{"entity": "researcher", "timestamp": "2026-08-20T21:36:34.062Z", "family": "Mari", "given": "Andrea", "initials": "A", "orcid": "0000-0002-1436-5591", "affiliations": ["Institute of Neuroscience, National Research Council, Padova, 35127, Italy."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b7dd1ab06074d1188e40713d8807c48.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b7dd1ab06074d1188e40713d8807c48"}}, "publications": [{"entity": "publication", "iuid": "97dcb877641d4da1b812ef995b72d5d3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/97dcb877641d4da1b812ef995b72d5d3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/97dcb877641d4da1b812ef995b72d5d3"}}, "title": "Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits.", "authors": [{"family": "Brown", "given": 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"initials": "I", "orcid": "0000-0002-2016-7049", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1691b459fdb84772b1e8595e8de617f3.json"}}, {"family": "Pedersen", "given": "Oluf", "initials": "O", "orcid": "0000-0002-3321-3972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0ef37542aea4e67a322b0d6179cd59e.json"}}, {"family": "Ruetten", "given": "Hartmut", "initials": "H"}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "DIRECT Consortium", "given": "", "initials": ""}, {"family": "Adamski", "given": "Jerzy", "initials": "J", "orcid": "0000-0001-9259-0199", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6871f2a0d4414a58be2e7f26a59d3ca9.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Pearson", "given": "Ewan R", "initials": "ER", "orcid": "0000-0001-9237-8585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e27e9e47f1cc4a969268eb5a65b8045b.json"}}, {"family": "Dermitzakis", "given": "Emmanouil T", "initials": "ET", "orcid": "0000-0002-9302-6490", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6683f17defc34cad9389fd7fef36aca4.json"}}, {"family": "Vi\u00f1uela", "given": "Ana", "initials": "A", "orcid": "0000-0003-3771-8537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02cba70871df48eb84c17e82f95baae4.json"}}], "type": "journal article", "published": "2023-08-21", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "5062", "issn-l": "2041-1723"}, "abstract": "We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant associates with multiple molecular phenotypes over multiple genomic regions. The highest proportion of share genetic regulation is detected between gene expression and proteins (66.6%), with a further median shared genetic associations across 49 different tissues of 78.3% and 62.4% between plasma proteins and gene expression. We represent the genetic and molecular associations in networks including 2828 known GWAS variants, showing that GWAS variants are more often connected to gene expression in trans than other molecular phenotypes in the network. Our work provides a roadmap to understanding molecular networks and deriving the underlying mechanism of action of GWAS variants using different molecular phenotypes in an accessible tissue.", "doi": "10.1038/s41467-023-40569-3", "pmid": "37604891", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10442420"}, {"db": "pii", "key": "10.1038/s41467-023-40569-3"}], "notes": [], "created": "2026-08-20T08:52:44.576Z", "modified": "2026-08-20T08:52:45.407Z"}, {"entity": "publication", "iuid": "0a5faded2b8248c6be219660ec518362", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0a5faded2b8248c6be219660ec518362.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0a5faded2b8248c6be219660ec518362"}}, "title": "Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study", "authors": [{"family": "Vi\u00f1uela", "given": "Ana", "initials": "A", "orcid": "0000-0003-3771-8537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02cba70871df48eb84c17e82f95baae4.json"}}, {"family": "Brown", "given": "Andrew A", "initials": "AA", "orcid": "0000-0002-8087-3033", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b690d27df56b44dc8a070e4265afc8ca.json"}}, {"family": "Fernandez", "given": "Juan", "initials": "J"}, {"family": "Hong", "given": "Mun Gwan", "initials": "MG", "orcid": "0000-0001-8603-8293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d12504acae5c4f31b83f75c3d7786cd4.json"}}, {"family": "Brorsson", "given": "Caroline A", "initials": "CA", "orcid": "0000-0003-3473-1744", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/93356b705c444fe883e86e24c76f8abd.json"}}, {"family": "Koivula", "given": "Robert W", "initials": "RW", "orcid": "0000-0002-1646-4163", "researcher": {"href": 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"initials": "GN"}, {"family": "Haid", "given": "Mark", "initials": "M", "orcid": "0000-0001-6118-1333", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c4398da6ddb245bdb982ac3a0b352c40.json"}}, {"family": "Hansen", "given": "Torben", "initials": "T"}, {"family": "Hansen", "given": "Tue", "initials": "T"}, {"family": "Hattersley", "given": "Andrew T", "initials": "AT"}, {"family": "Heggie", "given": "Alison J", "initials": "AJ"}, {"family": "Howald", "given": "C\u00e9dric", "initials": "C"}, {"family": "Jones", "given": "Angus G", "initials": "AG"}, {"family": "Kokkola", "given": "Tarja", "initials": "T", "orcid": "0000-0002-3303-3912", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc389880431a46e49fcbe0eae12908ea.json"}}, {"family": "Laakso", "given": "Markku", "initials": "M"}, {"family": "Mahajan", "given": "Anubha", "initials": "A", "orcid": "0000-0001-5585-3420", "researcher": {"href": 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"initials": "M"}, {"family": "Romano", "given": "Luciana", "initials": "L"}, {"family": "Rutters", "given": "Femke", "initials": "F"}, {"family": "Sharma", "given": "Sapna", "initials": "S"}, {"family": "Teare", "given": "Harriet", "initials": "H"}, {"family": "T\u2019Hart", "given": "Leen M", "initials": "LM"}, {"family": "Tsirigos", "given": "Kostas", "initials": "K"}, {"family": "Vangipurapu", "given": "Jagadish", "initials": "J"}, {"family": "Vestergaard", "given": "Henrik", "initials": "H"}, {"family": "Brunak", "given": "S\u00f8ren", "initials": "S"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Frost", "given": "Gary", "initials": "G"}, {"family": "Grallert", "given": "Harald", "initials": "H"}, {"family": "Jablonka", "given": "Bernd", "initials": "B"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI", "orcid": "0000-0002-4393-0510", "researcher": {"href": 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"https://publications-affiliated.scilifelab.se/researcher/6683f17defc34cad9389fd7fef36aca4.json"}}], "type": "posted-content", "published": "2021-03-29", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.03.26.21254347", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:03:36.179Z", "modified": "2026-08-20T10:03:36.507Z"}, {"entity": "publication", "iuid": "77910c659eba495088c76361a47a6739", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/77910c659eba495088c76361a47a6739.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/77910c659eba495088c76361a47a6739"}}, "title": "Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study.", "authors": [{"family": "Bizzotto", "given": "Roberto", "initials": "R", "orcid": "0000-0002-8251-1730", "researcher": {"href": 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"orcid": "0000-0002-1646-4163", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ceb821c78774b9f8931463351046f1f.json"}}, {"family": "Brage", "given": "Soren", "initials": "S"}, {"family": "Kaye", "given": "Jane", "initials": "J"}, {"family": "Hattersley", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-5620-473X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dfbb9bb951f04ed3ac56eb4890d3186a.json"}}, {"family": "Heggie", "given": "Alison", "initials": "A"}, {"family": "McEvoy", "given": "Donna", "initials": "D"}, {"family": "'t Hart", "given": "Leen M", "initials": "LM"}, {"family": "Beulens", "given": "Joline W", "initials": "JW", "orcid": "0000-0002-4181-0937", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26b2b48b79a942e8ab9cb7382585ce21.json"}}, {"family": "Elders", "given": "Petra", "initials": "P"}, {"family": "Musholt", "given": "Petra B", "initials": "PB"}, {"family": "Ridderstr\u00e5le", "given": "Martin", "initials": "M", "orcid": "0000-0002-3270-9167", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ce961d525f784428b1b6cdd4d3ed0c1a.json"}}, {"family": "Hansen", "given": "Tue H", "initials": "TH"}, {"family": "Allin", "given": "Kristine H", "initials": "KH", "orcid": "0000-0002-6880-5759", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57d2acb6ed9146908728b751c105a37c.json"}}, {"family": "Hansen", "given": "Torben", "initials": "T", "orcid": "0000-0001-8748-3831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e9a365eccb44b28b293c7decc6f4b9f.json"}}, {"family": "Vestergaard", "given": "Henrik", "initials": "H"}, {"family": "Lundgaard", "given": "Agnete T", "initials": "AT"}, {"family": "Thomsen", "given": "Henrik S", "initials": "HS"}, {"family": "De Masi", "given": "Federico", "initials": "F"}, {"family": "Tsirigos", "given": "Konstantinos D", "initials": "KD"}, {"family": "Brunak", "given": "S\u00f8ren", "initials": "S"}, {"family": "Vi\u00f1uela", "given": "Ana", "initials": "A"}, {"family": "Mahajan", "given": "Anubha", "initials": "A", "orcid": "0000-0001-5585-3420", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41b3d44662484e0289f07fa25d045cf4.json"}}, {"family": "McDonald", "given": "Timothy J", "initials": "TJ", "orcid": "0000-0003-3559-6660", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/11b833983c5d4416bceac079dcee38d6.json"}}, {"family": "Kokkola", "given": "Tarja", "initials": "T"}, {"family": "Forgie", "given": "Ian M", "initials": "IM"}, {"family": "Giordano", "given": "Giuseppe N", "initials": "GN"}, {"family": "Pavo", "given": "Imre", "initials": "I"}, {"family": "Ruetten", "given": "Hartmut", "initials": "H"}, {"family": "Dermitzakis", "given": "Emmanouil", "initials": "E"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI"}, {"family": "Pedersen", "given": "Oluf", "initials": "O"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM"}, {"family": "Adamski", "given": "Jerzy", "initials": "J"}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8263a26f474946de8b61a2080051d37b.json"}}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "Pearson", "given": "Ewan R", "initials": "ER", "orcid": "0000-0001-9237-8585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e27e9e47f1cc4a969268eb5a65b8045b.json"}}, {"family": "Mari", "given": "Andrea", "initials": "A", "orcid": "0000-0002-1436-5591", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b7dd1ab06074d1188e40713d8807c48.json"}}, {"family": "IMI DIRECT consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Diabetes Care", "issn": "1935-5548", "volume": "44", "issue": "2", "pages": "511-518", "issn-l": null}, "abstract": "We investigated the processes underlying glycemic deterioration in type 2 diabetes (T2D).\n\nA total of 732 recently diagnosed patients with T2D from the Innovative Medicines Initiative Diabetes Research on Patient Stratification (IMI DIRECT) study were extensively phenotyped over 3 years, including measures of insulin sensitivity (OGIS), \u03b2-cell glucose sensitivity (GS), and insulin clearance (CLIm) from mixed meal tests, liver enzymes, lipid profiles, and baseline regional fat from MRI. The associations between the longitudinal metabolic patterns and HbA1c deterioration, adjusted for changes in BMI and in diabetes medications, were assessed via stepwise multivariable linear and logistic regression.\n\nFaster HbA1c progression was independently associated with faster deterioration of OGIS and GS and increasing CLIm; visceral or liver fat, HDL-cholesterol, and triglycerides had further independent, though weaker, roles (R 2 = 0.38). A subgroup of patients with a markedly higher progression rate (fast progressors) was clearly distinguishable considering these variables only (discrimination capacity from area under the receiver operating characteristic = 0.94). The proportion of fast progressors was reduced from 56% to 8-10% in subgroups in which only one trait among OGIS, GS, and CLIm was relatively stable (odds ratios 0.07-0.09). T2D polygenic risk score and baseline pancreatic fat, glucagon-like peptide 1, glucagon, diet, and physical activity did not show an independent role.\n\nDeteriorating insulin sensitivity and \u03b2-cell function, increasing insulin clearance, high visceral or liver fat, and worsening of the lipid profile are the crucial factors mediating glycemic deterioration of patients with T2D in the initial phase of the disease. Stabilization of a single trait among insulin sensitivity, \u03b2-cell function, and insulin clearance may be relevant to prevent progression.", "doi": "10.2337/dc20-1567", "pmid": "33323478", "labels": [], "xrefs": [{"db": "pii", "key": "dc20-1567"}, {"db": "figshare", "key": "10.2337/figshare.13222205"}], "notes": [], "created": "2026-08-20T13:03:02.855Z", "modified": "2026-08-20T13:03:03.150Z"}]}