{"entity": "researcher", "timestamp": "2026-08-23T09:27:01.871Z", "family": "De Laere", "given": "Bram", "initials": "B", "orcid": "0000-0002-1174-0384", "affiliations": ["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.", "Department of Human Structure and Repair, Ghent University, Ghent, Belgium."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/47c1a5bde62340a99745e003228b65e8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/47c1a5bde62340a99745e003228b65e8"}}, "publications": [{"entity": "publication", "iuid": "f511fdd9cd9b48b7b139d6dbef9c17c7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f511fdd9cd9b48b7b139d6dbef9c17c7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f511fdd9cd9b48b7b139d6dbef9c17c7"}}, "title": "Author Correction: Androgen receptor pathway inhibitors and taxanes in metastatic prostate cancer: an outcome-adaptive randomized platform trial.", "authors": [{"family": "De Laere", "given": "Bram", "initials": "B", "orcid": "0000-0002-1174-0384", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/47c1a5bde62340a99745e003228b65e8.json"}}, {"family": "Crippa", "given": "Alessio", "initials": "A", "orcid": "0000-0002-2254-2420", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4c2fd732f944e33a63499167999b625.json"}}, {"family": "Discacciati", "given": "Andrea", "initials": "A"}, {"family": "Larsson", "given": "Berit", "initials": "B"}, {"family": "Persson", "given": "Maria", "initials": "M"}, {"family": "Johansson", "given": "Susanne", "initials": "S"}, {"family": "D'hondt", "given": "Sanne", "initials": "S", "orcid": "0000-0002-7604-3117", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c2c87bc36ff8407d8c468a2a6c6e21c4.json"}}, {"family": "Bergstr\u00f6m", "given": "Rebecka", "initials": "R", "orcid": "0000-0001-7609-0733", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8bb4083a4898441b9e5fcbacd7b987a9.json"}}, {"family": "Chellappa", "given": "Venkatesh", "initials": "V"}, {"family": "Mayrhofer", "given": "Markus", "initials": "M"}, {"family": "Banijamali", "given": "Mahsan", "initials": "M"}, {"family": "Kotsalaynen", "given": "Anastasijia", "initials": "A"}, {"family": "Schelstraete", "given": "C\u00e9line", "initials": "C"}, {"family": "Vanwelkenhuyzen", "given": "Jan Pieter", "initials": "JP", "orcid": "0000-0001-6180-1889", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04f85400995743efabdf60232aea2849.json"}}, {"family": "Hj\u00e4lm-Eriksson", "given": "Marie", "initials": "M"}, {"family": "Pettersson", "given": "Linn", "initials": "L"}, {"family": "Ull\u00e9n", "given": "Anders", "initials": "A"}, {"family": "Lumen", "given": "Nicolaas", "initials": "N"}, {"family": "Enblad", "given": "Gunilla", "initials": "G", "orcid": "0000-0002-0594-724X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a285fb437854e2c998356b1a3124416.json"}}, {"family": "Thellenberg Karlsson", "given": "Camilla", "initials": "C", "orcid": "0000-0002-7061-7255", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/72bb3151d82e43a9a4bd6014574bbc40.json"}}, {"family": "J\u00e4nes", "given": "Elin", "initials": "E"}, {"family": "Sandz\u00e9n", "given": "Johan", "initials": "J", "orcid": "0009-0005-8044-3817", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad2629ad7cac4560a9ae4e6bb23b3a11.json"}}, {"family": "Schatteman", "given": "Peter", "initials": "P"}, {"family": "Nyre Vigmostad", "given": "Maria", "initials": "M", "orcid": "0009-0008-8574-686X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/47e5dbb3a4454f72bbc6c6912e83fe1b.json"}}, {"family": "Olsson", "given": "Martha", "initials": "M"}, {"family": "Ghysel", "given": "Christophe", "initials": "C"}, {"family": "Sautois", "given": "Brieuc", "initials": "B", "orcid": "0000-0002-0029-7735", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5967304ddf74a8594c74298b543098d.json"}}, {"family": "De Roock", "given": "Wendy", "initials": "W"}, {"family": "Van Bruwaene", "given": "Siska", "initials": "S"}, {"family": "Anden", "given": "Mats", "initials": "M"}, {"family": "Verbiene", "given": "Ingrida", "initials": "I"}, {"family": "De Maeseneer", "given": "Daan", "initials": "D", "orcid": "0000-0002-0339-5621", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6148db6688e44089868564b3e18f3d2.json"}}, {"family": "Everaert", "given": "Els", "initials": "E"}, {"family": "Darras", "given": "Jochen", "initials": "J"}, {"family": "Aksnessether", "given": "Bj\u00f8rg Y", "initials": "BY"}, {"family": "Luyten", "given": "Daisy", "initials": "D"}, {"family": "Strijbos", "given": "Michiel", "initials": "M"}, {"family": "Mortezavi", "given": "Ashkan", "initials": "A"}, {"family": "Oldenburg", "given": "Jan", "initials": "J"}, {"family": "Ost", "given": "Piet", "initials": "P"}, {"family": "Eklund", "given": "Martin", "initials": "M", "orcid": "0000-0001-5032-5266", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06721510ebc8462386e0e6fc6c84315b.json"}}, {"family": "Gr\u00f6nberg", "given": "Henrik", "initials": "H", "orcid": "0000-0002-1073-2753", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/33927307bf964b2fa09e09c0c867b542.json"}}, {"family": "Lindberg", "given": "Johan", "initials": "J"}], "type": "published erratum", "published": "2024-11-00", "journal": {"title": "Nat. Med.", "issn": "1546-170X", "volume": "30", "issue": "11", "pages": "3381", "issn-l": "1078-8956"}, "abstract": null, "doi": "10.1038/s41591-024-03268-0", "pmid": "39198712", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11564099"}, {"db": "pii", "key": "10.1038/s41591-024-03268-0"}], "notes": [], "created": "2026-08-21T11:52:15.299Z", "modified": "2026-08-21T11:52:15.843Z"}, {"entity": "publication", "iuid": "8b75118a374744e197d0098908bed73a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8b75118a374744e197d0098908bed73a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8b75118a374744e197d0098908bed73a"}}, "title": "Increased Pathway Complexity Is a Prognostic Biomarker in Metastatic Castration-Resistant Prostate Cancer.", "authors": [{"family": "De Laere", "given": "Bram", "initials": "B", "orcid": "0000-0002-1174-0384", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/47c1a5bde62340a99745e003228b65e8.json"}}, {"family": "Crippa", "given": "Alessio", "initials": "A"}, {"family": "Mortezavi", "given": "Ashkan", "initials": "A", "orcid": "0000-0001-6307-2659", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf5810c600444a90bf422f4e79346de6.json"}}, {"family": "Ghysel", "given": "Christophe", "initials": "C"}, {"family": "Rajan", "given": "Prabhakar", "initials": "P"}, {"family": "Eklund", "given": "Martin", "initials": "M"}, {"family": "Wyatt", "given": "Alexander", "initials": "A"}, {"family": "Dirix", "given": "Luc", "initials": "L"}, {"family": "Ost", "given": "Piet", "initials": "P"}, {"family": "Gr\u00f6nberg", "given": "Henrik", "initials": "H"}, {"family": "Lindberg", "given": "Johan", "initials": "J", "orcid": "0000-0003-3610-6774", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e5102a5c0ee2436bb9f35d36188d3e69.json"}}], "type": "journal article", "published": "2021-03-30", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "volume": "13", "issue": "7", "issn-l": "2072-6694"}, "abstract": "Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease, characterized by common and rare driver gene alterations that provide a selective growth advantage for progressing tumour cells. We hypothesized that the number of distinct gene driver alteration-affected pathways or gene classes was associated with poor prognosis in patients initiating androgen receptor signalling inhibitors (ARSi). We performed a post hoc analysis of an amalgamated baseline circulating tumour DNA (ctDNA) mutational landscape dataset of ARSi-treated men with mCRPC (n = 342). We associated the detected hotspot, pathogenic, and/or high impact protein function-affecting perturbations in 39 genes into 13 pathways. Progression-free (PFS) and overall survival (OS) were analysed using Kaplan-Meier curves and multivariate Cox regression models. Driver gene alterations were detected in 192/342 (56.1%) evaluable patients. An increased number of affected pathways, coined pathway complexity index (PCI), resulted in a decremental PFS and OS, and was independently associated with prognosis once \u22653 pathway or gene classes were affected (PFS HR (95%CI): 1.7 (1.02-2.84), p = 0.04, and OS HR (95%CI): 2.5 (1.06-5.71), p = 0.04). Additionally, visceral disease and baseline PSA and plasma ctDNA levels were independently associated with poor prognosis. Elevated PCI is associated with poor ARSi outcome and supports comprehensive genomic profiling to better infer mCRPC prognosis.", "doi": "10.3390/cancers13071588", "pmid": "33808193", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8037684"}, {"db": "pii", "key": "cancers13071588"}], "notes": [], "created": "2026-08-21T13:01:40.299Z", "modified": "2026-08-21T13:01:40.430Z"}]}