{"entity": "researcher", "timestamp": "2026-09-24T01:05:55.963Z", "family": "Zhang", "given": "Xiaoqun", "initials": "X", "orcid": "0000-0002-9461-8682", "affiliations": ["Neuro Svenningsson, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/4395a11b24bf40308b6d3a8467763517.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/4395a11b24bf40308b6d3a8467763517"}}, "publications": [{"entity": "publication", "iuid": "76e5f848ccc041ac9b4fa821b20ba8b0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/76e5f848ccc041ac9b4fa821b20ba8b0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/76e5f848ccc041ac9b4fa821b20ba8b0"}}, "title": "Ultra-large virtual screening unveils potent agonists of the neuromodulatory orphan receptor GPR139.", "authors": [{"family": "Cabeza de Vaca", "given": "Israel", "initials": "I", "orcid": "0000-0002-6208-1091", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/defa085f944942239696861994f25e79.json"}}, {"family": "Trapkov", "given": "Boris", "initials": "B", "orcid": "0000-0003-1245-888X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1aff7885ecf14656b053ddfd6d94b17a.json"}}, {"family": "Shen", "given": "Ling", "initials": "L"}, {"family": "Vo", "given": "Duy Duc", "initials": "DD"}, {"family": "Zhang", "given": "Xiaoqun", "initials": "X", "orcid": "0000-0002-9461-8682", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4395a11b24bf40308b6d3a8467763517.json"}}, {"family": "Yang", "given": "Yunting", "initials": "Y"}, {"family": "Pezeshki", "given": "Mitra", "initials": "M", "orcid": "0009-0001-0155-7463", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d5cade660844b84980e852280aabedb.json"}}, {"family": "Zhang", "given": "Xuehan", "initials": "X"}, {"family": "B\u00e4llgren", "given": "Frida", "initials": "F"}, {"family": "Saleh", "given": "Aljona", "initials": "A"}, {"family": "Tarnovskiy", "given": "Andrii V", "initials": "AV"}, {"family": "Radchenko", "given": "Dmytro S", "initials": "DS", "orcid": "0000-0001-5444-7754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5a8f8993ce024259aa09cfae9a745a20.json"}}, {"family": "Moroz", "given": "Yurii S", "initials": "YS", "orcid": "0000-0001-6073-002X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/85e5c6a40d854426b96476233f59ccfa.json"}}, {"family": "Br\u00e4uner-Osborne", "given": "Hans", "initials": "H"}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Kihlberg", "given": "Jan", "initials": "J", "orcid": "0000-0002-4205-6040", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7edb4dfa7c4b4d6c8c4cf0282a9c9a1a.json"}}, {"family": "Liu", "given": "Zhi-Jie", "initials": "ZJ", "orcid": "0000-0001-7279-2893", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ab058d718354e5b96adef9dca906de2.json"}}, {"family": "Hauser", "given": "Alexander Sebastian", "initials": "AS", "orcid": "0000-0003-1098-6419", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b8ac3dae8d9543cfabc166986ce35847.json"}}, {"family": "Carlsson", "given": "Jens", "initials": "J", "orcid": "0000-0003-4623-2977", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/792c1cd4aca248dc94b967115ffa82df.json"}}], "type": "journal article", "published": "2025-12-09", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "17", "issue": "1", "pages": "129", "issn-l": "2041-1723"}, "abstract": "The orphan G protein-coupled receptor (GPCR) GPR139 attracts interest as a target for neuropsychiatric disorders. Whereas the physiological functions of GPR139 remain elusive, a high-resolution receptor structure is now available. To assess whether structural information enables ligand discovery, we computationally dock 235 million compounds to the GPR139 binding site. Of 68 top-ranked compounds evaluated experimentally, five are full agonists with potencies ranging from 160 nM to 3.6 \u00b5M. Structure-guided optimization identifies one of the most potent GPR139 agonists, and a cryo-EM structure of the receptor-ligand complex confirms the predicted binding mode. Functional characterization provides insights into GPR139 signalling, and one agonist elicits behavioural effects in mice. We also explore the potential to replace experimental structure determination with the deep-learning method AlphaFold3, revealing a limited capability of artificial intelligence to model receptor-ligand interactions for understudied GPCRs. The results demonstrate how high-resolution GPCR structures combined with large-library docking can accelerate drug discovery.", "doi": "10.1038/s41467-025-66845-y", "pmid": "41365886", "labels": {"SciLifeLab Fellow": "", "Jens Carlsson": ""}, "xrefs": [{"db": "pmc", "key": "PMC12775434"}, {"db": "pii", "key": "10.1038/s41467-025-66845-y"}], "notes": [], "created": "2026-09-23T09:12:16.102Z", "modified": "2026-09-23T09:12:16.377Z"}, {"entity": "publication", "iuid": "8954a707e76945b0aa8033f4558f525b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8954a707e76945b0aa8033f4558f525b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8954a707e76945b0aa8033f4558f525b"}}, "title": "Derivatization of Small Molecules using Deuterated Analog of Reactive Matrix to Facilitate Identification in Mass Spectrometry Imaging", "authors": [{"family": "Vallianatou", "given": "Theodosia", "initials": "T", "orcid": "0000-0002-1477-7756", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4374524ab2c14bd9ae46f904144dea63.json"}}, {"family": "Balestri", "given": "Lorenzo Jacopo Ilic", "initials": "LJI"}, {"family": "Nilsson", "given": "Anna", "initials": "A", "orcid": "0000-0002-6183-6931", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d381828fd204a249e5b4df03e7497f6.json"}}, {"family": "Zhang", "given": "Xiaoqun", "initials": "X", "orcid": "0000-0002-9461-8682", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4395a11b24bf40308b6d3a8467763517.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Odell", "given": "Luke R", "initials": "LR", "orcid": "0000-0001-7658-5103", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49395660c6af4fce9ad0f7f8fc793744.json"}}, {"family": "Andr\u00e9n", "given": "Per E", "initials": "PE"}, {"family": "Shariatgorji", "given": "Reza", "initials": "R", "orcid": "0000-0001-9484-0921", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76faa76e9dc445a3bbb1f470e9d33a23.json"}}], "type": "journal-article", "published": "2025-12-00", "journal": {"title": "Chemistry Methods", "issn": "2628-9725", "volume": "5", "issue": "12", "issn-l": null}, "abstract": null, "doi": "10.1002/cmtd.202500062", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T12:33:31.306Z", "modified": "2026-09-23T12:33:31.400Z"}, {"entity": "publication", "iuid": "9c4d418718f74e519074ed3eacb3ded1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9c4d418718f74e519074ed3eacb3ded1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9c4d418718f74e519074ed3eacb3ded1"}}, "title": "Enduring modulation of dorsal raphe nuclei regulates (R,S)-ketamine-mediated resilient stress-coping behavior.", "authors": [{"family": "Camargo", "given": "Anderson", "initials": "A"}, {"family": "Nilsson", "given": "Anna", "initials": "A"}, {"family": "Shariatgorji", "given": "Reza", "initials": "R"}, {"family": "Appleton", "given": "Ellen", "initials": "E"}, {"family": "Branzell", "given": "Niclas", "initials": "N"}, {"family": "Doyon", "given": "Daniel", "initials": "D"}, {"family": "Giovenzana", "given": "Mattia", "initials": "M", "orcid": "0009-0002-1384-3413", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc3d961b6085471bb2e8c57a1db0de0b.json"}}, {"family": "Zhang", "given": "Xiaoqun", "initials": "X", "orcid": "0000-0002-9461-8682", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4395a11b24bf40308b6d3a8467763517.json"}}, {"family": "Dautan", "given": "Daniel", "initials": "D"}, {"family": "Andren", "given": "Per E", "initials": "PE", "orcid": "0000-0002-4062-7743", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1dd27e8b238475383983480e10099f6.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}], "type": "journal article", "published": "2025-06-00", "journal": {"title": "Mol. Psychiatry", "issn": "1476-5578", "volume": "30", "issue": "6", "pages": "2504-2516", "issn-l": "1359-4184"}, "abstract": "Ketamine may be a novel pharmacologic approach to enhance resilience and protect against stress-related disorders, but the molecular targets underlying this response remain to be fully characterized. The multifunctional protein p11 is crucial in the pathophysiology of depression and antidepressant responses. However, it is still unclear whether p11 plays a role in the pro-resilience effects induced by ketamine. Here, we demonstrated that prophylactic administration of ketamine buffers passive stress-induced maladaptive phenotypes induced by chronic stress exposure. Spatial neurotransmitter and metabolite analysis revealed that prophylactic ketamine was also effective in blunting stress-induced disturbances of tryptophan metabolism in dorsal raphe nuclei (DRN). Additionally, we demonstrated that ketamine prevented chronic restraint stress-induced p11 reduction in DRN, a highly p11-enriched region. Furthermore, we provide novel evidence indicating that p11 deficiency regulates susceptibility to stress-induced depression-related phenotypes, and these behavioral maladaptations are dependent, at least in part, on p11 function in serotonergic neurons. Spatial neurotransmitter and metabolite analysis also showed a reduction of tryptophan and dopamine metabolism in DRN of serotonergic p11-deficient mice. Viral-mediated downregulation of p11 within DRN induced a stress-susceptible phenotype. Finally, our results also unveiled that the ability of ketamine to elicit a pro-resilience response against stress-induced maladaptive phenotypes was occluded when p11 was selectively deleted in serotonergic neurons. Altogether, we showed a previously unexplored role of the DRN circuit in regulating stress susceptibility and resilience-enhancing actions of ketamine.", "doi": "10.1038/s41380-024-02853-6", "pmid": "39592824", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12092261"}, {"db": "pii", "key": "10.1038/s41380-024-02853-6"}], "notes": [], "created": "2026-09-23T11:34:46.799Z", "modified": "2026-09-23T11:34:46.930Z"}, {"entity": "publication", "iuid": "f98dbb1664c44b5a8643ba272b89f74c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f98dbb1664c44b5a8643ba272b89f74c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f98dbb1664c44b5a8643ba272b89f74c"}}, "title": "Claustrum and dorsal endopiriform cortex complex cell-identity is determined by Nurr1 and regulates hallucinogenic-like states in mice.", "authors": [{"family": "Mantas", "given": "Ioannis", "initials": "I", "orcid": "0000-0001-6288-5439", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1039fe5afaeb467ebfbfc5b99a4a13b9.json"}}, {"family": "Flais", "given": "Ivana", "initials": "I"}, {"family": "Masarapu", "given": "Yuvarani", "initials": "Y", "orcid": "0000-0002-3267-2085", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ecae6e58dddd40b7a547bd7eb38aa4fd.json"}}, {"family": "Ionescu", "given": "Tudor", "initials": "T"}, {"family": "Frapard", "given": "Sol\u00e8ne", "initials": "S", "orcid": "0000-0002-2649-7225", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e911ee0112d04fe89b254e4624490460.json"}}, {"family": "Jung", "given": "Felix", "initials": "F"}, {"family": "Le Merre", "given": "Pierre", "initials": "P", "orcid": "0000-0003-4205-7411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ebebeabbd3a4bc89ea05d00cc47013a.json"}}, {"family": "Saarinen", "given": "Marcus", "initials": "M"}, {"family": "Tiklova", "given": "Katarina", "initials": "K"}, {"family": "Salmani", "given": "Behzad Yaghmaeian", "initials": "BY", "orcid": "0000-0002-4221-6243", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a2cd9cba2dc43f29a4fff6d0c729c83.json"}}, {"family": "Gillberg", "given": "Linda", "initials": "L"}, {"family": "Zhang", "given": "Xiaoqun", "initials": "X", "orcid": "0000-0002-9461-8682", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4395a11b24bf40308b6d3a8467763517.json"}}, {"family": "Chergui", "given": "Karima", "initials": "K"}, {"family": "Carl\u00e9n", "given": "Marie", "initials": "M", "orcid": "0000-0003-1658-1631", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5bb1bfff3214cca8753a75f5a251b93.json"}}, {"family": "Giacomello", "given": "Stefania", "initials": "S", "orcid": "0000-0003-0738-1574", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5a9c4a7494ba4284ab52158e6cbc85da.json"}}, {"family": "Hengerer", "given": "Bastian", "initials": "B", "orcid": "0000-0002-7811-9795", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/baaddee4cd7548998431491d4d85d14e.json"}}, {"family": "Perlmann", "given": "Thomas", "initials": "T"}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}], "type": "journal article", "published": "2024-09-18", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "8176", "issn-l": "2041-1723"}, "abstract": "The Claustrum/dorsal endopiriform cortex complex (CLA) is an enigmatic brain region with extensive glutamatergic projections to multiple cortical areas. The transcription factor Nurr1 is highly expressed in the CLA, but its role in this region is not understood. By using conditional gene-targeted mice, we show that Nurr1 is a crucial regulator of CLA neuron identity. Although CLA neurons remain intact in the absence of Nurr1, the distinctive gene expression pattern in the CLA is abolished. CLA has been hypothesized to control hallucinations, but little is known of how the CLA responds to hallucinogens. After the deletion of Nurr1 in the CLA, both hallucinogen receptor expression and signaling are lost. Furthermore, functional ultrasound and Neuropixel electrophysiological recordings revealed that the hallucinogenic-receptor agonists' effects on functional connectivity between prefrontal and sensorimotor cortices are altered in Nurr1-ablated mice. Our findings suggest that Nurr1-targeted strategies provide additional avenues for functional studies of the CLA.", "doi": "10.1038/s41467-024-52429-9", "pmid": "39289358", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11408527"}, {"db": "pii", "key": "10.1038/s41467-024-52429-9"}, {"db": "GEO", "key": "GSE229770"}, {"db": "GEO", "key": "GSE229732"}], "notes": [], "created": "2026-09-23T11:12:28.263Z", "modified": "2026-09-23T11:12:28.442Z"}]}