{"entity": "researcher", "timestamp": "2026-09-30T05:51:09.773Z", "family": "Di Bartolomeo", "given": "Francesca", "initials": "F", "orcid": "0000-0002-4302-0701", "affiliations": ["Department of Biology and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden.", "Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden.", "Department of Biotechnology and Nanomedicine, SINTEF Industry, 7465 Trondheim, Norway."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/30a08ee555334514b6c92052491a7d63.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/30a08ee555334514b6c92052491a7d63"}}, "publications": [{"entity": "publication", "iuid": "4e4f6d1900824d3baef49bc050fca5ac", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4e4f6d1900824d3baef49bc050fca5ac.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4e4f6d1900824d3baef49bc050fca5ac"}}, "title": "Building blocks are synthesized on demand during the yeast cell cycle.", "authors": [{"family": "Campbell", "given": "Kate", "initials": "K", "orcid": "0000-0002-4173-5260", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/25bc3f03899e405a8c6282dcb997d8cc.json"}}, {"family": "Westholm", "given": "Jakub", "initials": "J", "orcid": "0000-0002-6849-6220", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/966341b184974f0f81c34e36cadd74e0.json"}}, {"family": "Kasvandik", "given": "Sergo", "initials": "S", "orcid": "0000-0003-0218-2410", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/084408ba7c3b452db2ba58375388b044.json"}}, {"family": "Di Bartolomeo", "given": "Francesca", "initials": "F", "orcid": "0000-0002-4302-0701", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/30a08ee555334514b6c92052491a7d63.json"}}, {"family": "Mormino", "given": "Maurizio", "initials": "M", "orcid": "0000-0003-2055-5081", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d2a66fdf838481bb276f6a04bb6216e.json"}}, {"family": "Nielsen", "given": "Jens", "initials": "J", "orcid": "0000-0002-9955-6003", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/33f2b49a39ed4e54ba77dfe397ed3087.json"}}], "type": "journal article", "published": "2020-04-07", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "117", "issue": "14", "pages": "7575-7583", "issn-l": "0027-8424"}, "abstract": "For cells to replicate, a sufficient supply of biosynthetic precursors is needed, necessitating the concerted action of metabolism and protein synthesis during progressive phases of cell division. A global understanding of which biosynthetic processes are involved and how they are temporally regulated during replication is, however, currently lacking. Here, quantitative multiomics analysis is used to generate a holistic view of the eukaryal cell cycle, using the budding yeast Saccharomyces cerevisiae Protein synthesis and central carbon pathways such as glycolysis and amino acid metabolism are shown to synchronize their respective abundance profiles with division, with pathway-specific changes in metabolite abundance also being reflected by a relative increase in mitochondrial volume, as shown by quantitative fluorescence microscopy. These results show biosynthetic precursor production to be temporally regulated to meet phase-specific demands of eukaryal cell division.", "doi": "10.1073/pnas.1919535117", "pmid": "32213592", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7149230"}, {"db": "pii", "key": "1919535117"}], "notes": [], "created": "2026-09-23T08:43:18.070Z", "modified": "2026-09-23T08:43:18.335Z"}]}