{"entity": "researcher", "timestamp": "2026-09-25T01:18:24.276Z", "family": "Lyall", "given": "Donald M", "initials": "DM", "orcid": "0000-0003-3850-1487", "affiliations": ["Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/355e09323285410999bacaef10047b3a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/355e09323285410999bacaef10047b3a"}}, "publications": [{"entity": "publication", "iuid": "28cf8e3f77e344af887fd659d1c2f681", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/28cf8e3f77e344af887fd659d1c2f681.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/28cf8e3f77e344af887fd659d1c2f681"}}, "title": "Genetic variation in CADM2 as a link between psychological traits and obesity.", "authors": [{"family": "Morris", "given": "Julia", "initials": "J"}, {"family": "Bailey", "given": "Mark E S", "initials": "MES", "orcid": "0000-0002-9788-2278", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/876b94a993504943bc6854fe0a71d49c.json"}}, {"family": "Baldassarre", "given": "Damiano", "initials": "D"}, {"family": "Cullen", "given": "Breda", "initials": "B", "orcid": "0000-0002-7259-9505", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9eeb9eafd99d489c9e47a260341a622e.json"}}, {"family": "de Faire", "given": "Ulf", "initials": "U"}, {"family": "Ferguson", "given": "Amy", "initials": "A"}, {"family": "Gigante", "given": "Bruna", "initials": "B", "orcid": "0000-0003-4508-7990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5756c7fca760434da1fc7e001232eee3.json"}}, {"family": "Giral", "given": "Philippe", "initials": "P"}, {"family": "Goel", "given": "Anuj", "initials": "A"}, {"family": "Graham", "given": "Nicholas", "initials": "N"}, {"family": "Hamsten", "given": "Anders", "initials": "A"}, {"family": "Humphries", "given": "Steve E", "initials": "SE"}, {"family": "Johnston", "given": "Keira J A", "initials": "KJA", "orcid": "0000-0002-1370-3149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bd4bcb30c5734c9ab649cd1ace361422.json"}}, {"family": "Lyall", "given": "Donald M", "initials": "DM", "orcid": "0000-0003-3850-1487", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/355e09323285410999bacaef10047b3a.json"}}, {"family": "Lyall", "given": "Laura M", "initials": "LM"}, {"family": "Sennblad", "given": "Bengt", "initials": "B"}, {"family": "Silveira", "given": "Angela", "initials": "A"}, {"family": "Smit", "given": "Andries J", "initials": "AJ"}, {"family": "Tremoli", "given": "Elena", "initials": "E"}, {"family": "Veglia", "given": "Fabrizio", "initials": "F"}, {"family": "Ward", "given": "Joey", "initials": "J"}, {"family": "Watkins", "given": "Hugh", "initials": "H"}, {"family": "Smith", "given": "Daniel J", "initials": "DJ", "orcid": "0000-0002-2267-1951", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57e439f15a6f44eb98ae6d681e6ff829.json"}}, {"family": "Strawbridge", "given": "Rona J", "initials": "RJ", "orcid": "0000-0001-8506-3585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cccd06a2fb54f769c5710c8758f2ebe.json"}}], "type": "journal article", "published": "2019-05-14", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "9", "issue": "1", "pages": "7339", "issn-l": "2045-2322"}, "abstract": "CADM2 has been associated with a range of behavioural and metabolic traits, including physical activity, risk-taking, educational attainment, alcohol and cannabis use and obesity. Here, we set out to determine whether CADM2 contributes to mechanisms shared between mental and physical health disorders. We assessed genetic variants in the CADM2 locus for association with phenotypes in the UK Biobank, IMPROVE, PROCARDIS and SCARFSHEEP studies, before performing meta-analyses. A wide range of metabolic phenotypes were meta-analysed. Psychological phenotypes analysed in UK Biobank only were major depressive disorder, generalised anxiety disorder, bipolar disorder, neuroticism, mood instability and risk-taking behaviour. In UK Biobank, four, 88 and 172 genetic variants were significantly (p < 1 \u00d7 10-5) associated with neuroticism, mood instability and risk-taking respectively. In meta-analyses of 4 cohorts, we identified 362, 63 and 11 genetic variants significantly (p < 1 \u00d7 10-5) associated with BMI, SBP and CRP respectively. Genetic effects on BMI, CRP and risk-taking were all positively correlated, and were consistently inversely correlated with genetic effects on SBP, mood instability and neuroticism. Conditional analyses suggested an overlap in the signals for physical and psychological traits. Many significant variants had genotype-specific effects on CADM2 expression levels in adult brain and adipose tissues. CADM2 variants influence a wide range of both psychological and metabolic traits, suggesting common biological mechanisms across phenotypes via regulation of CADM2 expression levels in adipose tissue. Functional studies of CADM2 are required to fully understand mechanisms connecting mental and physical health conditions.", "doi": "10.1038/s41598-019-43861-9", "pmid": "31089183", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6517397"}, {"db": "pii", "key": "10.1038/s41598-019-43861-9"}], "notes": [], "created": "2026-09-23T09:17:07.207Z", "modified": "2026-09-23T09:17:07.511Z"}, {"entity": "publication", "iuid": "fef35b227c8b4718bc4a60261aecbbb7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fef35b227c8b4718bc4a60261aecbbb7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fef35b227c8b4718bc4a60261aecbbb7"}}, "title": "Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants.", "authors": [{"family": "Zhou", "given": "Ang", "initials": "A"}, {"family": "Taylor", "given": "Amy E", "initials": "AE"}, {"family": "Karhunen", "given": "Ville", "initials": "V"}, {"family": "Zhan", "given": "Yiqiang", "initials": "Y"}, {"family": "Rovio", "given": "Suvi P", "initials": "SP"}, {"family": "Lahti", "given": "Jari", "initials": "J", "orcid": "0000-0002-4310-5297", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c6397141bf954d8fa10a7e8e561ffe36.json"}}, {"family": "Sj\u00f6gren", "given": "Per", "initials": "P"}, {"family": "Byberg", "given": "Liisa", "initials": "L"}, {"family": "Lyall", "given": "Donald M", "initials": "DM", "orcid": "0000-0003-3850-1487", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/355e09323285410999bacaef10047b3a.json"}}, {"family": "Auvinen", "given": "Juha", "initials": "J"}, {"family": "Lehtim\u00e4ki", "given": "Terho", "initials": "T"}, {"family": "K\u00e4h\u00f6nen", "given": "Mika", "initials": "M"}, {"family": "Hutri-K\u00e4h\u00f6nen", "given": "Nina", "initials": "N"}, {"family": "Per\u00e4l\u00e4", "given": "Mia Maria", "initials": "MM"}, {"family": "Micha\u00eblsson", "given": "Karl", "initials": "K"}, {"family": "Mahajan", "given": "Anubha", "initials": "A", "orcid": "0000-0001-5585-3420", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41b3d44662484e0289f07fa25d045cf4.json"}}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Power", "given": "Chris", "initials": "C"}, {"family": "Eriksson", "given": "Johan G", "initials": "JG"}, {"family": "Raitakari", "given": "Olli T", "initials": "OT"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S", "orcid": "0000-0002-2452-1500", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40186021027c42e4b2ed6daf9c196a29.json"}}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL"}, {"family": "Veijola", "given": "Juha", "initials": "J"}, {"family": "J\u00e4rvelin", "given": "Marjo-Riitta", "initials": "MR"}, {"family": "Munaf\u00f2", "given": "Marcus R", "initials": "MR", "orcid": "0000-0002-4049-993X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a8c76569da740aca3ac62ae98995152.json"}}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "Llewellyn", "given": "David J", "initials": "DJ"}, {"family": "Hypp\u00f6nen", "given": "Elina", "initials": "E"}], "type": "journal article", "published": "2018-05-14", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "8", "issue": "1", "pages": "7526", "issn-l": "2045-2322"}, "abstract": "Coffee's long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian randomization to investigate the causal relationship between habitual coffee consumption and cognitive function in mid- to later life. This included up to 415,530 participants and 300,760 coffee drinkers from 10 meta-analysed European ancestry cohorts. In each cohort, composite cognitive scores that capture global cognition and memory were computed using available tests. A genetic score derived using CYP1A1/2 (rs2472297) and AHR (rs6968865) was chosen as a proxy for habitual coffee consumption. Null associations were observed when examining the associations of the genetic score with global and memory cognition (\u03b2 = -0.0007, 95% C.I. -0.009 to 0.008, P = 0.87; \u03b2 = -0.001, 95% C.I. -0.005 to 0.002, P = 0.51, respectively), with high consistency between studies (Pheterogeneity > 0.4 for both). Domain specific analyses using available cognitive measures in the UK Biobank also did not support effects by habitual coffee intake for reaction time, pairs matching, reasoning or prospective memory (P \u2265 0.05 for all). Despite the power to detect very small effects, our meta-analysis provided no evidence for causal long-term effects of habitual coffee consumption on global cognition or memory.", "doi": "10.1038/s41598-018-25919-2", "pmid": "29760501", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5951917"}, {"db": "pii", "key": "10.1038/s41598-018-25919-2"}], "notes": [], "created": "2018-12-05T12:40:32.732Z", "modified": "2026-09-23T13:29:38.388Z"}]}