{"entity": "researcher", "timestamp": "2026-09-25T23:03:01.468Z", "family": "R\u00f6nnelid", "given": "Olle", "initials": "O", "orcid": "0000-0003-1277-5885", "affiliations": ["Department of Biomedical and Clinical Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/53d56cb67dbc4632b77b60bd97f1ac33.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/53d56cb67dbc4632b77b60bd97f1ac33"}}, "publications": [{"entity": "publication", "iuid": "6b7969775f674dfaa807900ac15d62ef", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6b7969775f674dfaa807900ac15d62ef.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6b7969775f674dfaa807900ac15d62ef"}}, "title": "Carboxyl-group compounds activate voltage-gated potassium channels via a distinct mechanism.", "authors": [{"family": "R\u00f6nnelid", "given": "Olle", "initials": "O", "orcid": "0000-0003-1277-5885", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/53d56cb67dbc4632b77b60bd97f1ac33.json"}}, {"family": "Elinder", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-9125-5583", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6af26d4c0637492696fb91a3417fe902.json"}}], "type": "journal article", "published": "2024-07-01", "journal": {"title": "J. Gen. Physiol.", "issn": "1540-7748", "volume": "156", "issue": "7", "issn-l": "0022-1295"}, "abstract": "Voltage-gated ion channels are responsible for the electrical excitability of neurons and cardiomyocytes. Thus, they are obvious targets for pharmaceuticals aimed to modulate excitability. Compounds activating voltage-gated potassium (KV) channels are expected to reduce excitability. To search for new KV-channel activators, we performed a high-throughput screen of 10,000 compounds on a specially designed Shaker KV channel. Here, we report on a large family of channel-activating compounds with a carboxyl (COOH) group as the common motif. The most potent COOH activators are lipophilic (4 < LogP <7) and are suggested to bind at the interface between the lipid bilayer and the channel's positively charged voltage sensor. The negatively charged form of the COOH-group compounds is suggested to open the channel by electrostatically pulling the voltage sensor to an activated state. Several of the COOH-group compounds also activate the therapeutically important KV7.2/7.3 channel and can thus potentially be developed into antiseizure drugs. The COOH-group compounds identified in this study are suggested to act via the same site and mechanism of action as previously studied COOH-group compounds, such as polyunsaturated fatty acids and resin acids, but distinct from sites for several other types of potassium channel-activating compounds.", "doi": "10.1085/jgp.202313516", "pmid": "38832889", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11148469"}, {"db": "pii", "key": "276783"}], "notes": [], "created": "2026-09-23T13:36:03.108Z", "modified": "2026-09-23T13:36:03.168Z"}]}