{"entity": "researcher", "timestamp": "2026-09-27T16:16:21.938Z", "family": "Hochgerner", "given": "Hannah", "initials": "H", "orcid": "0000-0002-7739-666X", "affiliations": ["Division of Molecular Neurobiology, Dept. of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.", "Science for Life Laboratory, Solna, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f874cb6774846f48b62272ed04a672c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f874cb6774846f48b62272ed04a672c"}}, "publications": [{"entity": "publication", "iuid": "34524351aeeb4db39e3656d0f839c83a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/34524351aeeb4db39e3656d0f839c83a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/34524351aeeb4db39e3656d0f839c83a"}}, "title": "Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing.", "authors": [{"family": "Hochgerner", "given": "Hannah", "initials": "H", "orcid": "0000-0002-7739-666X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f874cb6774846f48b62272ed04a672c.json"}}, {"family": "Zeisel", "given": "Amit", "initials": "A"}, {"family": "L\u00f6nnerberg", "given": "Peter", "initials": "P"}, {"family": "Linnarsson", "given": "Sten", "initials": "S", "orcid": "0000-0002-3491-3444", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/638b2874e1144bf497bc96f9bce5ccb9.json"}}], "type": "journal article", "published": "2018-02-00", "journal": {"title": "Nat. Neurosci.", "issn": "1546-1726", "volume": "21", "issue": "2", "pages": "290-299", "issn-l": "1097-6256"}, "abstract": "The dentate gyrus of the hippocampus is a brain region in which neurogenesis persists into adulthood; however, the relationship between developmental and adult dentate gyrus neurogenesis has not been examined in detail. Here we used single-cell RNA sequencing to reveal the molecular dynamics and diversity of dentate gyrus cell types in perinatal, juvenile, and adult mice. We found distinct quiescent and proliferating progenitor cell types, linked by transient intermediate states to neuroblast stages and fully mature granule cells. We observed shifts in the molecular identity of quiescent and proliferating radial glia and granule cells during the postnatal period that were then maintained through adult stages. In contrast, intermediate progenitor cells, neuroblasts, and immature granule cells were nearly indistinguishable at all ages. These findings demonstrate the fundamental similarity of postnatal and adult neurogenesis in the hippocampus and pinpoint the early postnatal transformation of radial glia from embryonic progenitors to adult quiescent stem cells.", "doi": "10.1038/s41593-017-0056-2", "pmid": "29335606", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41593-017-0056-2"}], "notes": [], "created": "2018-12-05T12:49:10.238Z", "modified": "2026-09-23T06:32:27.939Z"}, {"entity": "publication", "iuid": "1b237879fd994c30a2eed34bc15bc1d6", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1b237879fd994c30a2eed34bc15bc1d6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1b237879fd994c30a2eed34bc15bc1d6"}}, "title": "STRT-seq-2i: dual-index 5' single cell and nucleus RNA-seq on an addressable microwell array.", "authors": [{"family": "Hochgerner", "given": "Hannah", "initials": "H", "orcid": "0000-0002-7739-666X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f874cb6774846f48b62272ed04a672c.json"}}, {"family": "L\u00f6nnerberg", "given": "Peter", "initials": "P"}, {"family": "Hodge", "given": "Rebecca", "initials": "R"}, {"family": "Mikes", "given": "Jaromir", "initials": "J", "orcid": "0000-0002-9941-7855", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b486baedd784487dbf3e5b7b33f950da.json"}}, {"family": "Heskol", "given": "Abeer", "initials": "A"}, {"family": "Hubschle", "given": "Hermann", "initials": "H"}, {"family": "Lin", "given": "Philip", "initials": "P"}, {"family": "Picelli", "given": "Simone", "initials": "S"}, {"family": "La Manno", "given": "Gioele", "initials": "G"}, {"family": "Ratz", "given": "Michael", "initials": "M"}, {"family": "Dunne", "given": "Jude", "initials": "J"}, {"family": "Husain", "given": "Syed", "initials": "S"}, {"family": "Lein", "given": "Ed", "initials": "E", "orcid": "0000-0001-9012-6552", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/667d53a701f24f339b9d8eec3eaaef1d.json"}}, {"family": "Srinivasan", "given": "Maithreyan", "initials": "M"}, {"family": "Zeisel", "given": "Amit", "initials": "A"}, {"family": "Linnarsson", "given": "Sten", "initials": "S"}], "type": "journal article", "published": "2017-11-27", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "7", "issue": "1", "pages": "16327", "issn-l": "2045-2322"}, "abstract": "Single-cell RNA-seq has become routine for discovering cell types and revealing cellular diversity, but archived human brain samples still pose a challenge to current high-throughput platforms. We present STRT-seq-2i, an addressable 9600-microwell array platform, combining sampling by limiting dilution or FACS, with imaging and high throughput at competitive cost. We applied the platform to fresh single mouse cortical cells and to frozen post-mortem human cortical nuclei, matching the performance of a previous lower-throughput platform while retaining a high degree of flexibility, potentially also for other high-throughput applications.", "doi": "10.1038/s41598-017-16546-4", "pmid": "29180631", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5703850"}, {"db": "pii", "key": "10.1038/s41598-017-16546-4"}], "notes": [], "created": "2018-12-05T12:53:15.006Z", "modified": "2026-09-23T07:47:54.591Z"}, {"entity": "publication", "iuid": "14751e846791460b86c086b66641220f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/14751e846791460b86c086b66641220f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/14751e846791460b86c086b66641220f"}}, "title": "STRT-seq-2i: dual-index 5\u2032 single cell and nucleus RNA-seq on an addressable microwell array", "authors": [{"family": "Hochgerner", "given": "Hannah", "initials": "H", "orcid": "0000-0002-7739-666X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f874cb6774846f48b62272ed04a672c.json"}}, {"family": "L\u00f6nnerberg", "given": "Peter", "initials": "P"}, {"family": "Hodge", "given": "Rebecca", "initials": "R"}, {"family": "Mikes", "given": "Jaromir", "initials": "J"}, {"family": "Heskol", "given": "Abeer", "initials": "A"}, {"family": "Hubschle", "given": "Hermann", "initials": "H"}, {"family": "Lin", "given": "Philip", "initials": "P"}, {"family": "Picelli", "given": "Simone", "initials": "S"}, {"family": "Manno", "given": "Gioele La", "initials": "GL"}, {"family": "Ratz", "given": "Michael", "initials": "M"}, {"family": "Dunne", "given": "Jude", "initials": "J"}, {"family": "Husain", "given": "Syed", "initials": "S"}, {"family": "Lein", "given": "Ed", "initials": "E"}, {"family": "Srinivasan", "given": "Maithreyan", "initials": "M"}, {"family": "Zeisel", "given": "Amit", "initials": "A"}, {"family": "Linnarsson", "given": "Sten", "initials": "S"}], "type": "posted-content", "published": "2017-04-20", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/126268", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T13:48:49.515Z", "modified": "2026-09-23T13:48:49.555Z"}]}