{"entity": "researcher", "timestamp": "2026-09-24T05:16:16.897Z", "family": "Valletta", "given": "Martina", "initials": "M", "orcid": "0000-0003-0139-8287", "affiliations": ["Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/40c63a55168d4a35bdd9d91428e39448.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/40c63a55168d4a35bdd9d91428e39448"}}, "publications": [{"entity": "publication", "iuid": "9f269f9f23664cb8b797c23d75e9a88e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9f269f9f23664cb8b797c23d75e9a88e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9f269f9f23664cb8b797c23d75e9a88e"}}, "title": "Kidney Function, Alzheimer Disease Blood Biomarkers, and Dementia Risk in Community-Dwelling Older Adults.", "authors": [{"family": "Gasparini", "given": "Francesca", "initials": "F", "orcid": "0009-0004-3818-9176", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c90e42701bc749d0948525ae91fe578e.json"}}, {"family": "Valletta", "given": "Martina", "initials": "M", "orcid": "0000-0003-0139-8287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40c63a55168d4a35bdd9d91428e39448.json"}}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL"}, {"family": "Beridze", "given": "Giorgi", "initials": "G"}, {"family": "Rizzuto", "given": "Debora", "initials": "D"}, {"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A"}, {"family": "Fredolini", "given": "Claudia", "initials": "C"}, {"family": "Dale", "given": "Matilda", "initials": "M"}, {"family": "Winblad", "given": "Bengt", "initials": "B"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Grande", "given": "Giulia", "initials": "G"}], "type": "journal article", "published": "2026-01-13", "journal": {"title": "Neurology", "issn": "1526-632X", "volume": "106", "issue": "1", "pages": "e214446", "issn-l": "0028-3878"}, "abstract": "Impaired kidney function has been linked to altered concentrations of blood biomarkers of Alzheimer disease (AD), but the underlying mechanisms and its potential role in dementia development remain poorly understood. We explored the associations between estimated glomerular filtration rate (eGFR), blood-based biomarkers of AD, and dementia development.\n\nData were extracted from the Swedish National Study on Aging and Care in Kungsholmen, an ongoing longitudinal population-based study. Kidney function was assessed using eGFR based on serum creatinine. AD biomarkers (amyloid beta [A\u03b242/40], phosphorylated tau [p-tau181 and p-tau217] and total tau [t-tau] proteins, neurofilament light chain [NfL], and glial fibrillary acidic protein [GFAP]) were measured from peripheral blood samples using the Simoa platform. Dementia was diagnosed according to DSM-IV criteria. Quantile regression models assessed the cross-sectional associations between eGFR and AD biomarkers; Cox regression models were used to examine the association of kidney function and biomarkers with incident dementia.\n\nAt baseline, 2,279 dementia-free participants with available blood samples were included (median age 72 (interquartile range, 61-81) years; 62% female). Lower eGFR was associated with higher median z-score levels of all examined AD blood biomarkers, except A\u03b242/40, following a nonlinear relationship. At eGFR = 30 mL/min/1.73 m2, estimated differences were as follows: p-tau181: \u03b2, 0.22 [95% CI 0.09-0.35]; p-tau217: \u03b2, 0.20 [95% CI 0.10-0.31]; t-tau: \u03b2, 0.24 [95% CI 0.05-0.42]; NfL: \u03b2, 0.88 [95% CI 0.80-0.95]; GFAP: \u03b2, 0.10 [95% CI 0.03-0.16]. During a mean follow-up period of 8.3 (SD, 4.3) years, 362 participants developed dementia. In multivariable-adjusted models, impaired kidney function (eGFR < 60 mL/min/1.73 m2) was not associated with an increased hazard of dementia compared with preserved kidney function (eGFR \u2265 60 mL/min/1.73 m2) (hazard ratio [HR], 0.93 [95% CI 0.72-1.21]). The relationship between increased (high vs low) NfL and dementia was stronger among individuals with impaired (vs preserved) kidney function (HR, 3.85 [95% CI 1.87-7.95] vs HR, 1.84 [95% CI 1.34-2.53], respectively).\n\nImpaired kidney function was associated with elevated circulating level of most AD blood biomarkers. However, the presence of impaired kidney function did not independently increase the risk of dementia but rather seemed to accelerate the clinical expression of underlying neurodegenerative pathology.", "doi": "10.1212/WNL.0000000000214446", "pmid": "41337685", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12687484"}], "notes": [], "created": "2026-09-23T09:10:59.999Z", "modified": "2026-09-23T09:11:00.097Z"}, {"entity": "publication", "iuid": "c35597fd7be64f3ba4de9f422502dfde", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c35597fd7be64f3ba4de9f422502dfde.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c35597fd7be64f3ba4de9f422502dfde"}}, "title": "Blood biomarkers of Alzheimer's disease and progression across different stages of cognitive decline in the community.", "authors": [{"family": "Valletta", "given": "Martina", "initials": "M", "orcid": "0000-0003-0139-8287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40c63a55168d4a35bdd9d91428e39448.json"}}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL", "orcid": "0000-0002-3099-4830", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3473c98810f247f7805ea747af1fdbbe.json"}}, {"family": "Gregorio", "given": "Caterina", "initials": "C", "orcid": "0000-0002-8163-1634", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a81270d6a50243c0a64044b16384c010.json"}}, {"family": "Rizzuto", "given": "Debora", "initials": "D"}, {"family": "Winblad", "given": "Bengt", "initials": "B", "orcid": "0000-0002-0011-1179", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa53d96890814cab88c6adaf1aaf4b8d.json"}}, {"family": "Canevelli", "given": "Marco", "initials": "M"}, {"family": "Andersson", "given": "Sarah", "initials": "S"}, {"family": "Dale", "given": "Matilda", "initials": "M", "orcid": "0000-0002-5788-7744", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ceec63ec0dea45eaa5ad3c4d34b10959.json"}}, {"family": "Fredolini", "given": "Claudia", "initials": "C", "orcid": "0000-0002-7674-2014", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cda0965cae2344aa9aaf9b1c5605b378.json"}}, {"family": "Laukka", "given": "Erika J", "initials": "EJ"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Grande", "given": "Giulia", "initials": "G", "orcid": "0000-0001-6312-3815", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/560ca11ae102481a8e29703d6c395553.json"}}], "type": "journal article", "published": "2025-11-23", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "10412", "issn-l": "2041-1723"}, "abstract": "Blood biomarkers of Alzheimer's disease (AD) are promising for dementia prediction, but their association with progression across intermediate stages of cognitive decline in the general population remains unclear. We followed 2148 dementia-free individuals from a Swedish population-based cohort for up to 16 years. Associations between baseline AD blood biomarkers and transitions between normal cognition, mild cognitive impairment (MCI), and dementia were examined. Lower amyloid-\u03b242/40 ratio and higher phosphorylated-tau181 (p-tau181), p-tau217, total-tau, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) were associated with faster progression from MCI to all-cause and AD dementia, with the strongest associations for NfL and p-tau217. Elevated NfL and GFAP were linked to reduced MCI reversion to normal cognition, whereas no biomarker was associated with MCI development from normal cognition. These findings show robust group-level associations and indicate that AD blood biomarkers may help stratify dementia risk at the MCI stage in the community.", "doi": "10.1038/s41467-025-66728-2", "pmid": "41276530", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12644782"}, {"db": "pii", "key": "10.1038/s41467-025-66728-2"}], "notes": [], "created": "2026-09-23T09:08:28.915Z", "modified": "2026-09-23T09:08:29.063Z"}, {"entity": "publication", "iuid": "edf36a43bbf54946b3637973de3b5c3f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/edf36a43bbf54946b3637973de3b5c3f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/edf36a43bbf54946b3637973de3b5c3f"}}, "title": "Blood-based biomarkers of Alzheimer's disease and incident dementia in the community.", "authors": [{"family": "Grande", "given": "Giulia", "initials": "G", "orcid": "0000-0001-6312-3815", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/560ca11ae102481a8e29703d6c395553.json"}}, {"family": "Valletta", "given": "Martina", "initials": "M", "orcid": "0000-0003-0139-8287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40c63a55168d4a35bdd9d91428e39448.json"}}, {"family": "Rizzuto", "given": "Debora", "initials": "D"}, {"family": "Xia", "given": "Xin", "initials": "X"}, {"family": "Qiu", "given": "Chengxuan", "initials": "C", "orcid": "0000-0003-1922-4912", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4a3f19bc7e049b09dd1d1c8a5b2f621.json"}}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Dale", "given": "Matilda", "initials": "M", "orcid": "0000-0002-5788-7744", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ceec63ec0dea45eaa5ad3c4d34b10959.json"}}, {"family": "Andersson", "given": "Sarah", "initials": "S"}, {"family": "Fredolini", "given": "Claudia", "initials": "C", "orcid": "0000-0002-7674-2014", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cda0965cae2344aa9aaf9b1c5605b378.json"}}, {"family": "Winblad", "given": "Bengt", "initials": "B", "orcid": "0000-0002-0011-1179", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa53d96890814cab88c6adaf1aaf4b8d.json"}}, {"family": "Laukka", "given": "Erika J", "initials": "EJ"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Vetrano", "given": "Davide L", "initials": "DL", "orcid": "0000-0002-3099-4830", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3473c98810f247f7805ea747af1fdbbe.json"}}], "type": "journal article", "published": "2025-06-00", "journal": {"title": "Nat. Med.", "issn": "1546-170X", "volume": "31", "issue": "6", "pages": "2027-2035", "issn-l": "1078-8956"}, "abstract": "Evidence regarding the clinical validity of blood biomarkers of Alzheimer's disease (AD) in the general population is limited. We estimated the hazard and predictive performance of six AD blood biomarkers for incident all-cause and AD dementia-the ratio of amyloid-\u03b2 42 to amyloid-\u03b2 40 and levels of tau phosphorylated at T217 (p-tau217), tau phosphorylated at T181 (p-tau181), total tau, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP)-in a cohort of 2,148 dementia-free older adults from Sweden, who were followed for up to 16 years. In multi-adjusted Cox regression models, elevated baseline levels of p-tau181, p-tau217, NfL, and GFAP were associated with a significantly increased hazard for all-cause and AD dementia, displaying a non-linear dose-response relationship. Elevated concentrations of p-tau181, p-tau217, NfL, and GFAP demonstrated strong predictive performance (area under the curve ranging from 70.9% to 82.6%) for 10-year all-cause and AD dementia, with negative predictive values exceeding 90% but low positive predictive values (PPVs). Combining p-tau217 with NfL or GFAP further improved prediction, with PPVs reaching 43%. Our findings suggest that these biomarkers have the potential to rule out impending dementia in community settings, but they might need to be combined with other biological or clinical markers to be used as screening tools.", "doi": "10.1038/s41591-025-03605-x", "pmid": "40140622", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12176656"}, {"db": "pii", "key": "10.1038/s41591-025-03605-x"}], "notes": [], "created": "2026-09-23T06:49:46.343Z", "modified": "2026-09-23T07:25:41.142Z"}, {"entity": "publication", "iuid": "eb01fcd3288444b6be37cb3f77115cc9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/eb01fcd3288444b6be37cb3f77115cc9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/eb01fcd3288444b6be37cb3f77115cc9"}}, "title": "Blood biomarkers of Alzheimer's disease in the community: Variation by chronic diseases and inflammatory status.", "authors": [{"family": "Valletta", "given": "Martina", "initials": "M", "orcid": "0000-0003-0139-8287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40c63a55168d4a35bdd9d91428e39448.json"}}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL"}, {"family": "Rizzuto", "given": "Debora", "initials": "D"}, {"family": "Winblad", "given": "Bengt", "initials": "B"}, {"family": "Canevelli", "given": "Marco", "initials": "M"}, {"family": "Andersson", "given": "Sarah", "initials": "S"}, {"family": "Dale", "given": "Matilda", "initials": "M"}, {"family": "Fredolini", "given": "Claudia", "initials": "C"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Grande", "given": "Giulia", "initials": "G"}], "type": "journal article", "published": "2024-06-00", "journal": {"title": "Alzheimers Dement", "issn": "1552-5279", "volume": "20", "issue": "6", "pages": "4115-4125", "issn-l": "1552-5260"}, "abstract": "We explored the variations of blood biomarkers of Alzheimer's disease (AD) by chronic diseases and systemic inflammation.\n\nWe explored the association of AD blood biomarkers with chronic diseases and systemic inflammation (interleukin-6 [IL-6]), in 2366 dementia-free participants of the Swedish National Study on Aging and Care-in Kungsholmen, using quantile regression models.\n\nA greater number of co-occurring chronic diseases was associated with higher concentrations of phosphorylated-tau 181 (p-tau181), total-tau (t-tau), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) (p < 0.01). Anemia, kidney, cerebrovascular, and heart diseases were associated with variations in the levels of AD blood biomarkers. Participants in the highest (vs. lowest) interleukin-6 (IL-6) tertile had higher NfL concentration. Systemic inflammation amplified the associations between several chronic diseases and p-tau181, t-tau, NfL, and GFAP.\n\nIn the community, the concentration of AD blood biomarkers varies in relation to medical conditions and systemic inflammation. Recognizing these influences is crucial for the accurate interpretation and clinical implementation of blood biomarkers.\n\nParticipants with a complex clinical profile (i.e., multiple co-occurring diseases or specific disease combinations) display elevated levels of AD blood-biomarkers. Anemia, heart, cerebrovascular, and kidney diseases are associated with variations is the levels of AD blood biomarkers in cognitively intact older adults. Systemic inflammation amplifies the association between several chronic diseases and AD blood biomarkers.", "doi": "10.1002/alz.13860", "pmid": "38717935", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11180869"}], "notes": [], "created": "2026-09-23T09:03:22.769Z", "modified": "2026-09-23T09:03:22.850Z"}]}