{"entity": "researcher", "timestamp": "2026-08-20T20:54:23.238Z", "family": "Chagin", "given": "Andrei S", "initials": "AS", "orcid": "0000-0002-2696-5850", "affiliations": ["Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg SE41346, Sweden.", "Science for Life Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg SE41346, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/5462b12a00ec40cc98abf23697a0a155.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/5462b12a00ec40cc98abf23697a0a155"}}, "publications": [{"entity": "publication", "iuid": "9d108c99e98c4d80a06c646b00e290c6", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9d108c99e98c4d80a06c646b00e290c6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9d108c99e98c4d80a06c646b00e290c6"}}, "title": "Growth hormone regulates the stem cell population in the growth plate.", "authors": [{"family": "Chu", "given": "Nelson Tsz Long", "initials": "NTL"}, {"family": "Zhou", "given": "Baoyi", "initials": "B"}, {"family": "Heinonen", "given": "Jussi O", "initials": "JO"}, {"family": "Dregval", "given": "Ostap", "initials": "O", "orcid": "0000-0002-9939-6492", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0505c2478e9d4dc7918d0eed413fae7b.json"}}, {"family": "Liu", "given": "Xin", "initials": "X"}, {"family": "Trompet", "given": "Dana", "initials": "D", "orcid": "0000-0001-9472-6184", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/475563d3b4094962932ae0c1ee0a7484.json"}}, {"family": "Tian", "given": "Xin", "initials": "X"}, {"family": "Newton", "given": "Phillip T", "initials": "PT"}, {"family": "S\u00e4vendahl", "given": "Lars", "initials": "L", "orcid": "0000-0003-1067-4976", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/542fce098ce94d62bd68fbe13fbb2ba2.json"}}, {"family": "Bendre", "given": "Ameya", "initials": "A"}, {"family": "Nilsson", "given": "Ola", "initials": "O"}, {"family": "Ohlsson", "given": "Claes", "initials": "C", "orcid": "0000-0002-9633-2805", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f3787ec4ade6486ba486cd97e4bc8f62.json"}}, {"family": "Chagin", "given": "Andrei S", "initials": "AS", "orcid": "0000-0002-2696-5850", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5462b12a00ec40cc98abf23697a0a155.json"}}], "type": "journal article", "published": "2025-12-02", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "122", "issue": "48", "pages": "e2512316122", "issn-l": "0027-8424"}, "abstract": "Growth hormone (GH) is a key systemic regulator of longitudinal bone growth and is widely used in pediatric endocrinology, including in patients without GH deficiency. Its primary target is the growth plate-a cartilaginous structure driving bone elongation-yet the cellular mechanisms underlying GH action remain incompletely understood. Here, we identify a direct role for GH in regulating a recently defined population of cartilaginous stem cells within the growth plate. Using multiple transgenic mouse models, we show that GH reduces the pool of slow-cycling, label-retaining stem cells by promoting their differentiation into transient progenitors. Clonal and lineage-tracing analyses reveal that these stem cells renew via population asymmetry and that GH promotes their committed cell division, leading to stem cell depletion. Conversely, genetic deletion of the GH receptor in stem cells impairs their ability to generate chondrocytes, confirming a direct GH effect. These findings support a general principle by which endocrine cues regulate tissue regeneration, establish a mechanistic link between GH signaling and cartilaginous stem cells, and provide a potential explanation for certain related clinical observations, such as the declining long-term efficacy of GH therapy.", "doi": "10.1073/pnas.2512316122", "pmid": "41289405", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12685065"}], "notes": [], "created": "2026-08-20T09:31:59.724Z", "modified": "2026-08-20T09:32:00.016Z"}, {"entity": "publication", "iuid": "1d3a92266e6b4a8bb44b912f9fc6b2da", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1d3a92266e6b4a8bb44b912f9fc6b2da.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1d3a92266e6b4a8bb44b912f9fc6b2da"}}, "title": "Secondary ossification center induces and protects growth plate structure.", "authors": [{"family": "Xie", "given": "Meng", "initials": "M", "orcid": "0000-0002-6388-9789", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/99ccaba9763a44ce8abb59161437a5db.json"}}, {"family": "Gol'din", "given": "Pavel", "initials": "P", "orcid": "0000-0001-6118-1384", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/11e06a7bed5d4222bdd23455da239fb5.json"}}, {"family": "Herdina", "given": "Anna Nele", "initials": "AN"}, {"family": "Estefa", "given": "Jordi", "initials": "J"}, {"family": "Medvedeva", "given": "Ekaterina V", "initials": "EV"}, {"family": "Li", "given": "Lei", "initials": "L"}, {"family": "Newton", "given": "Phillip T", "initials": "PT"}, {"family": "Kotova", "given": "Svetlana", "initials": "S"}, {"family": "Shavkuta", "given": "Boris", "initials": "B"}, {"family": "Saxena", "given": "Aditya", "initials": "A"}, {"family": "Shumate", "given": "Lauren T", "initials": "LT"}, {"family": "Metscher", "given": "Brian D", "initials": "BD", "orcid": "0000-0002-6514-4406", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef7737ae358c4fc982451afd33edbacc.json"}}, {"family": "Gro\u00dfschmidt", "given": "Karl", "initials": "K"}, {"family": "Nishimori", "given": "Shigeki", "initials": "S"}, {"family": "Akovantseva", "given": "Anastasia", "initials": "A"}, {"family": "Usanova", "given": "Anna P", "initials": "AP"}, {"family": "Kurenkova", "given": "Anastasiia D", "initials": "AD"}, {"family": "Kumar", "given": "Anoop", "initials": "A"}, {"family": "Arregui", "given": "Irene Linares", "initials": "IL"}, {"family": "Tafforeau", "given": "Paul", "initials": "P", "orcid": "0000-0002-5962-1683", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc796a4aa6db46959163e63987941090.json"}}, {"family": "Fried", "given": "Kaj", "initials": "K"}, {"family": "Carlstr\u00f6m", "given": "Mattias", "initials": "M"}, {"family": "Simon", "given": "Andr\u00e1s", "initials": "A", "orcid": "0000-0002-1018-1891", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7a372ee7f69f4c81890b8b6bdebdbd98.json"}}, {"family": "Gasser", "given": "Christian", "initials": "C"}, {"family": "Kronenberg", "given": "Henry M", "initials": "HM"}, {"family": "Bastepe", "given": "Murat", "initials": "M"}, {"family": "Cooper", "given": "Kimberly L", "initials": "KL", "orcid": "0000-0001-5892-8838", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/770e26e66fcc4695b67ad92efbed72bb.json"}}, {"family": "Timashev", "given": "Peter", "initials": "P"}, {"family": "Sanchez", "given": "Sophie", "initials": "S", "orcid": "0000-0002-3611-6836", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c7647316434c445a98baaa30ba295f90.json"}}, {"family": "Adameyko", "given": "Igor", "initials": "I", "orcid": "0000-0001-5471-0356", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9991e2eddb0840dca291de18a9d77d13.json"}}, {"family": "Eriksson", "given": "Anders", "initials": "A"}, {"family": "Chagin", "given": "Andrei S", "initials": "AS", "orcid": "0000-0002-2696-5850", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5462b12a00ec40cc98abf23697a0a155.json"}}], "type": "journal article", "published": "2020-10-16", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "9", "issn-l": "2050-084X"}, "abstract": "Growth plate and articular cartilage constitute a single anatomical entity early in development but later separate into two distinct structures by the secondary ossification center (SOC). The reason for such separation remains unknown. We found that evolutionarily SOC appears in animals conquering the land - amniotes. Analysis of the ossification pattern in mammals with specialized extremities (whales, bats, jerboa) revealed that SOC development correlates with the extent of mechanical loads. Mathematical modeling revealed that SOC reduces mechanical stress within the growth plate. Functional experiments revealed the high vulnerability of hypertrophic chondrocytes to mechanical stress and showed that SOC protects these cells from apoptosis caused by extensive loading. Atomic force microscopy showed that hypertrophic chondrocytes are the least mechanically stiff cells within the growth plate. Altogether, these findings suggest that SOC has evolved to protect the hypertrophic chondrocytes from the high mechanical stress encountered in the terrestrial environment.", "doi": "10.7554/eLife.55212", "pmid": "33063669", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7581430"}, {"db": "pii", "key": "55212"}], "notes": [], "created": "2026-08-20T13:53:05.309Z", "modified": "2026-08-20T13:53:05.620Z"}, {"entity": "publication", "iuid": "23dab60545934c6ba3812534360dd4e5", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/23dab60545934c6ba3812534360dd4e5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/23dab60545934c6ba3812534360dd4e5"}}, "title": "Author response: Secondary ossification center induces and protects growth plate structure", "authors": [{"family": "Xie", "given": "Meng", "initials": "M", "orcid": "0000-0002-6388-9789", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/99ccaba9763a44ce8abb59161437a5db.json"}}, {"family": "Gol'din", "given": "Pavel", "initials": "P", "orcid": "0000-0001-6118-1384", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/11e06a7bed5d4222bdd23455da239fb5.json"}}, {"family": "Herdina", "given": "Anna Nele", "initials": "AN"}, {"family": "Estefa", "given": "Jordi", "initials": "J"}, {"family": "Medvedeva", "given": "Ekaterina V", "initials": "EV"}, {"family": "Li", "given": "Lei", "initials": "L"}, {"family": "Newton", "given": "Phillip T", "initials": "PT"}, {"family": "Kotova", "given": "Svetlana", "initials": "S"}, {"family": "Shavkuta", "given": "Boris", "initials": "B"}, {"family": "Saxena", "given": "Aditya", "initials": "A"}, {"family": "Shumate", "given": "Lauren T", "initials": "LT"}, {"family": "Metscher", "given": "Brian D", "initials": "BD", "orcid": "0000-0002-6514-4406", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef7737ae358c4fc982451afd33edbacc.json"}}, {"family": "Gro\u00dfschmidt", "given": "Karl", "initials": "K"}, {"family": "Nishimori", "given": "Shigeki", "initials": "S"}, {"family": "Akovantseva", "given": "Anastasia", "initials": "A"}, {"family": "Usanova", "given": "Anna P", "initials": "AP"}, {"family": "Kurenkova", "given": "Anastasiia D", "initials": "AD"}, {"family": "Kumar", "given": "Anoop", "initials": "A"}, {"family": "Arregui", "given": "Irene Linares", "initials": "IL"}, {"family": "Tafforeau", "given": "Paul", "initials": "P", "orcid": "0000-0002-5962-1683", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc796a4aa6db46959163e63987941090.json"}}, {"family": "Fried", "given": "Kaj", "initials": "K"}, {"family": "Carlstr\u00f6m", "given": "Mattias", "initials": "M"}, {"family": "Simon", "given": "Andr\u00e1s", "initials": "A", "orcid": "0000-0002-1018-1891", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7a372ee7f69f4c81890b8b6bdebdbd98.json"}}, {"family": "Gasser", "given": "Christian", "initials": "C"}, {"family": "Kronenberg", "given": "Henry M", "initials": "HM"}, {"family": "Bastepe", "given": "Murat", "initials": "M"}, {"family": "Cooper", "given": "Kimberly L", "initials": "KL", "orcid": "0000-0001-5892-8838", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/770e26e66fcc4695b67ad92efbed72bb.json"}}, {"family": "Timashev", "given": "Peter", "initials": "P"}, {"family": "Sanchez", "given": "Sophie", "initials": "S", "orcid": "0000-0002-3611-6836", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c7647316434c445a98baaa30ba295f90.json"}}, {"family": "Adameyko", "given": "Igor", "initials": "I", "orcid": "0000-0001-5471-0356", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9991e2eddb0840dca291de18a9d77d13.json"}}, {"family": "Eriksson", "given": "Anders", "initials": "A"}, {"family": "Chagin", "given": "Andrei S", "initials": "AS", "orcid": "0000-0002-2696-5850", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5462b12a00ec40cc98abf23697a0a155.json"}}], "type": "peer-review", "published": "2020-09-04", "journal": {"issn-l": null}, "abstract": null, "doi": "10.7554/elife.55212.sa2", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:53:07.401Z", "modified": "2026-08-20T13:53:07.460Z"}, {"entity": "publication", "iuid": "df0143c9c2e641c58ea465c80ca73195", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/df0143c9c2e641c58ea465c80ca73195.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/df0143c9c2e641c58ea465c80ca73195"}}, "title": "Author response: Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage", "authors": [{"family": "Kaucka", "given": "Marketa", "initials": "M", "orcid": "0000-0002-8781-9769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a458c8d68ec049a287848d4051ff84e7.json"}}, {"family": "Zikmund", "given": "Tomas", "initials": "T"}, {"family": "Tesarova", "given": "Marketa", "initials": "M"}, {"family": "Gyllborg", "given": "Daniel", "initials": "D"}, {"family": "Hellander", "given": "Andreas", "initials": "A"}, {"family": "Jaros", "given": "Josef", "initials": "J"}, {"family": "Kaiser", "given": "Jozef", "initials": "J"}, {"family": "Petersen", "given": "Julian", "initials": "J"}, {"family": "Szarowska", "given": "Bara", "initials": "B"}, {"family": "Newton", "given": "Phillip T", "initials": "PT"}, {"family": "Dyachuk", "given": "Vyacheslav", "initials": "V"}, {"family": "Li", "given": "Lei", "initials": "L"}, {"family": "Qian", "given": "Hong", "initials": "H"}, {"family": "Johansson", "given": "Anne Sofie", "initials": "AS"}, {"family": "Mishina", "given": "Yuji", "initials": "Y"}, {"family": "Currie", "given": "Joshua D", "initials": "JD"}, {"family": "Tanaka", "given": "Elly M", "initials": "EM"}, {"family": "Erickson", "given": "Alek", "initials": "A"}, {"family": "Dudley", "given": "Andrew", "initials": "A"}, {"family": "Brismar", "given": "Hjalmar", "initials": "H", "orcid": "0000-0003-0578-4003", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04321d9fb805493db538489927a42c8f.json"}}, {"family": "Southam", "given": "Paul", "initials": "P"}, {"family": "Coen", "given": "Enrico", "initials": "E", "orcid": "0000-0001-8454-8767", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c3a6d6cd2a734485837ab289f6fd6020.json"}}, {"family": "Chen", "given": "Min", "initials": "M"}, {"family": "Weinstein", "given": "Lee S", "initials": "LS"}, {"family": "Hampl", "given": "Ales", "initials": "A"}, {"family": "Arenas", "given": "Ernest", "initials": "E"}, {"family": "Chagin", "given": "Andrei S", "initials": "AS", "orcid": "0000-0002-2696-5850", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5462b12a00ec40cc98abf23697a0a155.json"}}, {"family": "Fried", "given": "Kaj", "initials": "K"}, {"family": "Adameyko", "given": "Igor", "initials": "I", "orcid": "0000-0001-5471-0356", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9991e2eddb0840dca291de18a9d77d13.json"}}], "type": "peer-review", "published": "2017-03-31", "journal": {"issn-l": null}, "abstract": null, "doi": "10.7554/elife.25902.028", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:52:12.549Z", "modified": "2026-08-20T13:52:12.737Z"}]}