{"entity": "researcher", "timestamp": "2026-08-22T08:35:49.693Z", "family": "Montgomery", "given": "Scott", "initials": "S", "orcid": "0000-0001-6328-5494", "affiliations": ["Clinical Epidemiology and Biostatistics, School of Medical Sciences, \u00d6rebro University, \u00d6rebro, Sweden.", "Department of Epidemiology and Public Health, University College London, London, UK.", "Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/558159f8c8934d25b30effc337433350.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/558159f8c8934d25b30effc337433350"}}, "publications": [{"entity": "publication", "iuid": "bf7742a629e94fa2bc314fa79f7a3262", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bf7742a629e94fa2bc314fa79f7a3262.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bf7742a629e94fa2bc314fa79f7a3262"}}, "title": "Use of Antibiotics and Risk of Psychiatric Disorders in Newly Diagnosed Cancer Patients: A Population-Based Cohort Study in Sweden.", "authors": [{"family": "Hu", "given": "Kejia", "initials": "K", "orcid": "0000-0001-6680-8107", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a3db50670ad8437f92e155073db5d667.json"}}, {"family": "Smedby", "given": "Karin E", "initials": "KE"}, {"family": "Sj\u00f6lander", "given": "Arvid", "initials": "A"}, {"family": "Montgomery", "given": "Scott", "initials": "S", "orcid": "0000-0001-6328-5494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/558159f8c8934d25b30effc337433350.json"}}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur", "initials": "U", "orcid": "0000-0001-5382-946X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/16dcb423ea4947bc9bfaf3cd91a7e769.json"}}, {"family": "Engstrand", "given": "Lars", "initials": "L", "orcid": "0000-0002-7713-2373", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02d8684df81e42169e613de803446fbf.json"}}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c65cfa2c711f41428a39a9cdac12b2db.json"}}, {"family": "Fall", "given": "Katja", "initials": "K", "orcid": "0000-0002-3649-2639", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71681e4b08b94f4392ef89dba1eca16e.json"}}], "type": "journal article", "published": "2022-03-01", "journal": {"title": "Cancer Epidemiol Biomarkers Prev", "issn": "1538-7755", "volume": "31", "issue": "3", "pages": "528-535", "issn-l": null}, "abstract": "Antibiotic-induced dysbiosis is associated with an increased risk of depression and anxiety in the general population. A diagnosis of cancer is associated with an immediately and dramatically elevated risk of psychiatric disorders, but the potential influence of prediagnostic antibiotic-induced dysbiosis is unknown.\n\nBased on a national cohort of cancer patients in Sweden, we included 309,419 patients who were diagnosed with a first primary malignancy between July 2006 and December 2013. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of first-onset psychosis, depression, anxiety, or stress-related disorders during the first year after cancer diagnosis for antibiotic use during the year before cancer diagnosis.\n\nCompared with no antibiotic use, use of antibiotics was associated with a higher rate of the aforementioned psychiatric disorders (HR, 1.23; 95% CI, 1.16-1.30) after adjustment for sociodemographic factors, comorbidity, potential indications for antibiotics, and cancer stage and type. The magnitude of the association was higher for broad-spectrum antibiotics (HR, 1.27; 95% CI, 1.18-1.37), higher doses (HR, 1.32; 95% CI, 1.22-1.44), more frequent use (HR, 1.33; 95% CI, 1.21-1.46), and recent use (HR, 1.26; 95% CI, 1.17-1.35).\n\nUse of antibiotics, especially of broad-spectrum type, of high dose and frequency, with recent use, was associated with an aggravated risk of psychiatric disorders, compared with no antibiotic use.\n\nA better understanding of the microbiota-gut-brain axis may open up a wide avenue for the prevention and treatment of psychiatric disorders in cancer patients.", "doi": "10.1158/1055-9965.EPI-21-1095", "pmid": "35027429", "labels": [], "xrefs": [{"db": "pii", "key": "1055-9965.EPI-21-1095"}], "notes": [], "created": "2026-08-21T12:29:01.816Z", "modified": "2026-08-21T12:29:02.009Z"}, {"entity": "publication", "iuid": "04ae331c58ea4ebe9698737d79e6c6d6", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/04ae331c58ea4ebe9698737d79e6c6d6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/04ae331c58ea4ebe9698737d79e6c6d6"}}, "title": "Low stress resilience in late adolescence and risk of smoking, high alcohol consumption and drug use later in life.", "authors": [{"family": "Kennedy", "given": "Beatrice", "initials": "B", "orcid": "0000-0002-0066-4814", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb88fcd6bead49978b129dffe779d8a0.json"}}, {"family": "Chen", "given": "Ruoqing", "initials": "R"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Valdimarsdottir", "given": "Unnur", "initials": "U"}, {"family": "Montgomery", "given": "Scott", "initials": "S", "orcid": "0000-0001-6328-5494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/558159f8c8934d25b30effc337433350.json"}}, {"family": "Larsson", "given": "Henrik", "initials": "H"}, {"family": "Fall", "given": "Katja", "initials": "K"}], "type": "journal article", "published": "2019-06-00", "journal": {"title": "J Epidemiol Community Health", "issn": "1470-2738", "volume": "73", "issue": "6", "pages": "496-501", "issn-l": null}, "abstract": "While compromised stress resilience constitutes a recognised risk factor for somatic and psychiatric disease development in general, the knowledge about how individual variation in vulnerability to stress may specifically influence the long-term risks of disadvantageous health behaviours is limited.\n\nIn this Swedish cohort study, we aimed to investigate the association between stress resilience in late adolescence and adult use of addictive substances. We included 9381 men with information on psychological stress resilience measured during military conscription examinations, who later responded to an extensive health survey (mean age 34.0\u00b17.2 years) including detailed information on substance use. We modelled continuous outcomes using linear regression, binary outcomes with logistic regression and other categorical outcomes with multinomial logistic regression.\n\nWe found that low stress resilience in adolescence conferred increased risks of all studied measures of addictive behaviour. After adjusting for childhood socioeconomic information, low stress resilience was associated with adult current regular smoking (relative risk ratio: 5.85, 95% CI 4.32 to 7.93), higher nicotine dependence scores (beta: 0.76, 95% CI 0.29 to 1.23), hazardous use of alcohol (>14 alcoholic drink-equivalents per week, OR: 1.72, 95% CI 1.37 to 2.16), DSM-IV criteria for alcohol dependence (OR: 1.74, 95% CI 1.35 to 2.25), and drug use (OR: 1.77, 95% CI 1.51 to 2.08). The results remained largely unchanged after further adjustments for adult educational attainment and occupation as well as for additional conscription covariates.\n\nLow stress resilience in late adolescence appears to be associated with an increased risk of disadvantageous and addictive health behaviours in adulthood.", "doi": "10.1136/jech-2018-211815", "pmid": "30718261", "labels": [], "xrefs": [{"db": "pii", "key": "jech-2018-211815"}], "notes": [], "created": "2026-08-21T12:26:49.607Z", "modified": "2026-08-21T12:26:49.784Z"}]}