{"entity": "researcher", "timestamp": "2026-08-20T21:12:12.534Z", "family": "O'Brien", "given": "Jake W", "initials": "JW", "orcid": "0000-0001-9336-9656", "affiliations": ["Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba 4102 Queensland, Australia.", "Van 't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Amsterdam 1090 GD, The Netherlands."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/449a21afc3fe4470a98e0db190468675.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/449a21afc3fe4470a98e0db190468675"}}, "publications": [{"entity": "publication", "iuid": "44a116c32dae492391309c47a915abfb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/44a116c32dae492391309c47a915abfb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/44a116c32dae492391309c47a915abfb"}}, "title": "Discovery of Previously Unreported Per- and Polyfluoroalkyl Substances (PFAS) in Pooled Australian Human Serum Using Nontarget Analysis.", "authors": [{"family": "Dewapriya", "given": "Pradeep", "initials": "P", "orcid": "0000-0002-6383-1843", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/20fa77980f284da0bf7e2d4d6a8d38cb.json"}}, {"family": "Nilsson", "given": "Sandra", "initials": "S", "orcid": "0000-0002-1030-7167", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/acc9b99839b94d70be6e4f57d9081dc6.json"}}, {"family": "Ghorbani Gorji", "given": "Sara", "initials": "S", "orcid": "0000-0002-7413-1228", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a235dbe8ac44f1f8b067ebb2183fdb4.json"}}, {"family": "O'Brien", "given": "Jake W", "initials": "JW", "orcid": "0000-0001-9336-9656", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/449a21afc3fe4470a98e0db190468675.json"}}, {"family": "Br\u00e4unig", "given": "Jennifer", "initials": "J"}, {"family": "Jos\u00e9 G\u00f3mez Ramos", "given": "Mar\u00eda", "initials": "M"}, {"family": "Samanipour", "given": "Saer", "initials": "S", "orcid": "0000-0001-8270-6979", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e5c5e087f1414ed19838084b5113f775.json"}}, {"family": "Martin", "given": "Jonathan W", "initials": "JW", "orcid": "0000-0001-6265-4294", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02199c0d99674e2ea5e96e6589c07a00.json"}}, {"family": "Toms", "given": "Leisa-Maree L", "initials": "LL", "orcid": "0000-0002-1444-1638", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b8b63fc625f4745b5c7a5ecbeeec1bd.json"}}, {"family": "Mueller", "given": "Jochen F", "initials": "JF"}, {"family": "Kaserzon", "given": "Sarit L", "initials": "SL", "orcid": "0000-0002-6744-1279", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f7cf9ea83a284fb4be5ab894ea7142aa.json"}}, {"family": "Thomas", "given": "Kevin V", "initials": "KV", "orcid": "0000-0002-2155-100X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8702b01e942e43afb0d963004a571a0f.json"}}], "type": "journal article", "published": "2025-12-09", "journal": {"title": "Environ. Sci. Technol.", "issn": "1520-5851", "volume": "59", "issue": "48", "pages": "26081-26091", "issn-l": "0013-936X"}, "abstract": "Humans may be exposed to thousands of per- and polyfluoroalkyl substances (PFAS), yet only a small fraction of these are regularly monitored, potentially underestimating the associated risks. This study employed high-resolution mass spectrometry (HRMS)-based nontarget analysis to investigate previously unreported PFAS in pooled serum from Australians. Samples collected between 2002 and 2021 from men aged > 30 years in the general population (GP, n = 27) and firefighters (FF, n = 18), categorized into three age groups (31-45, 46-60, and \u2265 60), were analyzed. Fourteen PFAS were identified or structurally annotated, including six known (level 1a-1b) and seven suspects (level 2b-3a). Additionally, six suspects with CHF2 or CF3 functionalities were tentatively annotated. Two previously unreported PFAS in human serum, hydrogen-substituted 2:1 perfluoroether sulfonic acid (2:1 H-PFESA) and hexafluoro-1,2-propanediol (HFPrD), were detected in 42% and 56% of samples, respectively. Further analysis of these two compounds in broader GP serum pools, including six age groups and both sexes, revealed their presence even in children under five, with relatively high intensities. No clear temporal, age, sex, or occupation-related trends were observed, suggesting widespread ongoing population exposure. These findings underscore the need for expanded HRMS-based monitoring to better assess human PFAS exposure.", "doi": "10.1021/acs.est.5c04623", "pmid": "41297907", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T08:10:02.352Z", "modified": "2026-08-20T08:10:02.478Z"}, {"entity": "publication", "iuid": "6bfcd96de31f4c39a810c6dd89b5249f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6bfcd96de31f4c39a810c6dd89b5249f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6bfcd96de31f4c39a810c6dd89b5249f"}}, "title": "Novel Per- and Polyfluoroalkyl Substances Discovered in Cattle Exposed to AFFF-Impacted Groundwater.", "authors": [{"family": "Dewapriya", "given": "Pradeep", "initials": "P", "orcid": "0000-0002-6383-1843", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/20fa77980f284da0bf7e2d4d6a8d38cb.json"}}, {"family": "Nilsson", "given": "Sandra", "initials": "S", "orcid": "0000-0002-1030-7167", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/acc9b99839b94d70be6e4f57d9081dc6.json"}}, {"family": "Ghorbani Gorji", "given": "Sara", "initials": "S", "orcid": "0000-0002-7413-1228", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a235dbe8ac44f1f8b067ebb2183fdb4.json"}}, {"family": "O'Brien", "given": "Jake W", "initials": "JW", "orcid": "0000-0001-9336-9656", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/449a21afc3fe4470a98e0db190468675.json"}}, {"family": "Br\u00e4unig", "given": "Jennifer", "initials": "J"}, {"family": "G\u00f3mez Ramos", "given": "Mar\u00eda Jos\u00e9", "initials": "MJ"}, {"family": "Donaldson", "given": "Eric", "initials": "E"}, {"family": "Samanipour", "given": "Saer", "initials": "S", "orcid": "0000-0001-8270-6979", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e5c5e087f1414ed19838084b5113f775.json"}}, {"family": "Martin", "given": "Jonathan W", "initials": "JW", "orcid": "0000-0001-6265-4294", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02199c0d99674e2ea5e96e6589c07a00.json"}}, {"family": "Mueller", "given": "Jochen F", "initials": "JF"}, {"family": "Kaserzon", "given": "Sarit L", "initials": "SL", "orcid": "0000-0002-6744-1279", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f7cf9ea83a284fb4be5ab894ea7142aa.json"}}, {"family": "Thomas", "given": "Kevin V", "initials": "KV", "orcid": "0000-0002-2155-100X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8702b01e942e43afb0d963004a571a0f.json"}}], "type": "journal article", "published": "2023-09-12", "journal": {"title": "Environ. Sci. Technol.", "issn": "1520-5851", "volume": "57", "issue": "36", "pages": "13635-13645", "issn-l": "0013-936X"}, "abstract": "The leaching of per- and polyfluoroalkyl substances (PFASs) from Australian firefighting training grounds has resulted in extensive contamination of groundwater and nearby farmlands. Humans, farm animals, and wildlife in these areas may have been exposed to complex mixtures of PFASs from aqueous film-forming foams (AFFFs). This study aimed to identify PFAS classes in pooled whole blood (n = 4) and serum (n = 4) from cattle exposed to AFFF-impacted groundwater and potentially discover new PFASs in blood. Thirty PFASs were identified at various levels of confidence (levels 1a-5a), including three novel compounds: (i) perfluorohexanesulfonamido 2-hydroxypropanoic acid (FHxSA-HOPrA), (ii) methyl((perfluorohexyl)sulfonyl)sulfuramidous acid, and (iii) methyl((perfluorooctyl)sulfonyl)sulfuramidous acid, belonging to two different classes. Biotransformation intermediate, perfluorohexanesulfonamido propanoic acid (FHxSA-PrA), hitherto unreported in biological samples, was detected in both whole blood and serum. Furthermore, perfluoroalkyl sulfonamides, including perfluoropropane sulfonamide (FPrSA), perfluorobutane sulfonamide (FBSA), and perfluorohexane sulfonamide (FHxSA) were predominantly detected in whole blood, suggesting that these accumulate in the cell fraction of blood. The suspect screening revealed several fluoroalkyl chain-substituted PFAS. The results suggest that targeting only the major PFASs in the plasma or serum of AFFF-exposed mammals likely underestimates the toxicological risks associated with exposure. Future studies of AFFF-exposed populations should include whole-blood analysis with high-resolution mass spectrometry to understand the true extent of PFAS exposure.", "doi": "10.1021/acs.est.3c03852", "pmid": "37648245", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10501377"}], "notes": [], "created": "2026-08-20T08:09:48.528Z", "modified": "2026-08-20T08:09:48.863Z"}, {"entity": "publication", "iuid": "492d4806caab49db9fdff3fbd4323ae3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/492d4806caab49db9fdff3fbd4323ae3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/492d4806caab49db9fdff3fbd4323ae3"}}, "title": "The NORMAN Suspect List Exchange (NORMAN-SLE): facilitating European and worldwide collaboration on suspect screening in high resolution mass spectrometry.", "authors": [{"family": "Mohammed Taha", "given": "Hiba", "initials": "H", "orcid": "0000-0001-7820-4335", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0aab639674fc46378efd5d64000fd8e9.json"}}, {"family": "Aalizadeh", "given": "Reza", "initials": "R", "orcid": "0000-0001-9167-9060", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/70380d032d204f69a043b5815ea0da7b.json"}}, {"family": "Alygizakis", "given": "Nikiforos", "initials": "N", "orcid": "0000-0002-5727-4999", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e318f2574b9040f69214c14d1f4d72e8.json"}}, {"family": "Antignac", "given": "Jean-Philippe", "initials": "JP", "orcid": "0000-0001-9512-9314", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4e61f27dd4cb433d9ca8eb2805093791.json"}}, {"family": "Arp", "given": "Hans Peter H", "initials": "HPH", "orcid": "0000-0002-0747-8838", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/94f03795a8184c869ff5b0bba928f7a7.json"}}, {"family": "Bade", "given": "Richard", "initials": "R", "orcid": "0000-0003-2724-9183", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/658abc0605c94e50b31b759344486cbd.json"}}, {"family": "Baker", "given": "Nancy", "initials": "N", "orcid": "0000-0002-8351-9435", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a1603ba3fd14794bbb3017fe66f0b10.json"}}, {"family": "Belova", "given": "Lidia", "initials": "L", "orcid": "0000-0001-7147-384X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0e34968820d64d66b6374fe3b9c3b9e7.json"}}, {"family": "Bijlsma", "given": "Lubertus", "initials": "L", "orcid": "0000-0001-7005-8775", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41f941e1e87045f0a66eb06120dcf07c.json"}}, {"family": "Bolton", "given": "Evan E", "initials": "EE", "orcid": "0000-0002-5959-6190", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/43ba499c6c8a44088a25759c10463de9.json"}}, {"family": "Brack", "given": "Werner", "initials": "W", "orcid": "0000-0001-9269-6524", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/082310d9127d4946a7e4f01b0306577a.json"}}, {"family": "Celma", "given": "Alberto", "initials": "A", "orcid": "0000-0001-9763-8737", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e124fb0908ff456284de97889608e600.json"}}, {"family": "Chen", "given": "Wen-Ling", "initials": "WL", "orcid": "0000-0001-5143-0543", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22024e528c444a839a915cb65dcbf5ff.json"}}, {"family": "Cheng", "given": "Tiejun", "initials": "T", "orcid": "0000-0002-4486-3356", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0058164ebe0740019ae88acb061a18f0.json"}}, {"family": "Chirsir", "given": "Parviel", "initials": "P", "orcid": "0000-0002-9932-8609", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f8e48a76d5eb42a1980144064284bedb.json"}}, {"family": "\u010cirka", "given": "\u013dubo\u0161", "initials": "\u013d", "orcid": "0000-0001-9351-6855", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/850e5a09807542f798eb135a9b99b54f.json"}}, {"family": "D'Agostino", "given": "Lisa A", "initials": "LA", "orcid": "0000-0002-9734-324X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bacc67cfbefc47f5a746c895fbd0d546.json"}}, {"family": "Djoumbou Feunang", "given": "Yannick", "initials": "Y", "orcid": "0000-0001-7850-184X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/033ecf15c31b4c50ab09dfc1b5a60b66.json"}}, {"family": "Dulio", "given": "Valeria", "initials": "V", "orcid": "0000-0002-9436-9954", "researcher": {"href": 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"initials": "K"}, {"family": "Kirchner", "given": "Michal", "initials": "M", "orcid": "0000-0002-6917-3431", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f69c252f58bd497dbaaae9fa6f80a4c5.json"}}, {"family": "Koschorreck", "given": "Jan", "initials": "J", "orcid": "0000-0002-1043-3278", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/caaaa049053a44798c9a10963e1cce4f.json"}}, {"family": "Krauss", "given": "Martin", "initials": "M", "orcid": "0000-0002-0362-4244", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e2720ea72ae42e3aaf6b1fa4c4691a5.json"}}, {"family": "Krier", "given": "Jessy", "initials": "J", "orcid": "0000-0001-6986-5545", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e19c1eb858f345a8bddaec5eec87f087.json"}}, {"family": "Lamoree", "given": "Marja H", "initials": "MH", "orcid": "0000-0002-7373-7738", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a10dc77b5e5547489a423f9934790d95.json"}}, {"family": "Letzel", "given": "Marion", "initials": "M"}, {"family": "Letzel", "given": "Thomas", "initials": "T", "orcid": "0000-0003-1008-8790", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a84f32e0403f4869bb7f5a5ae9e7e551.json"}}, {"family": "Li", "given": "Qingliang", "initials": "Q", "orcid": "0000-0002-6453-236X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6ff791c2b87407fa8da4e711b0b5e68.json"}}, {"family": "Little", "given": "James", "initials": "J"}, {"family": "Liu", "given": "Yanna", "initials": "Y", "orcid": "0000-0001-7893-9876", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/734b3bae2f254a1e8252f573a60bebea.json"}}, {"family": "Lunderberg", "given": "David M", "initials": "DM", "orcid": "0000-0002-4439-9194", "researcher": {"href": 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"issn-l": null}, "abstract": "The NORMAN Association (https://www.norman-network.com/) initiated the NORMAN Suspect List Exchange (NORMAN-SLE; https://www.norman-network.com/nds/SLE/) in 2015, following the NORMAN collaborative trial on non-target screening of environmental water samples by mass spectrometry. Since then, this exchange of information on chemicals that are expected to occur in the environment, along with the accompanying expert knowledge and references, has become a valuable knowledge base for \"suspect screening\" lists. The NORMAN-SLE now serves as a FAIR (Findable, Accessible, Interoperable, Reusable) chemical information resource worldwide.\n\nThe NORMAN-SLE contains 99 separate suspect list collections (as of May 2022) from over 70 contributors around the world, totalling over 100,000 unique substances. The substance classes include per- and polyfluoroalkyl substances (PFAS), pharmaceuticals, pesticides, natural toxins, high production volume substances covered under the European REACH regulation (EC: 1272/2008), priority contaminants of emerging concern (CECs) and regulatory lists from NORMAN partners. Several lists focus on transformation products (TPs) and complex features detected in the environment with various levels of provenance and structural information. Each list is available for separate download. The merged, curated collection is also available as the NORMAN Substance Database (NORMAN SusDat). Both the NORMAN-SLE and NORMAN SusDat are integrated within the NORMAN Database System (NDS). The individual NORMAN-SLE lists receive digital object identifiers (DOIs) and traceable versioning via a Zenodo community (https://zenodo.org/communities/norman-sle), with a total of > 40,000 unique views, > 50,000 unique downloads and 40 citations (May 2022). NORMAN-SLE content is progressively integrated into large open chemical databases such as PubChem (https://pubchem.ncbi.nlm.nih.gov/) and the US EPA's CompTox Chemicals Dashboard (https://comptox.epa.gov/dashboard/), enabling further access to these lists, along with the additional functionality and calculated properties these resources offer. PubChem has also integrated significant annotation content from the NORMAN-SLE, including a classification browser (https://pubchem.ncbi.nlm.nih.gov/classification/#hid=101).\n\nThe NORMAN-SLE offers a specialized service for hosting suspect screening lists of relevance for the environmental community in an open, FAIR manner that allows integration with other major chemical resources. These efforts foster the exchange of information between scientists and regulators, supporting the paradigm shift to the \"one substance, one assessment\" approach. New submissions are welcome via the contacts provided on the NORMAN-SLE website (https://www.norman-network.com/nds/SLE/).\n\nThe online version contains supplementary material available at 10.1186/s12302-022-00680-6.", "doi": "10.1186/s12302-022-00680-6", "pmid": "36284750", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9587084"}, {"db": "pii", "key": "680"}], "notes": [], "created": "2026-08-20T12:19:25.309Z", "modified": "2026-08-20T12:19:28.198Z"}]}