{"entity": "researcher", "timestamp": "2026-09-30T04:27:21.655Z", "family": "Meng", "given": "Liesu", "initials": "L", "orcid": "0000-0003-1985-050X", "affiliations": ["Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.", "The Second affiliated hospital to Xi'an Jiaotong University and the Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, 710061, Xi'an, Shaanxi, China."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/50d145587afd4171a6c27cd00abc2cd3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/50d145587afd4171a6c27cd00abc2cd3"}}, "publications": [{"entity": "publication", "iuid": "bf91743a66e044b1adaee51b4574c80c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bf91743a66e044b1adaee51b4574c80c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bf91743a66e044b1adaee51b4574c80c"}}, "title": "Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation.", "authors": [{"family": "Norin", "given": "Ulrika", "initials": "U", "orcid": "0000-0003-1063-6339", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7d79bc148fd34a9894d6bb8e8d384530.json"}}, {"family": "Rintisch", "given": "Carola", "initials": "C"}, {"family": "Meng", "given": "Liesu", "initials": "L", "orcid": "0000-0003-1985-050X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/50d145587afd4171a6c27cd00abc2cd3.json"}}, {"family": "Forster", "given": "Florian", "initials": "F"}, {"family": "Ekman", "given": "Diana", "initials": "D"}, {"family": "Tuncel", "given": "Jonatan", "initials": "J"}, {"family": "Klocke", "given": "Katrin", "initials": "K"}, {"family": "B\u00e4cklund", "given": "Johan", "initials": "J"}, {"family": "Yang", "given": "Min", "initials": "M"}, {"family": "Bonner", "given": "Michael Y", "initials": "MY"}, {"family": "Lahore", "given": "Gonzalo Fernandez", "initials": "GF"}, {"family": "James", "given": "Jaime", "initials": "J"}, {"family": "Shchetynsky", "given": "Klementy", "initials": "K"}, {"family": "Bergquist", "given": "Maria", "initials": "M"}, {"family": "Gjertsson", "given": "Inger", "initials": "I"}, {"family": "Hubner", "given": "Norbert", "initials": "N", "orcid": "0000-0002-1218-6223", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f8fcb2e3ce2473b8a89b74727da5bb0.json"}}, {"family": "B\u00e4ckdahl", "given": "Liselotte", "initials": "L"}, {"family": "Holmdahl", "given": "Rikard", "initials": "R", "orcid": "0000-0002-4969-2576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aef6264212044f46a28c24d5fc147438.json"}}], "type": "journal article", "published": "2021-01-27", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "610", "issn-l": "2041-1723"}, "abstract": "The introduction of the CTLA-4 recombinant fusion protein has demonstrated therapeutic effects by selectively modulating T-cell activation in rheumatoid arthritis. Here we show, using a forward genetic approach, that a mutation in the SH3gl1 gene encoding the endocytic protein Endophilin A2 is associated with the development of arthritis in rodents. Defective expression of SH3gl1 affects T cell effector functions and alters the activation threshold of autoreactive T cells, thereby leading to complete protection from chronic autoimmune inflammatory disease in both mice and rats. We further show that SH3GL1 regulates human T cell signaling and T cell receptor internalization, and its expression is upregulated in rheumatoid arthritis patients. Collectively our data identify SH3GL1 as a key regulator of T cell activation, and as a potential target for treatment of autoimmune diseases.", "doi": "10.1038/s41467-020-20586-2", "pmid": "33504785", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7840939"}, {"db": "pii", "key": "10.1038/s41467-020-20586-2"}], "notes": [], "created": "2026-09-23T12:02:44.385Z", "modified": "2026-09-23T12:02:44.495Z"}]}