{"entity": "researcher", "timestamp": "2026-09-30T23:42:04.967Z", "family": "Steri", "given": "Maristella", "initials": "M", "orcid": "0000-0001-5869-3872", "affiliations": ["Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, 00185, Cagliari, Italy."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a9560ce25014eb489f7253717cf8a84.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a9560ce25014eb489f7253717cf8a84"}}, "publications": [{"entity": "publication", "iuid": "50ec755355ff484bab1051b78dc6d902", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/50ec755355ff484bab1051b78dc6d902.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/50ec755355ff484bab1051b78dc6d902"}}, "title": "PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.", "authors": [{"family": "van Setten", "given": "Jessica", "initials": "J", "orcid": "0000-0002-4934-7510", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca856aa0fba74d3099d5ebd8539dde0d.json"}}, {"family": "Brody", "given": "Jennifer A", "initials": "JA", "orcid": "0000-0001-8509-148X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f5e5e63068a4762ba2c4ca10f30aa78.json"}}, {"family": "Jamshidi", "given": "Yalda", "initials": "Y"}, {"family": "Swenson", "given": "Brenton R", "initials": "BR"}, {"family": "Butler", "given": "Anne M", "initials": "AM"}, {"family": "Campbell", "given": "Harry", "initials": "H"}, {"family": "Del Greco", "given": "Fabiola M", "initials": "FM"}, {"family": "Evans", "given": "Daniel S", "initials": "DS"}, {"family": "Gibson", "given": "Quince", "initials": "Q"}, {"family": "Gudbjartsson", "given": "Daniel F", "initials": "DF"}, {"family": "Kerr", "given": "Kathleen F", "initials": "KF", "orcid": "0000-0002-6438-9583", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51b81bfdbda149b1b0450ce6ea15c77b.json"}}, {"family": "Krijthe", "given": "Bouwe P", "initials": "BP"}, {"family": "Lyytik\u00e4inen", "given": "Leo-Pekka", "initials": "LP", "orcid": "0000-0002-7200-5455", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d541c99c43642538b7578fc4ff810ad.json"}}, {"family": "M\u00fcller", "given": "Christian", "initials": "C"}, {"family": "M\u00fcller-Nurasyid", "given": "Martina", "initials": "M", "orcid": "0000-0003-3793-5910", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29665b981f714acda0ab36b09ab04a22.json"}}, {"family": "Nolte", "given": "Ilja M", "initials": "IM", "orcid": "0000-0001-5047-4077", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2f5412b9a3a24cd9886c668836025c1b.json"}}, {"family": "Padmanabhan", "given": "Sandosh", "initials": "S"}, {"family": "Ritchie", "given": "Marylyn D", "initials": "MD", "orcid": "0000-0002-1208-1720", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c65a4166eff94fbf82136ebdc47f4bbc.json"}}, {"family": "Robino", "given": "Antonietta", "initials": "A"}, {"family": "Smith", "given": "Albert V", "initials": "AV", "orcid": "0000-0003-1942-5845", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51752e0d35a74befa66a65b95ceaad38.json"}}, {"family": "Steri", "given": "Maristella", "initials": "M", "orcid": "0000-0001-5869-3872", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a9560ce25014eb489f7253717cf8a84.json"}}, {"family": "Tanaka", "given": "Toshiko", "initials": "T"}, {"family": "Teumer", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8309-094X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a40a959d1b8480cb8268e00f77a0449.json"}}, {"family": "Trompet", "given": "Stella", "initials": "S"}, {"family": "Ulivi", "given": "Sheila", "initials": "S"}, {"family": "Verweij", "given": "Niek", "initials": "N", "orcid": "0000-0002-4303-7685", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ce7bbbc0c7c48d699dc9fc3ee251bf3.json"}}, {"family": "Yin", "given": "Xiaoyan", "initials": "X"}, {"family": "Arnar", "given": "David O", "initials": "DO"}, {"family": "Asselbergs", "given": "Folkert W", "initials": "FW", "orcid": "0000-0002-1692-8669", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/181a8a467ca54344b574d248cc98f1d3.json"}}, {"family": "Bader", "given": "Joel S", "initials": "JS", "orcid": "0000-0002-6020-4625", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/78745224dd8142709ccf7b51edf5ec98.json"}}, {"family": "Barnard", "given": "John", "initials": "J"}, {"family": "Bis", "given": "Josh", "initials": "J"}, {"family": "Blankenberg", "given": "Stefan", "initials": "S"}, {"family": "Boerwinkle", "given": "Eric", "initials": "E"}, {"family": "Bradford", "given": "Yuki", "initials": "Y"}, {"family": "Buckley", "given": "Brendan M", "initials": "BM"}, {"family": "Chung", "given": "Mina K", "initials": "MK"}, {"family": "Crawford", "given": "Dana", "initials": "D"}, {"family": "den Hoed", "given": "Marcel", "initials": "M"}, {"family": "Denny", "given": "Josh C", "initials": "JC"}, {"family": "Dominiczak", "given": "Anna F", "initials": "AF", "orcid": "0000-0003-4913-3608", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/115a24acd27247539747b672923a8ce3.json"}}, {"family": "Ehret", "given": "Georg B", "initials": "GB", "orcid": "0000-0002-5730-0675", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1fe0233af4614b8b870be7bb90772368.json"}}, {"family": "Eijgelsheim", "given": "Mark", "initials": "M"}, {"family": "Ellinor", "given": "Patrick T", "initials": "PT", "orcid": "0000-0002-2067-0533", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fd1830794e884e6e849fd4f7645c9b61.json"}}, {"family": "Felix", "given": "Stephan B", "initials": "SB"}, {"family": "Franco", "given": "Oscar H", "initials": "OH"}, {"family": "Franke", "given": "Lude", "initials": "L", "orcid": "0000-0002-5159-8802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e0a825c1d31c458e872fa6c79d30f02e.json"}}, {"family": "Harris", "given": "Tamara B", "initials": "TB"}, {"family": "Holm", "given": "Hilma", "initials": "H"}, {"family": "Ilaria", "given": "Gandin", "initials": "G"}, {"family": "Iorio", "given": "Annamaria", "initials": "A"}, {"family": "K\u00e4h\u00f6nen", "given": "Mika", "initials": "M"}, {"family": "Kolcic", "given": "Ivana", "initials": "I"}, {"family": "Kors", "given": "Jan A", "initials": "JA"}, {"family": "Lakatta", "given": "Edward G", "initials": "EG"}, {"family": "Launer", "given": "Lenore J", "initials": "LJ"}, {"family": "Lin", "given": "Honghuang", "initials": "H", "orcid": "0000-0003-3043-3942", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fcff923f48845b88239000f20875e7c.json"}}, {"family": "Lin", "given": "Henry J", "initials": "HJ"}, {"family": "Loos", "given": "Ruth J F", "initials": "RJF", "orcid": "0000-0002-8532-5087", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/179eb6511eba4d33b633599c5652e344.json"}}, {"family": "Lubitz", "given": "Steven A", "initials": "SA"}, {"family": "Macfarlane", "given": "Peter W", "initials": "PW"}, {"family": "Magnani", "given": "Jared W", "initials": "JW"}, {"family": "Leach", "given": "Irene Mateo", "initials": "IM"}, {"family": "Meitinger", "given": "Thomas", "initials": "T"}, {"family": "Mitchell", "given": "Braxton D", "initials": "BD"}, {"family": "Munzel", "given": "Thomas", "initials": "T", "orcid": "0000-0001-5503-4150", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b37d4ee9ac494a298d457236530ec5cd.json"}}, {"family": "Papanicolaou", "given": "George J", "initials": "GJ"}, {"family": "Peters", "given": "Annette", "initials": "A"}, {"family": "Pfeufer", "given": "Arne", "initials": "A"}, {"family": "Pramstaller", "given": "Peter P", "initials": "PP"}, {"family": "Raitakari", "given": "Olli T", "initials": "OT"}, {"family": "Rotter", "given": "Jerome I", "initials": "JI"}, {"family": "Rudan", "given": "Igor", "initials": "I", "orcid": "0000-0001-6993-6884", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c9e99f2bcc74658ae0bcffca0a0abee.json"}}, {"family": "Samani", "given": "Nilesh J", "initials": "NJ"}, {"family": "Schlessinger", "given": "David", "initials": "D"}, {"family": "Silva Aldana", "given": "Claudia T", "initials": "CT"}, {"family": "Sinner", "given": "Moritz F", "initials": "MF"}, {"family": "Smith", "given": "Jonathan D", "initials": "JD", "orcid": "0000-0002-0415-386X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f08d6773c2134268bda75050772d397f.json"}}, {"family": "Snieder", "given": "Harold", "initials": "H"}, {"family": "Soliman", "given": "Elsayed Z", "initials": "EZ", "orcid": "0000-0001-5632-8150", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4d53591cd5a46cab26b9e1dd2ce46c2.json"}}, {"family": "Spector", "given": "Timothy D", "initials": "TD"}, {"family": "Stott", "given": "David J", "initials": "DJ"}, {"family": "Strauch", "given": "Konstantin", "initials": "K"}, {"family": "Tarasov", "given": "Kirill V", "initials": "KV", "orcid": "0000-0001-7799-4670", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0e8bdb8f49349c980220b3a6c3f9ae3.json"}}, {"family": "Thorsteinsdottir", "given": "Unnur", "initials": "U"}, {"family": "Uitterlinden", "given": "Andre G", "initials": "AG"}, {"family": "Van Wagoner", "given": "David R", "initials": "DR", "orcid": "0000-0001-8250-9828", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6528e043f2445d1a87e83cf65906450.json"}}, {"family": "V\u00f6lker", "given": "Uwe", "initials": "U"}, {"family": "V\u00f6lzke", "given": "Henry", "initials": "H"}, {"family": "Waldenberger", "given": "Melanie", "initials": "M"}, {"family": "Jan Westra", "given": "Harm", "initials": "H", "orcid": "0000-0001-7038-567X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fdcf5e246bc341d2ae66f80b783a84ef.json"}}, {"family": "Wild", "given": "Philipp S", "initials": "PS"}, {"family": "Zeller", "given": "Tanja", "initials": "T"}, {"family": "Alonso", "given": "Alvaro", "initials": "A", "orcid": "0000-0002-2225-8323", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6707daa85da845408f0dba0de1447f67.json"}}, {"family": "Avery", "given": "Christy L", "initials": "CL"}, {"family": "Bandinelli", "given": "Stefania", "initials": "S"}, {"family": "Benjamin", "given": "Emelia J", "initials": "EJ", "orcid": "0000-0003-4076-2336", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/89bc31f5dd38446b9ffb36e68201e2da.json"}}, {"family": "Cucca", "given": "Francesco", "initials": "F", "orcid": "0000-0002-7414-1995", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2535f3e6f1f4487f976990152303456b.json"}}, {"family": "D\u00f6rr", "given": "Marcus", "initials": "M"}, {"family": "Ferrucci", "given": "Luigi", "initials": "L"}, {"family": "Gasparini", "given": "Paolo", "initials": "P"}, {"family": "Gudnason", "given": "Vilmundur", "initials": "V"}, {"family": "Hayward", "given": "Caroline", "initials": "C", "orcid": "0000-0002-9405-9550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/542b00d650124ce4a3776ae95571e2c1.json"}}, {"family": "Heckbert", "given": "Susan R", "initials": "SR"}, {"family": "Hicks", "given": "Andrew A", "initials": "AA", "orcid": "0000-0001-6320-0411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/08bfcbd859e848698883ad840f02594f.json"}}, {"family": "Jukema", "given": "J Wouter", "initials": "JW", "orcid": "0000-0002-3246-8359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51be7e89ccfd4bbe93b216028c57a376.json"}}, {"family": "K\u00e4\u00e4b", "given": "Stefan", "initials": "S"}, {"family": "Lehtim\u00e4ki", "given": "Terho", "initials": "T"}, {"family": "Liu", "given": "Yongmei", "initials": "Y"}, {"family": "Munroe", "given": "Patricia B", "initials": "PB", "orcid": "0000-0002-4176-2947", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e956b6f17a64fb4b478dbc59950a790.json"}}, {"family": "Parsa", "given": "Afshin", "initials": "A"}, {"family": "Polasek", "given": "Ozren", "initials": "O"}, {"family": "Psaty", "given": "Bruce M", "initials": "BM"}, {"family": "Roden", "given": "Dan M", "initials": "DM"}, {"family": "Schnabel", "given": "Renate B", "initials": "RB"}, {"family": "Sinagra", "given": "Gianfranco", "initials": "G", "orcid": "0000-0003-2700-8478", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/69fe49802ac14ff38123d7334a29c461.json"}}, {"family": "Stefansson", "given": "Kari", "initials": "K"}, {"family": "Stricker", "given": "Bruno H", "initials": "BH"}, {"family": "van der Harst", "given": "Pim", "initials": "P", "orcid": "0000-0002-2713-686X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/808139762faf4ad8a4eeb39f3a60b61f.json"}}, {"family": "van Duijn", "given": "Cornelia M", "initials": "CM"}, {"family": "Wilson", "given": "James F", "initials": "JF", "orcid": "0000-0001-5751-9178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513b6983cc9d478ab9d81c2f21579961.json"}}, {"family": "Gharib", "given": "Sina A", "initials": "SA"}, {"family": "de Bakker", "given": "Paul I W", "initials": "PIW"}, {"family": "Isaacs", "given": "Aaron", "initials": "A", "orcid": "0000-0001-5037-4834", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3032ae0243754d59ae39612d49257dfd.json"}}, {"family": "Arking", "given": "Dan E", "initials": "DE"}, {"family": "Sotoodehnia", "given": "Nona", "initials": "N"}], "type": "journal article", "published": "2018-07-25", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "9", "issue": "1", "pages": "2904", "issn-l": "2041-1723"}, "abstract": "Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genome-wide association study of over 92,000 European-descent individuals identifies 44 PR interval loci (34 novel). Examination of these loci reveals known and previously not-yet-reported biological processes involved in cardiac atrial electrical activity. Genes in these loci are over-represented in cardiac disease processes including heart block and atrial fibrillation. Variants in over half of the 44 loci were associated with atrial or blood transcript expression levels, or were in high linkage disequilibrium with missense variants. Six additional loci were identified either by meta-analysis of ~105,000 African and European-descent individuals and/or by pleiotropic analyses combining PR interval with heart rate, QRS interval, and atrial fibrillation. These findings implicate developmental pathways, and identify transcription factors, ion-channel genes, and cell-junction/cell-signaling proteins in atrio-ventricular conduction, identifying potential targets for drug development.", "doi": "10.1038/s41467-018-04766-9", "pmid": "30046033", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6060178"}, {"db": "pii", "key": "10.1038/s41467-018-04766-9"}], "notes": [], "created": "2019-01-17T13:55:47.312Z", "modified": "2026-09-23T07:44:50.750Z"}]}