{"entity": "researcher", "timestamp": "2026-08-25T09:31:16.371Z", "family": "Anij\u00e4rv", "given": "Toomas Erik", "initials": "TE", "orcid": "0000-0002-3650-4230", "affiliations": ["Clinical Memory Research Unit, Department of Clinical Sciences Malm\u00f6, Faculty of Medicine, Lund University, Lund, Sweden. toomas_erik.anijarv@med.lu.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/478837ec8fef4a8d9d4b39e088049614.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/478837ec8fef4a8d9d4b39e088049614"}}, "publications": [{"entity": "publication", "iuid": "41296afe1fb94394af66909057750160", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/41296afe1fb94394af66909057750160.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/41296afe1fb94394af66909057750160"}}, "title": "Hemispheric asymmetry of tau pathology is related to asymmetric amyloid deposition in Alzheimer's Disease.", "authors": [{"family": "Anij\u00e4rv", "given": "Toomas Erik", "initials": "TE", "orcid": "0000-0002-3650-4230", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/478837ec8fef4a8d9d4b39e088049614.json"}}, {"family": "Ossenkoppele", "given": "Rik", "initials": "R", "orcid": "0000-0003-1584-7477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9486d27ddd1b4b6485fa3ca10e0f3d82.json"}}, {"family": "Smith", "given": "Ruben", "initials": "R", "orcid": "0000-0001-7147-0112", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c69d9e76c884720afe20ce34b2c4d81.json"}}, {"family": "Pichet Binette", "given": "Alexa", "initials": "A", "orcid": "0000-0001-5218-3337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8f0967b7b694bcf96e30a051a5bbe9a.json"}}, {"family": "Collij", "given": "Lyduine E", "initials": "LE", "orcid": "0000-0001-6263-1762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6612222d48fd4bdcaa7c091d38efcc2b.json"}}, {"family": "Behjat", "given": "Harry H", "initials": "HH", "orcid": "0000-0001-6729-6801", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e5d1b40c4a8342eb841754961f1b3593.json"}}, {"family": "Rittmo", "given": "Jonathan", "initials": "J", "orcid": "0000-0001-5075-0166", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f46afd59d3a44a18a35c560c3d2e37f3.json"}}, {"family": "Karlsson", "given": "Linda", "initials": "L", "orcid": "0000-0002-0630-772X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ead4d76d56ff439ba30689e7dfe3aae2.json"}}, {"family": "Ahmadi", "given": "Khazar", "initials": "K", "orcid": "0000-0002-3371-6211", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5295cea5ead34b96a887d4055ccd659b.json"}}, {"family": "Strandberg", "given": "Olof", "initials": "O"}, {"family": "Alzheimer\u2019s Disease Neuroimaging Initiative", "given": "", "initials": ""}, {"family": "van Westen", "given": "Danielle", "initials": "D", "orcid": "0000-0001-8649-9874", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38afd81dca574f4a9884a1ce97b78e50.json"}}, {"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}, {"family": "Stomrud", "given": "Erik", "initials": "E"}, {"family": "Palmqvist", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-9267-1930", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fbd05e87cfb4057a1a7e41d9fb94aef.json"}}, {"family": "Mattsson-Carlgren", "given": "Niklas", "initials": "N", "orcid": "0000-0002-8885-7724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb26ae59b2a04f369c5ebc2f2375195a.json"}}, {"family": "Spotorno", "given": "Nicola", "initials": "N", "orcid": "0000-0001-5404-8788", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4851c8ec84264207bdf67c2fd04643da.json"}}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}], "type": "journal article", "published": "2025-09-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "8232", "issn-l": "2041-1723"}, "abstract": "The distribution of tau pathology in Alzheimer's disease (AD) shows remarkable inter-individual heterogeneity, including hemispheric asymmetry. However, the factors driving this asymmetry remain poorly understood. Here we explore whether tau asymmetry is linked to i) reduced inter-hemispheric brain connectivity (potentially restricting tau spread), or ii) asymmetry in amyloid-beta (A\u03b2) distribution (indicating greater hemisphere-specific vulnerability to AD pathology). We include 452 participants from the Swedish BioFINDER-2 cohort with evidence of both A\u03b2 pathology (CSF A\u03b242/40 or neocortical A\u03b2-PET) and tau pathology (temporal tau-PET), categorising them as left asymmetric (n = 102), symmetric (n = 306), or right asymmetric (n = 44) based on temporal lobe tau-PET uptake distribution. We assess edge-wise inter-hemispheric functional (RSfMRI; n = 318) and structural connectivity (dMRI; n = 352) but find no association between tau asymmetry and connectivity. In contrast, we observe a strong association between tau and A\u03b2 laterality patterns based on PET uptake (n = 233; \u03b2 = 0.632, p < 0.001), which we replicate in three independent cohorts (n = 234; \u03b2 = 0.535, p < 0.001). In a longitudinal A\u03b2-positive sample, we show that baseline A\u03b2 asymmetry predicts progression of tau laterality over time (n = 289; \u03b2 = 0.025, p = 0.028). These findings suggest that tau asymmetry is not associated with a weaker inter-hemispheric connectivity but might reflect hemispheric differences in vulnerability to A\u03b2 pathology, underscoring the role of regional vulnerability in determining the distribution of AD pathology.", "doi": "10.1038/s41467-025-63564-2", "pmid": "40913038", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12413461"}, {"db": "pii", "key": "10.1038/s41467-025-63564-2"}], "notes": [], "created": "2026-08-21T11:50:12.353Z", "modified": "2026-08-21T11:50:12.696Z"}]}