{"entity": "researcher", "timestamp": "2026-09-30T04:27:09.844Z", "family": "Normark", "given": "Staffan", "initials": "S", "orcid": "0000-0001-7917-3921", "affiliations": ["Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-17177 Stockholm, Sweden; staffan.normark@ki.se birgitta.henriques@ki.se.", "Lee Kong Chian School of Medicine and Singapore Centre on Environmental Life Sciences Engineering, Nanyang Technological University, Singapore 639798, Singapore."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/30a03a285f3b4e7d8f8d8326f7ec6455.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/30a03a285f3b4e7d8f8d8326f7ec6455"}}, "publications": [{"entity": "publication", "iuid": "43b90d82d62b499c8850d584450ca96a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/43b90d82d62b499c8850d584450ca96a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/43b90d82d62b499c8850d584450ca96a"}}, "title": "Capillary leakage provides nutrients and antioxidants for rapid pneumococcal proliferation in influenza-infected lower airways.", "authors": [{"family": "Sender", "given": "Vicky", "initials": "V", "orcid": "0000-0003-2174-946X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/504a59cfdc6e4d0ca06637cad238ebf6.json"}}, {"family": "Hentrich", "given": "Karina", "initials": "K", "orcid": "0000-0001-6660-7233", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/190bfde694054d50a3e638fb1179c46f.json"}}, {"family": "Pathak", "given": "Anuj", "initials": "A"}, {"family": "Tan Qian Ler", "given": "Alicia", "initials": "A", "orcid": "0000-0001-9298-4008", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ff7ffaa5c004717bf09fe3db393b24c.json"}}, {"family": "Embaie", "given": "Bethel Tesfai", "initials": "BT", "orcid": "0000-0002-7081-5032", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ff9366370702439898a8a955f822c637.json"}}, {"family": "Lundstr\u00f6m", "given": "Susanna L", "initials": "SL"}, {"family": "Gaetani", "given": "Massimiliano", "initials": "M", "orcid": "0000-0001-5610-0797", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a402c63fbe4f478daa286177f031b923.json"}}, {"family": "Bergstrand", "given": "Jan", "initials": "J"}, {"family": "Nakamoto", "given": "Rei", "initials": "R", "orcid": "0000-0001-7807-6548", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa3feef34c8849c59b9b01618a126397.json"}}, {"family": "Sham", "given": "Lok-To", "initials": "LT"}, {"family": "Widengren", "given": "Jerker", "initials": "J"}, {"family": "Normark", "given": "Staffan", "initials": "S", "orcid": "0000-0001-7917-3921", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/30a03a285f3b4e7d8f8d8326f7ec6455.json"}}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}], "type": "journal article", "published": "2020-12-08", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "117", "issue": "49", "pages": "31386-31397", "issn-l": "0027-8424"}, "abstract": "Influenza A virus (IAV)-related mortality is often due to secondary bacterial infections, primarily by pneumococci. Here, we study how IAV-modulated changes in the lungs affect bacterial replication in the lower respiratory tract (LRT). Bronchoalveolar lavages (BALs) from coinfected mice showed rapid bacterial proliferation 4 to 6 h after pneumococcal challenge. Metabolomic and quantitative proteomic analyses demonstrated capillary leakage with efflux of nutrients and antioxidants into the alveolar space. Pneumococcal adaptation to IAV-induced inflammation and redox imbalance increased the expression of the pneumococcal chaperone/protease HtrA. Presence of HtrA resulted in bacterial growth advantage in the IAV-infected LRT and protection from complement-mediated opsonophagocytosis due to capsular production. Absence of HtrA led to growth arrest in vitro that was partially restored by antioxidants. Pneumococcal ability to grow in the IAV-infected LRT depends on the nutrient-rich milieu with increased levels of antioxidants such as ascorbic acid and its ability to adapt to and cope with oxidative damage and immune clearance.", "doi": "10.1073/pnas.2012265117", "pmid": "33229573", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7733805"}, {"db": "pii", "key": "2012265117"}], "notes": [], "created": "2026-09-23T09:44:34.693Z", "modified": "2026-09-23T10:18:50.742Z"}]}