{"entity": "researcher", "timestamp": "2026-08-20T20:34:11.743Z", "family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "affiliations": ["Department of Onkology-Pathology, Science for Life Laboratories, Karolinska Institutet, Stockholm, Sweden. Ola.Larsson@ki.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804"}}, "publications": [{"entity": "publication", "iuid": "2598dba6b2ec40e6a4e38faa37025e37", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2598dba6b2ec40e6a4e38faa37025e37.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2598dba6b2ec40e6a4e38faa37025e37"}}, "title": "Translon: a single term for translated regions.", "authors": [{"family": "\u015awirski", "given": "Micha\u0142 I", "initials": "MI", "orcid": "0000-0002-8585-136X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/daf5a142439546a7b7cd210439724554.json"}}, {"family": "Tierney", "given": "Jack A S", "initials": "JAS", "orcid": "0000-0002-5331-3604", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/536a9d74aa5045a68dcc3d2433e8686c.json"}}, {"family": "Alb\u00e0", "given": "M Mar", "initials": "MM", "orcid": "0000-0002-7963-7375", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b14dd79387c4f75bfbf24b67f1d4ca9.json"}}, {"family": "Andreev", "given": "Dmitry E", "initials": "DE", "orcid": "0000-0001-5320-3045", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36a203947cc34c35af7fca9c277faff5.json"}}, {"family": "Aspden", "given": "Julie L", "initials": "JL", "orcid": "0000-0002-8537-6204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/30d5ae77bf134cf39c5120417a94d034.json"}}, {"family": "Atkins", "given": "John F", "initials": "JF", "orcid": "0000-0001-7933-0165", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d78917a7760f4b35a8bb8d781dea7c5f.json"}}, {"family": "Bassani-Sternberg", "given": "Michal", "initials": "M", "orcid": "0000-0002-1934-954X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38abdd9d55c1402c9f0099afc594e2a9.json"}}, {"family": "Berry", "given": "Marla J", "initials": "MJ", "orcid": "0000-0002-2428-586X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6342d3054265430cbac6551d7b5a9989.json"}}, {"family": "Biffo", "given": "Stefano", "initials": "S", "orcid": "0000-0002-3780-1050", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d3c863ea70a643fba02c9bcd7beb37ea.json"}}, {"family": "Boris-Lawrie", "given": "Kathleen", "initials": "K"}, {"family": "Borodovsky", "given": "Mark", "initials": "M", "orcid": "0000-0002-1401-4046", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9cb68fc0f05d4f5fb333d0e66571ec3f.json"}}, {"family": "Brierley", "given": "Ian", "initials": "I", "orcid": "0000-0003-3965-4370", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c390be0b3034aba9bd705e4664e28c1.json"}}, {"family": "Brook", "given": "Matthew", "initials": "M", "orcid": "0000-0003-1245-7385", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e615004e71974d5d83afab550f48d0c4.json"}}, {"family": "Brunet", "given": "Marie A", "initials": "MA", "orcid": "0000-0001-5973-3522", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac295800c5664f42880b227df4cb4938.json"}}, {"family": "Bujnicki", "given": "Janusz M", "initials": "JM", "orcid": "0000-0002-6633-165X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/849faed3ae904eebba43069f225960bf.json"}}, {"family": "Caliskan", "given": "Neva", "initials": "N", "orcid": "0000-0003-0435-4757", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7aef7adbfa9242abac425bb617fba4ae.json"}}, {"family": "Calviello", "given": "Lorenzo", "initials": "L", "orcid": "0000-0002-5600-0988", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eedc540b6d9740059cdf672df87616bd.json"}}, {"family": "Carvunis", "given": "Anne-Ruxandra", "initials": "AR", "orcid": "0000-0002-6474-6413", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8cc110d69c7425c8264d38bf7bd79b7.json"}}, {"family": "Cate", "given": "Jamie H D", "initials": "JHD", "orcid": "0000-0001-5965-7902", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/478823b0c4b340429c703851f12cbb98.json"}}, {"family": "Cenik", "given": "Can", "initials": "C", "orcid": "0000-0001-6370-0889", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1647c1a81dd94ff38d65ccbfe90deadc.json"}}, {"family": "Chang", "given": "Kung Yao", "initials": "KY", "orcid": "0000-0002-4469-0387", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c5eeca1f2b14a5fbd589d77fe58911d.json"}}, {"family": "Chen", "given": "Yiwen", "initials": "Y", "orcid": "0000-0002-7706-7540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bf00bc679a524553abc8680d3c13966e.json"}}, {"family": "Chothani", "given": "Sonia", "initials": "S", "orcid": "0000-0002-1010-7069", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2321f59366224d0f8256e505d783fdb9.json"}}, {"family": "Choudhary", "given": "Jyoti S", "initials": "JS", "orcid": "0000-0003-0881-5477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ea9f0b1f3188478d911447702c316243.json"}}, {"family": "Clark", "given": "Patricia L", "initials": "PL", "orcid": "0000-0001-5462-8248", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/714cf357e7e84679be3c6c2ad18c6a3f.json"}}, {"family": "Clauwaert", "given": "Jim", "initials": "J"}, {"family": "Cooley", "given": "Lynn", "initials": "L", "orcid": "0000-0003-4665-1258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4e796b18aad64687bfc89a857984b331.json"}}, {"family": "Dassi", "given": "Erik", "initials": "E", "orcid": "0000-0003-4487-0449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4c82cdf066c4052acab255d6e8a5d0e.json"}}, {"family": "Dean", "given": "Kellie", "initials": "K", "orcid": "0000-0002-3213-8181", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f2c9d7288c4645909c7b45e601d6e351.json"}}, {"family": "Diaz", "given": "Jean-Jacques", "initials": "JJ", "orcid": "0000-0002-7914-4319", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4289cbaf487a4887900ea9c45270683d.json"}}, {"family": "Dieterich", "given": "Christoph", "initials": "C", "orcid": "0000-0001-9468-6311", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a96a3cb9e094e478a88a3a212c34460.json"}}, {"family": "Dikstein", "given": "Rivka", "initials": "R", "orcid": "0000-0002-6251-4723", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d65ba046bda44e9babb43b3ab5c9065f.json"}}, {"family": "Dinman", "given": "Jonathan D", "initials": "JD", "orcid": "0000-0002-2402-9698", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/947f8aa98d194d94bdb33b6f4fce1c30.json"}}, {"family": "Dmitriev", "given": "Sergey E", "initials": "SE", "orcid": "0000-0002-1774-8475", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c686d8d2507492b8eac91074e338593.json"}}, {"family": "Dontsova", "given": "Olga A", "initials": "OA"}, {"family": "Dunham", "given": "Christine M", "initials": "CM", "orcid": "0000-0002-8821-688X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c136ef7914a4780926b7f6344bd597f.json"}}, {"family": "Eswarappa", "given": "Sandeep M", "initials": "SM", "orcid": "0000-0002-7903-5198", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf72dc7d222a4444ad726aa7d173be19.json"}}, {"family": "Farabaugh", "given": "Philip J", "initials": "PJ", "orcid": "0000-0002-5658-7141", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1edad8fe5d4e47b9879788c3b934690f.json"}}, {"family": "Faridi", "given": "Pouya", "initials": "P", "orcid": "0000-0002-2712-3356", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8dbef7962fe7450fb25313c9f61717db.json"}}, {"family": "Fierro-Monti", "given": "Ivo", "initials": "I", "orcid": "0000-0002-5460-2117", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad70a69f36314369b43818571fde0f75.json"}}, {"family": "Firth", "given": "Andrew E", "initials": "AE", "orcid": "0000-0002-7986-9520", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60bacf45d5fe496d9f73d0e3b74a6563.json"}}, {"family": "Gatfield", "given": "David", "initials": "D", "orcid": "0000-0001-5114-2824", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/233e4a708fb34f88bc3118f0ca8a4c38.json"}}, {"family": "Gebauer", "given": "F\u00e1tima", "initials": "F", "orcid": "0000-0001-7563-0013", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/be22737ffb054391bae0f4566fac91c2.json"}}, {"family": "Gelfand", "given": "Mikhail S", "initials": "MS", "orcid": "0000-0003-4181-0846", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8f5368c92c40453098626becf5fea26c.json"}}, {"family": "Gray", "given": "Nicola K", "initials": "NK", "orcid": "0000-0002-0413-1767", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bc989b51d8c24672ad61dbdd2e05729a.json"}}, {"family": "Green", "given": "Rachel", "initials": "R", "orcid": "0000-0001-9337-2003", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ecdc565bb9d4a53b2ad893bc95a6f16.json"}}, {"family": "Hill", "given": "Chris H", "initials": "CH", "orcid": "0000-0001-7037-0611", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b589b816a3e4afeaf3be4060ea0ecec.json"}}, {"family": "Hou", "given": "Ya-Ming", "initials": "YM", "orcid": "0000-0001-6546-2597", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8115eef0e85c4df085f2a753de5b4433.json"}}, {"family": "H\u00fcbner", "given": "Norbert", "initials": "N", "orcid": "0000-0002-1218-6223", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f8fcb2e3ce2473b8a89b74727da5bb0.json"}}, {"family": "Ignatova", "given": "Zoya", "initials": "Z", "orcid": "0000-0002-9478-8825", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9ff2bcc30ed4068a6c0b628f086a844.json"}}, {"family": "Ivanov", "given": "Pavel", "initials": "P", "orcid": "0000-0002-7986-7760", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/97e5a8913fa04346b59f6506352ada22.json"}}, {"family": "Iwasaki", "given": "Shintaro", "initials": "S", "orcid": "0000-0001-7724-3754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f3f0fec7bb5a4a08bbd4b3b7c920444c.json"}}, {"family": "Johnson", "given": "Rory", "initials": "R", "orcid": "0000-0003-4607-2782", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fe2468fba174f82916d8afd852ad724.json"}}, {"family": "Jomaa", "given": "Ahmad", "initials": "A", "orcid": "0000-0002-5543-7942", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/630784885d5e4aaabae79801cd510145.json"}}, {"family": "Jovanovic", "given": "Marko", "initials": "M", "orcid": "0000-0001-9707-3377", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1dc37784708248b49a1b2423135e0a1d.json"}}, {"family": "Jungreis", "given": "Irwin", "initials": "I", "orcid": "0000-0002-3197-5367", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/56f0daf23c054c59a0f58969dd5ac6db.json"}}, {"family": "Kellis", "given": "Manolis", "initials": "M", "orcid": "0000-0001-7113-9630", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9989fea905234f91aa4412731b93ab09.json"}}, {"family": "Kieft", "given": "Jeffrey S", "initials": "JS", "orcid": "0000-0002-3718-1891", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e84a902110a4f78ba9c5871d54f5d6b.json"}}, {"family": "Kochetov", "given": "Alex V", "initials": "AV"}, {"family": "Koonin", "given": "Eugene V", "initials": "EV", "orcid": "0000-0003-3943-8299", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1ab5826b43f46769b80afbc58ad4e81.json"}}, {"family": "Korostelev", "given": "Andrei A", "initials": "AA", "orcid": "0000-0003-1588-717X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/093c3cb39fdc4f9292ff88afec513474.json"}}, {"family": "Kufel", "given": "Joanna", "initials": "J", "orcid": "0000-0001-6810-2749", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/70cb7d6b9f844e24a133d2de51ce294c.json"}}, {"family": "Kulakovskiy", "given": "Ivan V", "initials": "IV", "orcid": "0000-0002-6554-8128", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0e08bda37e1140adae4669665d33e10e.json"}}, {"family": "Kurian", "given": "Leo", "initials": "L", "orcid": "0000-0001-7466-5169", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2757b8734bea4eceb7240b1d98c0b27e.json"}}, {"family": "Lafontaine", "given": "Denis L J", "initials": "DLJ", "orcid": "0000-0001-7295-6288", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9ca9bf9e09e45afa0da65f8ed40d8c7.json"}}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "Loughran", "given": "Gary", "initials": "G"}, {"family": "Luke\u0161", "given": "Julius", "initials": "J", "orcid": "0000-0002-0578-6618", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0593d9a6db6044fbaa6659fda0be473d.json"}}, {"family": "Mariotti", "given": "Marco", "initials": "M", "orcid": "0000-0002-7411-4161", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fd21551aee634f42b1f8b2c9720e947d.json"}}, {"family": "Martens-Uzunova", "given": "Elena S", "initials": "ES", "orcid": "0000-0002-5363-2525", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f74a4ede0ca148eb9d4361fdc7f0afc3.json"}}, {"family": "Martinez", "given": "Thomas F", "initials": "TF", "orcid": "0000-0002-4011-8164", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/abb8c6946cf44aa29ab3fbd816482d71.json"}}, {"family": "Matsumoto", "given": "Akinobu", "initials": "A", "orcid": "0000-0002-4077-3935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2574db3eb31c408d9f5327f6eca84483.json"}}, {"family": "McManus", "given": "Joel", "initials": "J", "orcid": "0000-0002-6605-2642", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1154f2331e5446aea6c28aeceeee3a21.json"}}, {"family": "Medenbach", "given": "Jan", "initials": "J", "orcid": "0000-0003-0749-7788", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d9e4c5a641e4aa68757e4a9b1162304.json"}}, {"family": "Melnikov", "given": "Sergey V", "initials": "SV"}, {"family": "Menschaert", "given": "Gerben", "initials": "G", "orcid": "0000-0002-7575-2085", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10413488ae7e428a99d7184f2ae5cde5.json"}}, {"family": "Merchante", "given": "Catharina", "initials": "C", "orcid": "0000-0003-2214-9562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/45d5ff64ce62424a834334f71eb76910.json"}}, {"family": "Mikl", "given": "Martin", "initials": "M", "orcid": "0000-0001-8913-7158", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b57ca06114054393a29ce7487f7da225.json"}}, {"family": "Miller", "given": "W Allen", "initials": "WA", "orcid": "0000-0003-0603-2751", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/341c5645fbb640ceac46572561c796c8.json"}}, {"family": "M\u00fchlemann", "given": "Oliver", "initials": "O", "orcid": "0000-0003-0657-1368", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eb9ce936ccb349c38e79a33789a55abf.json"}}, {"family": "Namy", "given": "Olivier", "initials": "O", "orcid": "0000-0002-1143-5961", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e5b761f20624e098e77f7a0819f73a1.json"}}, {"family": "Nedialkova", "given": "Danny D", "initials": "DD", "orcid": "0000-0001-8598-6021", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cdf7691ef20b4fdfad9f857c9e0d8c5c.json"}}, {"family": "Nosek", "given": "Jozef", "initials": "J", "orcid": "0000-0002-1020-5451", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/677137fc169f4f5fa839564abc966dbd.json"}}, {"family": "Orchard", "given": "Sandra", "initials": "S", "orcid": "0000-0002-8878-3972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/869478a873ea4465ab43ecef5aee865c.json"}}, {"family": "Ozreti\u0107", "given": "Petar", "initials": "P", "orcid": "0000-0001-9757-6636", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/69c33ca49db04611bc4a45a3420b2e5c.json"}}, {"family": "Pertea", "given": "Mihaela", "initials": "M", "orcid": "0000-0003-0762-8637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/59fc40021c3040ab8163e271f6fed420.json"}}, {"family": "Pervouchine", "given": "Dmitri D", "initials": "DD"}, {"family": "Rom\u00e3o", "given": "Lu\u00edsa", "initials": "L", "orcid": "0000-0002-5061-5287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0b4d1cac90a24737bf44cac441e98038.json"}}, {"family": "Ron", "given": "David", "initials": "D"}, {"family": "Roucou", "given": "Xavier", "initials": "X", "orcid": "0000-0001-9370-5584", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/17d9f6a0468d483e80cbe0072d9b0e1f.json"}}, {"family": "Rubtsova", "given": "Maria P", "initials": "MP"}, {"family": "Ruiz-Orera", "given": "Jorge", "initials": "J", "orcid": "0000-0002-8317-0034", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8657ee1a6255445fa8762d5c2e89a0ee.json"}}, {"family": "Saghatelian", "given": "Alan", "initials": "A", "orcid": "0000-0002-0427-563X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/120afa0313a845a1b377c18ddd55a5e3.json"}}, {"family": "Salzberg", "given": "Steven L", "initials": "SL", "orcid": "0000-0002-8859-7432", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0b5838d01a642578c636c337e82a918.json"}}, {"family": "Seale", "given": "Lucia A", "initials": "LA", "orcid": "0000-0002-0686-7516", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f05e4571460f48fd8f1e1548f7392663.json"}}, {"family": "Seoighe", "given": "Cathal", "initials": "C", "orcid": "0000-0003-0496-4029", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f18cf0a611994b58879e6778f756f4fc.json"}}, {"family": "Sergiev", "given": "Petr V", "initials": "PV", "orcid": "0000-0001-8866-1863", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65f6d258469846d38da2c1a6a0816265.json"}}, {"family": "Shah", "given": "Premal", "initials": "P", "orcid": "0000-0002-8424-4218", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6946cbb2d0444d03ba070899306cdbad.json"}}, {"family": "Shirokikh", "given": "Nikolay", "initials": "N", "orcid": "0000-0001-8249-358X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7e6ba0deb6fa465bbca85682a038d681.json"}}, {"family": "Slavoff", "given": "Sarah A", "initials": "SA", "orcid": "0000-0002-4443-2070", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/25999e9efb0046808fabf3335bce0c1f.json"}}, {"family": "Sonenberg", "given": "Nahum", "initials": "N", "orcid": "0000-0002-4707-8759", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa0667a833e54844808bce0d4d00609d.json"}}, {"family": "Stasevich", "given": "Timothy J", "initials": "TJ", "orcid": "0000-0002-0151-6274", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/af6f5c1b5b7f4b9d84d4d388faa55c08.json"}}, {"family": "Szczesny", "given": "Roman J", "initials": "RJ", "orcid": "0000-0002-0686-1632", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c4fe6eba70a24eb88e802ee09251eace.json"}}, {"family": "Tamm", "given": "Tiina", "initials": "T", "orcid": "0000-0001-9943-2097", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c0a7ed037a4480f8454c3a9e4fc60b3.json"}}, {"family": "Tch\u00f3rzewski", "given": "Marek", "initials": "M", "orcid": "0000-0002-0718-4223", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/86f1d373509e4823a1dacfa4127b85d6.json"}}, {"family": "Topisirovic", "given": "Ivan", "initials": "I", "orcid": "0000-0002-5510-9762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1bca1813f34c4864940ac6593044a9cc.json"}}, {"family": "Tremblay", "given": "Michel L", "initials": "ML"}, {"family": "Tuller", "given": "Tamir", "initials": "T", "orcid": "0000-0003-4194-7068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bdfccdb3a02745e28f1a397858e7e4b9.json"}}, {"family": "Ulitsky", "given": "Igor", "initials": "I", "orcid": "0000-0003-0555-6561", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa0f7da96c85457c95b82698508d288f.json"}}, {"family": "Val\u00e1\u0161ek", "given": "Leo\u0161 Shivaya", "initials": "LS", "orcid": "0000-0001-8123-8667", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a73e4c57d07b45188685deb3fbe83043.json"}}, {"family": "Van Damme", "given": "Petra", "initials": "P", "orcid": "0000-0001-9090-027X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ce601449a53470d9d765ad1373d6bd0.json"}}, {"family": "Viero", "given": "Gabriella", "initials": "G", "orcid": "0000-0002-6755-285X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c844aef9d1a146a5bccca6424c9136fd.json"}}, {"family": "Vizcaino", "given": "Juan Antonio", "initials": "JA", "orcid": "0000-0002-3905-4335", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81245410f3234e658147bc94f6b3dad2.json"}}, {"family": "Vogel", "given": "Christine", "initials": "C", "orcid": "0000-0002-2856-3118", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/175408d95b194f04a8e8cdaf90c20933.json"}}, {"family": "Wallace", "given": "Edward W J", "initials": "EWJ", "orcid": "0000-0001-8025-6361", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/05bb2b29eff74329b02d9db19397f364.json"}}, {"family": "Weissman", "given": "Jonathan S", "initials": "JS", "orcid": "0000-0003-2445-670X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/167955ef29a6467da39978796a45b39d.json"}}, {"family": "Westhof", "given": "Eric", "initials": "E", "orcid": "0000-0002-6172-5422", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b456ec58208e4ef8a904c5d4c5204c60.json"}}, {"family": "Whiffin", "given": "Nicola", "initials": "N", "orcid": "0000-0003-1554-6594", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c738b5f577f4c2f85df984f6c2ef75a.json"}}, {"family": "Wilson", "given": "Daniel N", "initials": "DN", "orcid": "0000-0003-3816-3828", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7c2d78750ccb42239a7363f99f58dcc5.json"}}, {"family": "Xie", "given": "Zhi", "initials": "Z", "orcid": "0000-0002-5589-4836", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f6b586aba1a94a9092e6f5360b8d16d9.json"}}, {"family": "Yewdell", "given": "Jonathan W", "initials": "JW", "orcid": "0000-0002-3826-1906", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d696816328e140119d0d21aaa071b3ef.json"}}, {"family": "Yordanova", "given": "Martina M", "initials": "MM", "orcid": "0000-0001-9693-3857", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4fc68392e93e47bdac1a23fe9fd1336e.json"}}, {"family": "Yu", "given": "Chien-Hung", "initials": "CH", "orcid": "0000-0003-0337-4473", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/31e0cb03fdfc484596ea24e4f2b83969.json"}}, {"family": "Yurchenko", "given": "Vyacheslav", "initials": "V", "orcid": "0000-0003-4765-3263", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b4432f19e214f7d8c5f537b0dc4ae71.json"}}, {"family": "Zagrovic", "given": "Bojan", "initials": "B", "orcid": "0000-0002-1616-6713", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/86236ffacf2b4f1ca8ed29bc110f0478.json"}}, {"family": "TRANSLACORE", "given": "", "initials": ""}, {"family": "Valen", "given": "Eivind", "initials": "E", "orcid": "0000-0003-1840-6108", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a3232e143b04064bc08681c3930847f.json"}}, {"family": "Baranov", "given": "Pavel V", "initials": "PV", "orcid": "0000-0001-9017-0270", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9db030a647f4a72a9244d2052bbbd86.json"}}], "type": "letter", "published": "2025-10-00", "journal": {"title": "Nat. Methods", "issn": "1548-7105", "volume": "22", "issue": "10", "pages": "2002-2006", "issn-l": "1548-7091"}, "abstract": null, "doi": "10.1038/s41592-025-02810-3", "pmid": "40890551", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41592-025-02810-3"}], "notes": [], "created": "2026-08-20T09:03:33.962Z", "modified": "2026-08-20T09:03:37.514Z"}, {"entity": "publication", "iuid": "a312b3ce8eec4855b16873537f95a8bb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a312b3ce8eec4855b16873537f95a8bb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a312b3ce8eec4855b16873537f95a8bb"}}, "title": "Plasticity of the mammalian integrated stress response.", "authors": [{"family": "Chen", "given": "Chien-Wen", "initials": "CW", "orcid": "0000-0002-1214-4058", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/31bfc8f68c7f46c184b233efccd23651.json"}}, {"family": "Papadopoli", "given": "David", "initials": "D"}, {"family": "Szkop", "given": "Krzysztof J", "initials": "KJ"}, {"family": "Guan", "given": "Bo-Jhih", "initials": "BJ"}, {"family": "Alzahrani", "given": "Mohammed", "initials": "M", "orcid": "0000-0001-7291-5275", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2b8c5964a93e47eea6601cc9b13ae343.json"}}, {"family": "Wu", "given": "Jing", "initials": "J", "orcid": "0009-0000-5199-1199", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac7a88e311aa495a93825a2a7065da88.json"}}, {"family": "Jobava", "given": "Raul", "initials": "R"}, {"family": "Asraf", "given": "Mais M", "initials": "MM"}, {"family": "Krokowski", "given": "Dawid", "initials": "D"}, {"family": "Vourekas", "given": "Anastasios", "initials": "A", "orcid": "0000-0002-1850-5635", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/85a3939de7c341b084bb7293bfb505b9.json"}}, {"family": "Merrick", "given": "William C", "initials": "WC"}, {"family": "Komar", "given": "Anton A", "initials": "AA"}, {"family": "Koromilas", "given": "Antonis E", "initials": "AE", "orcid": "0000-0003-1972-0799", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7825afc7ac8942819083ce7c570b5508.json"}}, {"family": "Gorospe", "given": "Myriam", "initials": "M", "orcid": "0000-0001-5439-3434", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f959a00a1c6d406892d949aeafed5a4f.json"}}, {"family": "Payea", "given": "Matthew J", "initials": "MJ", "orcid": "0000-0002-1960-4563", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7127b888bae44cd59c2e1d60eff38366.json"}}, {"family": "Wang", "given": "Fangfang", "initials": "F"}, {"family": "Clayton", "given": "Benjamin L L", "initials": "BLL", "orcid": "0000-0001-9552-404X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7d27aa75b2e84ddf8c7ac065d22db7fd.json"}}, {"family": "Tesar", "given": "Paul J", "initials": "PJ", "orcid": "0000-0003-1532-3155", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2126dba093aa4bfd8ed62c630333452e.json"}}, {"family": "Schaffer", "given": "Ashleigh", "initials": "A", "orcid": "0000-0002-1164-697X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c283750c40b41b7959efe3f42c9ccad.json"}}, {"family": "Miron", "given": "Alexander", "initials": "A"}, {"family": "Bederman", "given": "Ilya", "initials": "I", "orcid": "0000-0002-1909-5746", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d234b19b68564c858dbc42c1f5adf9b1.json"}}, {"family": "Jankowsky", "given": "Eckhard", "initials": "E"}, {"family": "Vogel", "given": "Christine", "initials": "C", "orcid": "0000-0002-2856-3118", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/175408d95b194f04a8e8cdaf90c20933.json"}}, {"family": "Val\u00e1\u0161ek", "given": "Leo\u0161 Shivaya", "initials": "LS", "orcid": "0000-0001-8123-8667", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a73e4c57d07b45188685deb3fbe83043.json"}}, {"family": "Dinman", "given": "Jonathan D", "initials": "JD", "orcid": "0000-0002-2402-9698", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/947f8aa98d194d94bdb33b6f4fce1c30.json"}}, {"family": "Zhang", "given": "Youwei", "initials": "Y", "orcid": "0000-0003-0011-7922", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/926e555efbff4fbd97f028680d69a960.json"}}, {"family": "Tirosh", "given": "Boaz", "initials": "B"}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "Topisirovic", "given": "Ivan", "initials": "I", "orcid": "0000-0002-5510-9762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1bca1813f34c4864940ac6593044a9cc.json"}}, {"family": "Hatzoglou", "given": "Maria", "initials": "M", "orcid": "0000-0003-2037-1231", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3fbc5330f8c84c548a8472bb81cf77f3.json"}}], "type": "journal article", "published": "2025-05-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "641", "issue": "8065", "pages": "1319-1328", "issn-l": "0028-0836"}, "abstract": "An increased level of phosphorylation of eukaryotic translation initiation factor 2 subunit-\u03b1 (eIF2\u03b1, encoded by EIF2S1; eIF2\u03b1-p) coupled with decreased guanine nucleotide exchange activity of eIF2B is a hallmark of the 'canonical' integrated stress response (c-ISR)1. It is unclear whether impaired eIF2B activity in human diseases including leukodystrophies2, which occurs in the absence of eIF2\u03b1-p induction, is synonymous with the c-ISR. Here we describe a mechanism triggered by decreased eIF2B activity, distinct from the c-ISR, which we term the split ISR (s-ISR). The s-ISR is characterized by translational and transcriptional programs that are different from those observed in the c-ISR. Opposite to the c-ISR, the s-ISR requires eIF4E-dependent translation of the upstream open reading frame 1 and subsequent stabilization of ATF4 mRNA. This is followed by altered expression of a subset of metabolic genes (for example, PCK2), resulting in metabolic rewiring required to maintain cellular bioenergetics when eIF2B activity is attenuated. Overall, these data demonstrate a plasticity of the mammalian ISR, whereby the loss of eIF2B activity in the absence of eIF2\u03b1-p induction activates the eIF4E-ATF4-PCK2 axis to maintain energy homeostasis.", "doi": "10.1038/s41586-025-08794-6", "pmid": "40140574", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12119373"}, {"db": "pii", "key": "10.1038/s41586-025-08794-6"}], "notes": [], "created": "2026-08-20T08:59:09.414Z", "modified": "2026-08-20T08:59:10.076Z"}, {"entity": "publication", "iuid": "c4b9cca27860453e84b806a7987f215d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c4b9cca27860453e84b806a7987f215d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c4b9cca27860453e84b806a7987f215d"}}, "title": "The Epstein-Barr virus deubiquitinase BPLF1 regulates stress-induced ribosome UFMylation and reticulophagy.", "authors": [{"family": "Liu", "given": "Jiangnan", "initials": "J", "orcid": "0000-0002-3086-7567", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c28ada139d64dca82657d1ee5f1d2b0.json"}}, {"family": "Nagy", "given": "Noemi", "initials": "N", "orcid": "0000-0002-7800-3493", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f27465b7465457c89f55ef01194da02.json"}}, {"family": "Ayala-Torres", "given": "Carlos", "initials": "C", "orcid": "0000-0002-2306-6788", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/789af2aa7d6543a9bdb157d59dceb458.json"}}, {"family": "Bleuse", "given": "Solenne", "initials": "S"}, {"family": "Aguilar-Alonso", "given": "Francisco", "initials": "F", "orcid": "0000-0003-4457-5642", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bf76e002fbd046b1840cc6988e559ea8.json"}}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "Masucci", "given": "Maria G", "initials": "MG", "orcid": "0000-0002-5541-2809", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ac1411f252f403485d658f2c74204f0.json"}}], "type": "journal article", "published": "2025-05-00", "journal": {"title": "Autophagy", "issn": "1554-8635", "volume": "21", "issue": "5", "pages": "996-1018", "issn-l": "1554-8627"}, "abstract": "The synthesis of membrane and secreted proteins is safeguarded by an endoplasmic reticulum-associated ribosome quality control (ER-RQC) that promotes the disposal of defective translation products by the proteasome or via a lysosome-dependent pathway involving the degradation of portions of the ER by macroautophagy (reticulophagy). The UFMylation of RPL26 on ER-stalled ribosomes is essential for activating the ER-RQC and reticulophagy. Here, we report that the viral deubiquitinase (vDUB) encoded in the N-terminal domain of the Epstein-Barr virus (EBV) large tegument protein BPLF1 hinders the UFMylation of RPL26 on ribosomes that stall at the ER, promotes the stabilization of ER-RQC substrates, and inhibits reticulophagy. The vDUB did not act as a de-UFMylase or interfere with the UFMylation of the ER membrane protein CYB5R3 by the UFL1 ligase. Instead, it copurified with ribosomes in sucrose gradients and abrogated a ZNF598- and LTN1-independent ubiquitination event required for RPL26 UFMylation. Physiological levels of BPLF1 impaired the UFMylation of RPL26 in productively EBV-infected cells, pointing to an important role of the enzyme in regulating the translation quality control that allows the efficient synthesis of viral proteins and the production of infectious virus.Abbreviation: BPLF1, BamH1 P fragment left open readingframe-1; CDK5RAP3, CDK5regulatory subunit associated protein 3; ChFP, mCherry fluorescent protein; DDRGK1, DDRGKdomain containing 1; EBV, Epstein-Barr virus; eGFP, enhancedGFP; ER-RQC, endoplasmicreticulum-associated ribosome quality control; LCL, EBV-carryinglymphoblastoid cell line; GFP, green fluorescent protein; RQC, ribosome quality control; SRP, signal recognition particle; UFM1, ubiquitin fold modifier 1; UFL1, UFM1 specific ligase 1.", "doi": "10.1080/15548627.2024.2440846", "pmid": "39842454", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12013442"}], "notes": [], "created": "2026-08-20T09:37:01.535Z", "modified": "2026-08-20T09:37:01.762Z"}, {"entity": "publication", "iuid": "aa8fbfaa74e3412fbef4871d1c15f9df", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/aa8fbfaa74e3412fbef4871d1c15f9df.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/aa8fbfaa74e3412fbef4871d1c15f9df"}}, "title": "Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR).", "authors": [{"family": "Loughran", "given": "Gary", "initials": "G", "orcid": "0000-0002-2683-5597", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c311a8bb78647dbb1d9f4151c5e408b.json"}}, {"family": "Andreev", "given": "Dmitry E", "initials": "DE", "orcid": "0000-0001-5320-3045", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36a203947cc34c35af7fca9c277faff5.json"}}, {"family": "Terenin", "given": "Ilya M", "initials": "IM"}, {"family": "Namy", "given": "Olivier", "initials": "O", "orcid": "0000-0002-1143-5961", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e5b761f20624e098e77f7a0819f73a1.json"}}, {"family": "Mikl", "given": "Martin", "initials": "M", "orcid": "0000-0001-8913-7158", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b57ca06114054393a29ce7487f7da225.json"}}, {"family": "Yordanova", "given": "Martina M", "initials": "MM"}, {"family": "McManus", "given": "C Joel", "initials": "CJ", "orcid": "0000-0002-6605-2642", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1154f2331e5446aea6c28aeceeee3a21.json"}}, {"family": "Firth", "given": "Andrew E", "initials": "AE"}, {"family": "Atkins", "given": "John F", "initials": "JF", "orcid": "0000-0001-7933-0165", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d78917a7760f4b35a8bb8d781dea7c5f.json"}}, {"family": "Fraser", "given": "Christopher S", "initials": "CS", "orcid": "0000-0001-9626-7743", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b7f1730af67400f9a838543d1e35fe9.json"}}, {"family": "Ignatova", "given": "Zoya", "initials": "Z", "orcid": "0000-0002-9478-8825", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9ff2bcc30ed4068a6c0b628f086a844.json"}}, {"family": "Iwasaki", "given": "Shintaro", "initials": "S", "orcid": "0000-0001-7724-3754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f3f0fec7bb5a4a08bbd4b3b7c920444c.json"}}, {"family": "Kufel", "given": "Joanna", "initials": "J"}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "Leidel", "given": "Sebastian A", "initials": "SA"}, {"family": "Mankin", "given": "Alexander S", "initials": "AS", "orcid": "0000-0002-3301-827X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51ec2601418a4be1aa88cd6fd0446e07.json"}}, {"family": "Mariotti", "given": "Marco", "initials": "M", "orcid": "0000-0002-7411-4161", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fd21551aee634f42b1f8b2c9720e947d.json"}}, {"family": "Tanenbaum", "given": "Marvin E", "initials": "ME", "orcid": "0000-0001-8762-0090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ab6de46d021a44558494cc2ce946b46e.json"}}, {"family": "Topisirovic", "given": "Ivan", "initials": "I", "orcid": "0000-0002-5510-9762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1bca1813f34c4864940ac6593044a9cc.json"}}, {"family": "V\u00e1zquez-Laslop", "given": "Nora", "initials": "N", "orcid": "0000-0003-2256-693X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0e7993c94c0e4df68b0854c5b67d5167.json"}}, {"family": "Viero", "given": "Gabriela", "initials": "G"}, {"family": "Caliskan", "given": "Neva", "initials": "N", "orcid": "0000-0003-0435-4757", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7aef7adbfa9242abac425bb617fba4ae.json"}}, {"family": "Chen", "given": "Yiwen", "initials": "Y"}, {"family": "Clark", "given": "Patricia L", "initials": "PL", "orcid": "0000-0001-5462-8248", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/714cf357e7e84679be3c6c2ad18c6a3f.json"}}, {"family": "Dinman", "given": "Jonathan D", "initials": "JD", "orcid": "0000-0002-2402-9698", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/947f8aa98d194d94bdb33b6f4fce1c30.json"}}, {"family": "Farabaugh", "given": "Philip J", "initials": "PJ", "orcid": "0000-0002-5658-7141", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1edad8fe5d4e47b9879788c3b934690f.json"}}, {"family": "Gilbert", "given": "Wendy V", "initials": "WV"}, {"family": "Ivanov", "given": "Pavel", "initials": "P", "orcid": "0000-0002-7986-7760", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/97e5a8913fa04346b59f6506352ada22.json"}}, {"family": "Kieft", "given": "Jeffrey S", "initials": "JS", "orcid": "0000-0002-3718-1891", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e84a902110a4f78ba9c5871d54f5d6b.json"}}, {"family": "M\u00fchlemann", "given": "Oliver", "initials": "O"}, {"family": "Sachs", "given": "Matthew S", "initials": "MS", "orcid": "0000-0001-9891-9223", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4116cf26f3b4f79b5c02f0f4402d438.json"}}, {"family": "Shatsky", "given": "Ivan N", "initials": "IN"}, {"family": "Sonenberg", "given": "Nahum", "initials": "N", "orcid": "0000-0002-4707-8759", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa0667a833e54844808bce0d4d00609d.json"}}, {"family": "Steckelberg", "given": "Anna-Lena", "initials": "AL"}, {"family": "Willis", "given": "Anne E", "initials": "AE", "orcid": "0000-0002-1470-8531", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7b11e8c4039c42b7bdc43cb6b7f4fa85.json"}}, {"family": "Woodside", "given": "Michael T", "initials": "MT"}, {"family": "Valasek", "given": "Leos Shivaya", "initials": "LS", "orcid": "0000-0001-8123-8667", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a73e4c57d07b45188685deb3fbe83043.json"}}, {"family": "Dmitriev", "given": "Sergey E", "initials": "SE", "orcid": "0000-0002-1774-8475", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c686d8d2507492b8eac91074e338593.json"}}, {"family": "Baranov", "given": "Pavel V", "initials": "PV", "orcid": "0000-0001-9017-0270", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9db030a647f4a72a9244d2052bbbd86.json"}}], "type": "journal article", "published": "2025-03-00", "journal": {"title": "Nat. Struct. Mol. Biol.", "issn": "1545-9985", "volume": "32", "issue": "3", "pages": "418-430", "issn-l": "1545-9985"}, "abstract": "Dual reporters encoding two distinct proteins within the same mRNA have had a crucial role in identifying and characterizing unconventional mechanisms of eukaryotic translation. These mechanisms include initiation via internal ribosomal entry sites (IRESs), ribosomal frameshifting, stop codon readthrough and reinitiation. This design enables the expression of one reporter to be influenced by the specific mechanism under investigation, while the other reporter serves as an internal control. However, challenges arise when intervening test sequences are placed between these two reporters. Such sequences can inadvertently impact the expression or function of either reporter, independent of translation-related changes, potentially biasing the results. These effects may occur due to cryptic regulatory elements inducing or affecting transcription initiation, splicing, polyadenylation and antisense transcription as well as unpredictable effects of the translated test sequences on the stability and activity of the reporters. Unfortunately, these unintended effects may lead to misinterpretation of data and the publication of incorrect conclusions in the scientific literature. To address this issue and to assist the scientific community in accurately interpreting dual-reporter experiments, we have developed comprehensive guidelines. These guidelines cover experimental design, interpretation and the minimal requirements for reporting results. They are designed to aid researchers conducting these experiments as well as reviewers, editors and other investigators who seek to evaluate published data.", "doi": "10.1038/s41594-025-01492-x", "pmid": "40033152", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS2090291"}, {"db": "pmc", "key": "PMC12246961"}, {"db": "pii", "key": "10.1038/s41594-025-01492-x"}], "notes": [], "created": "2026-08-20T09:03:55.131Z", "modified": "2026-08-20T09:03:55.608Z"}, {"entity": "publication", "iuid": "c28257475a734348b03f533c06754345", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c28257475a734348b03f533c06754345.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c28257475a734348b03f533c06754345"}}, "title": "SMYD5 methylation of rpL40 links ribosomal output to gastric cancer.", "authors": [{"family": "Park", "given": "Juhyung", "initials": "J", "orcid": "0009-0008-6916-2784", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d6ef7bb356e410aa4219c27b08168e2.json"}}, {"family": "Wu", "given": "Jibo", "initials": "J"}, {"family": "Szkop", "given": "Krzysztof J", "initials": "KJ"}, {"family": "Jeong", "given": "Jinho", "initials": "J", "orcid": "0000-0002-1224-7196", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bbbe0377fe2b431cb698f1e0bd671776.json"}}, {"family": "Jovanovic", "given": "Predrag", "initials": "P", "orcid": "0000-0002-0090-0047", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8084427ad2da44ba918b3cc9d77cf8f1.json"}}, {"family": "Husmann", "given": "Dylan", "initials": "D", "orcid": "0000-0003-1995-7892", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/da68a9ed090d49e1a79e83ed0f9ac49a.json"}}, {"family": "Flores", "given": "Natasha M", "initials": "NM"}, {"family": "Francis", "given": "Joel W", "initials": "JW"}, {"family": "Chen", "given": "Ying-Jiun C", "initials": "YC", "orcid": "0000-0002-6290-0771", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/69277ae5a9474a08bc61176a010b39db.json"}}, {"family": "Benitez", "given": "Ana Morales", "initials": "AM", "orcid": "0000-0002-1021-5262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5345b04beb854f1e9a3bb483bdf2143d.json"}}, {"family": "Zahn", "given": "Emily", "initials": "E"}, {"family": "Song", "given": "Shumei", "initials": "S", "orcid": "0000-0002-8128-6287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0fb1a3e2dd3e4c608db294f5a977d97f.json"}}, {"family": "Ajani", "given": "Jaffer A", "initials": "JA", "orcid": "0000-0001-9946-0629", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13eb316de9424a65a37353d6341598be.json"}}, {"family": "Wang", "given": "Linghua", "initials": "L", "orcid": "0000-0001-9380-0266", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/366de0ac4cd74b6cbecc846bd466bae3.json"}}, {"family": "Singh", "given": "Kamini", "initials": "K"}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "Garcia", "given": "Benjamin A", "initials": "BA", "orcid": "0000-0003-3596-4750", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3818fa278ebd4ab29155f78bd12ec54e.json"}}, {"family": "Topisirovic", "given": "Ivan", "initials": "I", "orcid": "0000-0002-5510-9762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1bca1813f34c4864940ac6593044a9cc.json"}}, {"family": "Gozani", "given": "Or", "initials": "O", "orcid": "0000-0002-1365-4463", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb41c98a37274469a378ec1aee3c2e3a.json"}}, {"family": "Mazur", "given": "Pawel K", "initials": "PK", "orcid": "0000-0002-5820-8344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dab982893e314975be2b45e274ee5d62.json"}}], "type": "journal article", "published": "2024-08-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "632", "issue": "8025", "pages": "656-663", "issn-l": "0028-0836"}, "abstract": "Dysregulated transcription due to disruption in histone lysine methylation dynamics is an established contributor to tumorigenesis1,2. However, whether analogous pathologic epigenetic mechanisms act directly on the ribosome to advance oncogenesis is unclear. Here we find that trimethylation of the core ribosomal protein L40 (rpL40) at lysine 22 (rpL40K22me3) by the lysine methyltransferase SMYD5 regulates mRNA translation output to promote malignant progression of gastric adenocarcinoma (GAC) with lethal peritoneal ascites. A biochemical-proteomics strategy identifies the monoubiquitin fusion protein partner rpL40 (ref. 3) as the principal physiological substrate of SMYD5 across diverse samples. Inhibiting the SMYD5-rpL40K22me3 axis in GAC cell lines reprogrammes protein synthesis to attenuate oncogenic gene expression signatures. SMYD5 and rpL40K22me3 are upregulated in samples from patients with GAC and negatively correlate with clinical outcomes. SMYD5 ablation in vivo in familial and sporadic mouse models of malignant GAC blocks metastatic disease, including peritoneal carcinomatosis. Suppressing SMYD5 methylation of rpL40 inhibits human cancer cell and patient-derived GAC xenograft growth and renders them hypersensitive to inhibitors of PI3K and mTOR. Finally, combining SMYD5 depletion with PI3K-mTOR inhibition and chimeric antigen receptor T cell administration cures an otherwise lethal in vivo mouse model of aggressive GAC-derived peritoneal carcinomatosis. Together, our work uncovers a ribosome-based epigenetic mechanism that facilitates the evolution of malignant GAC and proposes SMYD5 targeting as part of a potential combination therapy to treat this cancer.", "doi": "10.1038/s41586-024-07718-0", "pmid": "39048817", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS2037119"}, {"db": "pmc", "key": "PMC11625416"}, {"db": "pii", "key": "10.1038/s41586-024-07718-0"}], "notes": [], "created": "2026-08-20T08:58:56.543Z", "modified": "2026-08-20T08:58:57.111Z"}, {"entity": "publication", "iuid": "31ae34fa1f734e2ca2b4aedef66bd4cd", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/31ae34fa1f734e2ca2b4aedef66bd4cd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/31ae34fa1f734e2ca2b4aedef66bd4cd"}}, "title": "Control of protein synthesis through mRNA pseudouridylation by dyskerin.", "authors": [{"family": "Pederiva", "given": "Chiara", "initials": "C", "orcid": "0000-0002-9682-8405", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e1da89ab5b94668a067157f5bf847dc.json"}}, {"family": "Trevisan", "given": "Davide M", "initials": "DM", "orcid": "0000-0003-4221-9441", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d83269d952442bc9f6e1901f0596b50.json"}}, {"family": "Peirasmaki", "given": "Dimitra", "initials": "D"}, {"family": "Chen", "given": "Shan", "initials": "S"}, {"family": "Savage", "given": "Sharon A", "initials": "SA", "orcid": "0000-0001-6006-0740", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac53f7e9f3154c66b35b175849c1e915.json"}}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "Ule", "given": "Jernej", "initials": "J", "orcid": "0000-0002-2452-4277", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0069e934521242c98273b8b334324674.json"}}, {"family": "Baranello", "given": "Laura", "initials": "L", "orcid": "0000-0001-6039-1849", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/249ce47702914b009281dde6c8ef402d.json"}}, {"family": "Agostini", "given": "Federico", "initials": "F", "orcid": "0000-0002-5453-2737", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc126b42b76c456b828eb2d86c7619e4.json"}}, {"family": "Farnebo", "given": "Marianne", "initials": "M", "orcid": "0000-0002-2677-558X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e68c11795c834f7e858a05c110c3e9b2.json"}}], "type": "journal article", "published": "2023-07-28", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "9", "issue": "30", "pages": "eadg1805", "issn-l": "2375-2548"}, "abstract": "Posttranscriptional modifications of mRNA have emerged as regulators of gene expression. Although pseudouridylation is the most abundant, its biological role remains poorly understood. Here, we demonstrate that the pseudouridine synthase dyskerin associates with RNA polymerase II, binds to thousands of mRNAs, and is responsible for their pseudouridylation, an action that occurs in chromatin and does not appear to require a guide RNA with full complementarity. In cells lacking dyskerin, mRNA pseudouridylation is reduced, while at the same time, de novo protein synthesis is enhanced, indicating that this modification interferes with translation. Accordingly, mRNAs with fewer pseudouridines due to knockdown of dyskerin are translated more efficiently. Moreover, mRNA pseudouridylation is severely reduced in patients with dyskeratosis congenita caused by inherited mutations in the gene encoding dyskerin (i.e., DKC1). Our findings demonstrate that pseudouridylation by dyskerin modulates mRNA translatability, with important implications for both normal development and disease.", "doi": "10.1126/sciadv.adg1805", "pmid": "37506213", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10381945"}], "notes": [], "created": "2026-08-20T11:58:42.930Z", "modified": "2026-08-20T11:58:43.225Z"}, {"entity": "publication", "iuid": "88d4e19738fc423b8fbd486d4c0388e1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/88d4e19738fc423b8fbd486d4c0388e1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/88d4e19738fc423b8fbd486d4c0388e1"}}, "title": "MNK2 deficiency potentiates \u03b2-cell regeneration via translational regulation.", "authors": [{"family": "Karampelias", "given": "Christos", "initials": "C"}, {"family": "Watt", "given": "Kathleen", "initials": "K"}, {"family": "Mattsson", "given": "Charlotte L", "initials": "CL"}, {"family": "Ruiz", "given": "\u00c1ngel Fern\u00e1ndez", "initials": "\u00c1F"}, {"family": "Rezanejad", "given": "Habib", "initials": "H"}, {"family": "Mi", "given": "Jiarui", "initials": "J"}, {"family": "Liu", "given": "Xiaojing", "initials": "X"}, {"family": "Chu", "given": "Lianhe", "initials": "L"}, {"family": "Locasale", "given": "Jason W", "initials": "JW", "orcid": "0000-0002-7766-3502", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ea4fb5ff8aa48659f870bed9fd2ff66.json"}}, {"family": "Korbutt", "given": "Gregory S", "initials": "GS"}, {"family": "Rovira", "given": "Meritxell", "initials": "M"}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "Andersson", "given": "Olov", "initials": "O", "orcid": "0000-0001-6715-781X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2f39763e006e48309fc287cdb644ffe4.json"}}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Nat. Chem. Biol.", "issn": "1552-4469", "volume": "18", "issue": "9", "pages": "942-953", "issn-l": "1552-4450"}, "abstract": "Regenerating pancreatic \u03b2-cells is a potential curative approach for diabetes. We previously identified the small molecule CID661578 as a potent inducer of \u03b2-cell regeneration, but its target and mechanism of action have remained unknown. We now screened 257 million yeast clones and determined that CID661578 targets MAP kinase-interacting serine/threonine kinase 2 (MNK2), an interaction we genetically validated in vivo. CID661578 increased \u03b2-cell neogenesis from ductal cells in zebrafish, neonatal pig islet aggregates and human pancreatic ductal organoids. Mechanistically, we found that CID661578 boosts protein synthesis and regeneration by blocking MNK2 from binding eIF4G in the translation initiation complex at the mRNA cap. Unexpectedly, this blocking activity augmented eIF4E phosphorylation depending on MNK1 and bolstered the interaction between eIF4E and eIF4G, which is necessary for both hypertranslation and \u03b2-cell regeneration. Taken together, our findings demonstrate a targetable role of MNK2-controlled translation in \u03b2-cell regeneration, a role that warrants further investigation in diabetes.", "doi": "10.1038/s41589-022-01047-x", "pmid": "35697798", "labels": [], "xrefs": [{"db": "mid", "key": "EMS144580"}, {"db": "pmc", "key": "PMC7613404"}, {"db": "pii", "key": "10.1038/s41589-022-01047-x"}], "notes": [], "created": "2026-08-20T09:01:31.726Z", "modified": "2026-08-20T09:01:31.787Z"}, {"entity": "publication", "iuid": "9e53af5ff81547c885197550abde3b5c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9e53af5ff81547c885197550abde3b5c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9e53af5ff81547c885197550abde3b5c"}}, "title": "PABP prevents the untimely decay of select mRNA populations in human cells.", "authors": [{"family": "Kajjo", "given": "Sam", "initials": "S", "orcid": "0000-0002-9289-881X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04be248dfea9411db5f5b38a90286131.json"}}, {"family": "Sharma", "given": "Sahil", "initials": "S", "orcid": "0000-0003-3829-0835", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1d9be72a410c419ba140e0855c67f79e.json"}}, {"family": "Chen", "given": "Shan", "initials": "S"}, {"family": "Brothers", "given": "William R", "initials": "WR", "orcid": "0000-0001-8962-7974", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/166032c51f964ec28ebc3214bee1f31f.json"}}, {"family": "Cott", "given": "Megan", "initials": "M", "orcid": "0000-0003-4288-9605", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de7f7f4f79ec47f5821607537e1d3f20.json"}}, {"family": "Hasaj", "given": "Benedeta", "initials": "B"}, {"family": "Jovanovic", "given": "Predrag", "initials": "P"}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "Fabian", "given": "Marc R", "initials": "MR", "orcid": "0000-0003-3700-7604", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/43a20f4f83e141b4b61ad195945322e2.json"}}], "type": "journal article", "published": "2022-03-15", "journal": {"title": "EMBO J.", "issn": "1460-2075", "volume": "41", "issue": "6", "pages": "e108650", "issn-l": "0261-4189"}, "abstract": "Gene expression is tightly regulated at the levels of both mRNA translation and stability. The poly(A)-binding protein (PABP) is thought to play a role in regulating these processes by binding the mRNA 3' poly(A) tail and interacting with both the translation and mRNA deadenylation machineries. In this study, we directly investigate the impact of PABP on translation and stability of endogenous mRNAs in human cells. Remarkably, our transcriptome-wide analysis only detects marginal mRNA translation changes in PABP-depleted cells. In contrast, rapidly depleting PABP alters mRNA abundance and stability, albeit non-uniformly. Otherwise stable transcripts, including those encoding proteins with constitutive functions, are destabilized in PABP-depleted cells. In contrast, many unstable mRNAs, including those encoding proteins with regulatory functions, decay at similar rates in presence or absence of PABP. Moreover, PABP depletion-induced cell death can partially be suppressed by disrupting the mRNA decapping and 5'-3' decay machinery. Finally, we provide evidence that the LSM1-7 complex promotes decay of \"stable\" mRNAs in PABP-depleted cells. Taken together, these findings suggest that PABP plays an important role in preventing the untimely decay of select mRNA populations.", "doi": "10.15252/embj.2021108650", "pmid": "35156721", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8922270"}], "notes": [], "created": "2026-08-20T12:51:42.700Z", "modified": "2026-08-20T12:51:42.907Z"}, {"entity": "publication", "iuid": "c298aa3790034b738557ff0ede15be3b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c298aa3790034b738557ff0ede15be3b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c298aa3790034b738557ff0ede15be3b"}}, "title": "Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.", "authors": [{"family": "Lee", "given": "Bianca J", "initials": "BJ"}, {"family": "Boyer", "given": "Jacob A", "initials": "JA"}, {"family": "Burnett", "given": "G Leslie", "initials": "GL", "orcid": "0000-0003-2514-9373", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/879e7c7ba2174b4b9ec20a77ee8fac49.json"}}, {"family": "Thottumkara", "given": "Arun P", "initials": "AP"}, {"family": "Tibrewal", "given": "Nidhi", "initials": "N"}, {"family": "Wilson", "given": "Stacy L", "initials": "SL"}, {"family": "Hsieh", "given": "Tientien", "initials": "T"}, {"family": "Marquez", "given": "Abby", "initials": "A"}, {"family": "Lorenzana", "given": "Edward G", "initials": "EG"}, {"family": "Evans", "given": "James W", "initials": "JW"}, {"family": "Hulea", "given": "Laura", "initials": "L", "orcid": "0000-0001-7585-7760", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35a90eec621f48ad838baf8d6f956b5f.json"}}, {"family": "Kiss", "given": "Gert", "initials": "G"}, {"family": "Liu", "given": "Hui", "initials": "H"}, {"family": "Lee", "given": "Dong", "initials": "D"}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "McLaughlan", "given": "Shannon", "initials": "S"}, {"family": "Topisirovic", "given": "Ivan", "initials": "I"}, {"family": "Wang", "given": "Zhengping", "initials": "Z"}, {"family": "Wang", "given": "Zhican", "initials": "Z"}, {"family": "Zhao", "given": "Yongyuan", "initials": "Y"}, {"family": "Wildes", "given": "David", "initials": "D"}, {"family": "Aggen", "given": "James B", "initials": "JB"}, {"family": "Singh", "given": "Mallika", "initials": "M"}, {"family": "Gill", "given": "Adrian L", "initials": "AL"}, {"family": "Smith", "given": "Jacqueline A M", "initials": "JAM", "orcid": "0000-0001-5028-8725", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/780df57cc7854ef9bb5b9929311ea5e1.json"}}, {"family": "Rosen", "given": "Neal", "initials": "N", "orcid": "0000-0002-8307-654X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad3f0ef93f454fb1b541d0795dec3dd3.json"}}], "type": "published erratum", "published": "2021-11-00", "journal": {"title": "Nat. Chem. Biol.", "issn": "1552-4469", "volume": "17", "issue": "11", "pages": "1209", "issn-l": "1552-4450"}, "abstract": null, "doi": "10.1038/s41589-021-00905-4", "pmid": "34616097", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41589-021-00905-4"}], "notes": [], "created": "2026-08-20T09:00:32.002Z", "modified": "2026-08-20T09:00:32.106Z"}, {"entity": "publication", "iuid": "6a87d95b01e0464d95a2e9f7b41afbea", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6a87d95b01e0464d95a2e9f7b41afbea.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6a87d95b01e0464d95a2e9f7b41afbea"}}, "title": "Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.", "authors": [{"family": "Lee", "given": "Bianca J", "initials": "BJ"}, {"family": "Boyer", "given": "Jacob A", "initials": "JA"}, {"family": "Burnett", "given": "G Leslie", "initials": "GL", "orcid": "0000-0003-2514-9373", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/879e7c7ba2174b4b9ec20a77ee8fac49.json"}}, {"family": "Thottumkara", "given": "Arun P", "initials": "AP"}, {"family": "Tibrewal", "given": "Nidhi", "initials": "N"}, {"family": "Wilson", "given": "Stacy L", "initials": "SL"}, {"family": "Hsieh", "given": "Tientien", "initials": "T"}, {"family": "Marquez", "given": "Abby", "initials": "A"}, {"family": "Lorenzana", "given": "Edward G", "initials": "EG"}, {"family": "Evans", "given": "James W", "initials": "JW"}, {"family": "Hulea", "given": "Laura", "initials": "L", "orcid": "0000-0001-7585-7760", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35a90eec621f48ad838baf8d6f956b5f.json"}}, {"family": "Kiss", "given": "Gert", "initials": "G"}, {"family": "Liu", "given": "Hui", "initials": "H"}, {"family": "Lee", "given": "Dong", "initials": "D"}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "McLaughlan", "given": "Shannon", "initials": "S"}, {"family": "Topisirovic", "given": "Ivan", "initials": "I"}, {"family": "Wang", "given": "Zhengping", "initials": "Z"}, {"family": "Wang", "given": "Zhican", "initials": "Z"}, {"family": "Zhao", "given": "Yongyuan", "initials": "Y"}, {"family": "Wildes", "given": "David", "initials": "D"}, {"family": "Aggen", "given": "James B", "initials": "JB"}, {"family": "Singh", "given": "Mallika", "initials": "M"}, {"family": "Gill", "given": "Adrian L", "initials": "AL"}, {"family": "Smith", "given": "Jacqueline A M", "initials": "JAM", "orcid": "0000-0001-5028-8725", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/780df57cc7854ef9bb5b9929311ea5e1.json"}}, {"family": "Rosen", "given": "Neal", "initials": "N", "orcid": "0000-0002-8307-654X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad3f0ef93f454fb1b541d0795dec3dd3.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Nat. Chem. Biol.", "issn": "1552-4469", "volume": "17", "issue": "10", "pages": "1065-1074", "issn-l": "1552-4450"}, "abstract": "The clinical benefits of pan-mTOR active-site inhibitors are limited by toxicity and relief of feedback inhibition of receptor expression. To address these limitations, we designed a series of compounds that selectively inhibit mTORC1 and not mTORC2. These 'bi-steric inhibitors' comprise a rapamycin-like core moiety covalently linked to an mTOR active-site inhibitor. Structural modification of these components modulated their affinities for their binding sites on mTOR and the selectivity of the bi-steric compound. mTORC1-selective compounds potently inhibited 4EBP1 phosphorylation and caused regressions of breast cancer xenografts. Inhibition of 4EBP1 phosphorylation was sufficient to block cancer cell growth and was necessary for maximal antitumor activity. At mTORC1-selective doses, these compounds do not alter glucose tolerance, nor do they relieve AKT-dependent feedback inhibition of HER3. Thus, in preclinical models, selective inhibitors of mTORC1 potently inhibit tumor growth while causing less toxicity and receptor reactivation as compared to pan-mTOR inhibitors.", "doi": "10.1038/s41589-021-00813-7", "pmid": "34168367", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1730601"}, {"db": "pmc", "key": "PMC9249104"}, {"db": "pii", "key": "10.1038/s41589-021-00813-7"}], "notes": [], "created": "2026-08-20T09:00:28.357Z", "modified": "2026-08-20T09:00:28.543Z"}, {"entity": "publication", "iuid": "84c9632e840d48e6b0ce1f78032ce771", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/84c9632e840d48e6b0ce1f78032ce771.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/84c9632e840d48e6b0ce1f78032ce771"}}, "title": "Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.", "authors": [{"family": "Lee", "given": "Bianca J", "initials": "BJ"}, {"family": "Boyer", "given": "Jacob A", "initials": "JA"}, {"family": "Burnett", "given": "G Leslie", "initials": "GL", "orcid": "0000-0003-2514-9373", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/879e7c7ba2174b4b9ec20a77ee8fac49.json"}}, {"family": "Thottumkara", "given": "Arun P", "initials": "AP"}, {"family": "Tibrewal", "given": "Nidhi", "initials": "N"}, {"family": "Wilson", "given": "Stacy L", "initials": "SL"}, {"family": "Hsieh", "given": "Tientien", "initials": "T"}, {"family": "Marquez", "given": "Abby", "initials": "A"}, {"family": "Lorenzana", "given": "Edward G", "initials": "EG"}, {"family": "Evans", "given": "James W", "initials": "JW"}, {"family": "Hulea", "given": "Laura", "initials": "L", "orcid": "0000-0001-7585-7760", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35a90eec621f48ad838baf8d6f956b5f.json"}}, {"family": "Kiss", "given": "Gert", "initials": "G"}, {"family": "Liu", "given": "Hui", "initials": "H"}, {"family": "Lee", "given": "Dong", "initials": "D"}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "McLaughlan", "given": "Shannon", "initials": "S"}, {"family": "Topisirovic", "given": "Ivan", "initials": "I"}, {"family": "Wang", "given": "Zhengping", "initials": "Z"}, {"family": "Wang", "given": "Zhican", "initials": "Z"}, {"family": "Zhao", "given": "Yongyuan", "initials": "Y"}, {"family": "Wildes", "given": "David", "initials": "D"}, {"family": "Aggen", "given": "James B", "initials": "JB"}, {"family": "Singh", "given": "Mallika", "initials": "M"}, {"family": "Gill", "given": "Adrian L", "initials": "AL"}, {"family": "Smith", "given": "Jacqueline A M", "initials": "JAM", "orcid": "0000-0001-5028-8725", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/780df57cc7854ef9bb5b9929311ea5e1.json"}}, {"family": "Rosen", "given": "Neal", "initials": "N", "orcid": "0000-0002-8307-654X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad3f0ef93f454fb1b541d0795dec3dd3.json"}}], "type": "published erratum", "published": "2021-08-00", "journal": {"title": "Nat. Chem. Biol.", "issn": "1552-4469", "volume": "17", "issue": "8", "pages": "925", "issn-l": "1552-4450"}, "abstract": null, "doi": "10.1038/s41589-021-00843-1", "pmid": "34188221", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41589-021-00843-1"}], "notes": [], "created": "2026-08-20T09:00:30.233Z", "modified": "2026-08-20T09:00:30.325Z"}, {"entity": "publication", "iuid": "0562f7ae9ae74ce9be218b4602dcd4c7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0562f7ae9ae74ce9be218b4602dcd4c7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0562f7ae9ae74ce9be218b4602dcd4c7"}}, "title": "The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer.", "authors": [{"family": "Ghaddar", "given": "Nour", "initials": "N"}, {"family": "Wang", "given": "Shuo", "initials": "S"}, {"family": "Woodvine", "given": "Bethany", "initials": "B", "orcid": "0000-0001-8359-6476", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b06f2ec71304b0196962103c15aefe9.json"}}, {"family": "Krishnamoorthy", "given": "Jothilatha", "initials": "J"}, {"family": "van Hoef", "given": "Vincent", "initials": "V"}, {"family": "Darini", "given": "Cedric", "initials": "C"}, {"family": "Kazimierczak", "given": "Urszula", "initials": "U"}, {"family": "Ah-Son", "given": "Nicolas", "initials": "N"}, {"family": "Popper", "given": "Helmuth", "initials": "H", "orcid": "0000-0003-4970-1265", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c125771dd9d40b28c0ec1108a2efdb8.json"}}, {"family": "Johnson", "given": "Myriam", "initials": "M"}, {"family": "Officer", "given": "Leah", "initials": "L", "orcid": "0000-0002-3690-2386", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9244a991003b48c4a624ff9fc105c50c.json"}}, {"family": "Teod\u00f3sio", "given": "Ana", "initials": "A", "orcid": "0000-0002-1386-6730", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f87a35d99867490aaf8e1120130837a8.json"}}, {"family": "Broggini", "given": "Massimo", "initials": "M", "orcid": "0000-0002-8138-9358", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b1e8ef5869dd4419a5c540a3071e7217.json"}}, {"family": "Mann", "given": "Koren K", "initials": "KK"}, {"family": "Hatzoglou", "given": "Maria", "initials": "M", "orcid": "0000-0003-2037-1231", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3fbc5330f8c84c548a8472bb81cf77f3.json"}}, {"family": "Topisirovic", "given": "Ivan", "initials": "I", "orcid": "0000-0002-5510-9762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1bca1813f34c4864940ac6593044a9cc.json"}}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "Le Quesne", "given": "John", "initials": "J", "orcid": "0000-0003-3552-7446", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6bbfa845cda4379b505dbb0091edcf6.json"}}, {"family": "Koromilas", "given": "Antonis E", "initials": "AE", "orcid": "0000-0003-1972-0799", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7825afc7ac8942819083ce7c570b5508.json"}}], "type": "journal article", "published": "2021-07-30", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "4651", "issn-l": "2041-1723"}, "abstract": "The integrated stress response (ISR) is an essential stress-support pathway increasingly recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in lung adenocarcinoma (LUAD) development, the most common histological type of lung cancer and a leading cause of cancer death worldwide. Increased phosphorylation of the translation initiation factor eIF2 (p-eIF2\u03b1), the focal point of ISR, is related to invasiveness, increased growth, and poor outcome in 928 LUAD patients. Dissection of ISR mechanisms in KRAS-driven lung tumorigenesis in mice demonstrated that p-eIF2\u03b1 causes the translational repression of dual specificity phosphatase 6 (DUSP6), resulting in increased phosphorylation of the extracellular signal-regulated kinase (p-ERK). Treatments with ISR inhibitors, including a memory-enhancing drug with limited toxicity, provides a suitable therapeutic option for KRAS-driven lung cancer insofar as they substantially reduce tumor growth and prolong mouse survival. Our data provide a rationale for the implementation of ISR-based regimens in LUAD treatment.", "doi": "10.1038/s41467-021-24661-0", "pmid": "34330898", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8324901"}, {"db": "pii", "key": "10.1038/s41467-021-24661-0"}], "notes": [], "created": "2026-08-20T08:51:39.836Z", "modified": "2026-08-20T08:51:40.199Z"}, {"entity": "publication", "iuid": "4288addfa25a47f3884be39dc34c3e89", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4288addfa25a47f3884be39dc34c3e89.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4288addfa25a47f3884be39dc34c3e89"}}, "title": "Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR.", "authors": [{"family": "Kaspar", "given": "Sophie", "initials": "S", "orcid": "0000-0002-0844-6432", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0cdeeebe478446cd86b3ae0be238ac03.json"}}, {"family": "Oertlin", "given": "Christian", "initials": "C"}, {"family": "Szczepanowska", "given": "Karolina", "initials": "K", "orcid": "0000-0003-4689-2350", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4526c9fd1045408d99d9f081e4331d0d.json"}}, {"family": "Kukat", "given": "Alexandra", "initials": "A", "orcid": "0000-0002-8610-0189", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/99feea57ad6c43c5b243857e88977bc6.json"}}, {"family": "Senft", "given": "Katharina", "initials": "K", "orcid": "0000-0003-2294-6481", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b044634fdab9416eae21512d1d57a822.json"}}, {"family": "Lucas", "given": "Christina", "initials": "C", "orcid": "0000-0002-6575-3877", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b3ace6f7382f4d27bce2152f8a114ed9.json"}}, {"family": "Brodesser", "given": "Susanne", "initials": "S", "orcid": "0000-0001-5631-0663", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9bb2fb66786b410d8e61f0cda2c435e5.json"}}, {"family": "Hatzoglou", "given": "Maria", "initials": "M", "orcid": "0000-0003-2037-1231", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3fbc5330f8c84c548a8472bb81cf77f3.json"}}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "Topisirovic", "given": "Ivan", "initials": "I", "orcid": "0000-0002-5510-9762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1bca1813f34c4864940ac6593044a9cc.json"}}, {"family": "Trifunovic", "given": "Aleksandra", "initials": "A", "orcid": "0000-0002-5472-3517", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1bec355885e34065983da151480f5cfe.json"}}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "7", "issue": "22", "issn-l": "2375-2548"}, "abstract": "In response to disturbed mitochondrial gene expression and protein synthesis, an adaptive transcriptional response sharing a signature of the integrated stress response (ISR) is activated. We report an intricate interplay between three transcription factors regulating the mitochondrial stress response: CHOP, C/EBP\u03b2, and ATF4. We show that CHOP acts as a rheostat that attenuates prolonged ISR, prevents unfavorable metabolic alterations, and postpones the onset of mitochondrial cardiomyopathy. Upon mitochondrial dysfunction, CHOP interaction with C/EBP\u03b2 is needed to adjust ATF4 levels, thus preventing overactivation of the ATF4-regulated transcriptional program. Failure of this interaction switches ISR from an acute to a chronic state, leading to early respiratory chain deficiency, energy crisis, and premature death. Therefore, contrary to its previously proposed role as a transcriptional activator of mitochondrial unfolded protein response, our results highlight a role of CHOP in the fine-tuning of mitochondrial ISR in mammals.", "doi": "10.1126/sciadv.abf0971", "pmid": "34039602", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8153728"}, {"db": "pii", "key": "7/22/eabf0971"}], "notes": [], "created": "2026-08-20T11:58:37.274Z", "modified": "2026-08-20T11:58:37.736Z"}, {"entity": "publication", "iuid": "a6b7adee60494701a2f85944ffc7a263", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a6b7adee60494701a2f85944ffc7a263.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a6b7adee60494701a2f85944ffc7a263"}}, "title": "MNK2 governs the macrophage antiinflammatory phenotype.", "authors": [{"family": "Bartish", "given": "Margarita", "initials": "M"}, {"family": "Tong", "given": "Dongmei", "initials": "D", "orcid": "0000-0002-3468-5293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e94324e1bc364322a170ef2785b01280.json"}}, {"family": "Pan", "given": "Yangxun", "initials": "Y", "orcid": "0000-0002-3887-5852", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d127d52e0fbe4027962770f0a47ac877.json"}}, {"family": "Wallerius", "given": "Majken", "initials": "M"}, {"family": "Liu", "given": "Hui", "initials": "H"}, {"family": "Ristau", "given": "Johannes", "initials": "J"}, {"family": "de Souza Ferreira", "given": "Sabrina", "initials": "S", "orcid": "0000-0002-1779-8528", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/56a734d62fc64ec79d050b5406c54702.json"}}, {"family": "Wallmann", "given": "Tatjana", "initials": "T"}, {"family": "van Hoef", "given": "Vincent", "initials": "V"}, {"family": "Masvidal", "given": "Laia", "initials": "L"}, {"family": "Kerzel", "given": "Thomas", "initials": "T", "orcid": "0000-0003-0763-5319", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e87e0ced240453cb9b2ed61540c89b4.json"}}, {"family": "Joly", "given": "Anne-Laure", "initials": "AL", "orcid": "0000-0002-9686-5281", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9dea107c5a5b473aa743c82c2223dbe9.json"}}, {"family": "Goncalves", "given": "Christophe", "initials": "C"}, {"family": "Preston", "given": "Samuel E J", "initials": "SEJ", "orcid": "0000-0002-2618-8326", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c03256716e6469db55a93fd33699266.json"}}, {"family": "Ebrahimian", "given": "Talin", "initials": "T"}, {"family": "Seitz", "given": "Christina", "initials": "C"}, {"family": "Bergh", "given": "Jonas", "initials": "J"}, {"family": "Pietras", "given": "Kristian", "initials": "K", "orcid": "0000-0001-6738-4705", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c29a7ab65c34459a6ab014663c59f05.json"}}, {"family": "Lehoux", "given": "Stephanie", "initials": "S"}, {"family": "Naldini", "given": "Luigi", "initials": "L"}, {"family": "Andersson", "given": "John", "initials": "J", "orcid": "0000-0003-2799-6349", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b75b9a004fc40c794f17d23003ab4e3.json"}}, {"family": "Squadrito", "given": "Mario Leonardo", "initials": "ML", "orcid": "0000-0002-1188-0299", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3daffd8d76f94589b9bdc3b1fe0aa12e.json"}}, {"family": "Del Rinc\u00f3n", "given": "Sonia V", "initials": "SV"}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "Rolny", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2020-11-03", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "117", "issue": "44", "pages": "27556-27565", "issn-l": "0027-8424"}, "abstract": "Tumor-associated macrophages (TAMs) continuously fine tune their immune modulatory properties, but how gene expression programs coordinate this immune cell plasticity is largely unknown. Selective mRNA translation, controlled by MNK1/MNK2 and mTOR pathways impinging on eIF4E, facilitates reshaping of proteomes without changes in abundance of corresponding mRNAs. Using polysome profiling developed for small samples we show that, during tumor growth, gene expression in TAMs is predominately modulated via mRNA-selective changes in translational efficiencies. These alterations in gene expression paralleled accumulation of antiinflammatory macrophages with augmented phosphorylation of eIF4E, a target of the MNK1 and MNK2 kinases, known to selectively modulate mRNA translation. Furthermore, suppression of the MNK2, but not the mTOR signaling pathway, reprogrammed antiinflammatory macrophages toward a proinflammatory phenotype with the ability to activate CD8+ T cells. Thus, selective changes of mRNA translation depending on MNK2 signaling represents a key node regulating macrophage antiinflammatory functions.", "doi": "10.1073/pnas.1920377117", "pmid": "33077599", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7959504"}, {"db": "pii", "key": "1920377117"}], "notes": [], "created": "2026-08-20T09:30:33.446Z", "modified": "2026-08-20T09:30:33.781Z"}, {"entity": "publication", "iuid": "c66f785cbde64d5d88f885e51de31749", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c66f785cbde64d5d88f885e51de31749.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c66f785cbde64d5d88f885e51de31749"}}, "title": "Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis.", "authors": [{"family": "Kusnadi", "given": "Eric P", "initials": "EP", "orcid": "0000-0002-6278-1864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a31c75bec0c4455e81314ee47e6ef1b1.json"}}, {"family": "Trigos", "given": "Anna S", "initials": "AS", "orcid": "0000-0002-5915-2952", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/58d90dab87a74a1cadc2a00d809694ad.json"}}, {"family": "Cullinane", "given": "Carleen", "initials": "C", "orcid": "0000-0001-5833-6605", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d7d38594fb548af9dd3086397b08560.json"}}, {"family": "Goode", "given": "David L", "initials": "DL"}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "Devlin", "given": "Jennifer R", "initials": "JR"}, {"family": "Chan", "given": "Keefe T", "initials": "KT", "orcid": "0000-0001-6114-3724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1886b61e2ae7497abe58430800b93ad9.json"}}, {"family": "De Souza", "given": "David P", "initials": "DP"}, {"family": "McConville", "given": "Malcolm J", "initials": "MJ", "orcid": "0000-0002-7107-7887", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f024447096c4ae09f44a6d30d9fe6ef.json"}}, {"family": "McArthur", "given": "Grant A", "initials": "GA"}, {"family": "Thomas", "given": "George", "initials": "G", "orcid": "0000-0002-1236-1714", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/354fc3f88d1046d9a403061177206727.json"}}, {"family": "Sanij", "given": "Elaine", "initials": "E", "orcid": "0000-0002-2063-7813", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ec884e76bc046a8bed1537fefca1ea8.json"}}, {"family": "Poortinga", "given": "Gretchen", "initials": "G"}, {"family": "Hannan", "given": "Ross D", "initials": "RD"}, {"family": "Hannan", "given": "Katherine M", "initials": "KM"}, {"family": "Kang", "given": "Jian", "initials": "J", "orcid": "0000-0001-9998-4975", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c07f6507de94b6091a88f4c0e8b77b4.json"}}, {"family": "Pearson", "given": "Richard B", "initials": "RB", "orcid": "0000-0001-5919-5090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24b6c4683bc0449089a0b45567707143.json"}}], "type": "journal article", "published": "2020-11-02", "journal": {"title": "EMBO J.", "issn": "1460-2075", "volume": "39", "issue": "21", "pages": "e105111", "issn-l": "0261-4189"}, "abstract": "Elevated ribosome biogenesis in oncogene-driven cancers is commonly targeted by DNA-damaging cytotoxic drugs. Our previous first-in-human trial of CX-5461, a novel, less genotoxic agent that specifically inhibits ribosome biogenesis via suppression of RNA polymerase I (Pol I) transcription, revealed single-agent efficacy in refractory blood cancers. Despite this clinical response, patients were not cured. In parallel, we demonstrated a marked improvement in the in vivo efficacy of CX-5461 in combination with PI3K/AKT/mTORC1 pathway inhibitors. Here, we reveal the molecular basis for this improved efficacy observed in vivo, which is associated with specific suppression of translation of mRNAs encoding regulators of cellular metabolism. Importantly, acquired resistance to this cotreatment is driven by translational rewiring that results in dysregulated cellular metabolism and induction of a cAMP-dependent pathway critical for the survival of blood cancers including lymphoma and acute myeloid leukemia. Our studies thus identify key molecular mechanisms underpinning the response of blood cancers to selective inhibition of ribosome biogenesis and define metabolic vulnerabilities that will facilitate the rational design of more effective regimens for Pol I-directed therapies.", "doi": "10.15252/embj.2020105111", "pmid": "32945574", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7604608"}], "notes": [], "created": "2026-08-20T12:51:33.814Z", "modified": "2026-08-20T12:51:34.126Z"}, {"entity": "publication", "iuid": "53807bfb3ae44f8e891b9e6b4d8840e3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/53807bfb3ae44f8e891b9e6b4d8840e3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/53807bfb3ae44f8e891b9e6b4d8840e3"}}, "title": "RITA requires eIF2\u03b1-dependent modulation of mRNA translation for its anti-cancer activity.", "authors": [{"family": "Ristau", "given": "Johannes", "initials": "J"}, {"family": "van Hoef", "given": "Vincent", "initials": "V"}, {"family": "Peuget", "given": "Sylvain", "initials": "S", "orcid": "0000-0002-3315-1935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/511ecb3ab7d7478f87a1dfc6562a6f5e.json"}}, {"family": "Zhu", "given": "Jiawei", "initials": "J"}, {"family": "Guan", "given": "Bo-Jhih", "initials": "BJ"}, {"family": "Liang", "given": "Shuo", "initials": "S"}, {"family": "Hatzoglou", "given": "Maria", "initials": "M"}, {"family": "Topisirovic", "given": "Ivan", "initials": "I", "orcid": "0000-0002-5510-9762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1bca1813f34c4864940ac6593044a9cc.json"}}, {"family": "Selivanova", "given": "Galina", "initials": "G"}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}], "type": "journal article", "published": "2019-11-07", "journal": {"title": "Cell Death Dis", "issn": "2041-4889", "volume": "10", "issue": "11", "pages": "845", "issn-l": "2041-4889"}, "abstract": "Tumor protein 53 (p53, encoded by the TP53 gene) is a key tumor suppressor regulating cell fates in response to internal and external stresses. As TP53 is mutated or silenced in a majority of tumors, reactivation of p53 by small molecules represents a promising strategy in cancer therapeutics. One such agent is RITA (reactivation of p53 and induction of tumor cell apoptosis), which restores p53 expression in cells with hyperactive HDM2 and induces apoptosis. Yet, mechanisms underlying the anticancer activity of RITA are incompletely understood. Here we show that RITA suppresses mRNA translation independently of p53 by inducing eIF2\u03b1 phosphorylation. Surprisingly, reactivation of p53 following RITA treatment is critically dependent on eIF2\u03b1 phosphorylation. Moreover, inhibition of eIF2\u03b1 phosphorylation attenuates pro-apoptotic and anti-neoplastic effects of RITA, while inducing phosphorylation of eIF2\u03b1 enhances the anticancer activity of RITA. Collectively, these findings demonstrate that the translational machinery plays a major role in determining the antineoplastic activity of RITA, and suggest that combining p53 activators and translation modulators may be beneficial.", "doi": "10.1038/s41419-019-2074-3", "pmid": "31699971", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6838152"}, {"db": "pii", "key": "10.1038/s41419-019-2074-3"}], "notes": [], "created": "2026-08-20T08:49:30.605Z", "modified": "2026-08-20T08:49:30.788Z"}, {"entity": "publication", "iuid": "eb153ddfc3df449cb850a06015ac86db", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/eb153ddfc3df449cb850a06015ac86db.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/eb153ddfc3df449cb850a06015ac86db"}}, "title": "Distinct Cancer-Promoting Stromal Gene Expression Depending on Lung Function.", "authors": [{"family": "Sandri", "given": "Brian J", "initials": "BJ", "orcid": "0000-0003-4935-6502", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e340f89d83ca40f0a1ca78a6594ca1e2.json"}}, {"family": "Masvidal", "given": "Laia", "initials": "L"}, {"family": "Murie", "given": "Carl", "initials": "C"}, {"family": "Bartish", "given": "Margarita", "initials": "M"}, {"family": "Avdulov", "given": "Svetlana", "initials": "S"}, {"family": "Higgins", "given": "LeeAnn", "initials": "L"}, {"family": "Markowski", "given": "Todd", "initials": "T"}, {"family": "Peterson", "given": "Mark", "initials": "M"}, {"family": "Bergh", "given": "Jonas", "initials": "J"}, {"family": "Yang", "given": "Ping", "initials": "P"}, {"family": "Rolny", "given": "Charlotte", "initials": "C"}, {"family": "Limper", "given": "Andrew H", "initials": "AH"}, {"family": "Griffin", "given": "Timothy J", "initials": "TJ"}, {"family": "Bitterman", "given": "Peter B", "initials": "PB"}, {"family": "Wendt", "given": "Chris H", "initials": "CH", "orcid": "0000-0002-0924-8745", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b0954f45f624e13aef0b3a9d1a9d048.json"}}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}], "type": "journal article", "published": "2019-08-01", "journal": {"title": "Am. J. Respir. Crit. Care Med.", "issn": "1535-4970", "volume": "200", "issue": "3", "pages": "348-358", "issn-l": "1073-449X"}, "abstract": "Rationale: Chronic obstructive pulmonary disease is an independent risk factor for lung cancer, but the underlying molecular mechanisms are unknown. We hypothesized that lung stromal cells activate pathological gene expression programs that support oncogenesis.Objectives: To identify molecular mechanisms operating in the lung stroma that support the development of lung cancer.Methods: The study included subjects with and without lung cancer across a spectrum of lung-function values. We conducted a multiomics analysis of nonmalignant lung tissue to quantify the transcriptome, translatome, and proteome.Measurements and Main Results: Cancer-associated gene expression changes predominantly manifested as alterations in the efficiency of mRNA translation modulating protein levels in the absence of corresponding changes in mRNA levels. The molecular mechanisms that drove these cancer-associated translation programs differed based on lung function. In subjects with normal to mildly impaired lung function, the mammalian target of rapamycin (mTOR) pathway served as an upstream driver, whereas in subjects with severe airflow obstruction, pathways downstream of pathological extracellular matrix emerged. Consistent with a role during cancer initiation, both the mTOR and extracellular matrix gene expression programs paralleled the activation of previously identified procancer secretomes. Furthermore, an in situ examination of lung tissue showed that stromal fibroblasts expressed cancer-associated proteins from two procancer secretomes: one that included IL-6 (in cases of mild or no airflow obstruction), and one that included BMP1 (in cases of severe airflow obstruction).Conclusions: Two distinct stromal gene expression programs that promote cancer initiation are activated in patients with lung cancer depending on lung function. Our work has implications both for screening strategies and for personalized approaches to cancer treatment.", "doi": "10.1164/rccm.201801-0080OC", "pmid": "30742544", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6680296"}], "notes": [], "created": "2026-08-20T12:16:27.355Z", "modified": "2026-08-20T12:16:27.496Z"}, {"entity": "publication", "iuid": "6d1bb3e6bdf04887a099653d7f1e2bd1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6d1bb3e6bdf04887a099653d7f1e2bd1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6d1bb3e6bdf04887a099653d7f1e2bd1"}}, "title": "An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis.", "authors": [{"family": "Smith", "given": "Harvey W", "initials": "HW"}, {"family": "Hirukawa", "given": "Alison", "initials": "A"}, {"family": "Sanguin-Gendreau", "given": "Virginie", "initials": "V"}, {"family": "Nandi", "given": "Ipshita", "initials": "I"}, {"family": "Dufour", "given": "Catherine R", "initials": "CR"}, {"family": "Zuo", "given": "Dongmei", "initials": "D"}, {"family": "Tandoc", "given": "Kristofferson", "initials": "K"}, {"family": "Leibovitch", "given": "Matthew", "initials": "M"}, {"family": "Singh", "given": "Salendra", "initials": "S"}, {"family": "Rennhack", "given": "Jonathan P", "initials": "JP"}, {"family": "Swiatnicki", "given": "Matthew", "initials": "M"}, {"family": "Lavoie", "given": "Cynthia", "initials": "C"}, {"family": "Papavasiliou", "given": "Vasilios", "initials": "V"}, {"family": "Temps", "given": "Carolin", "initials": "C"}, {"family": "Carragher", "given": "Neil O", "initials": "NO"}, {"family": "Unciti-Broceta", "given": "Asier", "initials": "A", "orcid": "0000-0003-1029-2855", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d3c9f3d1ab5a46668c5c43091b065395.json"}}, {"family": "Savage", "given": "Paul", "initials": "P", "orcid": "0000-0003-2881-6717", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a1d2227759734a1e84d16928f4c5c468.json"}}, {"family": "Basik", "given": "Mark", "initials": "M"}, {"family": "van Hoef", "given": "Vincent", "initials": "V"}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "Cooper", "given": "Caroline L", "initials": "CL"}, {"family": "Vargas Calderon", "given": "Ana Cristina", "initials": "AC"}, {"family": "Beith", "given": "Jane", "initials": "J"}, {"family": "Millar", "given": "Ewan", "initials": "E"}, {"family": "Selinger", "given": "Christina", "initials": "C"}, {"family": "Gigu\u00e8re", "given": "Vincent", "initials": "V", "orcid": "0000-0001-9567-3694", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71ce97337546454fb49554814f160dc5.json"}}, {"family": "Park", "given": "Morag", "initials": "M"}, {"family": "Harris", "given": "Lyndsay N", "initials": "LN"}, {"family": "Varadan", "given": "Vinay", "initials": "V"}, {"family": "Andrechek", "given": "Eran R", "initials": "ER"}, {"family": "O'Toole", "given": "Sandra A", "initials": "SA"}, {"family": "Topisirovic", "given": "Ivan", "initials": "I", "orcid": "0000-0002-5510-9762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1bca1813f34c4864940ac6593044a9cc.json"}}, {"family": "Muller", "given": "William J", "initials": "WJ"}], "type": "journal article", "published": "2019-07-01", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "10", "issue": "1", "pages": "2901", "issn-l": "2041-1723"}, "abstract": "Dysregulation of histone modifications promotes carcinogenesis by altering transcription. Breast cancers frequently overexpress the histone methyltransferase EZH2, the catalytic subunit of Polycomb Repressor Complex 2 (PRC2). However, the role of EZH2 in this setting is unclear due to the context-dependent functions of PRC2 and the heterogeneity of breast cancer. Moreover, the mechanisms underlying PRC2 overexpression in cancer are obscure. Here, using multiple models of breast cancer driven by the oncogene ErbB2, we show that the tyrosine kinase c-Src links energy sufficiency with PRC2 overexpression via control of mRNA translation. By stimulating mitochondrial ATP production, c-Src suppresses energy stress, permitting sustained activation of the mammalian/mechanistic target of rapamycin complex 1 (mTORC1), which increases the translation of mRNAs encoding the PRC2 subunits Ezh2 and Suz12. We show that Ezh2 overexpression and activity are pivotal in ErbB2-mediated mammary tumourigenesis. These results reveal the hitherto unknown c-Src/mTORC1/PRC2 axis, which is essential for ErbB2-driven carcinogenesis.", "doi": "10.1038/s41467-019-10681-4", "pmid": "31263101", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6603039"}, {"db": "pii", "key": "10.1038/s41467-019-10681-4"}], "notes": [], "created": "2026-08-20T08:50:40.813Z", "modified": "2026-08-20T08:50:40.987Z"}]}