{"entity": "researcher", "timestamp": "2026-10-05T01:23:17.047Z", "family": "Zhou \u5468\u5955\u5c91", "given": "Yicen", "initials": "Y", "orcid": "0009-0001-9650-649X", "affiliations": ["Department of Biomedical Sciences, College of Biomedicine, City University of Hong Kong, Hong Kong Special Administrative Region 999077, China."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/506e9e636c1d4d5ebcbb92af4c641235.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/506e9e636c1d4d5ebcbb92af4c641235"}}, "publications": [{"entity": "publication", "iuid": "a22ab24bf07b44438471ccc5b5711d6b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a22ab24bf07b44438471ccc5b5711d6b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a22ab24bf07b44438471ccc5b5711d6b"}}, "title": "MoRNiNG: A Database of RNA Modification Sites Associated with RNA Secondary Structure Dynamics.", "authors": [{"family": "Zhou \u5468\u5955\u5c91", "given": "Yicen", "initials": "Y", "orcid": "0009-0001-9650-649X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/506e9e636c1d4d5ebcbb92af4c641235.json"}}, {"family": "Lyu \u5415\u5584\u946b", "given": "Shanxin", "initials": "S", "orcid": "0009-0008-3827-7562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ecfd8e34c8dd472a87edb5bcb7a1a1c5.json"}}, {"family": "Liew \u5218\u6653\u8587", "given": "Shiau Wei", "initials": "SW", "orcid": "0000-0002-2424-9084", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26396e395e7d4875aa61f1847bcf27b4.json"}}, {"family": "Mou \u725f\u5e0c", "given": "Xi", "initials": "X", "orcid": "0000-0002-0264-4702", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bd08b585fb9a48d6b2b0a94172b49d20.json"}}, {"family": "Hoffecker", "given": "Ian", "initials": "I", "orcid": "0000-0001-6941-4576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d1a249b0d0d34c6e827dc2b15eb33a9f.json"}}, {"family": "Yan \u4e25\u5065", "given": "Jian", "initials": "J", "orcid": "0000-0002-1267-2870", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cfbee3d812904939ba0c98219dde4f45.json"}}, {"family": "Li \u674e\u715c", "given": "Yu", "initials": "Y", "orcid": "0000-0002-3664-6722", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b0d0dfad923344e983b4e15de5f7e259.json"}}, {"family": "Kwok \u90ed\u9a8f\u6770", "given": "Chun Kit", "initials": "CK", "orcid": "0000-0001-9175-8543", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6be6347acdc042959657e1221454aa7e.json"}}, {"family": "Zhang \u5f20\u7ee7\u6797", "given": "Jilin", "initials": "J", "orcid": "0000-0002-9976-1605", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/59d5fd56d8bc40a9b96e1b495de959fd.json"}}], "type": "journal article", "published": "2026-06-26", "journal": {"title": "Genomics Proteomics Bioinformatics", "issn": "2210-3244", "volume": "24", "issue": "2", "issn-l": null}, "abstract": "RNA structures are essential building blocks of functional RNA molecules. Profiling secondary structures in vivo and in real time remains challenging because RNAs exhibit dynamic structures and complex conformations. In addition to the canonical stem-loop secondary structure, the non-canonical RNA G-quadruplex (rG4) structure has attracted interest for its potential as a drug target. Early studies have demonstrated that RNAs can form distinct secondary structures. However, how distinct RNA structures formed from the same RNA sequence function within the transcriptome is poorly understood, and the factors that drive and regulate structural transitions remain to be investigated. Inspired by the ability of a HOXB9 segment to form multiple structures, we found that many RNA segments across the transcriptome exhibit multi-faceted structure-forming potential. In the case of HOXB9, we demonstrated that N6-methyladenosine (m6A) modification influences RNA structure and binding to RNA-binding proteins (RBPs). Therefore, we collected RNA modification sites naturally occurring within the putative G-quadruplex-forming sequences (PQSs) of transcripts and developed MoRNiNG, a database for RNA modifications in natural rG4 structures. MoRNiNG is organized into reliability tiers determined by the resolution of RNA modification sites and is designed to accommodate various large datasets. We experimentally validated the influence of m6A, 5-methylcytosine (m5C), and adenosine-to-inosine (A-to-I) editing on rG4-forming sequences, providing evidence to support the modification switch concept. The diversity and transition of secondary structures from the same RNA segment offer valuable insights into the regulation of RNA structural dynamics. MoRNiNG is freely accessible at https://www.cityu.edu.hk/bms/morning.", "doi": "10.1093/gpbjnl/qzaf106", "pmid": "41237312", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC13506053"}, {"db": "pii", "key": "8323522"}], "notes": [], "created": "2026-10-01T08:30:04.628Z", "modified": "2026-10-01T08:30:04.954Z"}]}