{"entity": "researcher", "timestamp": "2026-08-20T21:12:58.100Z", "family": "Lau", "given": "Joey", "initials": "J", "orcid": "0000-0002-8302-3253", "affiliations": ["Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f5eb1f51bb1455998df895c889f7309.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f5eb1f51bb1455998df895c889f7309"}}, "publications": [{"entity": "publication", "iuid": "a7740def41024df6b9b34524bf1d45ad", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a7740def41024df6b9b34524bf1d45ad.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a7740def41024df6b9b34524bf1d45ad"}}, "title": "Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells.", "authors": [{"family": "Luo", "given": "Zhengkang", "initials": "Z"}, {"family": "Lundin", "given": "Sara", "initials": "S"}, {"family": "Mejia-Cordova", "given": "Mariela", "initials": "M"}, {"family": "Hassani", "given": "Imane", "initials": "I"}, {"family": "Blixt", "given": "Martin", "initials": "M"}, {"family": "Hjelmqvist", "given": "Daisy", "initials": "D"}, {"family": "Lau", "given": "Joey", "initials": "J", "orcid": "0000-0002-8302-3253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f5eb1f51bb1455998df895c889f7309.json"}}, {"family": "Espes", "given": "Daniel", "initials": "D"}, {"family": "Carlsson", "given": "Per-Ola", "initials": "PO"}, {"family": "Sandler", "given": "Stellan", "initials": "S"}, {"family": "Singh", "given": "Kailash", "initials": "K", "orcid": "0000-0002-6771-7757", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/64dc76ffd32c4c2f824837132dcab1c7.json"}}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "22", "issue": "23", "issn-l": null}, "abstract": "The anti-inflammatory role of regulatory B cells (Breg cells) has been associated with IL-35 based on studies of experimental autoimmune uveitis and encephalitis. The role of Breg cells and IL-35+ Breg cells for type 1 diabetes (T1D) remains to be investigated. We studied PBMCs from T1D subjects and healthy controls (HC) and found lowered proportions of Breg cells and IL-35+ Breg cells in T1D. To elucidate the role of Breg cells, the lymphoid organs of two mouse models of T1D were examined. Lower proportions of Breg cells and IL-35+ Breg cells were found in the animal models of T1D compared with control mice. In addition, the systemic administration of recombinant mouse IL-35 prevented hyperglycemia after multiple low dose streptozotocin (MLDSTZ) injections and increased the proportions of Breg cells and IL-35+ Breg cells. A higher proportion of IFN-\u03b3+ cells among Breg cells were found in the PBMCs of the T1D subjects. In the MLDSTZ mice, IL-35 administration decreased the proportions of IFN-\u03b3+ cells among the Breg cells. Our data illustrate that Breg cells may play an important role in the development of T1D and that IL-35 treatment prevents the development of hyperglycemia by maintaining the phenotype of the Breg cells under an experimental T1D condition.", "doi": "10.3390/ijms222312988", "pmid": "34884797", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8657454"}, {"db": "pii", "key": "ijms222312988"}], "notes": [], "created": "2026-08-20T13:41:32.520Z", "modified": "2026-08-20T13:41:32.616Z"}, {"entity": "publication", "iuid": "4483b18743b14bb1a2babad1da90d3ca", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4483b18743b14bb1a2babad1da90d3ca.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4483b18743b14bb1a2babad1da90d3ca"}}, "title": "Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma.", "authors": [{"family": "van Hooren", "given": "Luuk", "initials": "L", "orcid": "0000-0002-0780-5827", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5faf9219a47d426ba7dfe9cfb1f68418.json"}}, {"family": "Vaccaro", "given": "Alessandra", "initials": "A"}, {"family": "Ramachandran", "given": "Mohanraj", "initials": "M"}, {"family": "Vazaios", "given": "Konstantinos", "initials": "K"}, {"family": "Libard", "given": "Sylwia", "initials": "S"}, {"family": "van de Walle", "given": "Tiarne", "initials": "T"}, {"family": "Georganaki", "given": "Maria", "initials": "M"}, {"family": "Huang", "given": "Hua", "initials": "H"}, {"family": "Pietil\u00e4", "given": "Ilkka", "initials": "I"}, {"family": "Lau", "given": "Joey", "initials": "J", "orcid": "0000-0002-8302-3253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f5eb1f51bb1455998df895c889f7309.json"}}, {"family": "Ulvmar", "given": "Maria H", "initials": "MH"}, {"family": "Karlsson", "given": "Mikael C I", "initials": "MCI", "orcid": "0000-0001-5582-614X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0e5ec40c808e467c95d42e4d35395093.json"}}, {"family": "Zetterling", "given": "Maria", "initials": "M"}, {"family": "Mangsbo", "given": "Sara M", "initials": "SM"}, {"family": "Jakola", "given": "Asgeir S", "initials": "AS"}, {"family": "Olsson Bontell", "given": "Thomas", "initials": "T"}, {"family": "Smits", "given": "Anja", "initials": "A"}, {"family": "Essand", "given": "Magnus", "initials": "M", "orcid": "0000-0002-9725-0422", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2e56cdd77634c01ab6d98dea8c60430.json"}}, {"family": "Dimberg", "given": "Anna", "initials": "A", "orcid": "0000-0003-4422-9125", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f5d91c4b8784d8081a41604bb3d78d4.json"}}], "type": "journal article", "published": "2021-07-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "4127", "issn-l": "2041-1723"}, "abstract": "Gliomas are brain tumors characterized by an immunosuppressive microenvironment. Immunostimulatory agonistic CD40 antibodies (\u03b1CD40) are in clinical development for solid tumors, but are yet to be evaluated for glioma. Here, we demonstrate that systemic delivery of \u03b1CD40 in preclinical glioma models induces the formation of tertiary lymphoid structures (TLS) in proximity of meningeal tissue. In treatment-na\u00efve glioma patients, the presence of TLS correlates with increased T cell infiltration. However, systemic delivery of \u03b1CD40 induces hypofunctional T cells and impairs the response to immune checkpoint inhibitors in pre-clinical glioma models. This is associated with a systemic induction of suppressive CD11b+ B cells post-\u03b1CD40 treatment, which accumulate in the tumor microenvironment. Our work unveils the pleiotropic effects of \u03b1CD40 therapy in glioma and reveals that immunotherapies can modulate TLS formation in the brain, opening up for future opportunities to regulate the immune response.", "doi": "10.1038/s41467-021-24347-7", "pmid": "34226552", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8257767"}, {"db": "pii", "key": "10.1038/s41467-021-24347-7"}], "notes": [], "created": "2026-08-20T08:51:35.457Z", "modified": "2026-08-20T08:51:35.651Z"}]}