{"entity": "researcher", "timestamp": "2026-08-20T21:11:42.182Z", "family": "Sundgren", "given": "Pia C", "initials": "PC", "orcid": "0000-0001-9237-1236", "affiliations": ["Division of Diagnostic Radiology, Department of Clinical Sciences, Lund, Lund University, Lund 221 00, Sweden.", "Lund Bioimaging Centre, Lund University, Lund 221 00, Sweden.", "Department of Medical Imaging and Function, Sk\u00e5ne University Hospital, Lund 221 85, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e580179d7d74958a5c1d509e581ddcc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e580179d7d74958a5c1d509e581ddcc"}}, "publications": [{"entity": "publication", "iuid": "b48ded17901f445fb5121eb3348ab401", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b48ded17901f445fb5121eb3348ab401.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b48ded17901f445fb5121eb3348ab401"}}, "title": "Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted.", "authors": [{"family": "Governa", "given": "Valeria", "initials": "V", "orcid": "0000-0001-9999-0590", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38fa13ff35d2468e9a61eec381c1f91f.json"}}, {"family": "de Oliveira", "given": "Kelin Gon\u00e7alves", "initials": "KG", "orcid": "0000-0003-1646-5657", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f774f99247314765b97114edc82199f1.json"}}, {"family": "B\u00e5ng-Rudenstam", "given": "Anna", "initials": "A", "orcid": "0000-0003-2706-9502", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3fea3b51f73f4175b859cde49e99e5e7.json"}}, {"family": "Offer", "given": "Svenja", "initials": "S", "orcid": "0009-0005-1159-4769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cae1ab36ab44c918c0eaa3fcc21c68b.json"}}, {"family": "Cerezo-Maga\u00f1a", "given": "Myriam", "initials": "M", "orcid": "0000-0001-9752-8917", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c8019362baf45b394e839c00f7ac1d5.json"}}, {"family": "Li", "given": "Jiaxin", "initials": "J", "orcid": "0000-0002-5401-6855", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf6133b6e1c1438db5a2cafb42eae2fb.json"}}, {"family": "Beyer", "given": "Sarah", "initials": "S", "orcid": "0000-0001-8021-9624", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7460c1560454e29805fae14da7f99e2.json"}}, {"family": "Johansson", "given": "Maria C", "initials": "MC", "orcid": "0000-0003-0075-3187", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ce5f12cf2e24399b8b1a2f90a647e6e.json"}}, {"family": "M\u00e5nsson", "given": "Ann-Sofie", "initials": "AS", "orcid": "0000-0002-5984-3470", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9b3c8e6d27ad4029be4738d5816e0234.json"}}, {"family": "Edvardsson", "given": "Charlotte", "initials": "C", "orcid": "0009-0001-2046-7826", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/66126ee2a8bb40e2b20b131bacda396a.json"}}, {"family": "Durmo", "given": "Faris", "initials": "F", "orcid": "0000-0001-7364-5991", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/848a1ef86fe3467cad9437801dbd66f0.json"}}, {"family": "Gustafsson", "given": "Emma", "initials": "E", "orcid": "0009-0007-7005-912X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7d13e2b988714edc8b43efde369feec5.json"}}, {"family": "Boukredine", "given": "Axel", "initials": "A", "orcid": "0009-0006-3714-6769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a59ab55aa0794efc870cdec487e9dbde.json"}}, {"family": "Jeannot", "given": "Pauline", "initials": "P", "orcid": "0000-0003-0158-440X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/167869db86f0456fbb7a535ae8d89b35.json"}}, {"family": "Schmidt", "given": "Katja", "initials": "K", "orcid": "0000-0002-0973-6933", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/64466e9e703d46c985f6705573168bd0.json"}}, {"family": "Gezelius", "given": "Emelie", "initials": "E", "orcid": "0000-0002-7349-8108", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b141ce31bda40039dd006c2bfa8f661.json"}}, {"family": "Menard", "given": "Julien A", "initials": "JA", "orcid": "0009-0007-4652-399X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b32e557ab6fa450e9d0b4173b2a7b6a1.json"}}, {"family": "Garza", "given": "Raquel", "initials": "R", "orcid": "0000-0002-2524-3055", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dad049ba2c40499ba3587f6cc5d6a706.json"}}, {"family": "Jakobsson", "given": "Johan", "initials": "J", "orcid": "0000-0003-0669-7673", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1387f53f92df4c5f9c1fc91dd5230fba.json"}}, {"family": "de Neergaard", "given": "Therese", "initials": "T", "orcid": "0000-0002-6969-0375", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24f61a7c404b495bbb184a3af049a921.json"}}, {"family": "Sundgren", "given": "Pia C", "initials": "PC", "orcid": "0000-0001-9237-1236", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e580179d7d74958a5c1d509e581ddcc.json"}}, {"family": "Tiihonen", "given": "Aliisa M", "initials": "AM", "orcid": "0000-0003-3703-9673", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02077b27162c411388742c9094e1d165.json"}}, {"family": "Haapasalo", "given": "Hannu", "initials": "H"}, {"family": "Rautajoki", "given": "Kirsi J", "initials": "KJ", "orcid": "0000-0001-6549-7810", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ac12df0ec93441f90dcad31fe170143.json"}}, {"family": "Nordenfelt", "given": "Pontus", "initials": "P", "orcid": "0000-0002-9481-9951", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81dea1d4ace2429f8082a127bc93c691.json"}}, {"family": "Darabi", "given": "Anna", "initials": "A", "orcid": "0000-0003-4326-8149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb9f19a0c8694ee79ca515a79976d146.json"}}, {"family": "Forsberg-Nilsson", "given": "Karin", "initials": "K", "orcid": "0000-0003-0692-6245", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6636b7d9d0e24ac2a15ccd0e9f631ed1.json"}}, {"family": "Pietras", "given": "Alexander", "initials": "A", "orcid": "0000-0002-5783-9347", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9d48aa66cee48b9828c0ac374c75362.json"}}, {"family": "Talbot", "given": "Hugo", "initials": "H", "orcid": "0000-0001-9774-8573", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/28e1c9cf68e6408dbcf4ac2c031fb468.json"}}, {"family": "Bengzon", "given": "Johan", "initials": "J"}, {"family": "Belting", "given": "Mattias", "initials": "M", "orcid": "0000-0003-1585-5434", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9763a47486d410fb5034fb2603f3a02.json"}}], "type": "journal article", "published": "2024-10-30", "journal": {"title": "Sci Transl Med", "issn": "1946-6242", "volume": "16", "issue": "771", "pages": "eadk1168", "issn-l": "1946-6234"}, "abstract": "Glioblastoma presents a formidable clinical challenge because of its complex microenvironment. Here, we characterized tumor-associated foam cells (TAFs), a type of lipid droplet-loaded macrophage, in human glioblastoma. Through extensive analyses of patient tumors, together with in vitro and in vivo investigations, we found that TAFs exhibit distinct protumorigenic characteristics related to hypoxia, mesenchymal transition, angiogenesis, and impaired phagocytosis, and their presence correlates with worse outcomes for patients with glioma. We further demonstrated that TAF formation is facilitated by lipid scavenging from extracellular vesicles released by glioblastoma cells. We found that targeting key enzymes involved in lipid droplet formation, such as diacylglycerol O-acyltransferase or long-chain acyl-CoA synthetase, effectively disrupted TAF functionality. Together, these data highlight TAFs as a prominent immune cell population in glioblastoma and provide insights into their contribution to the tumor microenvironment. Disrupting lipid droplet formation to target TAFs may represent an avenue for future therapeutic development for glioblastoma.", "doi": "10.1126/scitranslmed.adk1168", "pmid": "39475570", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:59:55.851Z", "modified": "2026-08-20T11:59:56.532Z"}, {"entity": "publication", "iuid": "e4c03509339a4a7487c366bc3827bc47", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e4c03509339a4a7487c366bc3827bc47.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e4c03509339a4a7487c366bc3827bc47"}}, "title": "Ultrasensitive Immunoprofiling of Plasma Extracellular Vesicles Identifies Syndecan-1 as a Potential Tool for Minimally Invasive Diagnosis of Glioma.", "authors": [{"family": "Indira Chandran", "given": "Vineesh", "initials": "V"}, {"family": "Welinder", "given": "Charlotte", "initials": "C", "orcid": "0000-0001-9626-0576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5715a70ce8df4a5d84ad88709791772a.json"}}, {"family": "M\u00e5nsson", "given": "Ann-Sofie", "initials": "AS"}, {"family": "Offer", "given": "Svenja", "initials": "S"}, {"family": "Freyhult", "given": "Eva", "initials": "E", "orcid": "0000-0003-0226-1047", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13486bb11790445fa37f592a42e6a7ed.json"}}, {"family": "Pernemalm", "given": "Maria", "initials": "M", "orcid": "0000-0003-4624-031X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c34e0806a3d142019ae8e16de8d720ef.json"}}, {"family": "Lund", "given": "Sigrid M", "initials": "SM"}, {"family": "Pedersen", "given": "Shona", "initials": "S", "orcid": "0000-0001-6636-0293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/daa11d544a2545b0aa2a7ec6083fc079.json"}}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J"}, {"family": "Marko-Varga", "given": "Gyorgy", "initials": "G"}, {"family": "Johansson", "given": "Maria C", "initials": "MC"}, {"family": "Englund", "given": "Elisabet", "initials": "E", "orcid": "0000-0002-2708-2443", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d415783747141269a6d9a843afc861d.json"}}, {"family": "Sundgren", "given": "Pia C", "initials": "PC", "orcid": "0000-0001-9237-1236", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e580179d7d74958a5c1d509e581ddcc.json"}}, {"family": "Belting", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2019-05-15", "journal": {"title": "Clin. Cancer Res.", "issn": "1557-3265", "volume": "25", "issue": "10", "pages": "3115-3127", "issn-l": "1078-0432"}, "abstract": "Liquid biopsy has great potential to improve the management of brain tumor patients at high risk of surgery-associated complications. Here, the aim was to explore plasma extracellular vesicle (plEV) immunoprofiling as a tool for noninvasive diagnosis of glioma.\n\nPlEV isolation and analysis were optimized using advanced mass spectrometry, nanoparticle tracking analysis, and electron microscopy. We then established a new procedure that combines size exclusion chromatography isolation and proximity extension assay-based ultrasensitive immunoprofiling of plEV proteins that was applied on a well-defined glioma study cohort (n = 82).\n\nAmong potential candidates, we for the first time identify syndecan-1 (SDC1) as a plEV constituent that can discriminate between high-grade glioblastoma multiforme (GBM, WHO grade IV) and low-grade glioma [LGG, WHO grade II; area under the ROC curve (AUC): 0.81; sensitivity: 71%; specificity: 91%]. These findings were independently validated by ELISA. Tumor SDC1 mRNA expression similarly discriminated between GBM and LGG in an independent glioma patient population from The Cancer Genome Atlas cohort (AUC: 0.91; sensitivity: 79%; specificity: 91%). In experimental studies with GBM cells, we show that SDC1 is efficiently sorted to secreted EVs. Importantly, we found strong support of plEVSDC1 originating from GBM tumors, as plEVSDC1 correlated with SDC1 protein expression in matched patient tumors, and plEVSDC1 was decreased postoperatively depending on the extent of surgery.\n\nOur studies support the concept of circulating plEVs as a tool for noninvasive diagnosis and monitoring of gliomas and should move this field closer to the goal of improving the management of cancer patients.", "doi": "10.1158/1078-0432.CCR-18-2946", "pmid": "30679164", "labels": [], "xrefs": [{"db": "pii", "key": "1078-0432.CCR-18-2946"}], "notes": [], "created": "2026-08-20T12:12:08.365Z", "modified": "2026-08-20T12:12:08.608Z"}]}