{"entity": "researcher", "timestamp": "2026-08-20T20:43:07.842Z", "family": "Ghia", "given": "Paolo", "initials": "P", "orcid": "0000-0003-3750-7342", "affiliations": ["Universit\u00e0 Vita-Salute San Raffaele and IRCC Ospedale San Raffaele, Milan, Italy."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/475d35f1a3c446819b2f24be819c2dee.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/475d35f1a3c446819b2f24be819c2dee"}}, "publications": [{"entity": "publication", "iuid": "048922da2a384daa953047cd1a0fa998", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/048922da2a384daa953047cd1a0fa998.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/048922da2a384daa953047cd1a0fa998"}}, "title": "Clinical and transcriptomic characterization of patients with chronic lymphocytic leukemia harboring t(14;19): an ERIC study.", "authors": [{"family": "Visentin", "given": "Andrea", "initials": "A", "orcid": "0000-0003-0271-7200", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10a25bb174034d55a6a2f0fccb036f02.json"}}, {"family": "Gaffo", "given": "Enrico", "initials": "E", "orcid": "0000-0001-6338-7677", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a30412a5d86429d99d9ab62bf7be0b2.json"}}, {"family": "F\u00fcrstenau", "given": "Moritz", "initials": "M", "orcid": "0000-0002-6593-0140", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f3c1950a80040ada1cda908470910c9.json"}}, {"family": "Rogers", "given": "Kerry A", "initials": "KA"}, {"family": "Panagiotis", "given": "Baliakas", "initials": "B", "orcid": "0000-0002-5634-7156", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a31997db1ee4ef1aaff75e423b8ccfb.json"}}, {"family": "Cui", "given": "Chenghua", "initials": "C"}, {"family": "Miller", "given": 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{"href": "https://publications-affiliated.scilifelab.se/researcher/f223eed5e0dc4decad48346341db0f6b.json"}}, {"family": "Cuneo", "given": "Antonio", "initials": "A"}, {"family": "Ghia", "given": "Paolo", "initials": "P", "orcid": "0000-0003-3750-7342", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/475d35f1a3c446819b2f24be819c2dee.json"}}, {"family": "Stamatopoulos", "given": "Kostas", "initials": "K", "orcid": "0000-0001-8529-640X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06f6107d6f774ee6acb2c66ecfcb90cc.json"}}, {"family": "Trentin", "given": "Livio", "initials": "L", "orcid": "0000-0003-1222-6149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/820ab4c1a5534ada88d9c318fa8aa2e1.json"}}, {"family": "Bortoluzzi", "given": "Stefania", "initials": "S", "orcid": "0000-0001-8240-3070", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0831daa98b3b4ea980ccd20da78a22fb.json"}}], "type": "journal article", "published": "2025-12-00", "journal": {"title": "Leukemia", "issn": "1476-5551", "volume": "39", "issue": "12", "pages": "2957-2967", "issn-l": "0887-6924"}, "abstract": "In chronic lymphocytic leukemia (CLL), the role of complex karyotype (CK) for prognostic stratification remains a topic of debate, and the impact of specific cytogenetic abnormalities is still unclear. This study aims to investigate the clinical and biological features of CLL with t(14;19)(q32;q13) (tCLL) involving the BCL3 gene. Patients with tCLL were younger and more commonly presented unmutated IGHV gene, subset #8 stereotypy, trisomy of chromosome 12, and complex karyotype than other patients without t(14;19) (oCLL). The presence of t(14;19) was associated with a shorter time to treatment and overall survival compared to oCLL. Gene expression analysis revealed a unique transcriptome profile in tCLL, characterized by the upregulation of BCL3 and the activation of B-cell receptor, PI3K-Akt. Conversely, apoptosis-related pathways were suppressed in tCLL. While the BTK gene was upregulated, the BCL2L11 gene, coding for the pro-apoptotic protein BIM, was downregulated. Notably, patients with tCLL were characterized by a trend (p = 0.058) for a longer time to the next treatment with BTK inhibitors (BTKi) compared to those treated with a venetoclax-based (Ven-based) regimen. We underscore the adverse outcomes of tCLL, its distinct molecular features and gene expression patterns. Therefore, our data suggest that identifying tCLL could help tailor therapeutic approaches.", "doi": "10.1038/s41375-025-02755-8", "pmid": "40973766", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12634426"}, {"db": "pii", "key": "10.1038/s41375-025-02755-8"}], "notes": [], "created": "2026-08-20T08:47:27.388Z", "modified": "2026-08-20T08:47:52.757Z"}, {"entity": "publication", "iuid": "4dcc7aa2e98e41e5924199166195f148", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4dcc7aa2e98e41e5924199166195f148.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4dcc7aa2e98e41e5924199166195f148"}}, "title": "The evolving landscape of COVID-19 and post-COVID condition in patients with chronic lymphocytic leukemia: A study by ERIC, the European research initiative on CLL.", "authors": [{"family": "Visentin", "given": "Andrea", "initials": "A", "orcid": "0000-0003-0271-7200", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10a25bb174034d55a6a2f0fccb036f02.json"}}, {"family": "Chatzikonstantinou", "given": "Thomas", "initials": "T", "orcid": "0000-0003-4105-1253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a205228c1594457fbd55004721eb19c3.json"}}, {"family": "Scarf\u00f2", "given": "Lydia", "initials": "L", "orcid": "0000-0002-0844-0989", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7697d7b279ae48a387843c617f30fa3c.json"}}, {"family": "Kapetanakis", "given": "Anargyros", "initials": "A", "orcid": "0000-0002-5770-8654", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6dabcfc8a904913a5f44441b30fb9cc.json"}}, {"family": "Demosthenous", "given": "Christos", "initials": "C", "orcid": "0000-0002-2008-7954", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/147aee2210fa4325bf08d88d92054a51.json"}}, {"family": 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"J"}, {"family": "Orsucci", "given": "Lorella", "initials": "L"}, {"family": "Papaioannou", "given": "Maria", "initials": "M"}, {"family": "Pavlovsky", "given": "Miguel Arturo", "initials": "MA"}, {"family": "Piskunova", "given": "Inga", "initials": "I"}, {"family": "Popov", "given": "Viola Maria", "initials": "VM"}, {"family": "Quaglia", "given": "Francesca Maria", "initials": "FM"}, {"family": "Quaresmini", "given": "Giulia", "initials": "G"}, {"family": "Qvist", "given": "Kristian", "initials": "K"}, {"family": "Rigolin", "given": "Gian Matteo", "initials": "GM", "orcid": "0000-0002-8370-5190", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f66f2d62db5d49d2a7443f5e0b5d3eed.json"}}, {"family": "Ruchlemer", "given": "Rosa", "initials": "R", "orcid": "0000-0001-8349-0794", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7080290ab374d69a3c85484bb71bd11.json"}}, {"family": "\u0160imkovi\u010d", "given": "Martin", "initials": "M"}, {"family": "\u0160pa\u010dek", "given": "Martin", "initials": "M"}, {"family": "Sportoletti", "given": "Paolo", "initials": "P", "orcid": "0000-0002-5630-9862", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c6ab8837a35443f0a3ef319ca9b4f683.json"}}, {"family": "Stanca", "given": "Oana", "initials": "O"}, {"family": "Tadmor", "given": "Tamar", "initials": "T", "orcid": "0000-0002-3435-8612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ce4288f837e475e8ad1ea911d78fa4c.json"}}, {"family": "Capasso", "given": "Antonella", "initials": "A"}, {"family": "Del Poeta", "given": "Giovanni", "initials": "G"}, {"family": "Gutwein", "given": "Odit", "initials": "O"}, {"family": "Karlsson", "given": "Linda Katharina", "initials": "LK"}, {"family": "Milosevic", "given": "Ivana", "initials": "I"}, {"family": "Mir\u00e1s", "given": "Fatima", "initials": "F"}, {"family": "Reda", "given": "Gianluigi", "initials": "G", "orcid": "0000-0003-4687-7089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc2be38bcf024aa4a06c571c1ed7ffcf.json"}}, {"family": "Saghumyan", "given": "Gevorg", "initials": "G"}, {"family": "Shrestha", "given": "Amit", "initials": "A"}, {"family": "Te Raa", "given": "Doreen", "initials": "D"}, {"family": "Tonino", "given": "Sanne H", "initials": "SH"}, {"family": "Van Der Spek", "given": "Ellen", "initials": "E"}, {"family": "van Gelder", "given": "Michel", "initials": "M"}, {"family": "van Kampen", "given": "Roel", "initials": "R"}, {"family": "Wasik-Szczepanek", "given": "Ewa", "initials": "E"}, {"family": "Wr\u00f3bel", "given": "Tomasz", "initials": "T"}, {"family": "Segundo", "given": "Lucrecia Y\u00e1\u00f1ez San", "initials": "LYS"}, {"family": "Yassin", "given": "Mohamed", "initials": "M", "orcid": "0000-0002-1144-8076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40a808948be848ed8c749a1d3b842b56.json"}}, {"family": "Pocali", "given": "Barbara", "initials": "B"}, {"family": "Vandenberghe", "given": "Elisabeth", "initials": "E"}, {"family": "Iyengar", "given": "Sunil", "initials": "S"}, {"family": "Varettoni", "given": "Marzia", "initials": "M", "orcid": "0000-0001-7304-1629", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/399b2772fab646c38c128e7d14eca17b.json"}}, {"family": "Vitale", "given": "Candida", "initials": "C"}, {"family": "Coscia", "given": "Marta", "initials": "M"}, {"family": "Rambaldi", "given": "Alessandro", "initials": "A"}, {"family": "Montserrat", "given": "Emili", "initials": "E"}, {"family": "Cuneo", "given": "Antonio", "initials": "A"}, {"family": "Stavroyianni", "given": "Niki", "initials": "N"}, {"family": "Trentin", "given": "Livio", "initials": "L", "orcid": "0000-0003-1222-6149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/820ab4c1a5534ada88d9c318fa8aa2e1.json"}}, {"family": "Stamatopoulos", "given": "Kostas", "initials": "K", "orcid": "0000-0001-8529-640X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06f6107d6f774ee6acb2c66ecfcb90cc.json"}}, {"family": "Ghia", "given": "Paolo", "initials": "P", "orcid": "0000-0003-3750-7342", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/475d35f1a3c446819b2f24be819c2dee.json"}}], "type": "multicenter study", "published": "2023-12-00", "journal": {"title": "Am. J. Hematol.", "issn": "1096-8652", "volume": "98", "issue": "12", "pages": "1856-1868", "issn-l": "0361-8609"}, "abstract": "In this retrospective international multicenter study, we describe the clinical characteristics and outcomes of patients with chronic lymphocytic leukemia (CLL) and related disorders (small lymphocytic lymphoma and high-count monoclonal B lymphocytosis) infected by SARS-CoV-2, including the development of post-COVID condition. Data from 1540 patients with CLL infected by SARS-CoV-2 from January 2020 to May 2022 were included in the analysis and assigned to four phases based on cases disposition and SARS-CoV-2 variants emergence. Post-COVID condition was defined according to the WHO criteria. Patients infected during the most recent phases of the pandemic, though carrying a higher comorbidity burden, were less often hospitalized, rarely needed intensive care unit admission, or died compared to patients infected during the initial phases. The 4-month overall survival (OS) improved through the phases, from 68% to 83%, p = .0015. Age, comorbidity, CLL-directed treatment, but not vaccination status, emerged as risk factors for mortality. Among survivors, 6.65% patients had a reinfection, usually milder than the initial one, and 16.5% developed post-COVID condition. The latter was characterized by fatigue, dyspnea, lasting cough, and impaired concentration. Infection severity was the only risk factor for developing post-COVID. The median time to resolution of the post-COVID condition was 4.7 months. OS in patients with CLL improved during the different phases of the pandemic, likely due to the improvement of prophylactic and therapeutic measures against SARS-CoV-2 as well as the emergence of milder variants. However, mortality remained relevant and a significant number of patients developed post-COVID conditions, warranting further investigations.", "doi": "10.1002/ajh.27093", "pmid": "37772428", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T06:28:29.653Z", "modified": "2026-08-20T06:28:31.016Z"}, {"entity": "publication", "iuid": "21da3bc10c124fba848c5665f16e4db7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/21da3bc10c124fba848c5665f16e4db7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/21da3bc10c124fba848c5665f16e4db7"}}, "title": "COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study.", "authors": [{"family": "Chatzikonstantinou", "given": "Thomas", "initials": "T", "orcid": "0000-0003-4105-1253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a205228c1594457fbd55004721eb19c3.json"}}, {"family": "Kapetanakis", "given": "Anargyros", "initials": "A"}, {"family": "Scarf\u00f2", "given": "Lydia", "initials": "L"}, {"family": "Karakatsoulis", "given": "Georgios", "initials": "G"}, {"family": "Allsup", "given": "David", "initials": "D", "orcid": "0000-0001-6159-6109", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6828c5d394184614a53484294f16c63d.json"}}, {"family": "Cabrero", "given": "Alejandro Alonso", "initials": "AA"}, {"family": "Andres", "given": "Martin", "initials": "M", "orcid": "0000-0001-9891-2988", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/99825a6c9821483a92cda6867ed92efe.json"}}, {"family": "Antic", "given": "Darko", "initials": "D"}, {"family": "Baile", "given": "M\u00f3nica", "initials": "M"}, {"family": "Baliakas", "given": "Panagiotis", "initials": "P"}, {"family": "Bron", "given": "Dominique", "initials": "D"}, {"family": "Capasso", "given": "Antonella", "initials": "A"}, {"family": "Chatzileontiadou", "given": "Sofia", "initials": "S"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Correa", "given": "Juan-Gonzalo", "initials": "JG"}, {"family": "Cu\u00e9llar-Garc\u00eda", "given": "Carolina", "initials": "C"}, {"family": "De Paoli", "given": "Lorenzo", "initials": "L"}, {"family": "De Paolis", "given": "Maria Rosaria", "initials": "MR"}, {"family": "Del Poeta", "given": "Giovanni", "initials": "G"}, {"family": "Demosthenous", "given": "Christos", "initials": "C"}, {"family": "Dimou", "given": "Maria", "initials": "M", "orcid": "0000-0001-8197-9895", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22308a24178f41adad1c7b4f86f8c833.json"}}, {"family": "Donaldson", "given": "David", "initials": "D"}, {"family": "Doubek", "given": "Michael", "initials": "M", "orcid": "0000-0002-1269-6282", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/69820fa805ac43ad892da50ac25d3e72.json"}}, {"family": "Efstathopoulou", "given": "Maria", "initials": "M"}, {"family": "Eichhorst", "given": "Barbara", "initials": "B"}, {"family": "El-Ashwah", "given": "Shaimaa", "initials": "S"}, {"family": "Enrico", "given": "Alicia", "initials": "A", "orcid": "0000-0002-1983-6145", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/515a92b72f0b48a597dd6f8353f549a9.json"}}, {"family": "Espinet", "given": "Blanca", "initials": "B", "orcid": "0000-0002-4294-8145", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b59addc668aa47be999e82efa5a6a9df.json"}}, {"family": "Farina", "given": "Lucia", "initials": "L"}, {"family": "Ferrari", "given": "Angela", "initials": "A"}, {"family": "Foglietta", "given": "Myriam", "initials": "M"}, {"family": "Frederiksen", "given": "Henrik", "initials": "H", "orcid": "0000-0001-8905-0220", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c755655ce9f14212902091a939c9dcd2.json"}}, {"family": "F\u00fcrstenau", "given": "Moritz", "initials": "M", "orcid": "0000-0002-6593-0140", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f3c1950a80040ada1cda908470910c9.json"}}, {"family": "Garc\u00eda-Marco", "given": "Jos\u00e9 A", "initials": "JA", "orcid": "0000-0002-8993-5982", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5935bc47fa584de296fa2fce95786e85.json"}}, {"family": "Garc\u00eda-Serra", "given": "Roc\u00edo", "initials": "R", "orcid": "0000-0003-4857-1016", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4633fa4a15949fea6f87c84535f9dbf.json"}}, {"family": "Gentile", "given": "Massimo", "initials": "M"}, {"family": "Gimeno", "given": "Eva", "initials": "E"}, {"family": "Glenth\u00f8j", "given": "Andreas", "initials": "A"}, {"family": "Gomes da Silva", "given": "Maria", "initials": "M"}, {"family": "Gutwein", "given": "Odit", "initials": "O"}, {"family": "Hakobyan", "given": "Yervand K", "initials": "YK", "orcid": "0000-0002-9074-7831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/164d8ef5b0804300b99b85c5393c48b0.json"}}, {"family": "Herishanu", "given": "Yair", "initials": "Y"}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9 \u00c1ngel", "initials": "J\u00c1", "orcid": "0000-0003-4550-757X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c34957e1a2494a36816584b742e24f30.json"}}, {"family": "Herold", "given": "Tobias", "initials": "T", "orcid": "0000-0002-9615-9432", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1375d1c9275948e0b82afe363f3bbdfa.json"}}, {"family": "Innocenti", "given": "Idanna", "initials": "I"}, {"family": "Itchaki", "given": "Gilad", "initials": "G"}, {"family": "Jaksic", "given": "Ozren", "initials": "O"}, {"family": "Janssens", "given": "Ann", "initials": "A"}, {"family": "Kalashnikova", "given": "\u041elga B", "initials": "\u041eB", "orcid": "0000-0002-1856-1055", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6e234bc02a543cfa5fe0aace31cca64.json"}}, {"family": "Kalici\u0144ska", "given": "El\u017cbieta", "initials": "E"}, {"family": "Karlsson", "given": "Linda Katharina", "initials": "LK", "orcid": "0000-0003-3317-7550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e3eee3fe8da4a3b91ebf99670eea462.json"}}, {"family": "Kater", "given": "Arnon P", "initials": "AP"}, {"family": "Kersting", "given": "Sabina", "initials": "S"}, {"family": "Labrador", "given": "Jorge", "initials": "J", "orcid": "0000-0002-3696-0287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ddd0476715fd42fa92167ac353829fe4.json"}}, {"family": "Lad", "given": "Deepesh", "initials": "D", "orcid": "0000-0003-3754-7774", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de9205532d2a40e5a1cdf2870957b3f0.json"}}, {"family": "Laurenti", "given": "Luca", "initials": "L"}, {"family": "Levin", "given": "Mark-David", "initials": "MD", "orcid": "0000-0003-2139-3547", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac8060ca33ae4c2d88f499787bd3456a.json"}}, {"family": "Lista", "given": "Enrico", "initials": "E"}, {"family": "Lopez-Garcia", "given": "Alberto", "initials": "A", "orcid": "0000-0002-5354-5261", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e0fa867746d14e9ea28a8e5ac1041b7c.json"}}, {"family": "Malerba", "given": "Lara", "initials": "L"}, {"family": "Marasca", "given": "Roberto", "initials": "R", "orcid": "0000-0002-6431-6878", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5424e54c248d47d08e88f019dc560f9b.json"}}, {"family": "Marchetti", "given": "Monia", "initials": "M", "orcid": "0000-0001-7615-0572", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e9ce74bf03b4418a59bfcf5d3d94e4f.json"}}, {"family": "Marquet", "given": "Juan", "initials": "J"}, {"family": "Mattsson", "given": "Mattias", "initials": "M"}, {"family": "Mauro", "given": "Francesca R", "initials": "FR"}, {"family": "Milosevic", "given": "Ivana", "initials": "I"}, {"family": "Mir\u00e1s", "given": "Fatima", "initials": "F"}, {"family": "Morawska", "given": "Marta", "initials": "M"}, {"family": "Motta", "given": "Marina", "initials": "M"}, {"family": "Munir", "given": "Talha", "initials": "T"}, {"family": "Murru", "given": "Roberta", "initials": "R"}, {"family": "Niemann", "given": "Carsten U", "initials": "CU", "orcid": "0000-0001-9880-5242", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/edc879406bd24389b773f08ceec3f823.json"}}, {"family": "Rodrigues", "given": "Raquel Nunes", "initials": "RN"}, {"family": "Olivieri", "given": "Jacopo", "initials": "J"}, {"family": "Orsucci", "given": "Lorella", "initials": "L"}, {"family": "Papaioannou", "given": "Maria", "initials": "M"}, {"family": "Pavlovsky", "given": "Miguel Arturo", "initials": "MA"}, {"family": "Piskunova", "given": "Inga", "initials": "I"}, {"family": "Popov", "given": "Viola Maria", "initials": "VM", "orcid": "0000-0002-1200-379X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c76e0ce7f5094aabba4b02d70c0fa02a.json"}}, {"family": "Quaglia", "given": "Francesca Maria", "initials": "FM", "orcid": "0000-0003-4347-3775", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d5b6e74655f741ffa2f0d112bbb4fc78.json"}}, {"family": "Quaresmini", "given": "Giulia", "initials": "G", "orcid": "0000-0002-0993-9693", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/12d35dab37ac4569bc29693ee59e7295.json"}}, {"family": "Qvist", "given": "Kristian", "initials": "K"}, {"family": "Reda", "given": "Gianluigi", "initials": "G", "orcid": "0000-0003-4687-7089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc2be38bcf024aa4a06c571c1ed7ffcf.json"}}, {"family": "Rigolin", "given": "Gian Matteo", "initials": "GM", "orcid": "0000-0002-8370-5190", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f66f2d62db5d49d2a7443f5e0b5d3eed.json"}}, {"family": "Ruchlemer", "given": "Rosa", "initials": "R"}, {"family": "Saghumyan", "given": "Gevorg", "initials": "G"}, {"family": "Shrestha", "given": "Amit", "initials": "A"}, {"family": "\u0160imkovi\u010d", "given": "Martin", "initials": "M"}, {"family": "\u0160pa\u010dek", "given": "Martin", "initials": "M"}, {"family": "Sportoletti", "given": "Paolo", "initials": "P"}, {"family": "Stanca", "given": "Oana", "initials": "O"}, {"family": "Stavroyianni", "given": "Niki", "initials": "N"}, {"family": "Tadmor", "given": "Tamar", "initials": "T", "orcid": "0000-0002-3435-8612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ce4288f837e475e8ad1ea911d78fa4c.json"}}, {"family": "Te Raa", "given": "Doreen", "initials": "D"}, {"family": "Tonino", "given": "Sanne H", "initials": "SH"}, {"family": "Trentin", "given": "Livio", "initials": "L", "orcid": "0000-0003-1222-6149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/820ab4c1a5534ada88d9c318fa8aa2e1.json"}}, {"family": "Van Der Spek", "given": "Ellen", "initials": "E"}, {"family": "van Gelder", "given": "Michel", "initials": "M"}, {"family": "van Kampen", "given": "Roel", "initials": "R"}, {"family": "Varettoni", "given": "Marzia", "initials": "M"}, {"family": "Visentin", "given": "Andrea", "initials": "A"}, {"family": "Vitale", "given": "Candida", "initials": "C", "orcid": "0000-0002-2592-8724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f78e00de5d57477aa5f65785c650a158.json"}}, {"family": "Wasik-Szczepanek", "given": "Ewa", "initials": "E"}, {"family": "Wr\u00f3bel", "given": "Tomasz", "initials": "T"}, {"family": "San Segundo", "given": "Lucrecia Y\u00e1\u00f1ez", "initials": "LY"}, {"family": "Yassin", "given": "Mohamed", "initials": "M"}, {"family": "Coscia", "given": "Marta", "initials": "M"}, {"family": "Rambaldi", "given": "Alessandro", "initials": "A"}, {"family": "Montserrat", "given": "Emili", "initials": "E"}, {"family": "Fo\u00e0", "given": "Robin", "initials": "R", "orcid": "0000-0002-5021-3026", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/12670d8c9f80419ebbd57a1dde9f9596.json"}}, {"family": "Cuneo", "given": "Antonio", "initials": "A"}, {"family": "Stamatopoulos", "given": "Kostas", "initials": "K", "orcid": "0000-0001-8529-640X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06f6107d6f774ee6acb2c66ecfcb90cc.json"}}, {"family": "Ghia", "given": "Paolo", "initials": "P", "orcid": "0000-0003-3750-7342", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/475d35f1a3c446819b2f24be819c2dee.json"}}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Leukemia", "issn": "1476-5551", "volume": "35", "issue": "12", "pages": "3444-3454", "issn-l": "0887-6924"}, "abstract": "Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41-0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02-1.04; HR = 1.79, 95% CI:1.04-3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.", "doi": "10.1038/s41375-021-01450-8", "pmid": "34725454", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8559135"}, {"db": "pii", "key": "10.1038/s41375-021-01450-8"}], "notes": [], "created": "2026-08-20T08:47:17.647Z", "modified": "2026-08-20T08:47:44.704Z"}, {"entity": "publication", "iuid": "bf16d891cf3342419b071e4d9328a41c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bf16d891cf3342419b071e4d9328a41c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bf16d891cf3342419b071e4d9328a41c"}}, "title": "Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: updated ERIC recommendations.", "authors": [{"family": "Rosenquist", "given": "R", "initials": "R"}, {"family": "Ghia", "given": "P", "initials": "P", "orcid": "0000-0003-3750-7342", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/475d35f1a3c446819b2f24be819c2dee.json"}}, {"family": "Hadzidimitriou", "given": "A", "initials": "A"}, {"family": "Sutton", "given": "L-A", "initials": "LA"}, {"family": "Agathangelidis", "given": "A", "initials": "A"}, {"family": "Baliakas", "given": "P", "initials": "P"}, {"family": "Darzentas", "given": "N", "initials": "N"}, {"family": "Giudicelli", "given": "V", "initials": "V"}, {"family": "Lefranc", "given": "M-P", "initials": "MP"}, {"family": "Langerak", "given": "A W", "initials": "AW"}, {"family": "Belessi", "given": "C", "initials": "C"}, {"family": "Davi", "given": "F", "initials": "F"}, {"family": "Stamatopoulos", "given": "K", "initials": "K"}], "type": "editorial", "published": "2017-07-00", "journal": {"title": "Leukemia", "issn": "1476-5551", "volume": "31", "issue": "7", "pages": "1477-1481", "issn-l": "0887-6924"}, "abstract": null, "doi": "10.1038/leu.2017.125", "pmid": "28439111", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5508071"}, {"db": "pii", "key": "leu2017125"}], "notes": [], "created": "2026-08-20T08:44:06.905Z", "modified": "2026-08-20T08:44:06.928Z"}]}