{"entity": "researcher", "timestamp": "2026-08-20T21:09:30.997Z", "family": "Wilson", "given": "James F", "initials": "JF", "orcid": "0000-0001-5751-9178", "affiliations": ["MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.", "Usher Institute, University of Edinburgh, Edinburgh, UK."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/513b6983cc9d478ab9d81c2f21579961.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/513b6983cc9d478ab9d81c2f21579961"}}, "publications": [{"entity": "publication", "iuid": "3be6ca68230e4eb882c7de0af5ecf519", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3be6ca68230e4eb882c7de0af5ecf519.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3be6ca68230e4eb882c7de0af5ecf519"}}, "title": "The genetic landscape of neuro-related proteins in human plasma.", "authors": [{"family": "Repetto", "given": "Linda", "initials": "L", "orcid": "0000-0002-7901-4549", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/69045c694f5a4e7495c5f51d4df720b6.json"}}, {"family": "Chen", "given": "Jiantao", "initials": "J", "orcid": "0000-0002-7214-2257", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f82d7835050b4903bbc3d6dff95ebf8b.json"}}, {"family": "Yang", "given": "Zhijian", "initials": "Z", "orcid": "0000-0003-4803-8633", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/37ba93e5f6b041e4a4bea6a345adfb72.json"}}, {"family": "Zhai", "given": "Ranran", "initials": "R", "orcid": "0000-0002-5834-9120", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0aaae5317db3468384510b9727a07e02.json"}}, {"family": "Timmers", "given": "Paul R H J", "initials": "PRHJ", "orcid": "0000-0002-5197-1267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1a7fb58cb2f4bd1b48f23be33de0c6e.json"}}, {"family": "Feng", "given": "Xiao", "initials": "X", "orcid": "0000-0001-8919-6000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/038fb589749d475183d682f9c3530026.json"}}, {"family": "Li", "given": "Ting", "initials": "T", "orcid": "0000-0002-9614-1566", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/032f6825c6bb4b1284c3b3cbd95099fc.json"}}, {"family": "Yao", "given": "Yue", "initials": "Y"}, {"family": "Maslov", "given": "Denis", "initials": "D", "orcid": "0000-0003-2806-5933", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8f6b346d03a48bdab23a9b67062935b.json"}}, {"family": "Timoshchuk", "given": "Anna", "initials": "A", "orcid": "0000-0001-8529-4498", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2f9b4737e1f94049bd6ac5a35b02846b.json"}}, {"family": "Tu", "given": "Fengyu", "initials": "F", "orcid": "0000-0001-8748-7250", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f4be639f23e46f8b3940fa080a5b2ac.json"}}, {"family": "Twait", "given": "Emma L", "initials": "EL"}, {"family": "May-Wilson", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-2668-5717", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d39731ddad649e88c6958a9fc03008b.json"}}, {"family": "Muckian", "given": "Marisa D", "initials": "MD", "orcid": "0000-0003-0419-3797", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c947aba8fd348c9ab744668e54ae67e.json"}}, {"family": "Prins", "given": "Bram P", "initials": "BP"}, {"family": "Png", "given": "Grace", "initials": "G"}, {"family": "Kooperberg", "given": "Charles", "initials": "C", "orcid": "0000-0002-7986-8560", "researcher": {"href": 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"0000-0002-8658-3790", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ddd1519890740048908a596709ae693.json"}}, {"family": "Peters", "given": "James E", "initials": "JE"}, {"family": "Gilly", "given": "Arthur", "initials": "A"}, {"family": "Karaleftheri", "given": "Maria", "initials": "M"}, {"family": "Tsafantakis", "given": "Emmanouil", "initials": "E"}, {"family": "Haessler", "given": "Jeffrey", "initials": "J"}, {"family": "Gyllensten", "given": "Ulf", "initials": "U"}, {"family": "Harris", "given": "Sarah E", "initials": "SE", "orcid": "0000-0002-4941-5106", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4056bf3ecf854b1c8a2189564f6e0ded.json"}}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0003-1422-2993", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/462fd4169f41418887a5a979e0808d87.json"}}, {"family": "G\u00f6teson", "given": "Andreas", "initials": "A", "orcid": "0000-0001-6118-6054", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0969aa99508042e6b508bc528b433d82.json"}}, {"family": "Lagging", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-5692-2755", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cbe502b854d248ddb6119b9e786b8558.json"}}, {"family": "Ikram", "given": "Mohammad Arfan", "initials": "MA", "orcid": "0000-0003-0372-8585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef9df12e0e6743f5a97d73c58e75443b.json"}}, {"family": "van Duijn", "given": "Cornelia M", "initials": "CM", "orcid": "0000-0002-2374-9204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f80ecaf200f24b4092c9a6ed77dfff8d.json"}}, {"family": "Jern", "given": "Christina", "initials": "C"}, {"family": "Land\u00e9n", "given": "Mikael", "initials": "M", "orcid": "0000-0002-4496-6451", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e788f5999d644719a8c4816c88d7de3.json"}}, {"family": "Langenberg", "given": "Claudia", "initials": "C", "orcid": "0000-0002-5017-7344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f287f3248cc24c6cbfc100c249b87418.json"}}, {"family": "Deary", "given": "Ian J", "initials": "IJ", "orcid": "0000-0002-1733-263X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/15fa758fb7d84cd9b38150291f2002b5.json"}}, {"family": "Marioni", "given": "Riccardo E", "initials": "RE", "orcid": "0000-0003-4430-4260", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e9bc46c3aa1b4e379bd2eebd8bb23756.json"}}, {"family": "Enroth", "given": "Stefan", "initials": "S"}, {"family": "Reiner", "given": "Alexander P", "initials": "AP", "orcid": "0000-0002-1427-4470", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/244e81f4f21645e9b66f7b2ba6a8eb07.json"}}, {"family": "Dedoussis", "given": "George", "initials": "G"}, {"family": "Zeggini", "given": "Eleftheria", "initials": "E"}, {"family": "Sharapov", "given": "Sodbo", "initials": "S", "orcid": "0000-0003-0279-4900", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b435f6d60c674f969172aeb5216a24ae.json"}}, {"family": "Aulchenko", "given": "Yurii S", "initials": "YS"}, {"family": "Butterworth", "given": "Adam S", "initials": "AS", "orcid": "0000-0002-6915-9015", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88842023860148bb8d155b5c18db72a8.json"}}, {"family": "M\u00e4larstig", "given": "Anders", "initials": "A", "orcid": "0000-0003-2608-1358", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32b012456e6f490e99b12f5fb1216ce8.json"}}, {"family": "Wilson", "given": "James F", "initials": "JF", "orcid": "0000-0001-5751-9178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513b6983cc9d478ab9d81c2f21579961.json"}}, {"family": "Navarro", "given": "Pau", "initials": "P", "orcid": "0000-0001-5576-8584", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd1c6be37f30445e8d11b73f7ea54099.json"}}, {"family": "Shen", "given": "Xia", "initials": "X", "orcid": "0000-0003-4390-1979", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fdf103b9d2464f7ca1ed1a8eb1a5808d.json"}}], "type": "journal article", "published": "2024-11-00", "journal": {"title": "Nat Hum Behav", "issn": "2397-3374", "volume": "8", "issue": "11", "pages": "2222-2234", "issn-l": null}, "abstract": "Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioural traits and the disease aetiology of neuropsychiatric disorders. Here the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,000 individuals for 184 neuro-related proteins in human plasma. The analysis identified 125 cis-regulatory protein quantitative trait loci (cis-pQTL) and 164 trans-pQTL. The mapped pQTL capture on average 50% of each protein's heritability. At the cis-pQTL, multiple proteins shared a genetic basis with human behavioural traits such as alcohol and food intake, smoking and educational attainment, as well as neurological conditions and psychiatric disorders such as pain, neuroticism and schizophrenia. Integrating with established drug information, the causal inference analysis validated 52 out of 66 matched combinations of protein targets and diseases or side effects with available drugs while suggesting hundreds of repurposing and new therapeutic targets.", "doi": "10.1038/s41562-024-01963-z", "pmid": "39210026", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41562-024-01963-z"}], "notes": [], "created": "2026-08-20T08:55:14.560Z", "modified": "2026-08-20T08:55:15.594Z"}, {"entity": "publication", "iuid": "36ee4097dcb24e8a9703b572d8310e5d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/36ee4097dcb24e8a9703b572d8310e5d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/36ee4097dcb24e8a9703b572d8310e5d"}}, "title": "Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.", "authors": [{"family": "Shrine", "given": "Nick", "initials": "N", "orcid": "0000-0003-3641-4371", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e5ea1864e344b0d9afa411230b30063.json"}}, {"family": "Guyatt", "given": "Anna L", "initials": "AL", "orcid": "0000-0003-1860-6337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/699fd6195c4743778182f19e60528f9f.json"}}, {"family": "Erzurumluoglu", "given": "A Mesut", "initials": "AM"}, {"family": "Jackson", "given": "Victoria E", "initials": "VE"}, {"family": "Hobbs", "given": "Brian D", "initials": "BD", "orcid": "0000-0001-9564-0745", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8a9e4dfd9044e2b9916206b979349cd.json"}}, {"family": "Melbourne", "given": "Carl A", "initials": "CA"}, {"family": "Batini", "given": "Chiara", "initials": "C"}, {"family": "Fawcett", "given": "Katherine A", "initials": "KA"}, {"family": "Song", "given": "Kijoung", "initials": "K"}, {"family": "Sakornsakolpat", "given": "Phuwanat", "initials": "P", "orcid": "0000-0002-4308-0974", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77168c1ef56d456e88a5327a437b7f52.json"}}, {"family": "Li", "given": "Xingnan", "initials": "X"}, {"family": "Boxall", "given": "Ruth", "initials": "R"}, {"family": "Reeve", "given": "Nicola F", "initials": "NF"}, {"family": "Obeidat", "given": "Ma'en", "initials": "M", "orcid": "0000-0002-5443-2752", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/422fc72fc8e54948af2939fb8ff12d1e.json"}}, {"family": "Zhao", "given": "Jing Hua", "initials": "JH"}, {"family": "Wielscher", "given": "Matthias", "initials": "M"}, {"family": "Understanding Society Scientific Group", "given": "", "initials": ""}, {"family": "Weiss", "given": "Stefan", "initials": "S", "orcid": "0000-0002-3553-4315", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ebf58f688caa49ab9e0a3e56349b1031.json"}}, {"family": "Kentistou", "given": "Katherine A", "initials": "KA", "orcid": "0000-0002-5816-664X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/772af07e040c4a24a9076e9a8a36723b.json"}}, {"family": "Cook", "given": "James P", "initials": "JP"}, {"family": "Sun", "given": "Benjamin B", "initials": "BB", "orcid": "0000-0001-6347-2281", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/da2eef8768f245dda8ef8f0f81d13715.json"}}, {"family": "Zhou", "given": "Jian", "initials": "J"}, {"family": "Hui", "given": "Jennie", "initials": "J"}, {"family": "Karrasch", "given": "Stefan", "initials": "S"}, {"family": "Imboden", "given": "Medea", "initials": "M"}, {"family": "Harris", "given": "Sarah E", "initials": "SE"}, {"family": "Marten", "given": "Jonathan", "initials": "J"}, {"family": "Enroth", "given": "Stefan", "initials": "S", "orcid": "0000-0002-5056-9137", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae9be8ef3b1145239a4e0231e2a148cd.json"}}, {"family": "Kerr", "given": "Shona M", "initials": "SM"}, {"family": "Surakka", "given": "Ida", "initials": "I"}, {"family": "Vitart", "given": "Veronique", "initials": "V", "orcid": "0000-0002-4991-3797", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3270297f0f1b4de4bb181d7be8e1f447.json"}}, {"family": "Lehtim\u00e4ki", "given": "Terho", "initials": "T"}, {"family": "Allen", "given": "Richard J", "initials": "RJ", "orcid": "0000-0002-8450-3056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b366f94bf4e4409cb74c0853177419e0.json"}}, {"family": "Bakke", "given": "Per S", "initials": "PS"}, {"family": "Beaty", "given": "Terri H", "initials": "TH", "orcid": "0000-0002-7644-1705", "researcher": {"href": 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"Ke", "initials": "K"}, {"family": "Hoffman", "given": "Joshua D", "initials": "JD"}, {"family": "Hokanson", "given": "John E", "initials": "JE"}, {"family": "Homuth", "given": "Georg", "initials": "G"}, {"family": "Joshi", "given": "Peter K", "initials": "PK", "orcid": "0000-0002-6361-5059", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67a2c02915a5435d8ff7e148eeab9cc8.json"}}, {"family": "Joubert", "given": "Philippe", "initials": "P"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Li", "given": "Xuan", "initials": "X"}, {"family": "Li", "given": "Liming", "initials": "L"}, {"family": "Lin", "given": "Kuang", "initials": "K"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Locantore", "given": "Nicholas", "initials": "N"}, {"family": "Luan", "given": "Jian'an", "initials": "J"}, {"family": "Mahajan", "given": "Anubha", "initials": "A", "orcid": "0000-0001-5585-3420", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41b3d44662484e0289f07fa25d045cf4.json"}}, {"family": "Maranville", "given": "Joseph C", "initials": "JC"}, {"family": "Murray", "given": "Alison", "initials": "A", "orcid": "0000-0003-4915-4847", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5a371a2e8a3248e88b970365d42822d9.json"}}, {"family": "Nickle", "given": "David C", "initials": "DC"}, {"family": "Packer", "given": "Richard", "initials": "R"}, {"family": "Parker", "given": "Margaret M", "initials": "MM"}, {"family": "Paynton", "given": "Megan L", "initials": "ML"}, {"family": "Porteous", "given": "David J", "initials": "DJ", "orcid": "0000-0003-1249-6106", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0db79d38a6564ed39dd6c3f462af40fc.json"}}, {"family": "Prokopenko", "given": "Dmitry", "initials": "D"}, {"family": "Qiao", "given": "Dandi", "initials": "D"}, {"family": "Rawal", "given": "Rajesh", 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"Jonathan", "initials": "J"}, {"family": "Wright", "given": "Alan", "initials": "A"}, {"family": "Zeggini", "given": "Eleftheria", "initials": "E", "orcid": "0000-0003-4238-659X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/94df27518bb34428a8b1f8f2b278d778.json"}}, {"family": "Howson", "given": "Joanna M M", "initials": "JMM", "orcid": "0000-0001-7618-0050", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a1dcd9d189da4d758df6a936d69cc5f6.json"}}, {"family": "O'Donnell", "given": "Christopher J", "initials": "CJ"}, {"family": "Spector", "given": "Tim", "initials": "T", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d79b7af2d7a4f1da46ac2ee2bb1eb0b.json"}}, {"family": "Nalls", "given": "Mike A", "initials": "MA", "orcid": "0000-0003-0319-4325", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/31da8ffb43154866ac25f1fec623ba74.json"}}, {"family": "Simonsick", "given": "Eleanor M", "initials": "EM"}, {"family": "Liu", "given": "Yongmei", "initials": "Y"}, {"family": "van Duijn", "given": "Cornelia M", "initials": "CM", "orcid": "0000-0002-2374-9204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f80ecaf200f24b4092c9a6ed77dfff8d.json"}}, {"family": "Butterworth", "given": "Adam S", "initials": "AS", "orcid": "0000-0002-6915-9015", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88842023860148bb8d155b5c18db72a8.json"}}, {"family": "Danesh", "given": "John N", "initials": "JN"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0996382f79af42938451d690a140a079.json"}}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0003-1422-2993", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/462fd4169f41418887a5a979e0808d87.json"}}, {"family": "Khaw", "given": "Kay-Tee", "initials": "KT"}, {"family": "Sun", "given": "Yan V", "initials": "YV", "orcid": "0000-0002-2838-1824", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60b03d484f0c4acb93802ce6e6048a10.json"}}, {"family": "Wilson", "given": "Peter W F", "initials": "PWF", "orcid": "0000-0002-5653-7056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e2fa5a1fb3634b88b3a50c4d31bd3a33.json"}}, {"family": "Cho", "given": "Kelly", "initials": "K"}, {"family": "Visscher", "given": "Peter M", "initials": "PM", "orcid": "0000-0002-2143-8760", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9232be0ea244fb7ab43593e04265c2e.json"}}, {"family": "Denny", "given": "Joshua C", "initials": "JC", "orcid": "0000-0002-3049-7332", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee3b66f9be524dfdb2d95834abad0cbf.json"}}, {"family": "Million Veteran Program", "given": "", "initials": ""}, {"family": "Lifelines Cohort Study", "given": "", "initials": ""}, {"family": "CHARGE consortium", "given": "", "initials": ""}, {"family": "ICBP Consortium", "given": "", "initials": ""}, {"family": "Levy", "given": "Daniel", "initials": "D"}, {"family": "Edwards", "given": "Todd L", "initials": "TL", "orcid": "0000-0003-4318-6119", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8c555d3f6704b69821f39dcac8984d5.json"}}, {"family": "Munroe", "given": "Patricia B", "initials": "PB", "orcid": "0000-0002-4176-2947", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e956b6f17a64fb4b478dbc59950a790.json"}}, {"family": "Snieder", "given": "Harold", "initials": "H", "orcid": "0000-0003-1949-2298", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb5a2135b774429596606e980c9268ec.json"}}, {"family": "Warren", "given": "Helen R", "initials": "HR", "orcid": "0000-0003-0511-1386", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d44ccb685e4b4a4894b8cba8c74333ff.json"}}], "type": "journal article", "published": "2024-05-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "56", "issue": "5", "pages": "778-791", "issn-l": "1061-4036"}, "abstract": "Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 \u00d7 10-8) from the largest single-stage blood pressure (BP) genome-wide association study to date (n = 1,028,980 European individuals). These associations explain more than 60% of single nucleotide polymorphism-based BP heritability. Comparing top versus bottom deciles of polygenic risk scores (PRSs) reveals clinically meaningful differences in BP (16.9 mmHg systolic BP, 95% CI, 15.5-18.2 mmHg, P = 2.22 \u00d7 10-126) and more than a sevenfold higher odds of hypertension risk (odds ratio, 7.33; 95% CI, 5.54-9.70; P = 4.13 \u00d7 10-44) in an independent dataset. Adding PRS into hypertension-prediction models increased the area under the receiver operating characteristic curve (AUROC) from 0.791 (95% CI, 0.781-0.801) to 0.826 (95% CI, 0.817-0.836, \u2206AUROC, 0.035, P = 1.98 \u00d7 10-34). We compare the 2,103 loci results in non-European ancestries and show significant PRS associations in a large African-American sample. Secondary analyses implicate 500 genes previously unreported for BP. Our study highlights the role of increasingly large genomic studies for precision health research.", "doi": "10.1038/s41588-024-01714-w", "pmid": "38689001", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11096100"}, {"db": "pii", "key": "10.1038/s41588-024-01714-w"}], "notes": [], "created": "2026-08-20T09:00:02.525Z", "modified": "2026-08-20T09:00:03.969Z"}, {"entity": "publication", "iuid": "979368b1c4084da68b7ed92bfa7c45c8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/979368b1c4084da68b7ed92bfa7c45c8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/979368b1c4084da68b7ed92bfa7c45c8"}}, "title": "Author Correction: Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.", "authors": [{"family": "Zhao", "given": "Jing Hua", "initials": "JH"}, {"family": "Stacey", "given": "David", "initials": "D"}, {"family": "Eriksson", "given": "Niclas", "initials": "N", "orcid": "0000-0002-2152-4343", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c2aa082be0ca4fe88eba557bc92a735a.json"}}, {"family": "Macdonald-Dunlop", "given": "Erin", "initials": "E", "orcid": "0000-0001-6569-6086", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8656c77fec794fd09fd5f8d8f2dea96c.json"}}, {"family": "Hedman", "given": "\u00c5sa K", "initials": "\u00c5K"}, {"family": "Kalnapenkis", "given": "Anette", "initials": "A"}, {"family": "Enroth", "given": "Stefan", "initials": "S", "orcid": "0000-0002-5056-9137", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae9be8ef3b1145239a4e0231e2a148cd.json"}}, {"family": "Cozzetto", "given": "Domenico", "initials": "D", "orcid": "0000-0001-6752-5432", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd70c7a269eb47378cbf0a39c9fd26e5.json"}}, {"family": "Digby-Bell", "given": "Jonathan", "initials": "J"}, {"family": "Marten", "given": "Jonathan", "initials": "J"}, {"family": "Folkersen", "given": "Lasse", "initials": "L", "orcid": "0000-0003-0708-9530", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de3038c0ebcd4cfa8e1bd2b657c84268.json"}}, {"family": "Herder", "given": "Christian", "initials": "C", "orcid": "0000-0002-2050-093X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3897a084bd464fd59a16e0096d74ff44.json"}}, {"family": "Jonsson", "given": "Lina", "initials": "L"}, {"family": "Bergen", "given": "Sarah E", "initials": "SE"}, {"family": "Gieger", "given": "Christian", "initials": "C", "orcid": "0000-0001-6986-9554", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f97cdfc9ee1f4dd2a741b672b5b593d1.json"}}, {"family": "Needham", "given": "Elise J", "initials": "EJ"}, {"family": "Surendran", "given": "Praveen", "initials": "P"}, {"family": "Estonian Biobank Research Team", "given": "", "initials": ""}, {"family": "Paul", "given": "Dirk S", "initials": "DS", "orcid": "0000-0002-8230-0116", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2169975c0a46456c9f29a2b7b3da0b30.json"}}, {"family": "Polasek", "given": "Ozren", "initials": "O"}, {"family": "Thorand", "given": "Barbara", "initials": "B", "orcid": "0000-0002-8416-6440", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1595d383d9f4ef091d369efdd59d0b7.json"}}, {"family": "Grallert", "given": "Harald", "initials": "H"}, {"family": "Roden", "given": "Michael", "initials": "M", "orcid": "0000-0001-8200-6382", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/129252fd2dd84739b242c5f77b855097.json"}}, {"family": "V\u00f5sa", "given": "Urmo", "initials": "U"}, {"family": "Esko", "given": "Tonu", "initials": "T"}, {"family": "Hayward", "given": "Caroline", "initials": "C", "orcid": "0000-0002-9405-9550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/542b00d650124ce4a3776ae95571e2c1.json"}}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0002-2915-4498", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0bac3e1e64949fcbac4b4d839e1144d.json"}}, {"family": "Gyllensten", "given": "Ulf", "initials": "U", "orcid": "0000-0002-6316-3355", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eacfdf2095e947e99ac45fe994261b72.json"}}, {"family": "Powell", "given": "Nick", "initials": "N"}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}, {"family": "Mattsson-Carlgren", "given": "Niklas", "initials": "N"}, {"family": "Joshi", "given": "Peter K", "initials": "PK", "orcid": "0000-0002-6361-5059", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67a2c02915a5435d8ff7e148eeab9cc8.json"}}, {"family": "Danesh", "given": "John", "initials": "J"}, {"family": "Padyukov", "given": "Leonid", "initials": "L", "orcid": "0000-0003-2950-5670", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/336dfd4ed41542338e3aae1e29ce1da2.json"}}, {"family": "Klareskog", "given": "Lars", "initials": "L", "orcid": "0000-0001-9601-6186", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f544b73aca2464db446ee389c9d091a.json"}}, {"family": "Land\u00e9n", "given": "Mikael", "initials": "M", "orcid": "0000-0002-4496-6451", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e788f5999d644719a8c4816c88d7de3.json"}}, {"family": "Wilson", "given": "James F", "initials": "JF", "orcid": "0000-0001-5751-9178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513b6983cc9d478ab9d81c2f21579961.json"}}, {"family": "Siegbahn", "given": "Agneta", "initials": "A"}, {"family": "Wallentin", "given": "Lars", "initials": "L"}, {"family": "M\u00e4larstig", "given": "Anders", "initials": "A", "orcid": "0000-0003-2608-1358", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32b012456e6f490e99b12f5fb1216ce8.json"}}, {"family": "Butterworth", "given": "Adam S", "initials": "AS", "orcid": "0000-0002-6915-9015", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88842023860148bb8d155b5c18db72a8.json"}}, {"family": "Peters", "given": "James E", "initials": "JE", "orcid": "0000-0002-9415-3440", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cdf78018d1448498239609190aade2d.json"}}], "type": "published erratum", "published": "2023-11-00", "journal": {"title": "Nat. Immunol.", "issn": "1529-2916", "volume": "24", "issue": "11", "pages": "1960", "issn-l": "1529-2908"}, "abstract": null, "doi": "10.1038/s41590-023-01635-6", "pmid": "37679551", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10602847"}, {"db": "pii", "key": "10.1038/s41590-023-01635-6"}], "notes": [], "created": "2026-08-20T09:01:39.922Z", "modified": "2026-08-20T09:01:40.109Z"}, {"entity": "publication", "iuid": "f02f8fd61e7946389946f5d4fbf2273c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f02f8fd61e7946389946f5d4fbf2273c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f02f8fd61e7946389946f5d4fbf2273c"}}, "title": "Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.", "authors": [{"family": "Zhao", "given": "Jing Hua", "initials": "JH"}, {"family": "Stacey", "given": "David", "initials": "D"}, {"family": "Eriksson", "given": "Niclas", "initials": "N", "orcid": "0000-0002-2152-4343", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c2aa082be0ca4fe88eba557bc92a735a.json"}}, {"family": "Macdonald-Dunlop", "given": "Erin", "initials": "E", "orcid": "0000-0001-6569-6086", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8656c77fec794fd09fd5f8d8f2dea96c.json"}}, {"family": "Hedman", "given": "\u00c5sa K", "initials": "\u00c5K"}, {"family": "Kalnapenkis", "given": "Anette", "initials": "A"}, {"family": "Enroth", "given": "Stefan", "initials": "S", "orcid": "0000-0002-5056-9137", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae9be8ef3b1145239a4e0231e2a148cd.json"}}, {"family": "Cozzetto", "given": "Domenico", "initials": "D", "orcid": "0000-0001-6752-5432", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd70c7a269eb47378cbf0a39c9fd26e5.json"}}, {"family": "Digby-Bell", "given": "Jonathan", "initials": "J"}, {"family": "Marten", "given": "Jonathan", "initials": "J"}, {"family": "Folkersen", "given": "Lasse", "initials": "L", "orcid": "0000-0003-0708-9530", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de3038c0ebcd4cfa8e1bd2b657c84268.json"}}, {"family": "Herder", "given": "Christian", "initials": "C", "orcid": "0000-0002-2050-093X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3897a084bd464fd59a16e0096d74ff44.json"}}, {"family": "Jonsson", "given": "Lina", "initials": "L"}, {"family": "Bergen", "given": "Sarah E", "initials": "SE"}, {"family": "Gieger", "given": "Christian", "initials": "C", "orcid": "0000-0001-6986-9554", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f97cdfc9ee1f4dd2a741b672b5b593d1.json"}}, {"family": "Needham", "given": "Elise J", "initials": "EJ"}, {"family": "Surendran", "given": "Praveen", "initials": "P"}, {"family": "Estonian Biobank Research Team", "given": "", "initials": ""}, {"family": "Paul", "given": "Dirk S", "initials": "DS", "orcid": "0000-0002-8230-0116", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2169975c0a46456c9f29a2b7b3da0b30.json"}}, {"family": "Polasek", "given": "Ozren", "initials": "O"}, {"family": "Thorand", "given": "Barbara", "initials": "B", "orcid": "0000-0002-8416-6440", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1595d383d9f4ef091d369efdd59d0b7.json"}}, {"family": "Grallert", "given": "Harald", "initials": "H"}, {"family": "Roden", "given": "Michael", "initials": "M", "orcid": "0000-0001-8200-6382", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/129252fd2dd84739b242c5f77b855097.json"}}, {"family": "V\u00f5sa", "given": "Urmo", "initials": "U"}, {"family": "Esko", "given": "Tonu", "initials": "T"}, {"family": "Hayward", "given": "Caroline", "initials": "C", "orcid": "0000-0002-9405-9550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/542b00d650124ce4a3776ae95571e2c1.json"}}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0002-2915-4498", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0bac3e1e64949fcbac4b4d839e1144d.json"}}, {"family": "Gyllensten", "given": "Ulf", "initials": "U", "orcid": "0000-0002-6316-3355", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eacfdf2095e947e99ac45fe994261b72.json"}}, {"family": "Powell", "given": "Nick", "initials": "N"}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}, {"family": "Mattsson-Carlgren", "given": "Niklas", "initials": "N"}, {"family": "Joshi", "given": "Peter K", "initials": "PK", "orcid": "0000-0002-6361-5059", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67a2c02915a5435d8ff7e148eeab9cc8.json"}}, {"family": "Danesh", "given": "John", "initials": "J"}, {"family": "Padyukov", "given": "Leonid", "initials": "L", "orcid": "0000-0003-2950-5670", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/336dfd4ed41542338e3aae1e29ce1da2.json"}}, {"family": "Klareskog", "given": "Lars", "initials": "L", "orcid": "0000-0001-9601-6186", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f544b73aca2464db446ee389c9d091a.json"}}, {"family": "Land\u00e9n", "given": "Mikael", "initials": "M", "orcid": "0000-0002-4496-6451", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e788f5999d644719a8c4816c88d7de3.json"}}, {"family": "Wilson", "given": "James F", "initials": "JF", "orcid": "0000-0001-5751-9178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513b6983cc9d478ab9d81c2f21579961.json"}}, {"family": "Siegbahn", "given": "Agneta", "initials": "A"}, {"family": "Wallentin", "given": "Lars", "initials": "L"}, {"family": "M\u00e4larstig", "given": "Anders", "initials": "A", "orcid": "0000-0003-2608-1358", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32b012456e6f490e99b12f5fb1216ce8.json"}}, {"family": "Butterworth", "given": "Adam S", "initials": "AS", "orcid": "0000-0002-6915-9015", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88842023860148bb8d155b5c18db72a8.json"}}, {"family": "Peters", "given": "James E", "initials": "JE", "orcid": "0000-0002-9415-3440", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cdf78018d1448498239609190aade2d.json"}}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Nat. Immunol.", "issn": "1529-2916", "volume": "24", "issue": "9", "pages": "1540-1551", "issn-l": "1529-2908"}, "abstract": "Circulating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,824 participants. We identified 180 pQTLs (59 cis, 121 trans). Integration of pQTL data with eQTL and disease genome-wide association studies provided insight into pathogenesis, implicating lymphotoxin-\u03b1 in multiple sclerosis. Using Mendelian randomization (MR) to assess causality in disease etiology, we identified both shared and distinct effects of specific proteins across immune-mediated diseases, including directionally discordant effects of CD40 on risk of rheumatoid arthritis versus multiple sclerosis and inflammatory bowel disease. MR implicated CXCL5 in the etiology of ulcerative colitis (UC) and we show elevated gut CXCL5 transcript expression in patients with UC. These results identify targets of existing drugs and provide a powerful resource to facilitate future drug target prioritization.", "doi": "10.1038/s41590-023-01588-w", "pmid": "37563310", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10457199"}, {"db": "pii", "key": "10.1038/s41590-023-01588-w"}], "notes": [], "created": "2026-08-20T09:01:37.758Z", "modified": "2026-08-20T09:01:38.213Z"}, {"entity": "publication", "iuid": "9b584b66544649dfae4781915c418be4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9b584b66544649dfae4781915c418be4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9b584b66544649dfae4781915c418be4"}}, "title": "An atlas of genetic scores to predict multi-omic traits.", "authors": [{"family": "Xu", "given": "Yu", "initials": "Y", "orcid": "0000-0002-7304-5045", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ac4920de9564d809602c26f92e4aeca.json"}}, {"family": "Ritchie", "given": "Scott C", "initials": "SC", "orcid": "0000-0002-8454-9548", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36a4d823852c4bae97ddc68a05030b72.json"}}, {"family": "Liang", "given": "Yujian", "initials": "Y"}, {"family": "Timmers", "given": "Paul R H J", "initials": "PRHJ", "orcid": "0000-0002-5197-1267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1a7fb58cb2f4bd1b48f23be33de0c6e.json"}}, {"family": "Pietzner", "given": "Maik", "initials": "M", "orcid": "0000-0003-3437-9963", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3304844cece945168cbec0b5e3d9a9cf.json"}}, {"family": "Lannelongue", "given": "Lo\u00efc", "initials": "L", "orcid": "0000-0002-9135-1345", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d2fdb81bd8c4b93af2d061f6421540f.json"}}, {"family": "Lambert", "given": "Samuel A", "initials": "SA", "orcid": "0000-0001-8222-008X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/23811479ba0a41a99a94f9c0d3f06bd4.json"}}, {"family": "Tahir", "given": "Usman A", "initials": "UA"}, {"family": "May-Wilson", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-2668-5717", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d39731ddad649e88c6958a9fc03008b.json"}}, {"family": "Foguet", "given": "Carles", "initials": "C", "orcid": "0000-0001-8494-9595", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c41865149ac74c4695959ced5ce4ec9f.json"}}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0002-2915-4498", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0bac3e1e64949fcbac4b4d839e1144d.json"}}, {"family": "Surendran", "given": "Praveen", "initials": "P"}, {"family": "Nath", "given": "Artika P", "initials": "AP"}, {"family": "Persyn", "given": "Elodie", "initials": "E", "orcid": "0000-0001-9104-1972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d882b5f4416425ab28deb0a35d905ef.json"}}, {"family": "Peters", "given": "James E", "initials": "JE", "orcid": "0000-0002-9415-3440", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cdf78018d1448498239609190aade2d.json"}}, {"family": "Oliver-Williams", "given": "Clare", "initials": "C"}, {"family": "Deng", "given": "Shuliang", "initials": "S"}, {"family": "Prins", "given": "Bram", "initials": "B", "orcid": "0000-0001-5774-034X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2677fba12f9549b193a0498b539cd793.json"}}, {"family": "Luan", "given": "Jian'an", "initials": "J", "orcid": "0000-0003-3137-6337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f2180f4f03be411ba2c80c18a78e6645.json"}}, {"family": "Bomba", "given": "Lorenzo", "initials": "L"}, {"family": "Soranzo", "given": "Nicole", "initials": "N", "orcid": "0000-0003-1095-3852", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/751b4656807c42f9a668ebb98e8da987.json"}}, {"family": "Di Angelantonio", "given": "Emanuele", "initials": "E"}, {"family": "Pirastu", "given": "Nicola", "initials": "N"}, {"family": "Tai", "given": "E Shyong", "initials": "ES", "orcid": "0000-0003-2929-8966", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d116286b0f524b6d835ef78c4f1dfd14.json"}}, {"family": "van Dam", "given": "Rob M", "initials": "RM"}, {"family": "Parkinson", "given": "Helen", "initials": "H"}, {"family": "Davenport", "given": "Emma E", "initials": "EE"}, {"family": "Paul", "given": "Dirk S", "initials": "DS", "orcid": "0000-0002-8230-0116", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2169975c0a46456c9f29a2b7b3da0b30.json"}}, {"family": "Yau", "given": "Christopher", "initials": "C", "orcid": "0000-0001-7615-8523", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bbc82d06ec19459d99e5809ddbf36145.json"}}, {"family": "Gerszten", "given": "Robert E", "initials": "RE", "orcid": "0000-0002-6767-7687", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ddb55dc5a54401d8d958fac1c46e8b8.json"}}, {"family": "M\u00e4larstig", "given": "Anders", "initials": "A", "orcid": "0000-0003-2608-1358", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32b012456e6f490e99b12f5fb1216ce8.json"}}, {"family": "Danesh", "given": "John", "initials": "J"}, {"family": "Sim", "given": "Xueling", "initials": "X", "orcid": "0000-0002-1233-7642", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b9aec75e482049f5b169a9cfc517a351.json"}}, {"family": "Langenberg", "given": "Claudia", "initials": "C", "orcid": "0000-0002-5017-7344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f287f3248cc24c6cbfc100c249b87418.json"}}, {"family": "Wilson", "given": "James F", "initials": "JF", "orcid": "0000-0001-5751-9178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513b6983cc9d478ab9d81c2f21579961.json"}}, {"family": "Butterworth", "given": "Adam S", "initials": "AS", "orcid": "0000-0002-6915-9015", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88842023860148bb8d155b5c18db72a8.json"}}, {"family": "Inouye", "given": "Michael", "initials": "M", "orcid": "0000-0001-9413-6520", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d1abe69d2ee548b9b754ebcd5eeabac7.json"}}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "616", "issue": "7955", "pages": "123-131", "issn-l": "0028-0836"}, "abstract": "The use of omic modalities to dissect the molecular underpinnings of common diseases and traits is becoming increasingly common. But multi-omic traits can be genetically predicted, which enables highly cost-effective and powerful analyses for studies that do not have multi-omics1. Here we examine a large cohort (the INTERVAL study2; n = 50,000 participants) with extensive multi-omic data for plasma proteomics (SomaScan, n = 3,175; Olink, n = 4,822), plasma metabolomics (Metabolon HD4, n = 8,153), serum metabolomics (Nightingale, n = 37,359) and whole-blood Illumina RNA sequencing (n = 4,136), and use machine learning to train genetic scores for 17,227 molecular traits, including 10,521 that reach Bonferroni-adjusted significance. We evaluate the performance of genetic scores through external validation across cohorts of individuals of European, Asian and African American ancestries. In addition, we show the utility of these multi-omic genetic scores by quantifying the genetic control of biological pathways and by generating a synthetic multi-omic dataset of the UK Biobank3 to identify disease associations using a phenome-wide scan. We highlight a series of biological insights with regard to genetic mechanisms in metabolism and canonical pathway associations with disease; for example, JAK-STAT signalling and coronary atherosclerosis. Finally, we develop a portal ( https://www.omicspred.org/ ) to facilitate public access to all genetic scores and validation results, as well as to serve as a platform for future extensions and enhancements of multi-omic genetic scores.", "doi": "10.1038/s41586-023-05844-9", "pmid": "36991119", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1905816"}, {"db": "pmc", "key": "PMC10323211"}, {"db": "pii", "key": "10.1038/s41586-023-05844-9"}], "notes": [], "created": "2026-08-20T08:58:33.726Z", "modified": "2026-08-20T08:58:34.418Z"}, {"entity": "publication", "iuid": "47baad2a3dc84380aeef0c6d4cf97660", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/47baad2a3dc84380aeef0c6d4cf97660.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/47baad2a3dc84380aeef0c6d4cf97660"}}, "title": "Unraveling Neuro-Proteogenomic Landscape and Therapeutic Implications for Human Behaviors and Psychiatric Disorders.", "authors": [{"family": "Repetto", "given": "Linda", "initials": "L"}, {"family": "Chen", "given": "Jiantao", "initials": "J"}, {"family": "Yang", "given": "Zhijian", "initials": "Z", "orcid": "0000-0003-4803-8633", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/37ba93e5f6b041e4a4bea6a345adfb72.json"}}, {"family": "Zhai", "given": "Ranran", "initials": "R", "orcid": "0000-0002-5834-9120", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0aaae5317db3468384510b9727a07e02.json"}}, {"family": "Timmers", "given": "Paul R H J", "initials": "PRHJ", "orcid": "0000-0002-5197-1267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1a7fb58cb2f4bd1b48f23be33de0c6e.json"}}, {"family": "Li", "given": "Ting", "initials": "T", "orcid": "0000-0002-9614-1566", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/032f6825c6bb4b1284c3b3cbd95099fc.json"}}, {"family": "Twait", "given": "Emma L", "initials": "EL"}, {"family": "May-Wilson", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-2668-5717", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d39731ddad649e88c6958a9fc03008b.json"}}, {"family": "Muckian", "given": "Marisa D", "initials": "MD"}, {"family": "Prins", "given": "Bram P", "initials": "BP"}, {"family": "Png", "given": "Grace", "initials": "G"}, {"family": "Kooperberg", "given": "Charles", "initials": "C"}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Hillary", "given": "Robert F", "initials": "RF"}, {"family": "Wheeler", "given": "Eleanor", "initials": "E", "orcid": "0000-0002-8616-6444", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fd1a2d0a53e442aa8900ef0e09b23b3.json"}}, {"family": "Pan", "given": "Lu", "initials": "L"}, {"family": "He", "given": "Yazhou", "initials": "Y"}, {"family": "Klasson", "given": "Sofia", "initials": "S"}, {"family": "Ahmad", "given": "Shahzad", "initials": "S"}, {"family": "Peters", "given": "James E", "initials": "JE"}, {"family": "Gilly", "given": "Arthur", "initials": "A"}, {"family": "Karaleftheri", "given": "Maria", "initials": "M"}, {"family": "Tsafantakis", "given": "Emmanouil", "initials": "E"}, {"family": "Haessler", "given": "Jeffrey", "initials": "J"}, {"family": "Gyllensten", "given": "Ulf", "initials": "U"}, {"family": "Harris", "given": "Sarah E", "initials": "SE", "orcid": "0000-0002-4941-5106", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4056bf3ecf854b1c8a2189564f6e0ded.json"}}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0003-1422-2993", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/462fd4169f41418887a5a979e0808d87.json"}}, {"family": "G\u00f6teson", "given": "Andreas", "initials": "A"}, {"family": "Lagging", "given": "Cecilia", "initials": "C"}, {"family": "Ikram", "given": 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"researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/15fa758fb7d84cd9b38150291f2002b5.json"}}, {"family": "Marioni", "given": "Riccardo E", "initials": "RE", "orcid": "0000-0003-4430-4260", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e9bc46c3aa1b4e379bd2eebd8bb23756.json"}}, {"family": "Enroth", "given": "Stefan", "initials": "S"}, {"family": "Reiner", "given": "Alexander P", "initials": "AP", "orcid": "0000-0002-1427-4470", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/244e81f4f21645e9b66f7b2ba6a8eb07.json"}}, {"family": "Dedoussis", "given": "George", "initials": "G"}, {"family": "Zeggini", "given": "Eleftheria", "initials": "E"}, {"family": "Butterworth", "given": "Adam S", "initials": "AS"}, {"family": "M\u00e4larstig", "given": "Anders", "initials": "A"}, {"family": "Wilson", "given": "James F", "initials": "JF", "orcid": "0000-0001-5751-9178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513b6983cc9d478ab9d81c2f21579961.json"}}, {"family": "Navarro", "given": "Pau", "initials": "P"}, {"family": "Shen", "given": "Xia", "initials": "X", "orcid": "0000-0003-4390-1979", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fdf103b9d2464f7ca1ed1a8eb1a5808d.json"}}], "type": "preprint", "published": "2023-03-31", "journal": {"title": "Res Sq", "issn": "2693-5015", "issn-l": null}, "abstract": "Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioral traits and the disease etiology of neuropsychiatric disorders. Here, the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,500 individuals for 184 neuro-related proteins in human plasma. The analysis identified 117 cis-regulatory protein quantitative trait loci (cis-pQTL) and 166 trans-pQTL. The mapped pQTL capture on average 50% of each protein's heritability. Mendelian randomization analyses revealed multiple proteins showing potential causal effects on neuro-related traits such as sleeping, smoking, feelings, alcohol intake, mental health, and psychiatric disorders. Integrating with established drug information, we validated 13 out of 13 matched combinations of protein targets and diseases or side effects with available drugs, while suggesting hundreds of re-purposing and new therapeutic targets. This consortium effort provides a large-scale proteogenomic resource for biomedical research on human behaviors and other neuro-related phenotypes.", "doi": "10.21203/rs.3.rs-2720355/v1", "pmid": "37034613", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10081382"}, {"db": "pii", "key": "rs.3.rs-2720355"}], "notes": [], "created": "2026-08-20T12:58:55.505Z", "modified": "2026-08-20T12:58:55.704Z"}, {"entity": "publication", "iuid": "967be0398ae444168838f6c87c44e030", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/967be0398ae444168838f6c87c44e030.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/967be0398ae444168838f6c87c44e030"}}, "title": "Physical activity and sedentary behavior; mechanistic insights and role in disease prevention", "authors": [{"family": "Hoed", "given": "Marcel den", "initials": "Md", "orcid": "0000-0001-8081-428X", "researcher": {"href": 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