{"entity": "researcher", "timestamp": "2026-09-25T23:01:33.023Z", "family": "B\u00fclow Anderberg", "given": "Sara", "initials": "S", "orcid": "0000-0002-8769-7036", "affiliations": ["Department of Surgical Sciences, Anesthesiology and Intensive Care, Uppsala University, 751 85, Uppsala, Sweden. sara.bulow@uu.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d751fe8045c4af89cd1a0b9db40c7aa.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d751fe8045c4af89cd1a0b9db40c7aa"}}, "publications": [{"entity": "publication", "iuid": "81cd876c1fbf44e8bf3fcaeb7e858815", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/81cd876c1fbf44e8bf3fcaeb7e858815.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/81cd876c1fbf44e8bf3fcaeb7e858815"}}, "title": "Association of corticosteroid therapy with reduced acute kidney injury and lower NET markers in severe COVID-19: an observational study.", "authors": [{"family": "B\u00fclow Anderberg", "given": "Sara", "initials": "S", "orcid": "0000-0002-8769-7036", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d751fe8045c4af89cd1a0b9db40c7aa.json"}}, {"family": "Huckriede", "given": "Joram", "initials": "J"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "de Vries", "given": "Femke", "initials": "F"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Nicolaes", "given": "Gerry A F", "initials": "GAF"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2024-09-28", "journal": {"title": "Intensive Care Med Exp", "issn": "2197-425X", "volume": "12", "issue": "1", "pages": "85", "issn-l": null}, "abstract": "Acute kidney injury (AKI) is common in critical cases of coronavirus disease 2019 (COVID-19) and associated with worse outcome. Dysregulated neutrophil extracellular trap (NET) formation is one of several suggested pathophysiological mechanisms involved in the development of COVID-19 associated AKI. The corticosteroid dexamethasone was implemented as a standard treatment for severe COVID-19 as of June 2020. A sub-analysis of a prospective observational single center study was performed to evaluate the effect of corticosteroid treatment on AKI development and NET markers in critical cases of COVID-19.\n\nTwo hundred and ten adult patients admitted to intensive care at a tertiary level hospital due to respiratory failure or shock secondary to SARS-CoV-2-infection between March 13th 2020 and January 14th 2021 were included in the study. Ninety-seven of those did not receive corticosteroids. One hundred and thirteen patients were treated with corticosteroids [dexamethasone (n = 98) or equivalent treatment (n = 15)], but the incidence of AKI was assessed only in patients that received corticosteroids before any registered renal dysfunction (n = 63). Corticosteroids were associated with a lower incidence of AKI (19% vs 55.8%, p < 0.001). Fewer patients demonstrated detectable concentrations of extracellular histones in plasma when treated with corticosteroids (8.7% vs 43.1%; p < 0.001). Extracellular histones and in particular non-proteolyzed histones were observed more frequently with increasing AKI severity (p < 0.001). MPO-DNA was found in lower concentrations in patients that received corticosteroids before established renal dysfunction (p = 0.03) and was found in higher concentrations in patients with AKI stage 3 (p = 0.03). Corticosteroids did not ameliorate established AKI during the first week of treatment.\n\nCorticosteroid treatment in severe COVID-19 is associated with a lower incidence of AKI and reduced concentrations of NET markers in plasma.", "doi": "10.1186/s40635-024-00670-3", "pmid": "39340756", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11438749"}, {"db": "pii", "key": "10.1186/s40635-024-00670-3"}], "notes": [], "created": "2026-09-23T13:01:45.888Z", "modified": "2026-09-23T13:01:45.956Z"}]}