{"entity": "researcher", "timestamp": "2026-09-24T12:16:47.843Z", "family": "Degerman", "given": "Sofie", "initials": "S", "orcid": "0000-0002-2783-0712", "affiliations": ["1Department of Medical Biosciences, Ume\u00e5 University, Blg 6M, 2nd floor, SE-90185 Ume\u00e5, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/57331f9b04b14b6f92ac91f256370033.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/57331f9b04b14b6f92ac91f256370033"}}, "publications": [{"entity": "publication", "iuid": "bca15bccbf8d43a88fbffc49460b6ed4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bca15bccbf8d43a88fbffc49460b6ed4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bca15bccbf8d43a88fbffc49460b6ed4"}}, "title": "DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia.", "authors": [{"family": "Borss\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Nordlund", "given": "Jessica", "initials": "J"}, {"family": "Haider", "given": "Zahra", "initials": "Z"}, {"family": "Landfors", "given": "Mattias", "initials": "M"}, {"family": "Larsson", "given": "P\u00e4r", "initials": "P"}, {"family": "Kanerva", "given": "Jukka", "initials": "J"}, {"family": "Schmiegelow", "given": "Kjeld", "initials": "K"}, {"family": "Flaegstad", "given": "Trond", "initials": "T"}, {"family": "J\u00f3nsson", "given": "\u00d3lafur G\u00edsli", "initials": "\u00d3G"}, {"family": "Frost", "given": "Britt-Marie", "initials": "BM"}, {"family": "Palle", "given": "Josefine", "initials": "J"}, {"family": "Forestier", "given": "Erik", "initials": "E"}, {"family": "Heyman", "given": "Mats", "initials": "M"}, {"family": "Hultdin", "given": "Magnus", "initials": "M"}, {"family": "L\u00f6nnerholm", "given": "Gudmar", "initials": "G"}, {"family": "Degerman", "given": "Sofie", "initials": "S", "orcid": "0000-0002-2783-0712", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57331f9b04b14b6f92ac91f256370033.json"}}], "type": "journal article", "published": "2018-03-05", "journal": {"title": "Clin Epigenetics", "issn": "1868-7083", "volume": "10", "issue": null, "pages": "31", "issn-l": "1868-7075"}, "abstract": "Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients.\n\nSix hundred and one BCP-ALL samples from Nordic pediatric patients (age 1-18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data.\n\nAmong the 137 patients that later relapsed, patients with a CIMP- profile (n = 42) at initial diagnosis had an inferior overall survival (pOS5years 33%) compared to CIMP+ patients (n = 95, pOS5years 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors.\n\nCIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL.", "doi": "10.1186/s13148-018-0466-3", "pmid": "29515676", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5836434"}, {"db": "pii", "key": "466"}], "notes": [], "created": "2018-12-05T12:46:37.040Z", "modified": "2026-09-23T10:36:05.648Z"}]}