{"entity": "researcher", "timestamp": "2026-08-22T09:13:07.419Z", "family": "Sundin", "given": "Mikael", "initials": "M", "orcid": "0000-0002-9871-0961", "affiliations": ["Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.", "Section of Paediatric Hematology, Immunology and Hematopoietic Cell Transplantation, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ac33ee541ac44e59158cfed73f4992d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ac33ee541ac44e59158cfed73f4992d"}}, "publications": [{"entity": "publication", "iuid": "207a761f257c44108404dbc8272eb3e7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/207a761f257c44108404dbc8272eb3e7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/207a761f257c44108404dbc8272eb3e7"}}, "title": "T-cell frequencies of CD8+ \u03b3\u03b4 and CD27+ \u03b3\u03b4 cells in the stem cell graft predict the outcome after allogeneic hematopoietic cell transplantation.", "authors": [{"family": "Gaballa", "given": "Ahmed", "initials": "A", "orcid": "0000-0002-5277-5129", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b062c2e7638440919938a93892cf7848.json"}}, {"family": "Stikvoort", "given": "Arwen", "initials": "A"}, {"family": "\u00d6nfelt", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Mattsson", "given": "Jonas", "initials": "J"}, {"family": "Sundin", "given": "Mikael", "initials": "M", "orcid": "0000-0002-9871-0961", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ac33ee541ac44e59158cfed73f4992d.json"}}, {"family": "Watz", "given": "Emma", "initials": "E"}, {"family": "Uhlin", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2019-10-00", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "volume": "54", "issue": "10", "pages": "1562-1574", "issn-l": null}, "abstract": "The impact of intra-graft T cells on the clinical outcome after allogeneic hematopoietic cell transplantation has been investigated. Most previous studies have focused on the role of \u03b1\u03b2 cells while \u03b3\u03b4 cells have received less attention. It has been an open question whether \u03b3\u03b4 cells are beneficial or not for patient outcome, especially with regards to graft versus host disease. In this study, graft composition of \u03b3\u03b4 cell subsets was analyzed and correlated to clinical outcome in 105 recipients who underwent allogeneic hematopoietic cell transplantation between 2013 and 2016. We demonstrate for the first time that grafts containing higher T-cell proportions of CD8+\u03b3\u03b4 cells were associated with increased cumulative incidence of acute graft versus host disease grade II-III (50% vs 22.6%; P = 0.008). Additionally, graft T-cell frequency of CD27+\u03b3\u03b4 cells was inversely correlated with relapse (P = 0.006) and CMV reactivation (P = 0.05). We conclude that clinical outcome after allogeneic hematopoietic cell transplantation is influenced by the proportions of distinct \u03b3\u03b4 cell subsets in the stem cell graft. We also provide evidence that CD8+\u03b3\u03b4 cells are potentially alloreactive and may play a role in acute graft versus host disease. This study illustrates the importance of better understanding of the role of distinct subsets of \u03b3\u03b4 cells in allogeneic hematopoietic cell transplantation.", "doi": "10.1038/s41409-019-0462-z", "pmid": "30723262", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41409-019-0462-z"}], "notes": [], "created": "2026-08-20T08:49:04.034Z", "modified": "2026-08-20T08:49:04.188Z"}]}