{"entity": "researcher", "timestamp": "2026-08-20T20:40:42.984Z", "family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "affiliations": ["Division of Affinity Proteomics, Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d"}}, "publications": [{"entity": "publication", "iuid": "fe5a284dda5743fb91cbc7646fe5afd1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fe5a284dda5743fb91cbc7646fe5afd1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fe5a284dda5743fb91cbc7646fe5afd1"}}, "title": "Proteome-scale autoantibody profiling in PSC: Associations with clinical phenotypes and evidence for neuroendocrine deregulations.", "authors": [{"family": "Cornillet", "given": "Martin", "initials": "M", "orcid": "0000-0001-7981-0927", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8f2b2dde303f445e8c47f726a9dbf6ae.json"}}, {"family": "B\u00e5ve", "given": "Aiva Lundberg", "initials": "AL"}, {"family": "Sun", "given": "Dan", "initials": "D"}, {"family": "Nouairia", "given": "Ghada", "initials": "G"}, {"family": "Villard", "given": "Christina", "initials": "C"}, {"family": "Grigoriadis", "given": "Aristeidis", "initials": "A"}, {"family": "von Seth", "given": "Erik", "initials": "E"}, {"family": "Jansson", "given": "Hannes", "initials": "H"}, {"family": "\u00c1lvez", "given": "Mar\u00eda Bueno", "initials": "MB", "orcid": "0000-0002-2669-7796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7d09e4780a445b9b432d494c76d07e8.json"}}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Edfors", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-0017-7987", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e213b04f8984c8eb00c68f5bc2f6a36.json"}}, {"family": "St\u00e5l", "given": "Per", "initials": "P"}, {"family": "SweHep consortium", "given": "", "initials": ""}, {"family": "Sparrelid", "given": "Ernesto", "initials": "E"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ded8cd7038b4c42ac16f62f89b9229c.json"}}, {"family": "Halfvarson", "given": "Jonas", "initials": "J", "orcid": "0000-0003-0122-7234", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4dfcde6a8f74a179e0bb0f37dee1f4b.json"}}, {"family": "Bergquist", "given": "Annika", "initials": "A"}], "type": "journal article", "published": "2026-03-00", "journal": {"title": "JHEP Rep", "issn": "2589-5559", "volume": "8", "issue": "3", "pages": "101719", "issn-l": null}, "abstract": "Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease with heterogeneous phenotypes and progression. Autoimmune traits, such as the presence of autoantibodies, are suspected to drive its heterogeneity.\n\nWe performed a proteome-scale autoantibody screen of IgG and IgA isotypes using >42,100 protein fragments. This was followed by a validation of 1,153 selected autoantibodies, in serum samples from 466 patients with PSC in a longitudinal setting using the SUPRIM cohort and 214 controls.\n\nWe identified autoantibodies associated with clinical phenotypes, biochemical and clinical severity, comorbidities, and disease progression (e.g. alkaline phosphatase and albumin level p <e-10, presence of hepatobiliary malignancies p <0.001, seroconversion before transplantation p <0.001). Rather than a single universal autoantibody marker, small patient subgroups were positive for various autoantibodies with variable specificity. Global analysis of autoantigen targets revealed an overrepresentation of proteins normally expressed in immune-privileged sites, including the brain, testis, and retina. When interrogating tissue-specific autoantigen co-expression linked to expression and splicing quantitative trait loci of PSC risk variants, the thyroid emerged as an additional relevant tissue. We also detected increased autoantibody diversity associated with PSC duration and end-stage disease, already observable several years before liver transplantation. Multiomics analysis across body compartments confirmed neuroendocrine dysregulation in PSC. Our results are provided as a resource for further studies.\n\nOverall, our data support the cryptic antigen and epitope-drifting autoimmune theories and indicate that neuroendocrine dysregulation may contribute to PSC pathogenesis.\n\nFrom a proteome-scale profiling of the SUPRIM cohort, we provide a short list of autoantibodies associated with clinical phenotypes and progression, along with the peptide sequences used to capture them. We identify across multiple datasets neuroendocrine deregulations in primary sclerosing cholangitis and provide a short list of related key plasma proteins. These data and technical details should facilitate validation studies, investigations of related pathophysiological mechanisms and development of low-cost tools for diagnostic or prognostic purposes.", "doi": "10.1016/j.jhepr.2025.101719", "pmid": "41732172", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12925457"}, {"db": "pii", "key": "S2589-5559(25)00402-1"}], "notes": [], "created": "2026-08-20T07:59:08.593Z", "modified": "2026-08-20T08:42:53.677Z"}, {"entity": "publication", "iuid": "b4162b0e192e47f185b537a36028e435", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b4162b0e192e47f185b537a36028e435.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b4162b0e192e47f185b537a36028e435"}}, "title": "Cerebrospinal fluid levels of NfM in relation to NfL and pNfH as prognostic markers in amyotrophic lateral sclerosis.", "authors": [{"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Mravinacov\u00e1", "given": "S\u00e1ra", "initials": "S", "orcid": "0000-0003-1848-910X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1e48837666642b18a977bb8a8c39603.json"}}, {"family": "Kl\u00e4ppe", "given": "Ulf", "initials": "U", "orcid": "0000-0001-5832-038X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3939bb5c873241299ce82d2aec37457a.json"}}, {"family": "\u00d6ijerstedt", "given": "Linn", "initials": "L", "orcid": "0000-0003-0635-6377", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d1c8d008d08491b9e40516ce0c5806a.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18365a2ea4ec4ca2baeb657cd1c8bd8f.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f920b41aab42f0a43a32bbe34035b2.json"}}, {"family": "Ingre", "given": "Caroline", "initials": "C", "orcid": "0000-0001-5327-7204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e6a44fc40ff4b38a3b1da5cf2e8661e.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}], "type": "journal article", "published": "2025-02-00", "journal": {"title": "Amyotroph Lateral Scler Frontotemporal Degener", "issn": "2167-9223", "volume": "26", "issue": "1-2", "pages": "113-123", "issn-l": null}, "abstract": "To evaluate the prognostic potential of neurofilament medium chain (NfM) in CSF from patients with ALS and explore its relationship with the extensively studied neurofilament light chain (NfL) and phosphorylated heavy chain (pNfH).\n\nCSF levels of NfL, NfM, and pNfH were analyzed in 235 samples from patients with ALS, ALS mimics, and healthy controls in a well-characterized cohort from Karolinska ALS Clinical Research Center in Stockholm, Sweden. NfM levels were analyzed using an antibody-based suspension bead-array and NfL and pNfH levels were measured using ELISA. Clinical data, including ALS Revised Functional Rating Scale (ALSFRS-R), and survival outcomes were utilized for disease progression estimations.\n\nIncreased NfM levels were observed in patients with ALS compared with mimics and healthy controls. Similarly, higher NfM levels were found in fast compared with slow progressing patients for baseline and longitudinal progression when evaluating both total and subscores of ALSFRS-R. These findings were consistent with the results observed for NfL and pNfH. All three proteins, used individually as well as in combination, showed comparable performance when classifying fast vs slow progressing patients (AUCs 0.78-0.85). For all neurofilaments, higher survival probability was observed for patients with low CSF levels.\n\nBased on this cross-sectional study, the prognostic value provided by NfM aligns with the more established markers, NfL and pNfH. Additional investigations with independent cohorts and longitudinal studies are needed to further assess the potential added value of NfM.", "doi": "10.1080/21678421.2024.2428930", "pmid": "39575564", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T09:37:40.836Z", "modified": "2026-08-20T09:37:41.085Z"}, {"entity": "publication", "iuid": "bea27aac30214f489afdb3c8ba1ddcd2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bea27aac30214f489afdb3c8ba1ddcd2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bea27aac30214f489afdb3c8ba1ddcd2"}}, "title": "Cerebrospinal fluid levels of NfM in relation to NfL and pNfH as prognostic markers in amyotrophic lateral sclerosis", "authors": [{"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Mravinacov\u00e1", "given": "S\u00e1ra", "initials": "S", "orcid": "0000-0003-1848-910X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1e48837666642b18a977bb8a8c39603.json"}}, {"family": "Kl\u00e4ppe", "given": "Ulf", "initials": "U", "orcid": "0000-0001-5832-038X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3939bb5c873241299ce82d2aec37457a.json"}}, {"family": "\u00d6ijerstedt", "given": "Linn", "initials": "L", "orcid": "0000-0003-0635-6377", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d1c8d008d08491b9e40516ce0c5806a.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18365a2ea4ec4ca2baeb657cd1c8bd8f.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f920b41aab42f0a43a32bbe34035b2.json"}}, {"family": "Ingre", "given": "Caroline", "initials": "C", "orcid": "0000-0001-5327-7204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e6a44fc40ff4b38a3b1da5cf2e8661e.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}], "type": "posted-content", "published": "2024-07-10", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.07.09.24310135", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:55:36.267Z", "modified": "2026-08-20T10:55:36.374Z"}, {"entity": "publication", "iuid": "7e607955637a4b4aafa78db842ae0bbb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7e607955637a4b4aafa78db842ae0bbb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7e607955637a4b4aafa78db842ae0bbb"}}, "title": "Addressing inter-individual variability in CSF levels of brain-derived proteins across neurodegenerative diseases", "authors": [{"family": "Mravinacov\u00e1", "given": "S\u00e1ra", "initials": "S"}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "de San Jos\u00e9", "given": "Nerea G\u00f3mez", "initials": "NG"}, {"family": "Anderl-Straub", "given": "Sarah", "initials": "S", "orcid": "0000-0003-1848-910X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1e48837666642b18a977bb8a8c39603.json"}}, {"family": "Diehl-Schmid", "given": "Janine", "initials": "J"}, {"family": "Fassbender", "given": "Klaus", "initials": "K"}, {"family": "Fliessbach", "given": "Klaus", "initials": "K"}, {"family": "Jahn", "given": "Holger", "initials": "H"}, {"family": "Kornhuber", "given": "Johannes", "initials": "J"}, {"family": "Landwehrmeyer", "given": "G Bernhard", "initials": "GB"}, {"family": "Lauer", "given": "Martin", "initials": "M"}, {"family": "Levin", "given": "Johannes", "initials": "J"}, {"family": "Ludolph", "given": "Albert C", "initials": "AC"}, {"family": "Prudlo", "given": "Johannes", "initials": "J"}, {"family": "Schneider", "given": "Anja", "initials": "A"}, {"family": "Schroeter", "given": "Matthias L", "initials": "ML"}, {"family": "Wiltfang", "given": "Jens", "initials": "J"}, {"family": "Steinacker", "given": "Petra", "initials": "P"}, {"family": "Otto", "given": "Markus", "initials": "M", "orcid": "0000-0003-4273-4267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5bee470b0e4e45a2b553d849d8299e2f.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}], "type": "posted-content", "published": "2024-05-27", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.05.27.24307739", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:54:55.969Z", "modified": "2026-08-20T10:54:56.092Z"}, {"entity": "publication", "iuid": "e5f9d25a238f4754b469ec1ab0e94c1e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e5f9d25a238f4754b469ec1ab0e94c1e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e5f9d25a238f4754b469ec1ab0e94c1e"}}, "title": "A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study.", "authors": [{"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "\u00d6ijerstedt", "given": "Linn", "initials": "L"}, {"family": "Remnest\u00e5l", "given": "Julia", "initials": "J"}, {"family": "Olofsson", "given": "Jennie", "initials": "J"}, {"family": "Ullgren", "given": "Abbe", "initials": "A"}, {"family": "Seelaar", "given": "Harro", "initials": "H"}, {"family": "van Swieten", "given": "John C", "initials": "JC"}, {"family": "Synofzik", "given": "Matthis", "initials": "M"}, {"family": "Sanchez-Valle", "given": "Raquel", "initials": "R"}, {"family": "Moreno", "given": "Fermin", "initials": "F"}, {"family": "Finger", "given": "Elizabeth", "initials": "E"}, {"family": "Masellis", "given": "Mario", "initials": "M"}, {"family": "Tartaglia", "given": "Carmela", "initials": "C"}, {"family": "Vandenberghe", "given": "Rik", "initials": "R"}, {"family": "Laforce", "given": "Robert", "initials": "R"}, {"family": "Galimberti", "given": "Daniela", "initials": "D"}, {"family": "Borroni", "given": "Barbara", "initials": "B"}, {"family": "Butler", "given": "Chris R", "initials": "CR"}, {"family": "Gerhard", "given": "Alexander", "initials": "A"}, {"family": "Ducharme", "given": "Simon", "initials": "S"}, {"family": "Rohrer", "given": "Jonathan D", "initials": "JD"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Graff", "given": "Caroline", "initials": "C"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Genetic Frontotemporal Dementia Initiative (GENFI)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-27", "journal": {"title": "Mol Neurodegener", "issn": "1750-1326", "volume": "16", "issue": "1", "pages": "79", "issn-l": "1750-1326"}, "abstract": "A detailed understanding of the pathological processes involved in genetic frontotemporal dementia is critical in order to provide the patients with an optimal future treatment. Protein levels in CSF have the potential to reflect different pathophysiological processes in the brain. We aimed to identify and evaluate panels of CSF proteins with potential to separate symptomatic individuals from individuals without clinical symptoms (unaffected), as well as presymptomatic individuals from mutation non-carriers.\n\nA multiplexed antibody-based suspension bead array was used to analyse levels of 111 proteins in CSF samples from 221 individuals from families with genetic frontotemporal dementia. The data was explored using LASSO and Random forest.\n\nWhen comparing affected individuals with unaffected individuals, 14 proteins were identified as potentially important for the separation. Among these, four were identified as most important, namely neurofilament medium polypeptide (NEFM), neuronal pentraxin 2 (NPTX2), neurosecretory protein VGF (VGF) and aquaporin 4 (AQP4). The combined profile of these four proteins successfully separated the two groups, with higher levels of NEFM and AQP4 and lower levels of NPTX2 in affected compared to unaffected individuals. VGF contributed to the models, but the levels were not significantly lower in affected individuals. Next, when comparing presymptomatic GRN and C9orf72 mutation carriers in proximity to symptom onset with mutation non-carriers, six proteins were identified with a potential to contribute to a separation, including progranulin (GRN).\n\nIn conclusion, we have identified several proteins with the combined potential to separate affected individuals from unaffected individuals, as well as proteins with potential to contribute to the separation between presymptomatic individuals and mutation non-carriers. Further studies are needed to continue the investigation of these proteins and their potential association to the pathophysiological mechanisms in genetic FTD.", "doi": "10.1186/s13024-021-00499-4", "pmid": "34838088", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8626910"}, {"db": "pii", "key": "10.1186/s13024-021-00499-4"}], "notes": [], "created": "2026-08-20T12:21:10.274Z", "modified": "2026-08-20T12:21:10.358Z"}, {"entity": "publication", "iuid": "59b004c7df1d4131a8eedb6051b9167b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/59b004c7df1d4131a8eedb6051b9167b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/59b004c7df1d4131a8eedb6051b9167b"}}, "title": "Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease.", "authors": [{"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Remnest\u00e5l", "given": "Julia", "initials": "J", "orcid": "0000-0002-3908-6476", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0122e5bb49d3421696fcbb64f99eea41.json"}}, {"family": "Yousef", "given": "Jamil", "initials": "J", "orcid": "0000-0001-5915-1258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0c4a7070f339466690b40d63ad6ea769.json"}}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "Markaki", "given": "Ioanna", "initials": "I", "orcid": "0000-0003-3328-5746", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f31c405d780a4beeb64971dabd57cafd.json"}}, {"family": "Carvalho", "given": "Stephanie", "initials": "S"}, {"family": "Corvol", "given": "Jean-Christophe", "initials": "JC", "orcid": "0000-0001-7325-0199", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81bf347acb7349dfa3d7c22483c1fba4.json"}}, {"family": "Kultima", "given": "Kim", "initials": "K", "orcid": "0000-0002-0680-1410", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7dd4024d15a43a4a2395315af99d580.json"}}, {"family": "Kilander", "given": "Lena", "initials": "L"}, {"family": "L\u00f6wenmark", "given": "Malin", "initials": "M"}, {"family": "Ingelsson", "given": "Martin", "initials": "M", "orcid": "0000-0001-5466-8370", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9cdd74196957459fa3618c6bd2c35ff8.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f920b41aab42f0a43a32bbe34035b2.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18365a2ea4ec4ca2baeb657cd1c8bd8f.json"}}, {"family": "Nellg\u00e5rd", "given": "Bengt", "initials": "B", "orcid": "0000-0001-6791-8893", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0815ffb8b9404272a26b28cb11f001ba.json"}}, {"family": "Brosseron", "given": "Frederic", "initials": "F", "orcid": "0000-0003-3137-7516", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d8a371f4aaa4ba59389f30bd9349c1f.json"}}, {"family": "Heneka", "given": "Michael T", "initials": "MT", "orcid": "0000-0003-4996-1630", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8da023abc6974d4582fe3c688a483950.json"}}, {"family": "Bosch", "given": "Beatriz", "initials": "B", "orcid": "0000-0002-6094-0024", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd5741747488412c9c8334a97e7302ad.json"}}, {"family": "Sanchez-Valle", "given": "Raquel", "initials": "R", "orcid": "0000-0001-7750-896X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2bba6a10e4cd4b0180ccc900d70fd869.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Ann Clin Transl Neurol", "issn": "2328-9503", "volume": "8", "issue": "7", "pages": "1456-1470", "issn-l": "2328-9503"}, "abstract": "Decreased amyloid beta (A\u03b2) 42 together with increased tau and phospho-tau in cerebrospinal fluid (CSF) is indicative of Alzheimer's disease (AD). However, the molecular pathophysiology underlying the slowly progressive cognitive decline observed in AD is not fully understood and it is not known what other CSF biomarkers may be altered in early disease stages.\n\nWe utilized an antibody-based suspension bead array to analyze levels of 216 proteins in CSF from AD patients, patients with mild cognitive impairment (MCI), and controls from two independent cohorts collected within the AETIONOMY consortium. Two additional cohorts from Sweden were used for biological verification.\n\nSix proteins, amphiphysin (AMPH), aquaporin 4 (AQP4), cAMP-regulated phosphoprotein 21 (ARPP21), growth-associated protein 43 (GAP43), neurofilament medium polypeptide (NEFM), and synuclein beta (SNCB) were found at increased levels in CSF from AD patients compared with controls. Next, we used CSF levels of A\u03b242 and tau for the stratification of the MCI patients and observed increased levels of AMPH, AQP4, ARPP21, GAP43, and SNCB in the MCI subgroups with abnormal tau levels compared with controls. Further characterization revealed strong to moderate correlations between these five proteins and tau concentrations.\n\nIn conclusion, we report six extensively replicated candidate biomarkers with the potential to reflect disease development. Continued evaluation of these proteins will determine to what extent they can aid in the discrimination of MCI patients with and without an underlying AD etiology, and if they have the potential to contribute to a better understanding of the AD continuum.", "doi": "10.1002/acn3.51402", "pmid": "34129723", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8283172"}], "notes": [], "created": "2026-08-20T06:27:18.835Z", "modified": "2026-08-20T06:27:19.431Z"}, {"entity": "publication", "iuid": "7eeee9d1d2884e55b87d5c50ba3abbad", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7eeee9d1d2884e55b87d5c50ba3abbad.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7eeee9d1d2884e55b87d5c50ba3abbad"}}, "title": "Association of CSF proteins with tau and amyloid \u03b2 levels in asymptomatic 70-year-olds.", "authors": [{"family": "Remnest\u00e5l", "given": "Julia", "initials": "J", "orcid": "0000-0002-3908-6476", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0122e5bb49d3421696fcbb64f99eea41.json"}}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "Sj\u00f6stedt", "given": "Evelina", "initials": "E", "orcid": "0000-0002-0327-7377", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec6fb5a1c88b44798144fd2de255fb00.json"}}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f920b41aab42f0a43a32bbe34035b2.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18365a2ea4ec4ca2baeb657cd1c8bd8f.json"}}, {"family": "Zettergren", "given": "Anna", "initials": "A"}, {"family": "Kern", "given": "Silke", "initials": "S"}, {"family": "Skoog", "given": "Ingmar", "initials": "I"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}], "type": "journal article", "published": "2021-03-02", "journal": {"title": "Alzheimers Res Ther", "issn": "1758-9193", "volume": "13", "issue": "1", "pages": "54", "issn-l": null}, "abstract": "Increased knowledge of the evolution of molecular changes in neurodegenerative disorders such as Alzheimer's disease (AD) is important for the understanding of disease pathophysiology and also crucial to be able to identify and validate disease biomarkers. While several biological changes that occur early in the disease development have already been recognized, the need for further characterization of the pathophysiological mechanisms behind AD still remains.\n\nIn this study, we investigated cerebrospinal fluid (CSF) levels of 104 proteins in 307 asymptomatic 70-year-olds from the H70 Gothenburg Birth Cohort Studies using a multiplexed antibody- and bead-based technology.\n\nThe protein levels were first correlated with the core AD CSF biomarker concentrations of total tau, phospho-tau and amyloid beta (A\u03b242) in all individuals. Sixty-three proteins showed significant correlations to either total tau, phospho-tau or A\u03b242. Thereafter, individuals were divided based on CSF A\u03b242/A\u03b240 ratio and Clinical Dementia Rating (CDR) score to determine if early changes in pathology and cognition had an effect on the correlations. We compared the associations of the analysed proteins with CSF markers between groups and found 33 proteins displaying significantly different associations for amyloid-positive individuals and amyloid-negative individuals, as defined by the CSF A\u03b242/A\u03b240 ratio. No differences in the associations could be seen for individuals divided by CDR score.\n\nWe identified a series of transmembrane proteins, proteins associated with or anchored to the plasma membrane, and proteins involved in or connected to synaptic vesicle transport to be associated with CSF biomarkers of amyloid and tau pathology in AD. Further studies are needed to explore these proteins' role in AD pathophysiology.", "doi": "10.1186/s13195-021-00789-5", "pmid": "33653397", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7923505"}, {"db": "pii", "key": "10.1186/s13195-021-00789-5"}], "notes": [], "created": "2026-08-20T12:22:13.883Z", "modified": "2026-08-20T12:23:59.358Z"}]}