9b6f8.json"}}, {"family": "Chu", "given": "Sarah M", "initials": "SM"}, {"family": "McCallum", "given": "Sara", "initials": "S", "orcid": "0000-0002-0289-1295", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee2cc7b68408411e9c7278416a08006e.json"}}, {"family": "Currier", "given": "Judith S", "initials": "JS", "orcid": "0000-0003-4279-4737", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/332c1eb440224e5d828ad3e378e10947.json"}}, {"family": "Fichtenbaum", "given": "Carl J", "initials": "CJ", "orcid": "0000-0002-6778-7253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8f33fe77cc70491aa7971e8a159bd879.json"}}, {"family": "Malvestutto", "given": "Carlos D", "initials": "CD", "orcid": "0000-0003-3156-2965", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/579e40a069684a539bd8a9aaeeb9f88b.json"}}, {"family": "Aberg", "given": "Judith A", "initials": "JA", "orcid": "0000-0001-8162-0284", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e3306ed88f5d4fedaecd6e6b130ff242.json"}}, {"family": "Bloomfield", "given": "Gerald S", "initials": "GS", "orcid": "0000-0002-7176-1611", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1d2f1345c72d441e98c065dcb4621102.json"}}, {"family": "Ribaudo", "given": "Heather J", "initials": "HJ", "orcid": "0000-0002-0394-3990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b304b28a37ac46a695a17dc359f09485.json"}}, {"family": "Zanni", "given": "Markella V", "initials": "MV", "orcid": "0000-0002-4711-3956", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2c49e94d43e4d9da2d85873013b6e71.json"}}, {"family": "Libby", "given": "Peter", "initials": "P", "orcid": "0000-0002-1502-502X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/39fb20acff0442bd92fc7931d3ee6cf9.json"}}, {"family": "Hornsby", "given": "Whitney", "initials": "W", "orcid": "0000-0002-0672-0338", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8ab7aefec20431caf36c130be364ec4.json"}}, {"family": "Lu", "given": "Michael T", "initials": "MT", "orcid": "0000-0003-4696-9610", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b4c2374e856464ab3a2c7bbf6cd0723.json"}}, {"family": "Douglas", "given": "Pamela S", "initials": "PS", "orcid": "0000-0001-9876-4049", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48b7c5b425e542c78387242bdd4b2b53.json"}}, {"family": "Grinspoon", "given": "Steven K", "initials": "SK"}, {"family": "Natarajan", "given": "Pradeep", "initials": "P", "orcid": "0000-0001-8402-7435", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe8bd48c61c047cd8e61c35d9e9ac650.json"}}], "type": "journal article", "published": "2025-11-06", "journal": {"title": "Arterioscler. Thromb. Vasc. Biol.", "issn": "1524-4636", "issn-l": "1079-5642"}, "abstract": "People with HIV (PWH) experience higher cardiovascular disease event rates not fully explained by traditional risk factors. Clonal hematopoiesis of indeterminate potential (CHIP), an emerging risk factor for cardiovascular disease in the general population, has been reported to be more prevalent in PWH.\n\nUsing high-coverage targeted CHIP sequencing in the REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) cardiovascular disease prevention trial, we investigated whether CHIP increases the risk of major adverse cardiovascular events (MACE) among PWH, as well as whether HIV-associated factors were associated with greater CHIP prevalence among PWH. We analyzed whole-exome and targeted sequencing from 4490 PWH without known cardiovascular disease; 1653 (36.8%) were female, and 2039 (45.4%) were Black. MACE was defined by including cardiovascular death, myocardial infarction, hospitalization for unstable angina, stroke, transient ischemic attack, peripheral artery disease, revascularization, or death from an undetermined cause.\n\nA total of 837 (18.6%) had CHIP driver mutations, with 385 (8.6%) at variant allele fraction \u22652% and 61 (1.4%) at variant allele fraction \u226510%. Although overall CHIP was not associated with MACE, the presence of large CHIP (variant allele fraction \u226510%) was associated with increased odds for the first occurrence of myocardial infarction or cardiac catheterization, or revascularization, despite low overall event rates. Adjustments for pitavastatin treatment did not attenuate this association. Furthermore, a larger CHIP clone size was associated with lower CD4 nadir and with increased risk of MACE.\n\nIn PWH in the REPRIEVE trial who were low-to-moderate risk for incident cardiovascular disease, CHIP was not associated with increased prospective risk of MACE. However, a large CHIP was associated with increased risk of myocardial infarction and revascularization.\n\nURL: https://www.clinicaltrials.gov; Unique identifier: NCT02344290.", "doi": "10.1161/ATVBAHA.125.322896", "pmid": "41195533", "labels": {"DDLS Fellow": null, "Abhishek Niroula": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT02344290"}], "notes": [], "created": "2025-11-17T15:51:17.831Z", "modified": "2025-11-17T15:51:18.341Z"}, {"entity": "publication", "iuid": "1c4caf654d8645899fe13fcf25900dfa", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1c4caf654d8645899fe13fcf25900dfa.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1c4caf654d8645899fe13fcf25900dfa"}}, "title": "Risk factors for clonal hematopoiesis of indeterminate potential in people with HIV: a report from the REPRIEVE trial.", "authors": [{"family": "Bhattacharya", "given": "Romit", "initials": "R", "orcid": "0000-0002-0782-4753", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/adea681afe7c431c91b30900a92baf8f.json"}}, {"family": "Uddin", "given": "Md Mesbah", "initials": "MM", "orcid": "0000-0003-1846-0411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/42f1ac7010c34ba997a3fd9e56c6a56a.json"}}, {"family": "Patel", "given": "Aniruddh P", "initials": "AP", "orcid": "0000-0001-7871-9638", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7bf68d8799f4946814bc4e6ea80ef2f.json"}}, {"family": "Niroula", "given": "Abhishek", "initials": "A", "orcid": "0000-0002-5904-0635", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/05df7afc7a494ba5af8a378e5ffa53f0.json"}}, {"family": "Finneran", "given": "Phoebe", "initials": "P"}, {"family": "Bernardo", "given": "Rachel", "initials": "R", "orcid": "0000-0001-7139-6899", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c5a8588e727e4bfb80b622375ccd5d89.json"}}, {"family": "Fitch", "given": "Kathleen V", "initials": "KV"}, {"family": "Lu", "given": "Michael T", "initials": "MT"}, {"family": "Bloomfield", "given": "Gerald S", "initials": "GS"}, {"family": "Malvestutto", "given": "Carlos", "initials": "C", "orcid": "0000-0003-3156-2965", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/579e40a069684a539bd8a9aaeeb9f88b.json"}}, {"family": "Aberg", "given": "Judy A", "initials": "JA", "orcid": "0000-0001-8162-0284", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e3306ed88f5d4fedaecd6e6b130ff242.json"}}, {"family": "Fichtenbaum", "given": "Carl J", "initials": "CJ", "orcid": "0000-0002-6778-7253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8f33fe77cc70491aa7971e8a159bd879.json"}}, {"family": "Hornsby", "given": "Whitney", "initials": "W", "orcid": "0000-0002-0672-0338", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8ab7aefec20431caf36c130be364ec4.json"}}, {"family": "Ribaudo", "given": "Heather J", "initials": "HJ", "orcid": "0000-0002-0394-3990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b304b28a37ac46a695a17dc359f09485.json"}}, {"family": "Libby", "given": "Peter", "initials": "P", "orcid": "0000-0002-1502-502X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/39fb20acff0442bd92fc7931d3ee6cf9.json"}}, {"family": "Ebert", "given": "Benjamin L", "initials": "BL", "orcid": "0000-0003-0197-5451", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/56e4f1c53a4348e2b0ceb44a38850a17.json"}}, {"family": "Zanni", "given": "Markella V", "initials": "MV"}, {"family": "Douglas", "given": "Pamela S", "initials": "PS", "orcid": "0000-0001-9876-4049", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48b7c5b425e542c78387242bdd4b2b53.json"}}, {"family": "Grinspoon", "given": "Steven K", "initials": "SK"}, {"family": "Natarajan", "given": "Pradeep", "initials": "P", "orcid": "0000-0001-8402-7435", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe8bd48c61c047cd8e61c35d9e9ac650.json"}}], "type": "journal article", "published": "2024-02-27", "journal": {"title": "Blood Adv", "issn": "2473-9529", "volume": "8", "issue": "4", "pages": "959-967", "issn-l": null}, "abstract": "Clonal hematopoiesis of indeterminate potential (CHIP), the clonal expansion of myeloid cells with leukemogenic mutations, results in increased coronary artery disease (CAD) risk. CHIP is more prevalent among people with HIV (PWH), but the risk factors are unknown. CHIP was identified among PWH in REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) using whole-exome sequencing. Logistic regression was used to associate sociodemographic factors and HIV-specific factors with CHIP adjusting for age, sex, and smoking status. In the studied global cohort of 4486 PWH, mean age was 49.9 (standard deviation [SD], 6.4) years; 1650 (36.8%) were female; and 3418 (76.2%) were non-White. CHIP was identified in 223 of 4486 (4.97%) and in 38 of 373 (10.2%) among those aged \u226560 years. Age (odds ratio [OR], 1.07; 95% confidence interval [CI], 1.05-1.09; P < .0001) and smoking (OR, 1.37; 95% CI, 1.14-1.66; P < .001) associated with increased odds of CHIP. Globally, participants outside of North America had lower odds of CHIP including sub-Saharan Africa (OR, 0.57; 95% CI, 0.4-0.81; P = .0019), South Asia (OR, 0.45; 95% CI, 0.23-0.80; P = .01), and Latin America/Caribbean (OR, 0.56; 95% CI, 0.34-0.87; P = .014). Hispanic/Latino ethnicity (OR, 0.38; 95% CI, 0.23-0.54; P = .002) associated with significantly lower odds of CHIP. Among HIV-specific factors, CD4 nadir <50 cells/mm3 associated with a 1.9-fold (95%CI, 1.21-3.05; P = .006) increased odds of CHIP, with the effect being significantly stronger among individuals with short duration of antiretroviral therapy (ART; OR, 4.15; 95% CI, 1.51-11.1; P = .005) (Pinteraction= .0492). Among PWH at low-to-moderate CAD risk on stable ART, smoking, CD4 nadir, North American origin, and non-Hispanic ethnicity associated with increased odds of CHIP. This trial was registered at www.ClinicalTrials.gov as NCT02344290.", "doi": "10.1182/bloodadvances.2023011324", "pmid": "38197863", "labels": {"Abhishek Niroula": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC10877123"}, {"db": "pii", "key": "507100"}, {"db": "ClinicalTrials.gov", "key": "NCT02344290"}], "notes": [], "created": "2025-03-18T15:48:38.411Z", "modified": "2025-03-18T15:49:07.099Z"}]}