{"entity": "researcher", "timestamp": "2026-08-20T20:36:25.407Z", "family": "Deiana", "given": "Marco", "initials": "M", "orcid": "0000-0002-7815-4494", "affiliations": ["Institute of Advanced Materials, Faculty of Chemistry, Wroc\u0142aw University of Science and Technology, Wyb. Wyspia\u0144skiego 27, 50-370 Wroc\u0142aw, Poland.", "Department of Medical Biochemistry and Biophysics, Ume\u00e5 University, 90187 Ume\u00e5, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/3bd27194cbcd411098f0a2c5341e0423.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/3bd27194cbcd411098f0a2c5341e0423"}}, "publications": [{"entity": "publication", "iuid": "b29be4239cbc4b56b42eb485d69d07ed", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b29be4239cbc4b56b42eb485d69d07ed.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b29be4239cbc4b56b42eb485d69d07ed"}}, "title": "Organelle-Specific Thiochromenocarbazole Imide Derivative as a Heavy-Atom-Free Type I Photosensitizer for Biomolecule-Triggered Image-Guided Photodynamic Therapy.", "authors": [{"family": "Saczuk", "given": "Karolina", "initials": "K"}, {"family": "Kassem", "given": "Ahmad", "initials": "A"}, {"family": "Dudek", "given": "Marta", "initials": "M", "orcid": "0000-0001-6749-0903", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8710cb4719a94c6c924b6f19f3d601c5.json"}}, {"family": "S\u00e1nchez", "given": "Dar\u00edo Puch\u00e1n", "initials": "DP", "orcid": "0009-0006-7176-080X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc962921b8bd4f3890c6d689a9a6fe8f.json"}}, {"family": "Khrouz", "given": "Lhoussain", "initials": "L"}, {"family": "Allain", "given": "Magali", "initials": "M"}, {"family": "Welch", "given": "Gregory C", "initials": "GC", "orcid": "0000-0002-3768-937X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2af0133b2efa407b8cb90494557c18eb.json"}}, {"family": "Sabouri", "given": "Nasim", "initials": "N", "orcid": "0000-0002-4541-7702", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8bbda597fa314881a10de1f7a6ad09ee.json"}}, {"family": "Monnereau", "given": "Cyrille", "initials": "C", "orcid": "0000-0002-8928-2416", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6bab902e3164fe4bc7510b8e671b46a.json"}}, {"family": "Josse", "given": "Pierre", "initials": "P"}, {"family": "Cabanetos", "given": "Cl\u00e9ment", "initials": "C", "orcid": "0000-0003-3781-887X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dbc477ef93be42398c3182ec637639f4.json"}}, {"family": "Deiana", "given": "Marco", "initials": "M", "orcid": "0000-0002-7815-4494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3bd27194cbcd411098f0a2c5341e0423.json"}}], "type": "journal article", "published": "2025-03-06", "journal": {"title": "J Phys Chem Lett", "issn": "1948-7185", "volume": "16", "issue": "9", "pages": "2273-2282", "issn-l": "1948-7185"}, "abstract": "Modern photodynamic therapy (PDT) demands next-generation photosensitizers (PSs) that overcome heavy-atom dependency and enhance efficacy beyond traditional, highly oxygen-dependent type II mechanisms. We introduce herein TCI-NH, as a thiochromenocarbazole imide derivative designed for type I photodynamic action. Upon light activation, TCI-NH efficiently favors superoxide (O2\u2022-) and PS-centered radical formation instead of singlet oxygen (1O2) generation. Its high luminescence efficiency and selective localization in both the endoplasmic reticulum and mitochondria enable precise, image-guided PDT. Notably, interactions with biomolecules, such as serum albumin or DNA, enhance TCI-NH's emission by up to 40-fold and amplify radical generation by up to 5-fold. With negligible dark toxicity, this results in \u223c120 nM photocytotoxicity along with an impressive phototherapeutic index exceeding 200. Real-time live-cell imaging revealed rapid, light-triggered cytotoxicity characterized by apoptotic body formation and extensive cellular damage. With its small size, heavy-atom-free structure, exceptional, organelle specificity, and therapeutic efficacy, TCI-NH sets a new benchmark for anticancer type I PDT.", "doi": "10.1021/acs.jpclett.5c00136", "pmid": "39988904", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11891978"}], "notes": [], "created": "2026-08-20T08:11:09.584Z", "modified": "2026-08-20T08:11:09.927Z"}]}