{"entity": "researcher", "timestamp": "2026-09-25T18:00:34.052Z", "family": "Haghdoost", "given": "Siamak", "initials": "S", "orcid": "0000-0002-2867-4774", "affiliations": ["Centre for Radiation Protection Research, Department of Molecular Biosciences, The Wenner-Gren Institute Stockholm University, 10691 Stockholm, Sweden.", "University of Caen Normandy, Department of medicine, Cimap-Laria, Advanced Resource Center for HADrontherapy in Europe (ARCHADE), 14076 Caen, France."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/413be44d1a5d41ebba956d5e03511ae0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/413be44d1a5d41ebba956d5e03511ae0"}}, "publications": [{"entity": "publication", "iuid": "c5155d8e47764b3d94e7a3323ed8cacb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c5155d8e47764b3d94e7a3323ed8cacb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c5155d8e47764b3d94e7a3323ed8cacb"}}, "title": "A Longitudinal Study of Individual Radiation Responses in Pediatric Patients Treated with Proton and Photon Radiotherapy, and Interventional Cardiology: Rationale and Research Protocol of the HARMONIC Project.", "authors": [{"family": "Andreassi", "given": "Maria Grazia", "initials": "MG", "orcid": "0000-0002-2163-0816", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c6fdc28432ce44ccadf629625664720c.json"}}, {"family": "Haddy", "given": "Nadia", "initials": "N"}, {"family": "Harms-Ringdahl", "given": "Mats", "initials": "M"}, {"family": "Campolo", "given": "Jonica", "initials": "J", "orcid": "0000-0002-1711-6216", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de83cacc1fa3433f947cc234cf2b26cc.json"}}, {"family": "Borghini", "given": "Andrea", "initials": "A", "orcid": "0000-0003-1061-8309", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec73f3460ade43fdbb06d07b2beb5e10.json"}}, {"family": "Chevalier", "given": "Fran\u00e7ois", "initials": "F", "orcid": "0000-0002-8488-2324", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a1c71986a0b745bc86218ba75d7ea176.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Fresneau", "given": "Brice", "initials": "B", "orcid": "0000-0001-7603-7828", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/47e514da2cd24f6eab26df6515341ba4.json"}}, {"family": "Bolle", "given": "Stephanie", "initials": "S"}, {"family": "Fuentes", "given": "Manuel", "initials": "M", "orcid": "0000-0002-7305-3766", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04c03eb224b4457599517a84bca5410c.json"}}, {"family": "Haghdoost", "given": "Siamak", "initials": "S", "orcid": "0000-0002-2867-4774", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/413be44d1a5d41ebba956d5e03511ae0.json"}}], "type": "journal article", "published": "2023-05-08", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "24", "issue": "9", "issn-l": null}, "abstract": "The Health Effects of Cardiac Fluoroscopy and Modern Radiotherapy (photon and proton) in Pediatrics (HARMONIC) is a five-year project funded by the European Commission that aimed to improve the understanding of the long-term ionizing radiation (IR) risks for pediatric patients. In this paper, we provide a detailed overview of the rationale, design, and methods for the biological aspect of the project with objectives to provide a mechanistic understanding of the molecular pathways involved in the IR response and to identify potential predictive biomarkers of individual response involved in long-term health risks. Biological samples will be collected at three time points: before the first exposure, at the end of the exposure, and one year after the exposure. The average whole-body dose, the dose to the target organ, and the dose to some important out-of-field organs will be estimated. State-of-the-art analytical methods will be used to assess the levels of a set of known biomarkers and also explore high-resolution approaches of proteomics and miRNA transcriptomes to provide an integrated assessment. By using bioinformatics and systems biology, biological pathways and novel pathways involved in the response to IR exposure will be deciphered.", "doi": "10.3390/ijms24098416", "pmid": "37176123", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10178896"}, {"db": "pii", "key": "ijms24098416"}], "notes": [], "created": "2026-09-23T12:15:57.849Z", "modified": "2026-09-23T12:15:58.084Z"}, {"entity": "publication", "iuid": "d9dbdaa216e94b4c98617831474e1070", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d9dbdaa216e94b4c98617831474e1070.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d9dbdaa216e94b4c98617831474e1070"}}, "title": "Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer.", "authors": [{"family": "Drobin", "given": "Kimi", "initials": "K"}, {"family": "Marczyk", "given": "Michal", "initials": "M", "orcid": "0000-0003-2508-5736", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c51ff1f80b5147899e5d13ec458e0fbf.json"}}, {"family": "Halle", "given": "Martin", "initials": "M"}, {"family": "Danielsson", "given": "Daniel", "initials": "D", "orcid": "0000-0001-9407-2774", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c699703b835647f19d31b9287f8d9ac2.json"}}, {"family": "Papiez", "given": "Anna", "initials": "A", "orcid": "0000-0003-0179-1302", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0bcbd70e9d6435e8a2577fea348a951.json"}}, {"family": "Sangsuwan", "given": "Traimate", "initials": "T", "orcid": "0000-0003-4051-8376", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f20fbeac4724fef9909e348ee60630e.json"}}, {"family": "Bendes", "given": "Annika", "initials": "A", "orcid": "0000-0001-9329-2353", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b84a8aa3e3b4439bb0b3a9fabdebcb70.json"}}, {"family": "Hong", "given": "Mun-Gwan", "initials": "MG", "orcid": "0000-0001-8603-8293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d12504acae5c4f31b83f75c3d7786cd4.json"}}, {"family": "Qundos", "given": "Ulrika", "initials": "U"}, {"family": "Harms-Ringdahl", "given": "Mats", "initials": "M"}, {"family": "Wers\u00e4ll", "given": "Peter", "initials": "P"}, {"family": "Polanska", "given": "Joanna", "initials": "J", "orcid": "0000-0001-8004-9864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ef314127f024e00b6893b07982fe3c1.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Haghdoost", "given": "Siamak", "initials": "S", "orcid": "0000-0002-2867-4774", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/413be44d1a5d41ebba956d5e03511ae0.json"}}], "type": "journal article", "published": "2020-03-22", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "volume": "12", "issue": "3", "issn-l": "2072-6694"}, "abstract": "Nearly half of all cancers are treated with radiotherapy alone or in combination with other treatments, where damage to normal tissues is a limiting factor for the treatment. Radiotherapy-induced adverse health effects, mostly of importance for cancer patients with long-term survival, may appear during or long time after finishing radiotherapy and depend on the patient's radiosensitivity. Currently, there is no assay available that can reliably predict the individual's response to radiotherapy. We profiled two study sets from breast (n = 29) and head-and-neck cancer patients (n = 74) that included radiosensitive patients and matched radioresistant controls.. We studied 55 single nucleotide polymorphisms (SNPs) in 33 genes by DNA genotyping and 130 circulating proteins by affinity-based plasma proteomics. In both study sets, we discovered several plasma proteins with the predictive power to find radiosensitive patients (adjusted p < 0.05) and validated the two most predictive proteins (THPO and STIM1) by sandwich immunoassays. By integrating genotypic and proteomic data into an analysis model, it was found that the proteins CHIT1, PDGFB, PNKD, RP2, SERPINC1, SLC4A, STIM1, and THPO, as well as the VEGFA gene variant rs69947, predicted radiosensitivity of our breast cancer (AUC = 0.76) and head-and-neck cancer (AUC = 0.89) patients. In conclusion, circulating proteins and a SNP variant of VEGFA suggest that processes such as vascular growth capacity, immune response, DNA repair and oxidative stress/hypoxia may be involved in an individual's risk of experiencing radiation-induced toxicity.", "doi": "10.3390/cancers12030753", "pmid": "32235817", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7140105"}, {"db": "pii", "key": "cancers12030753"}], "notes": [], "created": "2026-09-23T10:07:24.837Z", "modified": "2026-09-23T10:45:29.464Z"}]}