{"entity": "researcher", "timestamp": "2026-08-20T20:53:23.340Z", "family": "Kl\u00e4ppe", "given": "Ulf", "initials": "U", "orcid": "0000-0001-5832-038X", "affiliations": ["Department of Neurology, Karolinska University Hospital, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/3939bb5c873241299ce82d2aec37457a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/3939bb5c873241299ce82d2aec37457a"}}, "publications": [{"entity": "publication", "iuid": "b4162b0e192e47f185b537a36028e435", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b4162b0e192e47f185b537a36028e435.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b4162b0e192e47f185b537a36028e435"}}, "title": "Cerebrospinal fluid levels of NfM in relation to NfL and pNfH as prognostic markers in amyotrophic lateral sclerosis.", "authors": [{"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Mravinacov\u00e1", "given": "S\u00e1ra", "initials": "S", "orcid": "0000-0003-1848-910X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1e48837666642b18a977bb8a8c39603.json"}}, {"family": "Kl\u00e4ppe", "given": "Ulf", "initials": "U", "orcid": "0000-0001-5832-038X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3939bb5c873241299ce82d2aec37457a.json"}}, {"family": "\u00d6ijerstedt", "given": "Linn", "initials": "L", "orcid": "0000-0003-0635-6377", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d1c8d008d08491b9e40516ce0c5806a.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18365a2ea4ec4ca2baeb657cd1c8bd8f.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f920b41aab42f0a43a32bbe34035b2.json"}}, {"family": "Ingre", "given": "Caroline", "initials": "C", "orcid": "0000-0001-5327-7204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e6a44fc40ff4b38a3b1da5cf2e8661e.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}], "type": "journal article", "published": "2025-02-00", "journal": {"title": "Amyotroph Lateral Scler Frontotemporal Degener", "issn": "2167-9223", "volume": "26", "issue": "1-2", "pages": "113-123", "issn-l": null}, "abstract": "To evaluate the prognostic potential of neurofilament medium chain (NfM) in CSF from patients with ALS and explore its relationship with the extensively studied neurofilament light chain (NfL) and phosphorylated heavy chain (pNfH).\n\nCSF levels of NfL, NfM, and pNfH were analyzed in 235 samples from patients with ALS, ALS mimics, and healthy controls in a well-characterized cohort from Karolinska ALS Clinical Research Center in Stockholm, Sweden. NfM levels were analyzed using an antibody-based suspension bead-array and NfL and pNfH levels were measured using ELISA. Clinical data, including ALS Revised Functional Rating Scale (ALSFRS-R), and survival outcomes were utilized for disease progression estimations.\n\nIncreased NfM levels were observed in patients with ALS compared with mimics and healthy controls. Similarly, higher NfM levels were found in fast compared with slow progressing patients for baseline and longitudinal progression when evaluating both total and subscores of ALSFRS-R. These findings were consistent with the results observed for NfL and pNfH. All three proteins, used individually as well as in combination, showed comparable performance when classifying fast vs slow progressing patients (AUCs 0.78-0.85). For all neurofilaments, higher survival probability was observed for patients with low CSF levels.\n\nBased on this cross-sectional study, the prognostic value provided by NfM aligns with the more established markers, NfL and pNfH. Additional investigations with independent cohorts and longitudinal studies are needed to further assess the potential added value of NfM.", "doi": "10.1080/21678421.2024.2428930", "pmid": "39575564", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T09:37:40.836Z", "modified": "2026-08-20T09:37:41.085Z"}, {"entity": "publication", "iuid": "bea27aac30214f489afdb3c8ba1ddcd2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bea27aac30214f489afdb3c8ba1ddcd2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bea27aac30214f489afdb3c8ba1ddcd2"}}, "title": "Cerebrospinal fluid levels of NfM in relation to NfL and pNfH as prognostic markers in amyotrophic lateral sclerosis", "authors": [{"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Mravinacov\u00e1", "given": "S\u00e1ra", "initials": "S", "orcid": "0000-0003-1848-910X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1e48837666642b18a977bb8a8c39603.json"}}, {"family": "Kl\u00e4ppe", "given": "Ulf", "initials": "U", "orcid": "0000-0001-5832-038X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3939bb5c873241299ce82d2aec37457a.json"}}, {"family": "\u00d6ijerstedt", "given": "Linn", "initials": "L", "orcid": "0000-0003-0635-6377", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d1c8d008d08491b9e40516ce0c5806a.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18365a2ea4ec4ca2baeb657cd1c8bd8f.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f920b41aab42f0a43a32bbe34035b2.json"}}, {"family": "Ingre", "given": "Caroline", "initials": "C", "orcid": "0000-0001-5327-7204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e6a44fc40ff4b38a3b1da5cf2e8661e.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}], "type": "posted-content", "published": "2024-07-10", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.07.09.24310135", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:55:36.267Z", "modified": "2026-08-20T10:55:36.374Z"}, {"entity": "publication", "iuid": "8f32b4a0feec426aa7a3b473b819c5db", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8f32b4a0feec426aa7a3b473b819c5db.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8f32b4a0feec426aa7a3b473b819c5db"}}, "title": "Publisher Correction: Altered perivascular fibroblast activity precedes ALS disease onset.", "authors": [{"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}, {"family": "Skene", "given": "Nathan", "initials": "N"}, {"family": "Sanders", "given": "Folkert", "initials": "F"}, {"family": "Trusohamn", "given": "Marta", "initials": "M", "orcid": "0000-0002-0541-8903", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/234e99cb31064ecd97ce20cd6bed0671.json"}}, {"family": "Remnest\u00e5l", "given": "Julia", "initials": "J"}, {"family": "Szczepi\u0144ska", "given": "Anna", "initials": "A"}, {"family": "Aksoylu", "given": "Inci Sevval", "initials": "IS"}, {"family": "L\u00f6nnerberg", "given": "Peter", "initials": "P"}, {"family": "Ebarasi", "given": "Lwaki", "initials": "L"}, {"family": "Wouters", "given": "Stefan", "initials": "S", "orcid": "0000-0002-5243-6186", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f539b54a76a54f72a91cb8d32faf5f6e.json"}}, {"family": "Lehmann", "given": "Manuela", "initials": "M"}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "von Gohren Antequera", "given": "Inti", "initials": "I"}, {"family": "Domaniku", "given": "Aylin", "initials": "A", "orcid": "0000-0002-7785-2143", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95697e92a2ab473a822a823eb0f8b4c8.json"}}, {"family": "De Schaepdryver", "given": "Maxim", "initials": "M", "orcid": "0000-0003-2480-863X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d74bcbf7a0534626978de5911f54e9f8.json"}}, {"family": "De Vocht", "given": "Joke", "initials": "J"}, {"family": "Poesen", "given": "Koen", "initials": "K"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Anink", "given": "Jasper", "initials": "J"}, {"family": "Mijnsbergen", "given": "Caroline", "initials": "C"}, {"family": "Vergunst-Bosch", "given": "Hermieneke", "initials": "H"}, {"family": "H\u00fcbers", "given": "Annemarie", "initials": "A"}, {"family": "Kl\u00e4ppe", "given": "Ulf", "initials": "U", "orcid": "0000-0001-5832-038X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3939bb5c873241299ce82d2aec37457a.json"}}, {"family": "Rodriguez-Vieitez", "given": "Elena", "initials": "E"}, {"family": "Gilthorpe", "given": "Jonathan D", "initials": "JD", "orcid": "0000-0002-6884-4774", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b96eb721974441b2940f6f8a86ed8390.json"}}, {"family": "Hedlund", "given": "Eva", "initials": "E", "orcid": "0000-0001-6347-0075", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb646c0222e24fd1807f19a915b5b0c7.json"}}, {"family": "Harris", "given": "Robert A", "initials": "RA", "orcid": "0000-0003-4990-509X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7558fb5ceba54b689244b4e771714b76.json"}}, {"family": "Aronica", "given": "Eleonora", "initials": "E"}, {"family": "Van Damme", "given": "Philip", "initials": "P", "orcid": "0000-0002-4010-2357", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b455ddb4b88495fb728afc06b18e998.json"}}, {"family": "Ludolph", "given": "Albert", "initials": "A"}, {"family": "Veldink", "given": "Jan", "initials": "J", "orcid": "0000-0001-5572-9657", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2a35cf75e024b2fbb2750dbdb0cfd9c.json"}}, {"family": "Ingre", "given": "Caroline", "initials": "C"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "Lewandowski", "given": "Sebastian A", "initials": "SA", "orcid": "0000-0002-5935-0211", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2707f71ea5b641318c3479efafbdf5bc.json"}}], "type": "published erratum", "published": "2021-07-00", "journal": {"title": "Nat. Med.", "issn": "1546-170X", "volume": "27", "issue": "7", "pages": "1308", "issn-l": "1078-8956"}, "abstract": null, "doi": "10.1038/s41591-021-01414-6", "pmid": "34079107", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01414-6"}], "notes": [], "created": "2026-08-20T09:01:58.367Z", "modified": "2026-08-20T09:01:58.485Z"}, {"entity": "publication", "iuid": "0b4b5765a54d4b25a1480c67a55d1154", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0b4b5765a54d4b25a1480c67a55d1154.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0b4b5765a54d4b25a1480c67a55d1154"}}, "title": "Altered perivascular fibroblast activity precedes ALS disease onset.", "authors": [{"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}, {"family": "Skene", "given": "Nathan", "initials": "N"}, {"family": "Sanders", "given": "Folkert", "initials": "F"}, {"family": "Trusohamn", "given": "Marta", "initials": "M", "orcid": "0000-0002-0541-8903", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/234e99cb31064ecd97ce20cd6bed0671.json"}}, {"family": "Remnest\u00e5l", "given": "Julia", "initials": "J"}, {"family": "Szczepi\u0144ska", "given": "Anna", "initials": "A"}, {"family": "Aksoylu", "given": "Inci Sevval", "initials": "IS"}, {"family": "L\u00f6nnerberg", "given": "Peter", "initials": "P"}, {"family": "Ebarasi", "given": "Lwaki", "initials": "L"}, {"family": "Wouters", "given": "Stefan", "initials": "S", "orcid": "0000-0002-5243-6186", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f539b54a76a54f72a91cb8d32faf5f6e.json"}}, {"family": "Lehmann", "given": "Manuela", "initials": "M"}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "von Gohren Antequera", "given": "Inti", "initials": "I"}, {"family": "Domaniku", "given": "Aylin", "initials": "A", "orcid": "0000-0002-7785-2143", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95697e92a2ab473a822a823eb0f8b4c8.json"}}, {"family": "De Schaepdryver", "given": "Maxim", "initials": "M", "orcid": "0000-0003-2480-863X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d74bcbf7a0534626978de5911f54e9f8.json"}}, {"family": "De Vocht", "given": "Joke", "initials": "J"}, {"family": "Poesen", "given": "Koen", "initials": "K"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Anink", "given": "Jasper", "initials": "J"}, {"family": "Mijnsbergen", "given": "Caroline", "initials": "C"}, {"family": "Vergunst-Bosch", "given": "Hermieneke", "initials": "H"}, {"family": "H\u00fcbers", "given": "Annemarie", "initials": "A"}, {"family": "Kl\u00e4ppe", "given": "Ulf", "initials": "U", "orcid": "0000-0001-5832-038X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3939bb5c873241299ce82d2aec37457a.json"}}, {"family": "Rodriguez-Vieitez", "given": "Elena", "initials": "E"}, {"family": "Gilthorpe", "given": "Jonathan D", "initials": "JD", "orcid": "0000-0002-6884-4774", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b96eb721974441b2940f6f8a86ed8390.json"}}, {"family": "Hedlund", "given": "Eva", "initials": "E", "orcid": "0000-0001-6347-0075", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb646c0222e24fd1807f19a915b5b0c7.json"}}, {"family": "Harris", "given": "Robert A", "initials": "RA", "orcid": "0000-0003-4990-509X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7558fb5ceba54b689244b4e771714b76.json"}}, {"family": "Aronica", "given": "Eleonora", "initials": "E"}, {"family": "Van Damme", "given": "Philip", "initials": "P", "orcid": "0000-0002-4010-2357", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b455ddb4b88495fb728afc06b18e998.json"}}, {"family": "Ludolph", "given": "Albert", "initials": "A"}, {"family": "Veldink", "given": "Jan", "initials": "J", "orcid": "0000-0001-5572-9657", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2a35cf75e024b2fbb2750dbdb0cfd9c.json"}}, {"family": "Ingre", "given": "Caroline", "initials": "C"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "Lewandowski", "given": "Sebastian A", "initials": "SA", "orcid": "0000-0002-5935-0211", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2707f71ea5b641318c3479efafbdf5bc.json"}}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Nat. Med.", "issn": "1546-170X", "volume": "27", "issue": "4", "pages": "640-646", "issn-l": "1078-8956"}, "abstract": "Apart from well-defined factors in neuronal cells1, only a few reports consider that the variability of sporadic amyotrophic lateral sclerosis (ALS) progression can depend on less-defined contributions from glia2,3 and blood vessels4. In this study we use an expression-weighted cell-type enrichment method to infer cell activity in spinal cord samples from patients with sporadic ALS and mouse models of this disease. Here we report that patients with sporadic ALS present cell activity patterns consistent with two mouse models in which enrichments of vascular cell genes preceded microglial response. Notably, during the presymptomatic stage, perivascular fibroblast cells showed the strongest gene enrichments, and their marker proteins SPP1 and COL6A1 accumulated in enlarged perivascular spaces in patients with sporadic ALS. Moreover, in plasma of 574 patients with ALS from four independent cohorts, increased levels of SPP1 at disease diagnosis repeatedly predicted shorter survival with stronger effect than the established risk factors of bulbar onset or neurofilament levels in cerebrospinal fluid. We propose that the activity of the recently discovered perivascular fibroblast can predict survival of patients with ALS and provide a new conceptual framework to re-evaluate definitions of ALS etiology.", "doi": "10.1038/s41591-021-01295-9", "pmid": "33859435", "labels": [], "xrefs": [{"db": "mid", "key": "EMS151802"}, {"db": "pmc", "key": "PMC7613336"}, {"db": "pii", "key": "10.1038/s41591-021-01295-9"}, {"db": "figshare", "key": "10.6084/m9.figshare.11632794"}, {"db": "figshare", "key": "10.6084/m9.figshare.11635887"}, {"db": "figshare", "key": "10.6084/m9.figshare.11628891"}, {"db": "figshare", "key": "10.6084/m9.figshare.11628585"}, {"db": "figshare", "key": "10.6084/m9.figshare.14035616"}], "notes": [], "created": "2026-08-20T09:01:51.665Z", "modified": "2026-08-20T09:01:52.157Z"}]}