{"entity": "researcher", "timestamp": "2026-09-25T03:11:30.075Z", "family": "Gigante", "given": "Bruna", "initials": "B", "orcid": "0000-0003-4508-7990", "affiliations": ["Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.", "Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd University Hospital, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/5756c7fca760434da1fc7e001232eee3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/5756c7fca760434da1fc7e001232eee3"}}, "publications": [{"entity": "publication", "iuid": "f71bbf0f28b74406bc2d44dd11089059", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f71bbf0f28b74406bc2d44dd11089059.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f71bbf0f28b74406bc2d44dd11089059"}}, "title": "Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study-differences and similarities.", "authors": [{"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}, {"family": "Gummesson", "given": "Anders", "initials": "A"}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "Ahlstr\u00f6m", "given": "H\u00e5kan", "initials": "H"}, {"family": "Anger\u00e5s", "given": "Oskar", "initials": "O", "orcid": "0000-0002-3474-2438", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4777b51cdf8e4993bebcb6e56a50d291.json"}}, {"family": "Blomberg", "given": "Anders", "initials": "A"}, {"family": "Brandberg", "given": "John", "initials": "J"}, {"family": "Caidahl", "given": "Kenneth", "initials": "K"}, {"family": "Chorell", "given": "Elin", "initials": "E", "orcid": "0000-0002-8057-1684", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/55301da9c3f948b9bfb5bc27ed3bf0dd.json"}}, {"family": "Engvall", "given": "Jan Edvin", "initials": "JE"}, {"family": "Eriksson", "given": "Per", "initials": "P"}, {"family": "Erlinge", "given": "David", "initials": "D"}, {"family": "Gigante", "given": "Bruna", "initials": "B", "orcid": "0000-0003-4508-7990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5756c7fca760434da1fc7e001232eee3.json"}}, {"family": "Hjelmgren", "given": "Ola", "initials": "O"}, {"family": "Hultdin", "given": "Johan", "initials": "J"}, {"family": "Jernberg", "given": "Tomas", "initials": "T", "orcid": "0000-0003-1695-379X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a82eb1ecd69941878e6486de4bf601da.json"}}, {"family": "Kihlberg", "given": "Johan", "initials": "J"}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Magnusson", "given": "Martin", "initials": "M"}, {"family": "Nystr\u00f6m", "given": "Fredrik Hans", "initials": "FH"}, {"family": "Pirazzi", "given": "Carlo", "initials": "C"}, {"family": "Schiopu", "given": "Alexandru", "initials": "A", "orcid": "0000-0002-7587-5050", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dba446415bd84f97a7c9bb74afc27ae2.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "S\u00f6derberg", "given": "Stefan", "initials": "S"}, {"family": "\u00d6stgren", "given": "Carl Johan", "initials": "CJ"}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5faed1571d4742588095acc83e631dfc.json"}}], "type": "journal article", "published": "2025-09-29", "journal": {"title": "Cardiovasc Res", "issn": "1755-3245", "volume": "121", "issue": "11", "pages": "1649-1652", "issn-l": null}, "abstract": null, "doi": "10.1093/cvr/cvaf076", "pmid": "40327543", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12477672"}, {"db": "pii", "key": "8125826"}], "notes": [], "created": "2026-09-23T12:30:45.869Z", "modified": "2026-09-23T12:30:46.063Z"}, {"entity": "publication", "iuid": "49bfbf2107e540c4aba7cbc527d978f0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/49bfbf2107e540c4aba7cbc527d978f0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/49bfbf2107e540c4aba7cbc527d978f0"}}, "title": "Analysis of the genetic variants associated with circulating levels of sgp130. Results from the IMPROVE study.", "authors": [{"family": "Bonomi", "given": "Alice", "initials": "A"}, {"family": "Veglia", "given": "Fabrizio", "initials": "F"}, {"family": "Baldassarre", "given": "Damiano", "initials": "D"}, {"family": "Strawbridge", "given": "Rona J", "initials": "RJ", "orcid": "0000-0001-8506-3585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cccd06a2fb54f769c5710c8758f2ebe.json"}}, {"family": "Golabkesh", "given": "Zahra", "initials": "Z"}, {"family": "Sennblad", "given": "Bengt", "initials": "B", "orcid": "0000-0002-4360-8003", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5a39d035a6544946beab0e1bb097f000.json"}}, {"family": "Leander", "given": "Karin", "initials": "K"}, {"family": "Smit", "given": "Andries J", "initials": "AJ"}, {"family": "Giral", "given": "Philippe", "initials": "P"}, {"family": "Humphries", "given": "Steve E", "initials": "SE"}, {"family": "Tremoli", "given": "Elena", "initials": "E"}, {"family": "Hamsten", "given": "Anders", "initials": "A"}, {"family": "de Faire", "given": "Ulf", "initials": "U"}, {"family": "Gigante", "given": "Bruna", "initials": "B", "orcid": "0000-0003-4508-7990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5756c7fca760434da1fc7e001232eee3.json"}}, {"family": " on behalf of the IMPROVE study group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Genes Immun.", "issn": "1476-5470", "volume": "21", "issue": "2", "pages": "100-108", "issn-l": "1466-4879"}, "abstract": "The genes regulating circulating levels of soluble gp130 (sgp130), the antagonist of the inflammatory response in atherosclerosis driven by interleukin 6, are largely unknown. Aims of the present study were to identify genetic loci associated with circulating sgp130 and to explore the potential association between variants associated with sgp130 and markers of subclinical atherosclerosis. The study is based on IMPROVE (n = 3703), a cardiovascular multicentre study designed to investigate the determinants of carotid intima media thickness, a measure of subclinical atherosclerosis. Genomic DNA was genotyped by the CardioMetaboChip and ImmunoChip. About 360,842 SNPs were tested for association with log-transformed sgp130, using linear regression adjusted for age, gender, and population stratification using PLINK v1.07. A p value of 1 \u00d7 10-5 was chosen as threshold for significance value. In an exploratory analysis, SNPs associated with sgp130 were tested for association with c-IMT measures. We identified two SNPs significantly associated with sgp130 levels and 24 showing suggestive association with sgp130 levels. One SNP (rs17688225) on chromosome 14 was positively associated with sgp130 serum levels (\u03b2 = 0.03 SE = 0.007, p = 4.77 \u00d7 10-5) and inversely associated with c-IMT (c-IMTmean-max \u03b2 = -0.001 SE = 0.005, p = 0.0342). Our data indicate that multiple loci regulate sgp130 levels and suggest a possible common pathway between sgp130 and c-IMT measures.", "doi": "10.1038/s41435-019-0090-z", "pmid": "31932740", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7182533"}, {"db": "pii", "key": "10.1038/s41435-019-0090-z"}], "notes": [], "created": "2026-09-23T12:00:33.705Z", "modified": "2026-09-23T12:00:33.755Z"}, {"entity": "publication", "iuid": "28cf8e3f77e344af887fd659d1c2f681", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/28cf8e3f77e344af887fd659d1c2f681.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/28cf8e3f77e344af887fd659d1c2f681"}}, "title": "Genetic variation in CADM2 as a link between psychological traits and obesity.", "authors": [{"family": "Morris", "given": "Julia", "initials": "J"}, {"family": "Bailey", "given": "Mark E S", "initials": "MES", "orcid": "0000-0002-9788-2278", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/876b94a993504943bc6854fe0a71d49c.json"}}, {"family": "Baldassarre", "given": "Damiano", "initials": "D"}, {"family": "Cullen", "given": "Breda", "initials": "B", "orcid": "0000-0002-7259-9505", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9eeb9eafd99d489c9e47a260341a622e.json"}}, {"family": "de Faire", "given": "Ulf", "initials": "U"}, {"family": "Ferguson", "given": "Amy", "initials": "A"}, {"family": "Gigante", "given": "Bruna", "initials": "B", "orcid": "0000-0003-4508-7990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5756c7fca760434da1fc7e001232eee3.json"}}, {"family": "Giral", "given": "Philippe", "initials": "P"}, {"family": "Goel", "given": "Anuj", "initials": "A"}, {"family": "Graham", "given": "Nicholas", "initials": "N"}, {"family": "Hamsten", "given": "Anders", "initials": "A"}, {"family": "Humphries", "given": "Steve E", "initials": "SE"}, {"family": "Johnston", "given": "Keira J A", "initials": "KJA", "orcid": "0000-0002-1370-3149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bd4bcb30c5734c9ab649cd1ace361422.json"}}, {"family": "Lyall", "given": "Donald M", "initials": "DM", "orcid": "0000-0003-3850-1487", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/355e09323285410999bacaef10047b3a.json"}}, {"family": "Lyall", "given": "Laura M", "initials": "LM"}, {"family": "Sennblad", "given": "Bengt", "initials": "B"}, {"family": "Silveira", "given": "Angela", "initials": "A"}, {"family": "Smit", "given": "Andries J", "initials": "AJ"}, {"family": "Tremoli", "given": "Elena", "initials": "E"}, {"family": "Veglia", "given": "Fabrizio", "initials": "F"}, {"family": "Ward", "given": "Joey", "initials": "J"}, {"family": "Watkins", "given": "Hugh", "initials": "H"}, {"family": "Smith", "given": "Daniel J", "initials": "DJ", "orcid": "0000-0002-2267-1951", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57e439f15a6f44eb98ae6d681e6ff829.json"}}, {"family": "Strawbridge", "given": "Rona J", "initials": "RJ", "orcid": "0000-0001-8506-3585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cccd06a2fb54f769c5710c8758f2ebe.json"}}], "type": "journal article", "published": "2019-05-14", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "9", "issue": "1", "pages": "7339", "issn-l": "2045-2322"}, "abstract": "CADM2 has been associated with a range of behavioural and metabolic traits, including physical activity, risk-taking, educational attainment, alcohol and cannabis use and obesity. Here, we set out to determine whether CADM2 contributes to mechanisms shared between mental and physical health disorders. We assessed genetic variants in the CADM2 locus for association with phenotypes in the UK Biobank, IMPROVE, PROCARDIS and SCARFSHEEP studies, before performing meta-analyses. A wide range of metabolic phenotypes were meta-analysed. Psychological phenotypes analysed in UK Biobank only were major depressive disorder, generalised anxiety disorder, bipolar disorder, neuroticism, mood instability and risk-taking behaviour. In UK Biobank, four, 88 and 172 genetic variants were significantly (p < 1 \u00d7 10-5) associated with neuroticism, mood instability and risk-taking respectively. In meta-analyses of 4 cohorts, we identified 362, 63 and 11 genetic variants significantly (p < 1 \u00d7 10-5) associated with BMI, SBP and CRP respectively. Genetic effects on BMI, CRP and risk-taking were all positively correlated, and were consistently inversely correlated with genetic effects on SBP, mood instability and neuroticism. Conditional analyses suggested an overlap in the signals for physical and psychological traits. Many significant variants had genotype-specific effects on CADM2 expression levels in adult brain and adipose tissues. CADM2 variants influence a wide range of both psychological and metabolic traits, suggesting common biological mechanisms across phenotypes via regulation of CADM2 expression levels in adipose tissue. Functional studies of CADM2 are required to fully understand mechanisms connecting mental and physical health conditions.", "doi": "10.1038/s41598-019-43861-9", "pmid": "31089183", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6517397"}, {"db": "pii", "key": "10.1038/s41598-019-43861-9"}], "notes": [], "created": "2026-09-23T09:17:07.207Z", "modified": "2026-09-23T09:17:07.511Z"}]}