{"entity": "researcher", "timestamp": "2026-08-20T21:12:14.178Z", "family": "Pietzner", "given": "Maik", "initials": "M", "orcid": "0000-0003-3437-9963", "affiliations": ["MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK.", "Computational Medicine, Berlin Institute of Health at Charit\u00e9-Universit\u00e4tsmedizin Berlin, 10117, Berlin, Germany.", "Precision Healthcare University Research Institute, Queen Mary University of London, London, UK."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/3304844cece945168cbec0b5e3d9a9cf.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/3304844cece945168cbec0b5e3d9a9cf"}}, "publications": [{"entity": "publication", "iuid": "88d46598d38049e49334326bc3a3c0bc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/88d46598d38049e49334326bc3a3c0bc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/88d46598d38049e49334326bc3a3c0bc"}}, "title": "Author Correction: Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.", "authors": [{"family": "Iglesias", "given": "Maria Jesus", "initials": "MJ"}, {"family": "Sanchez-Rivera", "given": "Laura", "initials": "L"}, {"family": "Ibrahim-Kosta", "given": "Manal", "initials": "M"}, {"family": "Naudin", "given": "Cl\u00e9ment", "initials": "C", "orcid": "0000-0002-6777-9587", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f89e25cd7fcc4617ab5299c72fd17e0c.json"}}, {"family": "Munsch", "given": "Ga\u00eblle", "initials": "G", "orcid": "0000-0003-1564-9825", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed62bf6aa35643f283511d68d2aa4b01.json"}}, {"family": "Goumidi", "given": "Louisa", "initials": "L", "orcid": "0000-0003-4164-8471", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7d3df066e5e54e32bb99110289ab8a45.json"}}, {"family": "Farm", "given": "Maria", "initials": "M"}, {"family": "Smith", "given": "Philip M", "initials": "PM"}, {"family": "Thibord", "given": "Florian", "initials": "F"}, {"family": "Kral-Pointner", "given": "Julia Barbara", "initials": "JB"}, {"family": "Hong", "given": "Mun-Gwan", "initials": "MG", "orcid": "0000-0001-8603-8293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d12504acae5c4f31b83f75c3d7786cd4.json"}}, {"family": "Suchon", "given": "Pierre", "initials": "P"}, {"family": "Germain", "given": "Marine", "initials": "M"}, {"family": "Schrottmaier", "given": "Waltraud", "initials": "W", "orcid": "0000-0003-0550-4120", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ab65a615b9e477aa6206677e57025b0.json"}}, {"family": "Dusart", "given": "Philip", "initials": "P", "orcid": "0000-0003-2747-3214", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26cf50c230954da190746c16b5ac2b7d.json"}}, {"family": "Boland", "given": "Anne", "initials": "A"}, {"family": "Kotol", "given": "David", "initials": "D", "orcid": "0000-0002-5388-3826", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c41f8f491c474e6bba2047b5d04b4af5.json"}}, {"family": "Edfors", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-0017-7987", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e213b04f8984c8eb00c68f5bc2f6a36.json"}}, {"family": "Koprulu", "given": "Mine", "initials": "M", "orcid": "0000-0001-6870-4539", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8fa2ddd2cfa4bbeb9c0b043513a6701.json"}}, {"family": "Pietzner", "given": "Maik", "initials": "M", "orcid": "0000-0003-3437-9963", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3304844cece945168cbec0b5e3d9a9cf.json"}}, {"family": "Langenberg", "given": "Claudia", "initials": "C", "orcid": "0000-0002-5017-7344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f287f3248cc24c6cbfc100c249b87418.json"}}, {"family": "Damrauer", "given": "Scott M", "initials": "SM", "orcid": "0000-0001-8009-1632", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f35b78d4384d41f2bfae2639b23b1e82.json"}}, {"family": "Johnson", "given": "Andrew D", "initials": "AD", "orcid": "0000-0001-6369-5178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b268f8da3f247ba90dc37ea73d93c2f.json"}}, {"family": "Klarin", "given": "Derek M", "initials": "DM", "orcid": "0000-0002-4636-5780", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0b81fbf037ec4b4b8ac0013544539f00.json"}}, {"family": "Smith", "given": "Nicholas L", "initials": "NL"}, {"family": "Smadja", "given": "David M", "initials": "DM"}, {"family": "Holmstr\u00f6m", "given": "Margareta", "initials": "M"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Silveira", "given": "Angela", "initials": "A", "orcid": "0000-0003-2063-4935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d8cbafcc7f04ac3adda984af7d85a16.json"}}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Renn\u00e9", "given": "Thomas", "initials": "T"}, {"family": "Martinez-Perez", "given": "Angel", "initials": "A", "orcid": "0000-0002-5934-1454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0fa8f32fb99f46dcb16d3a64643dbbfa.json"}}, {"family": "Emmerich", "given": "Joseph", "initials": "J"}, {"family": "Deleuze", "given": "Jean-Francois", "initials": "JF", "orcid": "0000-0002-5358-4463", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/33bb50dc6b8045bd9dbbde4423f66129.json"}}, {"family": "Antovic", "given": "Jovan", "initials": "J"}, {"family": "Soria Fernandez", "given": "Jose Manuel", "initials": "JM"}, {"family": "Assinger", "given": "Alice", "initials": "A", "orcid": "0000-0002-5670-5910", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ccb6bb03693c4c799f4cbb53e6ff7049.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Souto Andres", "given": "Joan Carles", "initials": "JC", "orcid": "0000-0003-2092-5142", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/164af41db2204f2591c719a8b024d32a.json"}}, {"family": "Morange", "given": "Pierre-Emmanuel", "initials": "PE", "orcid": "0000-0002-9065-722X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/50bca11c313740c299901843e86e5d48.json"}}, {"family": "Butler", "given": "Lynn Marie", "initials": "LM", "orcid": "0000-0002-2352-8217", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca98647aea15499485d755977bd0869a.json"}}, {"family": "Tr\u00e9gou\u00ebt", "given": "David-Alexandre", "initials": "DA", "orcid": "0000-0001-9084-7800", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/74ca463a0d804b1ab97dac4750563220.json"}}, {"family": "Odeberg", "given": "Jacob", "initials": "J", "orcid": "0000-0003-0996-1644", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6abb3fc822a4cacbf1d45224f2442f5.json"}}], "type": "published erratum", "published": "2023-11-27", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "7752", "issn-l": "2041-1723"}, "abstract": null, "doi": "10.1038/s41467-023-43764-4", "pmid": "38012230", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10682365"}, {"db": "pii", "key": "10.1038/s41467-023-43764-4"}], "notes": [], "created": "2026-08-20T08:53:02.011Z", "modified": "2026-08-20T08:53:02.187Z"}, {"entity": "publication", "iuid": "3eab6f40adba4a1eaa807ee583bf2a28", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3eab6f40adba4a1eaa807ee583bf2a28.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3eab6f40adba4a1eaa807ee583bf2a28"}}, "title": "Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.", "authors": [{"family": "Iglesias", "given": "Maria Jesus", "initials": "MJ"}, {"family": "Sanchez-Rivera", "given": "Laura", "initials": "L"}, {"family": "Ibrahim-Kosta", "given": "Manal", "initials": "M"}, {"family": "Naudin", "given": "Cl\u00e9ment", "initials": "C", "orcid": "0000-0002-6777-9587", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f89e25cd7fcc4617ab5299c72fd17e0c.json"}}, {"family": "Munsch", "given": "Ga\u00eblle", "initials": "G", "orcid": "0000-0003-1564-9825", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed62bf6aa35643f283511d68d2aa4b01.json"}}, {"family": "Goumidi", "given": "Louisa", "initials": "L", "orcid": "0000-0003-4164-8471", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7d3df066e5e54e32bb99110289ab8a45.json"}}, {"family": "Farm", "given": "Maria", "initials": "M"}, {"family": "Smith", "given": "Philip M", "initials": "PM"}, {"family": "Thibord", "given": "Florian", "initials": "F"}, {"family": "Kral-Pointner", "given": "Julia Barbara", "initials": "JB"}, {"family": "Hong", "given": "Mun-Gwan", "initials": "MG", "orcid": "0000-0001-8603-8293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d12504acae5c4f31b83f75c3d7786cd4.json"}}, {"family": "Suchon", "given": "Pierre", "initials": "P"}, {"family": "Germain", "given": "Marine", "initials": "M"}, {"family": "Schrottmaier", "given": "Waltraud", "initials": "W", "orcid": "0000-0003-0550-4120", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ab65a615b9e477aa6206677e57025b0.json"}}, {"family": "Dusart", "given": "Philip", "initials": "P", "orcid": "0000-0003-2747-3214", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26cf50c230954da190746c16b5ac2b7d.json"}}, {"family": "Boland", "given": "Anne", "initials": "A"}, {"family": "Kotol", "given": "David", "initials": "D", "orcid": "0000-0002-5388-3826", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c41f8f491c474e6bba2047b5d04b4af5.json"}}, {"family": "Edfors", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-0017-7987", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e213b04f8984c8eb00c68f5bc2f6a36.json"}}, {"family": "Koprulu", "given": "Mine", "initials": "M", "orcid": "0000-0001-6870-4539", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8fa2ddd2cfa4bbeb9c0b043513a6701.json"}}, {"family": "Pietzner", "given": "Maik", "initials": "M", "orcid": "0000-0003-3437-9963", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3304844cece945168cbec0b5e3d9a9cf.json"}}, {"family": "Langenberg", "given": "Claudia", "initials": "C", "orcid": "0000-0002-5017-7344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f287f3248cc24c6cbfc100c249b87418.json"}}, {"family": "Damrauer", "given": "Scott M", "initials": "SM", "orcid": "0000-0001-8009-1632", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f35b78d4384d41f2bfae2639b23b1e82.json"}}, {"family": "Johnson", "given": "Andrew D", "initials": "AD", "orcid": "0000-0001-6369-5178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b268f8da3f247ba90dc37ea73d93c2f.json"}}, {"family": "Klarin", "given": "Derek M", "initials": "DM", "orcid": "0000-0002-4636-5780", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0b81fbf037ec4b4b8ac0013544539f00.json"}}, {"family": "Smith", "given": "Nicholas L", "initials": "NL"}, {"family": "Smadja", "given": "David M", "initials": "DM"}, {"family": "Holmstr\u00f6m", "given": "Margareta", "initials": "M"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Silveira", "given": "Angela", "initials": "A", "orcid": "0000-0003-2063-4935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d8cbafcc7f04ac3adda984af7d85a16.json"}}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Renn\u00e9", "given": "Thomas", "initials": "T"}, {"family": "Martinez-Perez", "given": "Angel", "initials": "A", "orcid": "0000-0002-5934-1454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0fa8f32fb99f46dcb16d3a64643dbbfa.json"}}, {"family": "Emmerich", "given": "Joseph", "initials": "J"}, {"family": "Deleuze", "given": "Jean-Francois", "initials": "JF", "orcid": "0000-0002-5358-4463", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/33bb50dc6b8045bd9dbbde4423f66129.json"}}, {"family": "Antovic", "given": "Jovan", "initials": "J"}, {"family": "Soria Fernandez", "given": "Jose Manuel", "initials": "JM"}, {"family": "Assinger", "given": "Alice", "initials": "A", "orcid": "0000-0002-5670-5910", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ccb6bb03693c4c799f4cbb53e6ff7049.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Souto Andres", "given": "Joan Carles", "initials": "JC", "orcid": "0000-0003-2092-5142", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/164af41db2204f2591c719a8b024d32a.json"}}, {"family": "Morange", "given": "Pierre-Emmanuel", "initials": "PE", "orcid": "0000-0002-9065-722X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/50bca11c313740c299901843e86e5d48.json"}}, {"family": "Butler", "given": "Lynn Marie", "initials": "LM", "orcid": "0000-0002-2352-8217", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca98647aea15499485d755977bd0869a.json"}}, {"family": "Tr\u00e9gou\u00ebt", "given": "David-Alexandre", "initials": "DA", "orcid": "0000-0001-9084-7800", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/74ca463a0d804b1ab97dac4750563220.json"}}, {"family": "Odeberg", "given": "Jacob", "initials": "J", "orcid": "0000-0003-0996-1644", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6abb3fc822a4cacbf1d45224f2442f5.json"}}], "type": "journal article", "published": "2023-06-07", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "3280", "issn-l": "2041-1723"}, "abstract": "Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there is a need for improved plasma biomarker-based tools for VTE diagnosis and risk prediction. Here we show, using proteomics profiling to screen plasma from patients with suspected acute VTE, and several case-control studies for VTE, how Complement Factor H Related 5 protein (CFHR5), a regulator of the alternative pathway of complement activation, is a VTE-associated plasma biomarker. In plasma, higher CFHR5 levels are associated with increased thrombin generation potential and recombinant CFHR5 enhanced platelet activation in vitro. GWAS analysis of ~52,000 participants identifies six loci associated with CFHR5 plasma levels, but Mendelian randomization do not demonstrate causality between CFHR5 and VTE. Our results indicate an important role for the regulation of the alternative pathway of complement activation in VTE and that CFHR5 represents a potential diagnostic and/or risk predictive plasma biomarker.", "doi": "10.1038/s41467-023-38383-y", "pmid": "37286573", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10247781"}, {"db": "pii", "key": "10.1038/s41467-023-38383-y"}], "notes": [], "created": "2026-08-20T08:52:37.351Z", "modified": "2026-08-20T08:52:38.261Z"}, {"entity": "publication", "iuid": "9b584b66544649dfae4781915c418be4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9b584b66544649dfae4781915c418be4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9b584b66544649dfae4781915c418be4"}}, "title": "An atlas of genetic scores to predict multi-omic traits.", "authors": [{"family": "Xu", "given": "Yu", "initials": "Y", "orcid": "0000-0002-7304-5045", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ac4920de9564d809602c26f92e4aeca.json"}}, {"family": "Ritchie", "given": "Scott C", "initials": "SC", "orcid": "0000-0002-8454-9548", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36a4d823852c4bae97ddc68a05030b72.json"}}, {"family": "Liang", "given": "Yujian", "initials": "Y"}, {"family": "Timmers", "given": "Paul R H J", "initials": "PRHJ", "orcid": "0000-0002-5197-1267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1a7fb58cb2f4bd1b48f23be33de0c6e.json"}}, {"family": "Pietzner", "given": "Maik", "initials": "M", "orcid": "0000-0003-3437-9963", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3304844cece945168cbec0b5e3d9a9cf.json"}}, {"family": "Lannelongue", "given": "Lo\u00efc", "initials": "L", "orcid": "0000-0002-9135-1345", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d2fdb81bd8c4b93af2d061f6421540f.json"}}, {"family": "Lambert", "given": "Samuel A", "initials": "SA", "orcid": "0000-0001-8222-008X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/23811479ba0a41a99a94f9c0d3f06bd4.json"}}, {"family": "Tahir", "given": "Usman A", "initials": "UA"}, {"family": "May-Wilson", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-2668-5717", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d39731ddad649e88c6958a9fc03008b.json"}}, {"family": "Foguet", "given": "Carles", "initials": "C", "orcid": "0000-0001-8494-9595", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c41865149ac74c4695959ced5ce4ec9f.json"}}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0002-2915-4498", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0bac3e1e64949fcbac4b4d839e1144d.json"}}, {"family": "Surendran", "given": "Praveen", "initials": "P"}, {"family": "Nath", "given": "Artika P", "initials": "AP"}, {"family": "Persyn", "given": "Elodie", "initials": "E", "orcid": "0000-0001-9104-1972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d882b5f4416425ab28deb0a35d905ef.json"}}, {"family": "Peters", "given": "James E", "initials": "JE", "orcid": "0000-0002-9415-3440", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cdf78018d1448498239609190aade2d.json"}}, {"family": "Oliver-Williams", "given": "Clare", "initials": "C"}, {"family": "Deng", "given": "Shuliang", "initials": "S"}, {"family": "Prins", "given": "Bram", "initials": "B", "orcid": "0000-0001-5774-034X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2677fba12f9549b193a0498b539cd793.json"}}, {"family": "Luan", "given": "Jian'an", "initials": "J", "orcid": "0000-0003-3137-6337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f2180f4f03be411ba2c80c18a78e6645.json"}}, {"family": "Bomba", "given": "Lorenzo", "initials": "L"}, {"family": "Soranzo", "given": "Nicole", "initials": "N", "orcid": "0000-0003-1095-3852", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/751b4656807c42f9a668ebb98e8da987.json"}}, {"family": "Di Angelantonio", "given": "Emanuele", "initials": "E"}, {"family": "Pirastu", "given": "Nicola", "initials": "N"}, {"family": "Tai", "given": "E Shyong", "initials": "ES", "orcid": "0000-0003-2929-8966", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d116286b0f524b6d835ef78c4f1dfd14.json"}}, {"family": "van Dam", "given": "Rob M", "initials": "RM"}, {"family": "Parkinson", "given": "Helen", "initials": "H"}, {"family": "Davenport", "given": "Emma E", "initials": "EE"}, {"family": "Paul", "given": "Dirk S", "initials": "DS", "orcid": "0000-0002-8230-0116", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2169975c0a46456c9f29a2b7b3da0b30.json"}}, {"family": "Yau", "given": "Christopher", "initials": "C", "orcid": "0000-0001-7615-8523", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bbc82d06ec19459d99e5809ddbf36145.json"}}, {"family": "Gerszten", "given": "Robert E", "initials": "RE", "orcid": "0000-0002-6767-7687", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ddb55dc5a54401d8d958fac1c46e8b8.json"}}, {"family": "M\u00e4larstig", "given": "Anders", "initials": "A", "orcid": "0000-0003-2608-1358", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32b012456e6f490e99b12f5fb1216ce8.json"}}, {"family": "Danesh", "given": "John", "initials": "J"}, {"family": "Sim", "given": "Xueling", "initials": "X", "orcid": "0000-0002-1233-7642", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b9aec75e482049f5b169a9cfc517a351.json"}}, {"family": "Langenberg", "given": "Claudia", "initials": "C", "orcid": "0000-0002-5017-7344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f287f3248cc24c6cbfc100c249b87418.json"}}, {"family": "Wilson", "given": "James F", "initials": "JF", "orcid": "0000-0001-5751-9178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513b6983cc9d478ab9d81c2f21579961.json"}}, {"family": "Butterworth", "given": "Adam S", "initials": "AS", "orcid": "0000-0002-6915-9015", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88842023860148bb8d155b5c18db72a8.json"}}, {"family": "Inouye", "given": "Michael", "initials": "M", "orcid": "0000-0001-9413-6520", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d1abe69d2ee548b9b754ebcd5eeabac7.json"}}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "616", "issue": "7955", "pages": "123-131", "issn-l": "0028-0836"}, "abstract": "The use of omic modalities to dissect the molecular underpinnings of common diseases and traits is becoming increasingly common. But multi-omic traits can be genetically predicted, which enables highly cost-effective and powerful analyses for studies that do not have multi-omics1. Here we examine a large cohort (the INTERVAL study2; n = 50,000 participants) with extensive multi-omic data for plasma proteomics (SomaScan, n = 3,175; Olink, n = 4,822), plasma metabolomics (Metabolon HD4, n = 8,153), serum metabolomics (Nightingale, n = 37,359) and whole-blood Illumina RNA sequencing (n = 4,136), and use machine learning to train genetic scores for 17,227 molecular traits, including 10,521 that reach Bonferroni-adjusted significance. We evaluate the performance of genetic scores through external validation across cohorts of individuals of European, Asian and African American ancestries. In addition, we show the utility of these multi-omic genetic scores by quantifying the genetic control of biological pathways and by generating a synthetic multi-omic dataset of the UK Biobank3 to identify disease associations using a phenome-wide scan. We highlight a series of biological insights with regard to genetic mechanisms in metabolism and canonical pathway associations with disease; for example, JAK-STAT signalling and coronary atherosclerosis. Finally, we develop a portal ( https://www.omicspred.org/ ) to facilitate public access to all genetic scores and validation results, as well as to serve as a platform for future extensions and enhancements of multi-omic genetic scores.", "doi": "10.1038/s41586-023-05844-9", "pmid": "36991119", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1905816"}, {"db": "pmc", "key": "PMC10323211"}, {"db": "pii", "key": "10.1038/s41586-023-05844-9"}], "notes": [], "created": "2026-08-20T08:58:33.726Z", "modified": "2026-08-20T08:58:34.418Z"}]}