{"entity": "researcher", "timestamp": "2026-08-20T21:24:31.164Z", "family": "Vargiu", "given": "Claudia Marina", "initials": "CM", "orcid": "0009-0009-2921-6829", "affiliations": ["IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c57306acd0a4f36a786bd7452ce821a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c57306acd0a4f36a786bd7452ce821a"}}, "publications": [{"entity": "publication", "iuid": "d5e68a98d6c94abb9646df1e1a48dec1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d5e68a98d6c94abb9646df1e1a48dec1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d5e68a98d6c94abb9646df1e1a48dec1"}}, "title": "Two-step detection of Lewy body pathology via smell-function testing and CSF \u03b1-synuclein seed amplification.", "authors": [{"family": "Mastenbroek", "given": "Sophie E", "initials": "SE", "orcid": "0009-0006-2759-9588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9732ea66d3d9402f9cb1b1a3e9b34fc8.json"}}, {"family": "Collij", "given": "Lyduine E", "initials": "LE", "orcid": "0000-0001-6263-1762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6612222d48fd4bdcaa7c091d38efcc2b.json"}}, {"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}, {"family": "Caldera", "given": "Serena", "initials": "S"}, {"family": "Serrano", "given": "Geidy E", "initials": "GE"}, {"family": "Adler", "given": "Charles H", "initials": "CH"}, {"family": "Vargiu", "given": "Claudia Marina", "initials": "CM", "orcid": "0009-0009-2921-6829", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c57306acd0a4f36a786bd7452ce821a.json"}}, {"family": "Palmqvist", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-9267-1930", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fbd05e87cfb4057a1a7e41d9fb94aef.json"}}, {"family": "Barkhof", "given": "Frederik", "initials": "F", "orcid": "0000-0003-3543-3706", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/adc9cefa2eb14e599fa41988ea003192.json"}}, {"family": "Parchi", "given": "Piero", "initials": "P", "orcid": "0000-0002-9444-9524", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a3f20dbf9b984aec85c74d9aea2eac69.json"}}, {"family": "Beach", "given": "Thomas G", "initials": "TG"}, {"family": "Ossenkoppele", "given": "Rik", "initials": "R", "orcid": "0000-0003-1584-7477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9486d27ddd1b4b6485fa3ca10e0f3d82.json"}}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}], "type": "journal article", "published": "2025-08-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "7182", "issn-l": "2041-1723"}, "abstract": "Cerebrospinal fluid (CSF) \u03b1-synuclein (\u03b1-syn) seed amplification assays (SAAs) can detect Lewy body pathology (LBP) with high accuracy but are invasive and costly. To address these challenges, this study evaluated a two-step workflow combining prescreening via smell-function testing with confirmatory CSF \u03b1-syn SAA testing only in individuals with reduced smell, for predicting postmortem LBP status. Among 358 autopsied participants, the two-step workflow predicted brain LBP with high accuracy overall (94%), and within clinical subgroups (clinical parkinsonism=95%; clinical Alzheimer's disease [AD]=94%; clinically unimpaired [CU]=93%). It reduced the need for confirmatory CSF testing by 43% overall (23% clinical parkinsonism; 35% clinical AD; 80% CU). In an independent in vivo cohort (N=1209), the workflow predicted CSF \u03b1-syn SAA status with 79% accuracy and reduced CSF testing by 26%. This approach may reduce invasive CSF testing, alleviating patient burden and lowering healthcare costs.", "doi": "10.1038/s41467-025-62458-7", "pmid": "40764485", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12325632"}, {"db": "pii", "key": "10.1038/s41467-025-62458-7"}], "notes": [], "created": "2026-08-20T08:54:03.905Z", "modified": "2026-08-20T08:54:04.105Z"}]}