{"entity": "researcher", "timestamp": "2026-08-20T20:34:40.578Z", "family": "Mikus", "given": "Maria", "initials": "M", "orcid": "0000-0001-6560-6124", "affiliations": ["Department of Protein Science, Division of Affinity Proteomics, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.", "Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/3533be0098e74080929f666064fd2e36.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/3533be0098e74080929f666064fd2e36"}}, "publications": [{"entity": "publication", "iuid": "7e4053f029b242d5af643b6432faf330", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7e4053f029b242d5af643b6432faf330.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7e4053f029b242d5af643b6432faf330"}}, "title": "Protein profiles in plasma: Development from infancy to 5 years of age.", "authors": [{"family": "Mikus", "given": "Maria", "initials": "M", "orcid": "0000-0001-6560-6124", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3533be0098e74080929f666064fd2e36.json"}}, {"family": "J\u00e4rnbert-Pettersson", "given": "Hans", "initials": "H"}, {"family": "Johansson", "given": "Catharina", "initials": "C"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Scheynius", "given": "Annika", "initials": "A"}, {"family": "Alm", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Proteomics Clin Appl", "issn": "1862-8354", "volume": "15", "issue": "4", "pages": "e2000038", "issn-l": "1862-8346"}, "abstract": "Little is known about the longitudinal development of different plasma protein levels during early childhood and particularly in relation to lifestyle factors. This study aimed to monitor the plasma proteome early in life and the influence of different lifestyles.\n\nA multiplex bead-based immunoassay was used to analyze plasma levels of 97 proteins in 280 blood samples longitudinally collected in children at 6, 12, 24, and 60 months of age living in families with an anthroposophic (n = 15), partly anthroposophic (n = 27), or non-anthroposophic (n = 28) lifestyle.\n\nA total of 68 proteins (70%) showed significantly altered plasma levels between 6 months and 5 years of age. In lifestyle stratified analysis, 59 of 97 (61%) proteins were altered over time within one or more of the three lifestyle groups. Nearly half of these proteins (28 out of 59) changed irrespective of lifestyle. The temporal changes represented four longitudinal trends of the plasma proteins during development, also following stratification of lifestyle.\n\nOur findings contribute to understand the development of the plasma proteome under the influence of lifestyle exposures in early childhood.", "doi": "10.1002/prca.202000038", "pmid": "33830667", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T06:34:54.806Z", "modified": "2026-08-20T06:34:54.906Z"}, {"entity": "publication", "iuid": "34bf3c0afe2e4305a3f8d9218f0abcf8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/34bf3c0afe2e4305a3f8d9218f0abcf8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/34bf3c0afe2e4305a3f8d9218f0abcf8"}}, "title": "CSF levels of apolipoprotein C1 and autotaxin found to associate with neuropathic pain and fibromyalgia.", "authors": [{"family": "Lind", "given": "Anne-Li", "initials": "AL"}, {"family": "Just", "given": "David", "initials": "D", "orcid": "0000-0001-6126-2256", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e3f1c16b8fe749a981ed650e6bde34fb.json"}}, {"family": "Mikus", "given": "Maria", "initials": "M", "orcid": "0000-0001-6560-6124", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3533be0098e74080929f666064fd2e36.json"}}, {"family": "Fredolini", "given": "Claudia", "initials": "C"}, {"family": "Ioannou", "given": "Marina", "initials": "M"}, {"family": "Gerdle", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-4316-1264", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cebe9592fa354cfa8d3666bb8119ae86.json"}}, {"family": "Ghafouri", "given": "Bijar", "initials": "B", "orcid": "0000-0002-6396-5104", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bee0492d8f794cbbb385600788db02d8.json"}}, {"family": "B\u00e4ckryd", "given": "Emmanuel", "initials": "E"}, {"family": "Tanum", "given": "Lars", "initials": "L", "orcid": "0000-0003-4001-6325", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8931e0cef3ab45b9b76441149d694c10.json"}}, {"family": "Gordh", "given": "Torsten", "initials": "T"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}], "type": "journal article", "published": "2019-10-15", "journal": {"title": "J Pain Res", "issn": "1178-7090", "volume": "12", "pages": "2875-2889", "issn-l": null}, "abstract": "Neuropathic pain and fibromyalgia are two common and poorly understood chronic pain conditions that lack satisfactory treatments, cause substantial suffering and societal costs. Today, there are no biological markers on which to base chronic pain diagnoses, treatment choices or to understand the pathophysiology of pain for the individual patient. This study aimed to investigate cerebrospinal fluid (CSF) protein profiles potentially associated with fibromyalgia and neuropathic pain.\n\nCSF samples were collected from 25 patients with neuropathic pain (two independent sets, n=14 patients for discovery, and n=11 for verification), 40 patients with fibromyalgia and 134 controls without neurological disease from two different populations. CSF protein profiling of 55 proteins was performed using antibody suspension bead array technology.\n\nWe found increased levels of apolipoprotein C1 (APOC1) in CSF of neuropathic pain patients compared to controls and there was a trend for increased levels also in fibromyalgia patients. In addition, levels of ectonucleotide pyrophosphatase family member 2 (ENPP2, also referred to as autotaxin) were increased in the CSF of fibromyalgia patients compared to all other groups including patients with neuropathic pain.\n\nThe increased levels of APOC1 and ENPP2 found in neuropathic pain and fibromyalgia patients may shed light on the underlying mechanisms of these conditions. Further investigation is required to elucidate their role in maintaining pain and other main symptoms of these disorders.", "doi": "10.2147/JPR.S215348", "pmid": "31686904", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6800548"}, {"db": "pii", "key": "215348"}], "notes": [], "created": "2026-08-20T13:02:20.087Z", "modified": "2026-08-20T13:02:20.290Z"}]}