{"entity": "researcher", "timestamp": "2026-08-20T21:11:46.081Z", "family": "Aittokallio", "given": "Tero", "initials": "T", "orcid": "0000-0002-0886-9769", "affiliations": ["Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.", "Helsinki Institute for Information Technology (HIIT), Department of Computer Science, Aalto University, Espoo, Finland.", "Institute for Cancer Research, Department of Cancer Genetics, Oslo University Hospital, Oslo, Norway.", "Centre for Biostatistics and Epidemiology (OCBE), Faculty of Medicine, University of Oslo, Oslo, Norway."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/433e429e6a5b49818cf54f5fc102fff7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/433e429e6a5b49818cf54f5fc102fff7"}}, "publications": [{"entity": "publication", "iuid": "303ca727bb294b8c9e22f801a127ea9e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/303ca727bb294b8c9e22f801a127ea9e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/303ca727bb294b8c9e22f801a127ea9e"}}, "title": "From Library to Landscape: Integrative Annotation Workflows for Compound Libraries in Drug Repurposing", "authors": [{"family": "Reinshagen", "given": "Jeanette", "initials": "J", "orcid": "0000-0002-8080-9170", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76a9ab71d84644c980ad0f1aee2565d3.json"}}, {"family": "Seashore-Ludlow", "given": "Brinton", "initials": "B", "orcid": "0000-0001-8658-5967", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a8ea4c3fdb14de1b651d0367b0a70a4.json"}}, {"family": "Gadiya", "given": "Yojana", "initials": "Y", "orcid": "0000-0002-7683-0452", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/870d6b76507b4b4ba3eab97417ef9509.json"}}, {"family": "Gustavsson", "given": "Anna Lena", "initials": "AL", "orcid": "0000-0003-4332-2336", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/93241ca0071040f4b371ca8d173dab9d.json"}}, {"family": "Tanoli", "given": "Ziaurrehman", "initials": "Z", "orcid": "0000-0003-2435-9862", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f9e45586ed9496a97cb8408ec39f5d4.json"}}, {"family": "Aittokallio", "given": "Tero", "initials": "T", "orcid": "0000-0002-0886-9769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/433e429e6a5b49818cf54f5fc102fff7.json"}}, {"family": "Huchting", "given": "Johanna", "initials": "J", "orcid": "0000-0001-6368-3273", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0e5a24e61ac84a7f91160b32365a74f3.json"}}, {"family": "Jenmalm-Jensen", "given": "Annika", "initials": "A", "orcid": "0000-0002-6053-8457", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0021e7f3324546b98af8d0d676c8cfc6.json"}}, {"family": "Gribbon", "given": "Philip", "initials": "P", "orcid": "0000-0001-7655-2459", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0c3e96ec00194af0882b4c3188b34917.json"}}, {"family": "Zaliani", "given": "Andrea", "initials": "A", "orcid": "0000-0002-1740-8390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/43d815becc3740cd813a0ec55374a385.json"}}, {"family": "Ballante", "given": "Flavio", "initials": "F", "orcid": "0000-0002-4831-3423", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8ce9aad230aa414886e3bf519937aad9.json"}}], "type": "posted-content", "published": "2025-07-29", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2025.07.23.666341", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:06:41.783Z", "modified": "2026-08-20T11:06:41.970Z"}, {"entity": "publication", "iuid": "95296c52bd3b4c108f944528c87402fb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/95296c52bd3b4c108f944528c87402fb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/95296c52bd3b4c108f944528c87402fb"}}, "title": "Drug response profiles in patient-derived cancer cells across histological subtypes of ovarian cancer: real-time therapy tailoring for a patient with low-grade serous carcinoma.", "authors": [{"family": "Murum\u00e4gi", "given": "Astrid", "initials": "A", "orcid": "0000-0002-7797-188X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/44376ab482ab42c3a4f3bbc68c27c97d.json"}}, {"family": "Ungureanu", "given": "Daniela", "initials": "D"}, {"family": "Khan", "given": "Suleiman", "initials": "S"}, {"family": "Arjama", "given": "Mariliina", "initials": "M"}, {"family": "V\u00e4lim\u00e4ki", "given": "Katja", "initials": "K"}, {"family": "Ianevski", "given": "Aleksandr", "initials": "A"}, {"family": "Ianevski", "given": "Philipp", "initials": "P"}, {"family": "Bergstr\u00f6m", "given": "Rebecka", "initials": "R"}, {"family": "Dini", "given": "Alice", "initials": "A", "orcid": "0000-0002-2720-4551", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c00ed4eb41e45629cfc525e737f99c4.json"}}, {"family": "Kanerva", "given": "Anna", "initials": "A"}, {"family": "Koivisto-Korander", "given": "Riitta", "initials": "R"}, {"family": "Tapper", "given": "Johanna", "initials": "J"}, {"family": "Lassus", "given": "Heini", "initials": "H", "orcid": "0000-0003-0598-5147", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c854daf0fada43ee97951cba27414def.json"}}, {"family": "Loukovaara", "given": "Mikko", "initials": "M"}, {"family": "M\u00e4gi", "given": "Andrus", "initials": "A"}, {"family": "Hirasawa", "given": "Akira", "initials": "A"}, {"family": "Aoki", "given": "Daisuke", "initials": "D"}, {"family": "Pieti\u00e4inen", "given": "Vilja", "initials": "V", "orcid": "0000-0003-3125-2406", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d24125e51334b94bce4ef70fed1e585.json"}}, {"family": "Pellinen", "given": "Teijo", "initials": "T", "orcid": "0000-0001-9652-7373", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e73595c0cc64a68a59cd95772784859.json"}}, {"family": "B\u00fctzow", "given": "Ralf", "initials": "R", "orcid": "0000-0003-4366-5099", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6e16836d19645bbbec8bb1a851a02e0.json"}}, {"family": "Aittokallio", "given": "Tero", "initials": "T", "orcid": "0000-0002-0886-9769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/433e429e6a5b49818cf54f5fc102fff7.json"}}, {"family": "Kallioniemi", "given": "Olli", "initials": "O"}], "type": "journal article", "published": "2023-02-00", "journal": {"title": "Br. J. Cancer", "issn": "1532-1827", "volume": "128", "issue": "4", "pages": "678-690", "issn-l": "0007-0920"}, "abstract": "Many efforts are underway to develop novel therapies against the aggressive high-grade serous ovarian cancers (HGSOCs), while our understanding of treatment options for low-grade (LGSOC) or mucinous (MUCOC) of ovarian malignancies is not developing as well. We describe here a functional precision oncology (fPO) strategy in epithelial ovarian cancers (EOC), which involves high-throughput drug testing of patient-derived ovarian cancer cells (PDCs) with a library of 526 oncology drugs, combined with genomic and transcriptomic profiling. HGSOC, LGSOC and MUCOC PDCs had statistically different overall drug response profiles, with LGSOCs responding better to targeted inhibitors than HGSOCs. We identified several subtype-specific drug responses, such as LGSOC PDCs showing high sensitivity to MDM2, ERBB2/EGFR inhibitors, MUCOC PDCs to MEK inhibitors, whereas HGSOCs showed strongest effects with CHK1 inhibitors and SMAC mimetics. We also explored several drug combinations and found that the dual inhibition of MEK and SHP2 was synergistic in MAPK-driven EOCs. We describe a clinical case study, where real-time fPO analysis of samples from a patient with metastatic, chemorefractory LGSOC with a CLU-NRG1 fusion guided clinical therapy selection. fPO-tailored therapy with afatinib, followed by trastuzumab and pertuzumab, successfully reduced tumour burden and blocked disease progression over a five-year period. In summary, fPO is a powerful approach for the identification of systematic drug response differences across EOC subtypes, as well as to highlight patient-specific drug regimens that could help to optimise therapies to individual patients in the future.", "doi": "10.1038/s41416-022-02067-z", "pmid": "36476658", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9938120"}, {"db": "pii", "key": "10.1038/s41416-022-02067-z"}], "notes": [], "created": "2026-08-20T08:49:06.144Z", "modified": "2026-08-20T08:49:06.456Z"}, {"entity": "publication", "iuid": "b4c37168301940ce9efedc7b49904d36", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b4c37168301940ce9efedc7b49904d36.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b4c37168301940ce9efedc7b49904d36"}}, "title": "Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia.", "authors": [{"family": "Malani", "given": "Disha", "initials": "D"}, {"family": "Kumar", "given": "Ashwini", "initials": "A"}, {"family": "Br\u00fcck", "given": "Oscar", "initials": "O"}, {"family": "Kontro", "given": "Mika", "initials": "M", "orcid": "0000-0001-6353-0664", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0661dd63c7df44d79aa7c50a309c55db.json"}}, {"family": "Yadav", "given": "Bhagwan", "initials": "B", "orcid": "0000-0002-3502-9335", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f979e77a9854141b2077a3d10164d08.json"}}, {"family": "Helles\u00f8y", "given": "Monica", "initials": "M", "orcid": "0000-0002-0115-7427", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65449b403fe24b85b0b1956e899ee9b8.json"}}, {"family": "Kuusanm\u00e4ki", "given": "Heikki", "initials": "H"}, {"family": "Dufva", "given": "Olli", "initials": "O"}, {"family": "Kankainen", "given": "Matti", "initials": "M"}, {"family": "Eldfors", "given": "Samuli", "initials": "S", "orcid": "0000-0001-5056-4750", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/84b0e10b975c44fc88a5997ca1ee09b7.json"}}, {"family": "Potdar", "given": "Swapnil", "initials": "S", "orcid": "0000-0002-2778-6918", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e17191dcbef4dc7917d15792cfe5d6e.json"}}, {"family": "Saarela", "given": "Jani", "initials": "J", "orcid": "0000-0001-7306-7175", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8ba79c74ec3c489ab321465d195c0844.json"}}, {"family": "Turunen", "given": "Laura", "initials": "L", "orcid": "0000-0003-0274-4794", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35779e69fefa43cdb2d13c9e7fd05df7.json"}}, {"family": "Parsons", "given": "Alun", "initials": "A"}, {"family": "V\u00e4strik", "given": "Imre", "initials": "I", "orcid": "0000-0001-6658-9311", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5cb6a5a735404b78823b54059bf0990c.json"}}, {"family": "Kivinen", "given": "Katja", "initials": "K"}, {"family": "Saarela", "given": "Janna", "initials": "J", "orcid": "0000-0002-0853-6219", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80f36bfb769b400fadd19daa0f80565c.json"}}, {"family": "R\u00e4ty", "given": "Riikka", "initials": "R"}, {"family": "Lehto", "given": "Minna", "initials": "M"}, {"family": "Wolf", "given": "Maija", "initials": "M"}, {"family": "Gjertsen", "given": "Bjorn Tore", "initials": "BT"}, {"family": "Mustjoki", "given": "Satu", "initials": "S", "orcid": "0000-0002-0816-8241", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77ae8c3136924c22b8f56b35a24fc507.json"}}, {"family": "Aittokallio", "given": "Tero", "initials": "T", "orcid": "0000-0002-0886-9769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/433e429e6a5b49818cf54f5fc102fff7.json"}}, {"family": "Wennerberg", "given": "Krister", "initials": "K", "orcid": "0000-0002-1352-4220", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40883b183a28459a9b7b515312c8c44c.json"}}, {"family": "Heckman", "given": "Caroline A", "initials": "CA", "orcid": "0000-0002-4324-8706", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0490f5eb61a4d92a44815d03de84af4.json"}}, {"family": "Kallioniemi", "given": "Olli", "initials": "O"}, {"family": "Porkka", "given": "Kimmo", "initials": "K"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Cancer Discov", "issn": "2159-8290", "volume": "12", "issue": "2", "pages": "388-401", "issn-l": "2159-8274"}, "abstract": "We generated ex vivo drug-response and multiomics profiling data for a prospective series of 252 samples from 186 patients with acute myeloid leukemia (AML). A functional precision medicine tumor board (FPMTB) integrated clinical, molecular, and functional data for application in clinical treatment decisions. Actionable drugs were found for 97% of patients with AML, and the recommendations were clinically implemented in 37 relapsed or refractory patients. We report a 59% objective response rate for the individually tailored therapies, including 13 complete responses, as well as bridging five patients with AML to allogeneic hematopoietic stem cell transplantation. Data integration across all cases enabled the identification of drug response biomarkers, such as the association of IL15 overexpression with resistance to FLT3 inhibitors. Integration of molecular profiling and large-scale drug response data across many patients will enable continuous improvement of the FPMTB recommendations, providing a paradigm for individualized implementation of functional precision cancer medicine. SIGNIFICANCE: Oncogenomics data can guide clinical treatment decisions, but often such data are neither actionable nor predictive. Functional ex vivo drug testing contributes significant additional, clinically actionable therapeutic insights for individual patients with AML. Such data can be generated in four days, enabling rapid translation through FPMTB.See related commentary by Letai, p. 290.This article is highlighted in the In This Issue feature, p. 275.", "doi": "10.1158/2159-8290.CD-21-0410", "pmid": "34789538", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9762335"}, {"db": "pii", "key": "2159-8290.CD-21-0410"}], "notes": [], "created": "2026-08-20T12:14:31.294Z", "modified": "2026-08-20T12:14:31.705Z"}]}