{"entity": "researcher", "timestamp": "2026-09-24T05:52:28.771Z", "family": "Maillo", "given": "Alberto", "initials": "A", "orcid": "0000-0002-3835-9794", "affiliations": ["Bioscience Program, Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology KAUST, Thuwal 23955, Saudi Arabia."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/4054f386499043f0b9fd8ea4ce5a605e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/4054f386499043f0b9fd8ea4ce5a605e"}}, "publications": [{"entity": "publication", "iuid": "2b361fbf6fd044c690a9776877209b17", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2b361fbf6fd044c690a9776877209b17.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2b361fbf6fd044c690a9776877209b17"}}, "title": "Uncovering the regulatory landscape of early human B cell lymphopoiesis and its implications in the pathogenesis of B-ALL.", "authors": [{"family": "Planell", "given": "N\u00faria", "initials": "N", "orcid": "0000-0001-7550-2433", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/335676fe9a9642dcb03f2aaf0c197993.json"}}, {"family": "Mart\u00ednez-de-Morentin", "given": "Xabier", "initials": "X", "orcid": "0000-0002-8358-9214", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/47fc54e595dd4df480155bdde603a8f1.json"}}, {"family": "Mouzo", "given": "Daniel", "initials": "D", "orcid": "0000-0002-0383-5703", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13ea821cd2fe49128b1f8c18ed9dc256.json"}}, {"family": "Lara-Astiaso", "given": "David", "initials": "D"}, {"family": "Vilas-Zornoza", "given": "Amaia", "initials": "A"}, {"family": "Mart\u00edn-Uriz", "given": "Patxi San", "initials": "PS", "orcid": "0000-0003-1483-4279", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7165cce0460347a297f30bd381a3b817.json"}}, {"family": "Alignani", "given": "Diego", "initials": "D", "orcid": "0000-0003-0241-1375", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/96cb2a393fe94e9a826c3fc70b7c8bb7.json"}}, {"family": "Paiva", "given": "Bruno", "initials": "B", "orcid": "0000-0003-1977-3815", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/364674822f714c8293de1db32a163beb.json"}}, {"family": "Maillo", "given": "Alberto", "initials": "A", "orcid": "0000-0002-3835-9794", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4054f386499043f0b9fd8ea4ce5a605e.json"}}, {"family": "Kurowska", "given": "Aleksandra", "initials": "A"}, {"family": "Berastegui", "given": "Nerea", "initials": "N", "orcid": "0000-0002-9868-0547", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec90f71d18ea46cd8df66804debec1e5.json"}}, {"family": "Garcia-Olloqui", "given": "Paula", "initials": "P", "orcid": "0000-0002-7983-2875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/01b6f2e2f65842cfa64e6329ad988bca.json"}}, {"family": "Urdangarin", "given": "Arantxa", "initials": "A"}, {"family": "Noori", "given": "Peri", "initials": "P"}, {"family": "Ortega-Legarreta", "given": "Asier", "initials": "A", "orcid": "0009-0000-3563-5362", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10a1eb932f2e41c282ae472c9ede6465.json"}}, {"family": "Hernaez", "given": "Mikel", "initials": "M", "orcid": "0000-0003-0443-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13276f226ed042afb92bf1425b67334a.json"}}, {"family": "Lagani", "given": "Vincenzo", "initials": "V", "orcid": "0000-0002-6552-6076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8832e0f50e14a23875a47949200ca6c.json"}}, {"family": "Kiani", "given": "Narsis", "initials": "N", "orcid": "0000-0002-0949-046X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5375b71b93f643cc8dc3a5ac8d1a67c2.json"}}, {"family": "Merkenschlager", "given": "Matthias", "initials": "M", "orcid": "0000-0003-2889-3288", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6257840a1b0c4478a38ec31b070fb13c.json"}}, {"family": "Ezponda", "given": "Teresa", "initials": "T", "orcid": "0000-0003-3682-7125", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/967a5c1eb13a428db835ef8531a69b87.json"}}, {"family": "Mart\u00edn-Subero", "given": "Jos\u00e9 I", "initials": "JI", "orcid": "0000-0001-8809-5195", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6b1944a98214848b864342473012567.json"}}, {"family": "Ram\u00edrez", "given": "Ricardo N", "initials": "RN", "orcid": "0000-0002-1259-5406", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/606cf67d57f441008ecb07b0e3e4705d.json"}}, {"family": "Tegner", "given": "Jesper", "initials": "J", "orcid": "0000-0002-9568-5588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b115e5faf68a4acbb6f947c711fd37ec.json"}}, {"family": "Prosper", "given": "Felipe", "initials": "F", "orcid": "0000-0001-6115-8790", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b062035045714ecd9d6cbca6fc60d433.json"}}, {"family": "Gomez-Cabrero", "given": "David", "initials": "D", "orcid": "0000-0003-4186-3788", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2f7905f6b864d3286b28b99dbb59627.json"}}], "type": "journal article", "published": "2025-10-10", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "11", "issue": "41", "pages": "eadw3110", "issn-l": "2375-2548"}, "abstract": "Dysregulation of early B cell lymphopoiesis-the process guiding cellular immunity development-can lead to malignancy, making it crucial to understand its regulatory mechanisms. We generated a multiomics resource comprising paired chromatin accessibility and gene expression profiles across eight human B cell precursor populations, providing a detailed characterization of early human B cell development. Integrative analysis revealed highly cell type-specific regulatory elements and enabled the reconstruction of the gene regulatory network governing differentiation. We identified putative candidate regulons, such as ELK3, enriched in pro-B cells and potentially involved in cell cycle progression. Regulons from bulk data were projected onto single-cell data, validating their activity and refining the regulatory landscape. This resource enabled identification of active regulatory programs and transformation-associated states in B cell acute lymphoblastic leukemia. The publicly available atlas provides a valuable resource for understanding B cell development and disease, supporting future efforts to decode regulatory programs in immunity and hematologic malignancies.", "doi": "10.1126/sciadv.adw3110", "pmid": "41071881", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12513440"}], "notes": [], "created": "2026-09-23T13:19:20.910Z", "modified": "2026-09-23T13:19:21.411Z"}, {"entity": "publication", "iuid": "ede928f77ef5406d9caac2a132746efa", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ede928f77ef5406d9caac2a132746efa.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ede928f77ef5406d9caac2a132746efa"}}, "title": "Foundation Models Meet Imbalanced Single-Cell Data When Learning Cell Type Annotations", "authors": [{"family": "Alsabbagh", "given": "Abdel Rahman", "initials": "AR", "orcid": "0009-0003-2777-732X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b46afe7193dd47a8a0437fc894cf05e7.json"}}, {"family": "de Infante", "given": "Alberto Maillo Ruiz", "initials": "AMR", "orcid": "0000-0002-3835-9794", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4054f386499043f0b9fd8ea4ce5a605e.json"}}, {"family": "Gomez-Cabrero", "given": "David", "initials": "D", "orcid": "0000-0003-4186-3788", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2f7905f6b864d3286b28b99dbb59627.json"}}, {"family": "Kiani", "given": "Narsis A", "initials": "NA", "orcid": "0000-0002-0949-046X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5375b71b93f643cc8dc3a5ac8d1a67c2.json"}}, {"family": "Khan", "given": "Sumeer Ahmad", "initials": "SA", "orcid": "0000-0002-3345-5904", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c26975353fe144209200135f5fd3e6ad.json"}}, {"family": "Tegn\u00e9r", "given": "Jesper N", "initials": "JN", "orcid": "0000-0002-9568-5588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b115e5faf68a4acbb6f947c711fd37ec.json"}}], "type": "posted-content", "published": "2023-10-27", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.10.24.563625", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T13:45:57.841Z", "modified": "2026-09-23T13:45:57.879Z"}]}