{"entity": "researcher", "timestamp": "2026-08-20T20:36:35.127Z", "family": "Jonasson", "given": "Mattias", "initials": "M", "orcid": "0000-0001-5528-3405", "affiliations": ["Wallenberg Centre for Molecular Medicine, Link\u00f6ping University, SE-581 83 Link\u00f6ping, Sweden.", "Department of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology, Faculty of Medicine and Health Sciences, Link\u00f6ping University, SE-581 83 Link\u00f6ping, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/55518b46d2b646ccafa1c598c50cb2af.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/55518b46d2b646ccafa1c598c50cb2af"}}, "publications": [{"entity": "publication", "iuid": "3ca09b7bdce44b52b955d0643c6b3b62", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3ca09b7bdce44b52b955d0643c6b3b62.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3ca09b7bdce44b52b955d0643c6b3b62"}}, "title": "SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus.", "authors": [{"family": "Serra", "given": "Linda", "initials": "L"}, {"family": "Nordin", "given": "Anna", "initials": "A"}, {"family": "Jonasson", "given": "Mattias", "initials": "M", "orcid": "0000-0001-5528-3405", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/55518b46d2b646ccafa1c598c50cb2af.json"}}, {"family": "Marenco", "given": "Carolina", "initials": "C"}, {"family": "Rovelli", "given": "Guido", "initials": "G"}, {"family": "Diebels", "given": "Annika", "initials": "A"}, {"family": "Gullo", "given": "Francesca", "initials": "F"}, {"family": "Ottolenghi", "given": "Sergio", "initials": "S"}, {"family": "Zambelli", "given": "Federico", "initials": "F"}, {"family": "Studer", "given": "Mich\u00e8le", "initials": "M", "orcid": "0000-0001-7105-2957", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d9f1dcf64f94d5cab0b1df4ce45face.json"}}, {"family": "Pavesi", "given": "Giulio", "initials": "G"}, {"family": "Cant\u00f9", "given": "Claudio", "initials": "C", "orcid": "0000-0003-1547-5415", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf8cf56e956942f4baa10f2772c13734.json"}}, {"family": "Nicolis", "given": "Silvia K", "initials": "SK", "orcid": "0000-0003-0378-3808", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6a76d76a2d244bfd856a8d944e71cd84.json"}}, {"family": "Mercurio", "given": "Sara", "initials": "S", "orcid": "0000-0003-3469-8323", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aa2f071cc4034e50ab76d81916b30f8b.json"}}], "type": "journal article", "published": "2025-08-15", "journal": {"title": "Biol Open", "issn": "2046-6390", "volume": "14", "issue": "8", "issn-l": "2046-6390"}, "abstract": "The thalamic dorsolateral geniculate nucleus (dLGN) receives visual input from the retina via the optic nerve, and projects to the cortical visual area, where eye-derived signals are elaborated. The transcription factors SOX2 and NR2F1 are directly involved in the differentiation of dLGN neurons, based on mouse work and patient mutations leading to vision defects. However, whether they regulate each other, or control common targets is still unclear. By RNA-seq analysis of neonatal dLGN from thalamo-specific Sox2 and Nr2f1 mouse mutants, we found a striking overlap of deregulated genes. Among them, Vgf, encoding a cytokine transported along thalamic-cortical axons is strongly downregulated in both mutants. Direct SOX2 binding to some of these genes was confirmed by CUT&RUN, which identified a SOX2 chromatin-binding pattern characteristic of the dLGN. Collectively, our genetic and molecular analyses on the SOX2 and NR2F1-coregulated genes contribute to our understanding of the gene regulatory network driving the differentiation and connectivity of thalamic neurons, and the vision impairments caused by mutations in these genes.", "doi": "10.1242/bio.062014", "pmid": "40631402", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12352279"}, {"db": "pii", "key": "368533"}], "notes": [], "created": "2026-08-20T12:38:10.503Z", "modified": "2026-08-20T12:38:10.692Z"}, {"entity": "publication", "iuid": "e63b7bef74d24951b7cafcd1cb96cd2c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e63b7bef74d24951b7cafcd1cb96cd2c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e63b7bef74d24951b7cafcd1cb96cd2c"}}, "title": "Construction of an atlas of transcription factor binding during mouse development identifies popular regulatory regions.", "authors": [{"family": "Nordin", "given": "Anna", "initials": "A", "orcid": "0000-0002-5868-4797", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8bef8cedd8544225bfec5435b7dfa597.json"}}, {"family": "Zambanini", "given": "Gianluca", "initials": "G", "orcid": "0000-0003-1275-6027", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b00dff2c6ddf4b3e9177af40d612c558.json"}}, {"family": "Enar Jonasson", "given": "Mattias", "initials": "M", "orcid": "0000-0001-5528-3405", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/55518b46d2b646ccafa1c598c50cb2af.json"}}, {"family": "Weiss", "given": "Tamina", "initials": "T", "orcid": "0009-0002-3605-0782", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e72c8aa90d334d09a4f6f3c627ada8e2.json"}}, {"family": "van de Grift", "given": "Yorick", "initials": "Y"}, {"family": "Pagella", "given": "Pierfrancesco", "initials": "P", "orcid": "0000-0001-6912-0957", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3280806842e04b08a4b595b30e1eee3f.json"}}, {"family": "Cant\u00f9", "given": "Claudio", "initials": "C", "orcid": "0000-0003-1547-5415", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf8cf56e956942f4baa10f2772c13734.json"}}], "type": "journal article", "published": "2025-03-15", "journal": {"title": "Development", "issn": "1477-9129", "volume": "152", "issue": "6", "issn-l": "0950-1991"}, "abstract": "Gene regulators physically associate with the genome, in a combinatorial fashion, to drive tissue-specific gene expression. Uncovering the genome-wide activity of all gene regulators across tissues is therefore needed to understand gene regulation during development. Here, we take a first step towards this goal. Using CUT&RUN, we systematically mapped genome-wide binding profiles of key transcription factors and co-factors that mediate ontogenetically relevant signaling pathways in select mouse tissues at two developmental stages. Computation of the datasets unveiled tissue- and time-specific activity for each gene regulator. We identified 'popular' regulatory regions that are bound by a multitude of regulators, which tend to be more evolutionarily conserved. Consistently, they lie near the transcription start site of genes for which dysregulation results in early embryonic lethality. Moreover, the human homologs of these regions are similarly bound by many gene regulators and are highly conserved, indicating a retained relevance for human development. This work constitutes a decisive step towards understanding how the genome is simultaneously read and used by gene regulators in a holistic fashion to drive embryonic development.", "doi": "10.1242/dev.204311", "pmid": "40013513", "labels": [], "xrefs": [{"db": "pii", "key": "367215"}], "notes": [], "created": "2026-08-20T12:38:27.004Z", "modified": "2026-08-20T12:38:27.145Z"}]}