{"entity": "researcher", "timestamp": "2026-08-20T20:58:34.109Z", "family": "Cerezo-Maga\u00f1a", "given": "Myriam", "initials": "M", "orcid": "0000-0001-9752-8917", "affiliations": ["Department of Clinical Sciences Lund, Section of Oncology, Lund University, Lund 221 85, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c8019362baf45b394e839c00f7ac1d5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c8019362baf45b394e839c00f7ac1d5"}}, "publications": [{"entity": "publication", "iuid": "b48ded17901f445fb5121eb3348ab401", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b48ded17901f445fb5121eb3348ab401.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b48ded17901f445fb5121eb3348ab401"}}, "title": "Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted.", "authors": [{"family": "Governa", "given": "Valeria", "initials": "V", "orcid": "0000-0001-9999-0590", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38fa13ff35d2468e9a61eec381c1f91f.json"}}, {"family": "de Oliveira", "given": "Kelin Gon\u00e7alves", "initials": "KG", "orcid": "0000-0003-1646-5657", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f774f99247314765b97114edc82199f1.json"}}, {"family": "B\u00e5ng-Rudenstam", "given": "Anna", "initials": "A", "orcid": "0000-0003-2706-9502", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3fea3b51f73f4175b859cde49e99e5e7.json"}}, {"family": "Offer", "given": "Svenja", "initials": "S", "orcid": "0009-0005-1159-4769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cae1ab36ab44c918c0eaa3fcc21c68b.json"}}, {"family": "Cerezo-Maga\u00f1a", "given": "Myriam", "initials": "M", "orcid": "0000-0001-9752-8917", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c8019362baf45b394e839c00f7ac1d5.json"}}, {"family": "Li", "given": "Jiaxin", "initials": "J", "orcid": "0000-0002-5401-6855", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf6133b6e1c1438db5a2cafb42eae2fb.json"}}, {"family": "Beyer", "given": "Sarah", "initials": "S", "orcid": "0000-0001-8021-9624", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7460c1560454e29805fae14da7f99e2.json"}}, {"family": "Johansson", "given": "Maria C", "initials": "MC", "orcid": "0000-0003-0075-3187", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ce5f12cf2e24399b8b1a2f90a647e6e.json"}}, {"family": "M\u00e5nsson", "given": "Ann-Sofie", "initials": "AS", "orcid": "0000-0002-5984-3470", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9b3c8e6d27ad4029be4738d5816e0234.json"}}, {"family": "Edvardsson", "given": "Charlotte", "initials": "C", "orcid": "0009-0001-2046-7826", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/66126ee2a8bb40e2b20b131bacda396a.json"}}, {"family": "Durmo", "given": "Faris", "initials": "F", "orcid": "0000-0001-7364-5991", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/848a1ef86fe3467cad9437801dbd66f0.json"}}, {"family": "Gustafsson", "given": "Emma", "initials": "E", "orcid": "0009-0007-7005-912X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7d13e2b988714edc8b43efde369feec5.json"}}, {"family": "Boukredine", "given": "Axel", "initials": "A", "orcid": "0009-0006-3714-6769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a59ab55aa0794efc870cdec487e9dbde.json"}}, {"family": "Jeannot", "given": "Pauline", "initials": "P", "orcid": "0000-0003-0158-440X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/167869db86f0456fbb7a535ae8d89b35.json"}}, {"family": "Schmidt", "given": "Katja", "initials": "K", "orcid": "0000-0002-0973-6933", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/64466e9e703d46c985f6705573168bd0.json"}}, {"family": "Gezelius", "given": "Emelie", "initials": "E", "orcid": "0000-0002-7349-8108", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b141ce31bda40039dd006c2bfa8f661.json"}}, {"family": "Menard", "given": "Julien A", "initials": "JA", "orcid": "0009-0007-4652-399X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b32e557ab6fa450e9d0b4173b2a7b6a1.json"}}, {"family": "Garza", "given": "Raquel", "initials": "R", "orcid": "0000-0002-2524-3055", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dad049ba2c40499ba3587f6cc5d6a706.json"}}, {"family": "Jakobsson", "given": "Johan", "initials": "J", "orcid": "0000-0003-0669-7673", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1387f53f92df4c5f9c1fc91dd5230fba.json"}}, {"family": "de Neergaard", "given": "Therese", "initials": "T", "orcid": "0000-0002-6969-0375", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24f61a7c404b495bbb184a3af049a921.json"}}, {"family": "Sundgren", "given": "Pia C", "initials": "PC", "orcid": "0000-0001-9237-1236", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e580179d7d74958a5c1d509e581ddcc.json"}}, {"family": "Tiihonen", "given": "Aliisa M", "initials": "AM", "orcid": "0000-0003-3703-9673", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02077b27162c411388742c9094e1d165.json"}}, {"family": "Haapasalo", "given": "Hannu", "initials": "H"}, {"family": "Rautajoki", "given": "Kirsi J", "initials": "KJ", "orcid": "0000-0001-6549-7810", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ac12df0ec93441f90dcad31fe170143.json"}}, {"family": "Nordenfelt", "given": "Pontus", "initials": "P", "orcid": "0000-0002-9481-9951", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81dea1d4ace2429f8082a127bc93c691.json"}}, {"family": "Darabi", "given": "Anna", "initials": "A", "orcid": "0000-0003-4326-8149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb9f19a0c8694ee79ca515a79976d146.json"}}, {"family": "Forsberg-Nilsson", "given": "Karin", "initials": "K", "orcid": "0000-0003-0692-6245", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6636b7d9d0e24ac2a15ccd0e9f631ed1.json"}}, {"family": "Pietras", "given": "Alexander", "initials": "A", "orcid": "0000-0002-5783-9347", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9d48aa66cee48b9828c0ac374c75362.json"}}, {"family": "Talbot", "given": "Hugo", "initials": "H", "orcid": "0000-0001-9774-8573", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/28e1c9cf68e6408dbcf4ac2c031fb468.json"}}, {"family": "Bengzon", "given": "Johan", "initials": "J"}, {"family": "Belting", "given": "Mattias", "initials": "M", "orcid": "0000-0003-1585-5434", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9763a47486d410fb5034fb2603f3a02.json"}}], "type": "journal article", "published": "2024-10-30", "journal": {"title": "Sci Transl Med", "issn": "1946-6242", "volume": "16", "issue": "771", "pages": "eadk1168", "issn-l": "1946-6234"}, "abstract": "Glioblastoma presents a formidable clinical challenge because of its complex microenvironment. Here, we characterized tumor-associated foam cells (TAFs), a type of lipid droplet-loaded macrophage, in human glioblastoma. Through extensive analyses of patient tumors, together with in vitro and in vivo investigations, we found that TAFs exhibit distinct protumorigenic characteristics related to hypoxia, mesenchymal transition, angiogenesis, and impaired phagocytosis, and their presence correlates with worse outcomes for patients with glioma. We further demonstrated that TAF formation is facilitated by lipid scavenging from extracellular vesicles released by glioblastoma cells. We found that targeting key enzymes involved in lipid droplet formation, such as diacylglycerol O-acyltransferase or long-chain acyl-CoA synthetase, effectively disrupted TAF functionality. Together, these data highlight TAFs as a prominent immune cell population in glioblastoma and provide insights into their contribution to the tumor microenvironment. Disrupting lipid droplet formation to target TAFs may represent an avenue for future therapeutic development for glioblastoma.", "doi": "10.1126/scitranslmed.adk1168", "pmid": "39475570", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:59:55.851Z", "modified": "2026-08-20T11:59:56.532Z"}, {"entity": "publication", "iuid": "3e361ab03510479f99e72aeadd8afd37", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3e361ab03510479f99e72aeadd8afd37.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3e361ab03510479f99e72aeadd8afd37"}}, "title": "Landscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization.", "authors": [{"family": "Governa", "given": "Valeria", "initials": "V"}, {"family": "Talbot", "given": "Hugo", "initials": "H", "orcid": "0000-0001-9774-8573", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/28e1c9cf68e6408dbcf4ac2c031fb468.json"}}, {"family": "Gon\u00e7alves de Oliveira", "given": "Kelin", "initials": "K", "orcid": "0000-0003-1646-5657", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f774f99247314765b97114edc82199f1.json"}}, {"family": "Cerezo-Maga\u00f1a", "given": "Myriam", "initials": "M", "orcid": "0000-0001-9752-8917", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c8019362baf45b394e839c00f7ac1d5.json"}}, {"family": "B\u00e5ng-Rudenstam", "given": "Anna", "initials": "A", "orcid": "0000-0003-2706-9502", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3fea3b51f73f4175b859cde49e99e5e7.json"}}, {"family": "Johansson", "given": "Maria C", "initials": "MC", "orcid": "0000-0003-0075-3187", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ce5f12cf2e24399b8b1a2f90a647e6e.json"}}, {"family": "M\u00e5nsson", "given": "Ann-Sofie", "initials": "AS", "orcid": "0000-0002-5984-3470", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9b3c8e6d27ad4029be4738d5816e0234.json"}}, {"family": "Forsberg-Nilsson", "given": "Karin", "initials": "K"}, {"family": "Marko-Varga", "given": "Gy\u00f6rgy", "initials": "G"}, {"family": "Enr\u00edquez P\u00e9rez", "given": "Julio", "initials": "J", "orcid": "0000-0002-6361-3272", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/836f9e769c34462ea7d6d9ac64345beb.json"}}, {"family": "Darabi", "given": "Anna", "initials": "A", "orcid": "0000-0003-4326-8149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb9f19a0c8694ee79ca515a79976d146.json"}}, {"family": "Malmstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0002-2889-7169", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c89da9268a4f47a8a99fd62de451aaa7.json"}}, {"family": "Bengzon", "given": "Johan", "initials": "J"}, {"family": "Welinder", "given": "Charlotte", "initials": "C", "orcid": "0000-0001-9626-0576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5715a70ce8df4a5d84ad88709791772a.json"}}, {"family": "Belting", "given": "Mattias", "initials": "M", "orcid": "0000-0003-1585-5434", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9763a47486d410fb5034fb2603f3a02.json"}}], "type": "journal article", "published": "2022-03-01", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "119", "issue": "9", "issn-l": "0027-8424"}, "abstract": "Therapeutic strategies directed at the tumor surfaceome (TS), including checkpoint inhibitor blocking antibodies, antibody drug conjugates (ADCs), and chimeric antigen receptor T (CAR-T) cells, provide a new armament to fight cancer. However, a remaining bottleneck is the lack of strategies to comprehensively interrogate patient tumors for potential TS targets. Here, we have developed a platform (tumor surfaceome mapping [TS-MAP]) integrated with a newly curated TS classifier (SURFME) that allows profiling of primary 3D cultures and intact patient glioma tumors with preserved tissue architecture. Moreover, TS-MAP specifically identifies proteins capable of endocytosis as tractable targets for ADCs and other modalities requiring toxic payload internalization. In high-grade gliomas that remain among the most aggressive forms of cancer, we show that cellular spatial organization (2D vs. 3D) fundamentally transforms the surfaceome and endocytome (e.g., integrins, proteoglycans, semaphorins, and cancer stem cell markers) with general implications for target screening approaches, as exemplified by an ADC targeting EGFR. The TS-MAP platform was further applied to profile the surfaceome and endocytome landscape in a cohort of freshly resected gliomas. We found a highly diverse TS repertoire between patient tumors, not directly associated with grade and histology, which highlights the need for individualized approaches. Our data provide additional layers of understanding fundamental to the future development of immunotherapy strategies, as well as procedures for proteomics-based target identification and selection. The TS-MAP platform should be widely applicable in efforts aiming at a better understanding of how to harness the TS for personalized immunotherapy.", "doi": "10.1073/pnas.2114456119", "pmid": "35217608", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8892282"}, {"db": "pii", "key": "2114456119"}], "notes": [], "created": "2026-08-20T09:31:01.542Z", "modified": "2026-08-20T09:31:01.946Z"}, {"entity": "publication", "iuid": "ccadf7f3c80a4dff89cf980fb68c23c9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ccadf7f3c80a4dff89cf980fb68c23c9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ccadf7f3c80a4dff89cf980fb68c23c9"}}, "title": "Hypoxic Induction of Exosome Uptake through Proteoglycan-Dependent Endocytosis Fuels the Lipid Droplet Phenotype in Glioma.", "authors": [{"family": "Cerezo-Maga\u00f1a", "given": "Myriam", "initials": "M", "orcid": "0000-0001-9752-8917", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c8019362baf45b394e839c00f7ac1d5.json"}}, {"family": "Christianson", "given": "Helena C", "initials": "HC"}, {"family": "van Kuppevelt", "given": "Toin H", "initials": "TH"}, {"family": "Forsberg-Nilsson", "given": "Karin", "initials": "K"}, {"family": "Belting", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Mol. Cancer Res.", "issn": "1557-3125", "volume": "19", "issue": "3", "pages": "528-540", "issn-l": "1541-7786"}, "abstract": "As an adaptive response to hypoxic stress, aggressive tumors rewire their metabolic phenotype into increased malignant behavior through extracellular lipid scavenging and storage in lipid droplets (LD). However, the underlying mechanisms and potential lipid source retrieved in the hypoxic tumor microenvironment remain poorly understood. Here, we show that exosome-like extracellular vesicles (EV), known as influential messengers in the tumor microenvironment, may also serve anabolic functions by transforming hypoxic, patient-derived human glioblastoma cell lines into the LD+ phenotype. EVs were internalized via a hypoxia-sensitive, endocytic mechanism that fueled LD formation through direct lipid transfer, and independently of fatty acid synthase activity. EVs can enter cells through multiple and yet ill-defined pathways. On a mechanistic level, we found that hypoxia-mediated EV uptake depends on increased heparan sulfate proteoglycan (HSPG) endocytosis that preferentially followed the lipid raft pathway. The functional relevance of HSPG was evidenced by the reversal of EV-mediated LD loading by targeting of HSPG receptor function. IMPLICATIONS: Together, our data extend the multifaceted role of EVs in cancer biology by showing their LD-inducing capacity in hypoxic glioma cells. Moreover, these findings highlight a potential function for HSPG-mediated endocytosis as a salvage pathway for EV retrieval during tumor stress conditions.", "doi": "10.1158/1541-7786.MCR-20-0560", "pmid": "33288734", "labels": [], "xrefs": [{"db": "pii", "key": "1541-7786.MCR-20-0560"}], "notes": [], "created": "2026-08-20T12:14:21.411Z", "modified": "2026-08-20T12:14:21.483Z"}]}