{"entity": "researcher", "timestamp": "2026-09-23T23:53:26.389Z", "family": "Backlund", "given": "Maria", "initials": "M", "orcid": "0000-0002-6253-816X", "affiliations": ["Department of Pharmacy, Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Uppsala University, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/3cbe928d448a4669908f38d58bbe5606.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/3cbe928d448a4669908f38d58bbe5606"}}, "publications": [{"entity": "publication", "iuid": "be2ceb3b1c964e8f8848075df52aa2eb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/be2ceb3b1c964e8f8848075df52aa2eb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/be2ceb3b1c964e8f8848075df52aa2eb"}}, "title": "Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.", "authors": [{"family": "Huseby", "given": "Douglas L", "initials": "DL", "orcid": "0000-0001-9974-578X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a46951ada9ef48b081abd9a244d45cc1.json"}}, {"family": "Cao", "given": "Sha", "initials": "S"}, {"family": "Zamaratski", "given": "Edouard", "initials": "E", "orcid": "0009-0003-2707-3648", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8fa8570c2f0748b4b7258afa6da4702e.json"}}, {"family": "Sooriyaarachchi", "given": "Sanjeewani", "initials": "S"}, {"family": "Ahmad", "given": "Shabbir", "initials": "S", "orcid": "0000-0003-2374-1197", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9a9fa8ea9eb43fa9642ff3da5618267.json"}}, {"family": "Bergfors", "given": "Terese", "initials": "T", "orcid": "0000-0002-6463-9116", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e78b0675662e47bab61d190df5cb2203.json"}}, {"family": "Krasnova", "given": "Laura", "initials": "L"}, {"family": "Pelss", "given": "Juris", "initials": "J"}, {"family": "Ikaunieks", "given": "Martins", "initials": "M"}, {"family": "Loza", "given": "Einars", "initials": "E"}, {"family": "Katkevics", "given": "Martins", "initials": "M", "orcid": "0000-0003-1547-0075", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac9168c241174ebfad578a075c78ae4a.json"}}, {"family": "Bobileva", "given": "Olga", "initials": "O", "orcid": "0000-0001-9600-1603", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22e7bc2a9a0b47d19241789339a361bf.json"}}, {"family": "Cirule", "given": "Helena", "initials": "H"}, {"family": "Gukalova", "given": "Baiba", "initials": "B", "orcid": "0000-0002-7057-4726", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b5941a1c14d74cfe92b33c496e4ce5bc.json"}}, {"family": "Grinberga", "given": "Solveiga", "initials": "S"}, {"family": "Backlund", "given": "Maria", "initials": "M", "orcid": "0000-0002-6253-816X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3cbe928d448a4669908f38d58bbe5606.json"}}, {"family": "Simoff", "given": "Ivailo", "initials": "I"}, {"family": "Leber", "given": "Anna T", "initials": "AT"}, {"family": "Berruga-Fern\u00e1ndez", "given": "Tal\u00eda", "initials": "T"}, {"family": "Antonov", "given": "Dmitry", "initials": "D"}, {"family": "Konda", "given": "Vivekananda R", "initials": "VR"}, {"family": "Lindstr\u00f6m", "given": "Stefan", "initials": "S", "orcid": "0009-0009-7396-9529", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/63b366b7f46948b8ba5648412eab63a1.json"}}, {"family": "Olanders", "given": "Gustav", "initials": "G", "orcid": "0000-0003-4713-8368", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67abdf5c2573420a89754f75647c04c9.json"}}, {"family": "Brandt", "given": "Peter", "initials": "P"}, {"family": "Baranczewski", "given": "Pawel", "initials": "P", "orcid": "0000-0001-5772-6791", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/327feae3833d425c9d5936f48627390c.json"}}, {"family": "Vingsbo Lundberg", "given": "Carina", "initials": "C", "orcid": "0000-0003-3408-3353", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eaa8939eb68b4d4a818ce784e6c7aaa0.json"}}, {"family": "Liepinsh", "given": "Edgars", "initials": "E", "orcid": "0000-0003-2213-8337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e6a02475a5a423bbc75a9b3de350e2b.json"}}, {"family": "Suna", "given": "Edgars", "initials": "E"}, {"family": "Jones", "given": "T Alwyn", "initials": "TA"}, {"family": "Mowbray", "given": "Sherry L", "initials": "SL", "orcid": "0000-0002-0732-6367", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/93f59b3d476e43f1bdf90e120e92e165.json"}}, {"family": "Hughes", "given": "Diarmaid", "initials": "D", "orcid": "0000-0002-7456-9182", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3977477b57784a1bb16dece0d61c5896.json"}}, {"family": "Karl\u00e9n", "given": "Anders", "initials": "A", "orcid": "0000-0001-9512-6981", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/032040a93855408fb5955bb3e8893431.json"}}], "type": "journal article", "published": "2024-04-09", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "121", "issue": "15", "pages": "e2317274121", "issn-l": "0027-8424"}, "abstract": "Here, we describe the identification of an antibiotic class acting via LpxH, a clinically unexploited target in lipopolysaccharide synthesis. The lipopolysaccharide synthesis pathway is essential in most Gram-negative bacteria and there is no analogous pathway in humans. Based on a series of phenotypic screens, we identified a hit targeting this pathway that had activity on efflux-defective strains of Escherichia coli. We recognized common structural elements between this hit and a previously published inhibitor, also with activity against efflux-deficient bacteria. With the help of X-ray structures, this information was used to design inhibitors with activity on efflux-proficient, wild-type strains. Optimization of properties such as solubility, metabolic stability and serum protein binding resulted in compounds having potent in vivo efficacy against bloodstream infections caused by the critical Gram-negative pathogens E. coli and Klebsiella pneumoniae. Other favorable properties of the series include a lack of pre-existing resistance in clinical isolates, and no loss of activity against strains expressing extended-spectrum-\u03b2-lactamase, metallo-\u03b2-lactamase, or carbapenemase-resistance genes. Further development of this class of antibiotics could make an important contribution to the ongoing struggle against antibiotic resistance.", "doi": "10.1073/pnas.2317274121", "pmid": "38579010", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11009625"}], "notes": [], "created": "2026-09-23T10:10:26.224Z", "modified": "2026-09-23T10:48:44.118Z"}, {"entity": "publication", "iuid": "befabca596b1481dbe2d78880a6a8fe1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/befabca596b1481dbe2d78880a6a8fe1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/befabca596b1481dbe2d78880a6a8fe1"}}, "title": "Imitation of \u03b2-lactam binding enables broad-spectrum metallo-\u03b2-lactamase inhibitors.", "authors": [{"family": "Brem", "given": "J\u00fcrgen", "initials": "J", "orcid": "0000-0002-0137-3226", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b999d433d25c4720877f5b6a9a91d6ee.json"}}, {"family": "Panduwawala", "given": "Tharindi", "initials": "T", "orcid": "0000-0001-7095-1336", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/19e7bca8e327404b9fede660f3887c19.json"}}, {"family": "Hansen", "given": "Jon Ulf", "initials": "JU"}, {"family": "Hewitt", "given": "Joanne", "initials": "J"}, {"family": "Liepins", "given": "Edgars", "initials": "E"}, {"family": "Donets", "given": "Pawel", "initials": "P", "orcid": "0000-0003-4358-2429", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9b79f40c68134baf941624313b33bb35.json"}}, {"family": "Espina", "given": "Laura", "initials": "L"}, {"family": "Farley", "given": "Alistair J M", "initials": "AJM"}, {"family": "Shubin", "given": "Kirill", "initials": "K"}, {"family": "Campillos", "given": "Gonzalo Gomez", "initials": "GG", "orcid": "0000-0002-2405-8421", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b975cef9da544136b4c0e78b716ac3ba.json"}}, {"family": "Kiuru", "given": "Paula", "initials": "P", "orcid": "0000-0001-6084-684X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ca0466ffae54f3388ab7c5780be8c02.json"}}, {"family": "Shishodia", "given": "Shifali", "initials": "S", "orcid": "0000-0001-8727-3877", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e3d81da9fe1449ebbad8beef44e65367.json"}}, {"family": "Krahn", "given": "Daniel", "initials": "D"}, {"family": "Le\u015bniak", "given": "Robert K", "initials": "RK"}, {"family": "Schmidt Adrian", "given": "Juliane", "initials": "J"}, {"family": "Calvopi\u00f1a", "given": "Karina", "initials": "K"}, {"family": "Turrientes", "given": "Mar\u00eda-Carmen", "initials": "MC"}, {"family": "Kavanagh", "given": "Madeline E", "initials": "ME", "orcid": "0000-0002-4735-1559", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0cfdec1007f9467fac2227584ef529dc.json"}}, {"family": "Lubriks", "given": "Dmitrijs", "initials": "D", "orcid": "0000-0002-8014-4172", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77c4808356df4321a5358fbb65ca90c4.json"}}, {"family": "Hinchliffe", "given": "Philip", "initials": "P"}, {"family": "Langley", "given": "Gareth W", "initials": "GW", "orcid": "0000-0003-0875-3712", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d09b8ac98f194880a53f88776d22e856.json"}}, {"family": "Aboklaish", "given": "Ali F", "initials": "AF"}, {"family": "Eneroth", "given": "Anders", "initials": "A"}, {"family": "Backlund", "given": "Maria", "initials": "M", "orcid": "0000-0002-6253-816X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3cbe928d448a4669908f38d58bbe5606.json"}}, {"family": "Baran", "given": "Andrei G", "initials": "AG"}, {"family": "Nielsen", "given": "Elisabet I", "initials": "EI", "orcid": "0000-0003-0725-214X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/106402da1d3b4205a886a629c9e2d82a.json"}}, {"family": "Speake", "given": "Michael", "initials": "M"}, {"family": "Kuka", "given": "Janis", "initials": "J"}, {"family": "Robinson", "given": "John", "initials": "J"}, {"family": "Grinberga", "given": "Solveiga", "initials": "S"}, {"family": "Robinson", "given": "Lindsay", "initials": "L"}, {"family": "McDonough", "given": "Michael A", "initials": "MA", "orcid": "0000-0003-4664-6942", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81f4c2f384e64f0d9a4e5976e0e5553a.json"}}, {"family": "Rydzik", "given": "Anna M", "initials": "AM"}, {"family": "Leissing", "given": "Thomas M", "initials": "TM"}, {"family": "Jimenez-Castellanos", "given": "Juan Carlos", "initials": "JC"}, {"family": "Avison", "given": "Matthew B", "initials": "MB"}, {"family": "Da Silva Pinto", "given": "Solange", "initials": "S"}, {"family": "Pannifer", "given": "Andrew D", "initials": "AD"}, {"family": "Martjuga", "given": "Marina", "initials": "M"}, {"family": "Widlake", "given": "Emma", "initials": "E", "orcid": "0000-0001-6721-8643", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a61229a08c5746fb9a0902411b2b2787.json"}}, {"family": "Priede", "given": "Martins", "initials": "M", "orcid": "0000-0002-9655-8345", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9d2f10a7152a4df1abe227a01fa89b93.json"}}, {"family": "Hopkins Navratilova", "given": "Iva", "initials": "I"}, {"family": "Gniadkowski", "given": "Marek", "initials": "M"}, {"family": "Belfrage", "given": "Anna Karin", "initials": "AK", "orcid": "0000-0002-6257-4064", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/55584bbd88db452a98b975e94f7d47a7.json"}}, {"family": "Brandt", "given": "Peter", "initials": "P", "orcid": "0000-0002-2885-2016", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/69fda8874d1a44e6887492c17e4dea2a.json"}}, {"family": "Yli-Kauhaluoma", "given": "Jari", "initials": "J", "orcid": "0000-0003-0370-7653", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e37f790969e4af498de2b8260f23322.json"}}, {"family": "Bacque", "given": "Eric", "initials": "E"}, {"family": "Page", "given": "Malcolm G P", "initials": "MGP", "orcid": "0000-0002-0276-8174", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7c6f7d35b53549649f44044d1605f005.json"}}, {"family": "Bj\u00f6rkling", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-7018-8334", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc52b0b5aa594829b7e01787d7e56d09.json"}}, {"family": "Tyrrell", "given": "Jonathan M", "initials": "JM"}, {"family": "Spencer", "given": "James", "initials": "J", "orcid": "0000-0002-4602-0571", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c15f4b51f91e4a97b4e5f5385947c437.json"}}, {"family": "Lang", "given": "Pauline A", "initials": "PA", "orcid": "0000-0003-3187-1469", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/28abfcb6da9b459d8a16e60ddba63f7d.json"}}, {"family": "Baranczewski", "given": "Pawel", "initials": "P", "orcid": "0000-0001-5772-6791", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/327feae3833d425c9d5936f48627390c.json"}}, {"family": "Cant\u00f3n", "given": "Rafael", "initials": "R", "orcid": "0000-0003-1675-3173", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/43de3f7302444428a5c4104eb81c42e3.json"}}, {"family": "McElroy", "given": "Stuart P", "initials": "SP"}, {"family": "Jones", "given": "Philip S", "initials": "PS"}, {"family": "Baquero", "given": "Fernando", "initials": "F"}, {"family": "Suna", "given": "Edgars", "initials": "E", "orcid": "0000-0002-3078-0576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/91beaefa8b2846709b4fd35d147f1e25.json"}}, {"family": "Morrison", "given": "Angus", "initials": "A"}, {"family": "Walsh", "given": "Timothy R", "initials": "TR"}, {"family": "Schofield", "given": "Christopher J", "initials": "CJ", "orcid": "0000-0002-0290-6565", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/78f0ed7fbda741e29e0d2dde3e946d06.json"}}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Nat Chem", "issn": "1755-4349", "volume": "14", "issue": "1", "pages": "15-24", "issn-l": null}, "abstract": "Carbapenems are vital antibiotics, but their efficacy is increasingly compromised by metallo-\u03b2-lactamases (MBLs). Here we report the discovery and optimization of potent broad-spectrum MBL inhibitors. A high-throughput screen for NDM-1 inhibitors identified indole-2-carboxylates (InCs) as potential \u03b2-lactamase stable \u03b2-lactam mimics. Subsequent structure-activity relationship studies revealed InCs as a new class of potent MBL inhibitor, active against all MBL classes of major clinical relevance. Crystallographic studies revealed a binding mode of the InCs to MBLs that, in some regards, mimics that predicted for intact carbapenems, including with respect to maintenance of the Zn(II)-bound hydroxyl, and in other regards mimics binding observed in MBL-carbapenem product complexes. InCs restore carbapenem activity against multiple drug-resistant Gram-negative bacteria and have a low frequency of resistance. InCs also have a good in vivo safety profile, and when combined with meropenem show a strong in vivo efficacy in peritonitis and thigh mouse infection models.", "doi": "10.1038/s41557-021-00831-x", "pmid": "34903857", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41557-021-00831-x"}], "notes": [], "created": "2026-09-23T07:47:18.691Z", "modified": "2026-09-23T07:47:19.629Z"}, {"entity": "publication", "iuid": "24ec030827f94f90822dc69c9810a210", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/24ec030827f94f90822dc69c9810a210.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/24ec030827f94f90822dc69c9810a210"}}, "title": "A Series of Analogues to the AT2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode.", "authors": [{"family": "Isaksson", "given": "Rebecka", "initials": "R", "orcid": "0000-0002-6389-5046", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c4ccf340bf2b4033b0dba2be62166373.json"}}, {"family": "Lindman", "given": "Jens", "initials": "J", "orcid": "0000-0003-4795-6117", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f8978a018464f779baf8fbfc707a7b8.json"}}, {"family": "Wannberg", "given": "Johan", "initials": "J", "orcid": "0000-0001-5494-0848", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2b5421ed72bb4f089164536d6cdf5768.json"}}, {"family": "Sallander", "given": "Jessica", "initials": "J", "orcid": "0000-0002-0408-5289", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2694649a2f3e41ba8e5573f00b929ef1.json"}}, {"family": "Backlund", "given": "Maria", "initials": "M", "orcid": "0000-0002-6253-816X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3cbe928d448a4669908f38d58bbe5606.json"}}, {"family": "Baraldi", "given": "Dhaniel", "initials": "D", "orcid": "0000-0002-9688-4183", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e05885b70d8247ec8a85e07539d661b4.json"}}, {"family": "Widdop", "given": "Robert", "initials": "R", "orcid": "0000-0002-6515-0435", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1484c2d1b7f94abc9ec11c6a367ae3c9.json"}}, {"family": "Hallberg", "given": "Mathias", "initials": "M", "orcid": "0000-0002-9835-870X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76184702a3c14996a2ab9db8ffdbe19f.json"}}, {"family": "\u00c5qvist", "given": "Johan", "initials": "J", "orcid": "0000-0003-2091-0610", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d07d382c9c554c5faaa0a027debd2125.json"}}, {"family": "Gutierrez de Teran", "given": "Hugo", "initials": "H", "orcid": "0000-0003-0459-3491", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c72d19657f0e4e6a963d29ee0ab2427d.json"}}, {"family": "Gising", "given": "Johan", "initials": "J", "orcid": "0000-0001-8852-6071", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35360120fcd544faba8998acdcc6d5bc.json"}}, {"family": "Larhed", "given": "Mats", "initials": "M", "orcid": "0000-0001-6258-0635", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/225695195abc4233bd141e6858e72e7f.json"}}], "type": "journal article", "published": "2019-01-00", "journal": {"title": "ChemistryOpen", "issn": "2191-1363", "volume": "8", "issue": "1", "pages": "114-125", "issn-l": "2191-1363"}, "abstract": "We here report on our continued studies of ligands binding to the promising drug target angiotensin II type 2 receptor (AT2R). Two series of compounds were synthesized and investigated. The first series explored the effects of adding small substituents to the phenyl ring of the known selective nonpeptide AT2R antagonist C38, generating small but significant shifts in AT2R affinity. One compound in the first series was equipotent to C38 and showed similar kinetic solubility, and stability in both human and mouse liver microsomes. The second series was comprised of new bicyclic derivatives, amongst which one ligand exhibited a five-fold improved affinity to AT2R as compared to C38. The majority of the compounds in the second series, including the most potent ligand, were inferior to C38 with regard to stability in both human and mouse microsomes. In contrast to our previously reported findings, ligands with shorter carbamate alkyl chains only demonstrated slightly improved stability in microsomes. Based on data presented herein, a more adequate, tentative model of the binding modes of ligand analogues to the prototype AT2R antagonist C38 is proposed, as deduced from docking redefined by molecular dynamic simulations.", "doi": "10.1002/open.201800282", "pmid": "30697513", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6346239"}, {"db": "pii", "key": "OPEN201800282"}], "notes": [], "created": "2026-09-23T12:06:20.214Z", "modified": "2026-09-23T12:06:20.534Z"}]}