{"entity": "researcher", "timestamp": "2026-10-01T12:34:25.454Z", "family": "Rosendal", "given": "Ebba", "initials": "E", "orcid": "0000-0001-8512-0535", "affiliations": ["Laboratory for Molecular Infection Medicine Sweden, Ume\u00e5 University, Ume\u00e5, Sweden.", "Department of Clinical Microbiology, Ume\u00e5 University, Ume\u00e5, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/527527132d9a4b8fa2c1a9747122923c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/527527132d9a4b8fa2c1a9747122923c"}}, "publications": [{"entity": "publication", "iuid": "1a03c41ac6fd4bf18112a7df46175edc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1a03c41ac6fd4bf18112a7df46175edc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1a03c41ac6fd4bf18112a7df46175edc"}}, "title": "LRP8 is a receptor for tick-borne encephalitis virus.", "authors": [{"family": "Mittler", "given": "Eva", "initials": "E", "orcid": "0000-0002-5935-6314", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4c5b31d68d184056b8d592e0ff16fc80.json"}}, {"family": "Tse", "given": "Alexandra L", "initials": "AL"}, {"family": "Tran", "given": "Pham-Tue-Hung", "initials": "PT", "orcid": "0000-0002-8366-9310", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e291c109dd347a499d9e774367f3a61.json"}}, {"family": "Florez", "given": "Catalina", "initials": "C"}, {"family": "Janer", "given": "Javier", "initials": "J"}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Kasikci", "given": "Ezgi", "initials": "E"}, {"family": "Mv", "given": "Vasantha Kumar", "initials": "VK"}, {"family": "Loomis", "given": "Michaela", "initials": "M"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c3d94a38dda465b83f13ec070fef017.json"}}, {"family": "Cazares", "given": "Erik", "initials": "E", "orcid": "0000-0002-4218-9775", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2b69421ab0854ac79ff43b3a7293cd0f.json"}}, {"family": "Bakken", "given": "Russell R", "initials": "RR"}, {"family": "Martin", "given": "Caroline K", "initials": "CK", "orcid": "0000-0001-9448-9182", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a998bd3fa22547b095ac67ba374b6a0a.json"}}, {"family": "Zeng", "given": "Xiankun", "initials": "X", "orcid": "0000-0003-3526-8755", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e54b8e4f3a6644cb84adb7a809b827ca.json"}}, {"family": "Raymond", "given": "Jo Lynne", "initials": "JL"}, {"family": "Shahsavani", "given": "Mansoureh", "initials": "M", "orcid": "0000-0002-6923-8389", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/287a52b1417641428216d70f2c99ab8e.json"}}, {"family": "Khanal", "given": "Sara", "initials": "S"}, {"family": "Wilkinson", "given": "Eric R", "initials": "ER"}, {"family": "Oktavia", "given": "Rischa Maya", "initials": "RM"}, {"family": "Slough", "given": "Megan M", "initials": "MM"}, {"family": "Haslwanter", "given": "Denise", "initials": "D", "orcid": "0000-0003-2727-0468", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0abaae9f68254631bc430b584dedc64d.json"}}, {"family": "Han", "given": "Julianna", "initials": "J"}, {"family": "Berrigan", "given": "Jacob", "initials": "J"}, {"family": "Rosendal", "given": "Ebba", "initials": "E", "orcid": "0000-0001-8512-0535", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/527527132d9a4b8fa2c1a9747122923c.json"}}, {"family": "Kielian", "given": "Margaret", "initials": "M", "orcid": "0000-0002-7395-4791", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/70245420f9fe465095a52226228853e9.json"}}, {"family": "Manicassamy", "given": "Balaji", "initials": "B", "orcid": "0000-0003-1964-0967", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ab3143d19b6148ae98682010d34f1de1.json"}}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK", "orcid": "0000-0001-6553-0940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8f5941f5d40d44ffa02ff6a9cecfbee5.json"}}, {"family": "Falk", "given": "Anna", "initials": "A", "orcid": "0000-0003-1634-8610", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a8825c33511418a83eceffdb530dadb.json"}}, {"family": "Barba-Spaeth", "given": "Giovanna", "initials": "G", "orcid": "0000-0003-2069-9501", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a38b802ee4e46e09c005bc1be85815a.json"}}, {"family": "Rey", "given": "Felix A", "initials": "FA", "orcid": "0000-0002-9953-7988", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f0dc8bc9eda741ec9408148e314fe489.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6265be732af0469d9d58bf5a46e8cf7d.json"}}, {"family": "Gavathiotis", "given": "Evripidis", "initials": "E", "orcid": "0000-0001-6319-8331", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/019589736fc145da94fcd9f1fc69ef1d.json"}}, {"family": "Herbert", "given": "Andrew S", "initials": "AS", "orcid": "0009-0001-5256-7733", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d7c87cfb68d4d06b3ad7a313b689190.json"}}, {"family": "Chandran", "given": "Kartik", "initials": "K", "orcid": "0000-0003-0232-7077", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2315206d98fc424988f645b0fea32571.json"}}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S", "orcid": "0000-0002-2446-4323", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/901576abf4ff4aa6963c9e8d0610f08d.json"}}], "type": "journal article", "published": "2025-10-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "646", "issue": "8086", "pages": "945-952", "issn-l": "0028-0836"}, "abstract": "Tick-borne encephalitis virus (TBEV) causes tick-borne encephalitis (TBE), a severe and sometimes life-threatening disease characterized by viral invasion of the central nervous system with symptoms of neuroinflammation1,2. As with other orthoflaviviruses-enveloped, arthropod-borne RNA viruses-host factors required for TBEV entry remain poorly defined. Here we used a genome-scale CRISPR-Cas9-based screen to identify LRP8, an apolipoprotein E and reelin receptor with high expression in the brain, as a TBEV receptor. LRP8 downregulation reduced TBEV infection in human cells, and its overexpression enhanced infection. LRP8 bound directly to the TBEV E glycoprotein and mediated viral attachment and internalization into cells. An LRP8-based soluble decoy blocked infection of human cell lines and neuronal cells and protected mice from lethal TBEV challenge. LRP8's role as a TBEV receptor has implications for TBEV neuropathogenesis and the development of antiviral countermeasures.", "doi": "10.1038/s41586-025-09500-2", "pmid": "40993380", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS2172163"}, {"db": "pmc", "key": "PMC13221092"}, {"db": "pii", "key": "10.1038/s41586-025-09500-2"}], "notes": [], "created": "2026-10-01T08:24:35.800Z", "modified": "2026-10-01T08:24:36.478Z"}]}