{"entity": "researcher", "timestamp": "2026-08-22T08:31:10.986Z", "family": "Haglund", "given": "Caj", "initials": "C", "orcid": "0000-0003-0456-4965", "affiliations": ["Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.", "Department of Surgery, Helsinki University Hospital and University of Helsinki, 00029 Helsinki, Finland."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/48130023e2eb4799b611bfbb0d8ca7a6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/48130023e2eb4799b611bfbb0d8ca7a6"}}, "publications": [{"entity": "publication", "iuid": "06a704d7bcce488d8d74ea398cbc8727", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/06a704d7bcce488d8d74ea398cbc8727.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/06a704d7bcce488d8d74ea398cbc8727"}}, "title": "N-Glycomic Profiling of Microsatellite Unstable Colorectal Cancer.", "authors": [{"family": "Ukkola", "given": "Iiris", "initials": "I"}, {"family": "Nummela", "given": "Pirjo", "initials": "P", "orcid": "0000-0002-2768-8816", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f03c81d7069742bfb1c0e17ecc9dca7d.json"}}, {"family": "Heiskanen", "given": "Annamari", "initials": "A"}, {"family": "Holm", "given": "Matilda", "initials": "M", "orcid": "0000-0001-8453-3936", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed98d76b8ec943b5a1d5bd72686ea6aa.json"}}, {"family": "Zafar", "given": "Sadia", "initials": "S"}, {"family": "Kero", "given": "Mia", "initials": "M"}, {"family": "Haglund", "given": "Caj", "initials": "C", "orcid": "0000-0003-0456-4965", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48130023e2eb4799b611bfbb0d8ca7a6.json"}}, {"family": "Satomaa", "given": "Tero", "initials": "T", "orcid": "0000-0001-8547-2661", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6cd09cf7e6a044de85b961896c872a1c.json"}}, {"family": "Kyt\u00f6l\u00e4", "given": "Soili", "initials": "S"}, {"family": "Ristim\u00e4ki", "given": "Ari", "initials": "A"}], "type": "journal article", "published": "2023-07-11", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "volume": "15", "issue": "14", "issn-l": "2072-6694"}, "abstract": "Aberrant glycosylation affects cancer progression and immune evasion. Approximately 15% of colorectal cancers (CRCs) demonstrate microsatellite instability (MSI) and display major differences in outcomes and therapeutic responses, as compared to corresponding microsatellite stable (MSS) tumors. We compared the N-glycan profiles of stage II and IV MSI CRC tumors, further subdivided into BRAFV600E wild-type and mutated subgroups (n = 10 in each subgroup), with each other and with those of paired non-neoplastic mucosal samples using mass spectrometry. Further, the N-glycans of BRAFV600E wild-type stage II MSI tumors were compared to corresponding MSS tumors (n = 9). Multiple differences in N-glycan profiles were identified between the MSI CRCs and control tissues, as well as between the stage II MSI and MSS samples. The MSI CRC tumors showed a lower relative abundance of high-mannose N-glycans than did the control tissues or the MSS CRCs. Among MSI CRC subgroups, acidic N-glycans showed tumor stage and BRAF mutation status-dependent variation. Specifically, the large, sulfated/phosphorylated, and putative terminal N-acetylhexosamine-containing acidic N-glycans differed between the MSI CRC subgroups, showing opposite changes in stages II and IV, when comparing BRAF mutated and wild-type tumors. Our results show that molecular subgroups of CRC exhibit characteristic glycan profiles that may explain certain carcinogenic properties of MSI tumors.", "doi": "10.3390/cancers15143571", "pmid": "37509233", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10376987"}, {"db": "pii", "key": "cancers15143571"}], "notes": [], "created": "2026-08-21T13:01:54.784Z", "modified": "2026-08-21T13:01:54.945Z"}]}