{"entity": "researcher", "timestamp": "2026-08-20T20:51:12.593Z", "family": "Kim", "given": "Jong Hyuk", "initials": "JH", "orcid": "0000-0002-1645-0036", "affiliations": [], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/3553b69d2420463ca6a24d52696a7da7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/3553b69d2420463ca6a24d52696a7da7"}}, "publications": [{"entity": "publication", "iuid": "6fbcd70f6fdd47ca8a9de8bc69c85c7d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6fbcd70f6fdd47ca8a9de8bc69c85c7d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6fbcd70f6fdd47ca8a9de8bc69c85c7d"}}, "title": "Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion.", "authors": [{"family": "Kim", "given": "Jong Hyuk", "initials": "JH", "orcid": "0000-0002-1645-0036", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3553b69d2420463ca6a24d52696a7da7.json"}}, {"family": "Schulte", "given": "Ashley J", "initials": "AJ", "orcid": "0009-0001-3114-7844", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dff7cb5e2ffe42a6a726370fba006723.json"}}, {"family": "Sarver", "given": "Aaron L", "initials": "AL", "orcid": "0000-0002-7098-301X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/beadd13747cb47319ec33a0189e53d54.json"}}, {"family": "Lee", "given": "Donghee", "initials": "D", "orcid": "0009-0005-4763-1437", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8ab7e28c5c44eb59c6e5fcdfd854aba.json"}}, {"family": "Angelos", "given": "Mathew G", "initials": "MG", "orcid": "0000-0002-9903-5021", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/606375e1eb2245e4a4d82b4fbd59668b.json"}}, {"family": "Frantz", "given": "Aric M", "initials": "AM", "orcid": "0009-0002-0451-0393", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/83b88d1f9f564e45bdd85ea79834b3a3.json"}}, {"family": "Forster", "given": "Colleen L", "initials": "CL", "orcid": "0000-0001-5593-882X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7a2713a420d44e4c8afddc5c34e33e2f.json"}}, {"family": "O'Brien", "given": "Timothy D", "initials": "TD", "orcid": "0000-0001-9742-0930", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7c093e1b3a44ec39a321a8428865c89.json"}}, {"family": "Cornax", "given": "Ingrid", "initials": "I", "orcid": "0009-0004-3688-9056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/392165707de44a3b81aaa32d9df9e1aa.json"}}, {"family": "O'Sullivan", "given": "M Gerard", "initials": "MG", "orcid": "0000-0002-5463-1153", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bef38481c6f246368c5ef5f2742898aa.json"}}, {"family": "Cheng", "given": "Nuojin", "initials": "N", "orcid": "0000-0001-6926-8994", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d3abf87dbd0448ecb3631056062a2eb3.json"}}, {"family": "Lewellen", "given": "Mitzi", "initials": "M", "orcid": "0009-0005-9026-9883", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d639a59fa1ef4cb8bd36cb765023c63d.json"}}, {"family": "Oseth", "given": "LeAnn", "initials": "L", "orcid": "0009-0001-9259-3776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c57f2daa06444a17bf617f0eae15d37e.json"}}, {"family": "Kumar", "given": "Sunil", "initials": "S", "orcid": "0000-0002-1112-088X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76c174002a114229b186481106d696e4.json"}}, {"family": "Bullman", "given": "Susan", "initials": "S", "orcid": "0000-0002-7713-0810", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67edad9be25e4ff8b31ae0a0495b34a2.json"}}, {"family": "Pedamallu", "given": "Chandra Sekhar", "initials": "CS", "orcid": "0000-0002-7899-0206", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bfeb738cca3c443388e13f2f0c7a1af2.json"}}, {"family": "Goyal", "given": "Sagar M", "initials": "SM", "orcid": "0000-0002-7781-3080", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2bfd8c2b945942a2a92b6a26ffdc07a6.json"}}, {"family": "Meyerson", "given": "Matthew", "initials": "M", "orcid": "0000-0002-9133-8108", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f6cb18decbaf4406bee815ef4eb83408.json"}}, {"family": "Lund", "given": "Troy C", "initials": "TC", "orcid": "0000-0001-9174-8919", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5a03b56b36ae42739bb6631f8977033c.json"}}, {"family": "Breen", "given": "Matthew", "initials": "M", "orcid": "0000-0002-8901-4155", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/095f4b50bfba438abcff667f8ca7a542.json"}}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/612a779b69494f1ca9b6c5f1d84fd711.json"}}, {"family": "Dickerson", "given": "Erin B", "initials": "EB", "orcid": "0000-0002-9757-4961", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7bc292f101d6424da83e53676c97f341.json"}}, {"family": "Kaufman", "given": "Dan S", "initials": "DS", "orcid": "0000-0002-2003-2494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/19dd6d7d4300442ca82b24096dadeb04.json"}}, {"family": "Modiano", "given": "Jaime F", "initials": "JF", "orcid": "0000-0001-6398-7648", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ba4bb579a21472dab716ebf61874801.json"}}], "type": "journal article", "published": "2024-06-11", "journal": {"title": "Cancer Res Commun", "issn": "2767-9764", "volume": "4", "issue": "6", "pages": "1467-1480", "issn-l": null}, "abstract": "Hemangiosarcoma and angiosarcoma are soft-tissue sarcomas of blood vessel-forming cells in dogs and humans, respectively. These vasoformative sarcomas are aggressive and highly metastatic, with disorganized, irregular blood-filled vascular spaces. Our objective was to define molecular programs which support the niche that enables progression of canine hemangiosarcoma and human angiosarcoma. Dog-in-mouse hemangiosarcoma xenografts recapitulated the vasoformative and highly angiogenic morphology and molecular characteristics of primary tumors. Blood vessels in the tumors were complex and disorganized, and they were lined by both donor and host cells. In a series of xenografts, we observed that the transplanted hemangiosarcoma cells created exuberant myeloid hyperplasia and gave rise to lymphoproliferative tumors of mouse origin. Our functional analyses indicate that hemangiosarcoma cells generate a microenvironment that supports expansion and differentiation of hematopoietic progenitor populations. Furthermore, gene expression profiling data revealed hemangiosarcoma cells expressed a repertoire of hematopoietic cytokines capable of regulating the surrounding stromal cells. We conclude that canine hemangiosarcomas, and possibly human angiosarcomas, maintain molecular properties that provide hematopoietic support and facilitate stromal reactions, suggesting their potential involvement in promoting the growth of hematopoietic tumors.\n\nWe demonstrate that hemangiosarcomas regulate molecular programs supporting hematopoietic expansion and differentiation, providing insights into their potential roles in creating a permissive stromal-immune environment for tumor progression.", "doi": "10.1158/2767-9764.CRC-23-0441", "pmid": "38757809", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11166094"}, {"db": "pii", "key": "745407"}], "notes": [], "created": "2026-08-20T12:14:53.714Z", "modified": "2026-08-20T12:14:54.666Z"}, {"entity": "publication", "iuid": "9b6c299c3be9475c925b30a7b62e0588", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9b6c299c3be9475c925b30a7b62e0588.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9b6c299c3be9475c925b30a7b62e0588"}}, "title": "Data from Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions", "authors": [{"family": "Kim", "given": "Jong Hyuk", "initials": "JH", "orcid": "0000-0002-1645-0036", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3553b69d2420463ca6a24d52696a7da7.json"}}, {"family": "Megquier", "given": "Kate", "initials": "K", "orcid": "0000-0002-1458-0865", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d84d6a467fac40d5a926885732eca967.json"}}, {"family": "Thomas", "given": "Rachael", "initials": "R", "orcid": "0000-0002-3029-8798", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d7613e07c9b242748a912e2ab73a5542.json"}}, {"family": "Sarver", "given": "Aaron L", "initials": "AL"}, {"family": "Song", "given": "Jung Min", "initials": "JM"}, {"family": "Kim", "given": "Yoon Tae", "initials": "YT"}, {"family": "Cheng", "given": "Nuojin", "initials": "N"}, {"family": "Schulte", "given": "Ashley J", "initials": "AJ"}, {"family": "Linden", "given": "Michael A", "initials": "MA"}, {"family": "Murugan", "given": "Paari", "initials": "P", "orcid": "0000-0003-4706-213X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6bf0a99d52e4f5abed4fad7da3c8e02.json"}}, {"family": "Oseth", "given": "LeAnn", "initials": "L"}, {"family": "Forster", "given": "Colleen L", "initials": "CL"}, {"family": "Elvers", "given": "Ingegerd", "initials": "I"}, {"family": "Swofford", "given": "Ross", "initials": "R", "orcid": "0000-0003-3676-8479", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/85b0174c633b417b933092763175bb1c.json"}}, {"family": "Turner-Maier", "given": "Jason", "initials": "J"}, {"family": "Karlsson", "given": "Elinor K", "initials": "EK", "orcid": "0000-0002-4343-3776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81b5c82fcb904394b6a6b1d811863fa0.json"}}, {"family": "Breen", "given": "Matthew", "initials": "M"}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K"}, {"family": "Modiano", "given": "Jaime F", "initials": "JF", "orcid": "0000-0001-6398-7648", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ba4bb579a21472dab716ebf61874801.json"}}], "type": "posted-content", "published": "2023-04-03", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1158/1541-7786.c.6545168.v1", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T12:14:04.142Z", "modified": "2026-08-20T12:14:04.329Z"}, {"entity": "publication", "iuid": "d05f4aeea1d543a6818bf3faaf86357e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d05f4aeea1d543a6818bf3faaf86357e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d05f4aeea1d543a6818bf3faaf86357e"}}, "title": "Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions.", "authors": [{"family": "Kim", "given": "Jong Hyuk", "initials": "JH", "orcid": "0000-0002-1645-0036", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3553b69d2420463ca6a24d52696a7da7.json"}}, {"family": "Megquier", "given": "Kate", "initials": "K", "orcid": "0000-0002-1458-0865", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d84d6a467fac40d5a926885732eca967.json"}}, {"family": "Thomas", "given": "Rachael", "initials": "R", "orcid": "0000-0002-3029-8798", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d7613e07c9b242748a912e2ab73a5542.json"}}, {"family": "Sarver", "given": "Aaron L", "initials": "AL"}, {"family": "Song", "given": "Jung Min", "initials": "JM"}, {"family": "Kim", "given": "Yoon Tae", "initials": "YT"}, {"family": "Cheng", "given": "Nuojin", "initials": "N"}, {"family": "Schulte", "given": "Ashley J", "initials": "AJ"}, {"family": "Linden", "given": "Michael A", "initials": "MA"}, {"family": "Murugan", "given": "Paari", "initials": "P", "orcid": "0000-0003-4706-213X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6bf0a99d52e4f5abed4fad7da3c8e02.json"}}, {"family": "Oseth", "given": "LeAnn", "initials": "L"}, {"family": "Forster", "given": "Colleen L", "initials": "CL"}, {"family": "Elvers", "given": "Ingegerd", "initials": "I"}, {"family": "Swofford", "given": "Ross", "initials": "R", "orcid": "0000-0003-3676-8479", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/85b0174c633b417b933092763175bb1c.json"}}, {"family": "Turner-Maier", "given": "Jason", "initials": "J"}, {"family": "Karlsson", "given": "Elinor K", "initials": "EK", "orcid": "0000-0002-4343-3776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81b5c82fcb904394b6a6b1d811863fa0.json"}}, {"family": "Breen", "given": "Matthew", "initials": "M"}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K"}, {"family": "Modiano", "given": "Jaime F", "initials": "JF", "orcid": "0000-0001-6398-7648", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ba4bb579a21472dab716ebf61874801.json"}}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Mol. Cancer Res.", "issn": "1557-3125", "volume": "19", "issue": "5", "pages": "847-861", "issn-l": "1541-7786"}, "abstract": "Sporadic angiosarcomas are aggressive vascular sarcomas whose rarity and genomic complexity present significant obstacles in deciphering the pathogenic significance of individual genetic alterations. Numerous fusion genes have been identified across multiple types of cancers, but their existence and significance remain unclear in sporadic angiosarcomas. In this study, we leveraged RNA-sequencing data from 13 human angiosarcomas and 76 spontaneous canine hemangiosarcomas to identify fusion genes associated with spontaneous vascular malignancies. Ten novel protein-coding fusion genes, including TEX2-PECAM1 and ATP8A2-FLT1, were identified in seven of the 13 human tumors, with two tumors showing mutations of TP53. HRAS and NRAS mutations were found in angiosarcomas without fusions or TP53 mutations. We found 15 novel protein-coding fusion genes including MYO16-PTK2, GABRA3-FLT1, and AKT3-XPNPEP1 in 11 of the 76 canine hemangiosarcomas; these fusion genes were seen exclusively in tumors of the angiogenic molecular subtype that contained recurrent mutations in TP53, PIK3CA, PIK3R1, and NRAS. In particular, fusion genes and mutations of TP53 cooccurred in tumors with higher frequency than expected by random chance, and they enriched gene signatures predicting activation of angiogenic pathways. Comparative transcriptomic analysis of human angiosarcomas and canine hemangiosarcomas identified shared molecular signatures associated with activation of PI3K/AKT/mTOR pathways. Our data suggest that genome instability induced by TP53 mutations might create a predisposition for fusion events that may contribute to tumor progression by promoting selection and/or enhancing fitness through activation of convergent angiogenic pathways in this vascular malignancy. IMPLICATIONS: This study shows that, while drive events of malignant vasoformative tumors of humans and dogs include diverse mutations and stochastic rearrangements that create novel fusion genes, convergent transcriptional programs govern the highly conserved morphologic organization and biological behavior of these tumors in both species.", "doi": "10.1158/1541-7786.MCR-20-0937", "pmid": "33649193", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1675846"}, {"db": "pmc", "key": "PMC8137578"}, {"db": "pii", "key": "1541-7786.MCR-20-0937"}], "notes": [], "created": "2026-08-20T12:14:23.333Z", "modified": "2026-08-20T12:14:23.423Z"}, {"entity": "publication", "iuid": "d365ac0a2fe941bbb47a27b146d888b1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d365ac0a2fe941bbb47a27b146d888b1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d365ac0a2fe941bbb47a27b146d888b1"}}, "title": "Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma.", "authors": [{"family": "Megquier", "given": "Kate", "initials": "K", "orcid": "0000-0002-1458-0865", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d84d6a467fac40d5a926885732eca967.json"}}, {"family": "Turner-Maier", "given": "Jason", "initials": "J"}, {"family": "Swofford", "given": "Ross", "initials": "R"}, {"family": "Kim", "given": "Jong-Hyuk", "initials": "JH", "orcid": "0000-0002-1645-0036", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3553b69d2420463ca6a24d52696a7da7.json"}}, {"family": "Sarver", "given": "Aaron L", "initials": "AL"}, {"family": "Wang", "given": "Chao", "initials": "C"}, {"family": "Sakthikumar", "given": "Sharadha", "initials": "S", "orcid": "0000-0002-7746-8264", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38967e663cdc4351ae2c0c090ab8c39e.json"}}, {"family": "Johnson", "given": "Jeremy", "initials": "J"}, {"family": "Koltookian", "given": "Michele", "initials": "M"}, {"family": "Lewellen", "given": "Mitzi", "initials": "M"}, {"family": "Scott", "given": "Milcah C", "initials": "MC"}, {"family": "Schulte", "given": "Ashley J", "initials": "AJ"}, {"family": "Borst", "given": "Luke", "initials": "L"}, {"family": "Tonomura", "given": "Noriko", "initials": "N"}, {"family": "Alfoldi", "given": "Jessica", "initials": "J"}, {"family": "Painter", "given": "Corrie", "initials": "C"}, {"family": "Thomas", "given": "Rachael", "initials": "R", "orcid": "0000-0002-3029-8798", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d7613e07c9b242748a912e2ab73a5542.json"}}, {"family": "Karlsson", "given": "Elinor K", "initials": "EK", "orcid": "0000-0002-4343-3776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81b5c82fcb904394b6a6b1d811863fa0.json"}}, {"family": "Breen", "given": "Matthew", "initials": "M"}, {"family": "Modiano", "given": "Jaime F", "initials": "JF", "orcid": "0000-0001-6398-7648", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ba4bb579a21472dab716ebf61874801.json"}}, {"family": "Elvers", "given": "Ingegerd", "initials": "I"}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K"}], "type": "journal article", "published": "2019-12-00", "journal": {"title": "Mol. Cancer Res.", "issn": "1557-3125", "volume": "17", "issue": "12", "pages": "2410-2421", "issn-l": "1541-7786"}, "abstract": "Angiosarcoma is a highly aggressive cancer of blood vessel-forming cells with few effective treatment options and high patient mortality. It is both rare and heterogenous, making large, well-powered genomic studies nearly impossible. Dogs commonly suffer from a similar cancer, called hemangiosarcoma, with breeds like the golden retriever carrying heritable genetic factors that put them at high risk. If the clinical similarity of canine hemangiosarcoma and human angiosarcoma reflects shared genomic etiology, dogs could be a critically needed model for advancing angiosarcoma research. We assessed the genomic landscape of canine hemangiosarcoma via whole-exome sequencing (47 golden retriever hemangiosarcomas) and RNA sequencing (74 hemangiosarcomas from multiple breeds). Somatic coding mutations occurred most frequently in the tumor suppressor TP53 (59.6% of cases) as well as two genes in the PI3K pathway: the oncogene PIK3CA (29.8%) and its regulatory subunit PIK3R1 (8.5%). The predominant mutational signature was the age-associated deamination of cytosine to thymine. As reported in human angiosarcoma, CDKN2A/B was recurrently deleted and VEGFA, KDR, and KIT recurrently gained. We compared the canine data to human data recently released by The Angiosarcoma Project, and found many of the same genes and pathways significantly enriched for somatic mutations, particularly in breast and visceral angiosarcomas. Canine hemangiosarcoma closely models the genomic landscape of human angiosarcoma of the breast and viscera, and is a powerful tool for investigating the pathogenesis of this devastating disease. IMPLICATIONS: We characterize the genomic landscape of canine hemangiosarcoma and demonstrate its similarity to human angiosarcoma.", "doi": "10.1158/1541-7786.MCR-19-0221", "pmid": "31570656", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1540746"}, {"db": "pmc", "key": "PMC7067513"}, {"db": "pii", "key": "1541-7786.MCR-19-0221"}], "notes": [], "created": "2026-08-20T12:14:09.684Z", "modified": "2026-08-20T12:14:09.813Z"}]}