{"entity": "researcher", "timestamp": "2026-08-22T06:59:01.079Z", "family": "Da Silva Rodrigues", "given": "Rui", "initials": "R", "orcid": "0000-0001-7620-872X", "affiliations": ["Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ede811078d34b62a29e07a448354dbf.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ede811078d34b62a29e07a448354dbf"}}, "publications": [{"entity": "publication", "iuid": "5c8a0b9d88f4418893d7e9be0824cefc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5c8a0b9d88f4418893d7e9be0824cefc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5c8a0b9d88f4418893d7e9be0824cefc"}}, "title": "SARS-CoV-2 (COVID-19)-specific T cell and B cell responses in convalescent rheumatoid arthritis: Monozygotic twins pair case observation.", "authors": [{"family": "Arruda", "given": "Lucas C M", "initials": "LCM", "orcid": "0000-0002-8573-9618", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/84d25ce6da6a4b21a4f147c6192386cd.json"}}, {"family": "Gaballa", "given": "Ahmed", "initials": "A"}, {"family": "Da Silva Rodrigues", "given": "Rui", "initials": "R", "orcid": "0000-0001-7620-872X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ede811078d34b62a29e07a448354dbf.json"}}, {"family": "Makower", "given": "Bartek", "initials": "B"}, {"family": "Uhlin", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "Scand. J. Immunol.", "issn": "1365-3083", "volume": "95", "issue": "5", "pages": "e13151", "issn-l": "0300-9475"}, "abstract": "Rheumatoid arthritis (RA) patients present higher risk of SARS-CoV-2 infection (COVID-19), and proper management of the disease in this population requires a better understanding of how the immune system controls the virus. We analyzed the T cell and B cell phenotypes, and their repertoire in a pair of monozygotic twins with RA mismatched for COVID-19 infection. Twin- was not infected, while Twin+ was infected and effectively controlled the infection. We found no significant changes on the \u03b1\u03b2 T cell composition, while \u03b3\u03b4 T cells and B cells presented considerable expansion of memory population in Twin+ and robust T/B cell responses to several SARS-CoV-2 peptides. T cell receptor \u03b2/\u03b3-chain and immunoglobulin heavy chain next-generation sequencing depicted a remarkable higher diversity in Twin+ compared with Twin-, despite no significant changes being found in variable/joining family usage. Repertoire overlap analyses showed that, although being identical twins, very few clones were shared between them, indicating that COVID-19 may lead to deep changes on the immune cell repertoire in RA patients. Altogether, our results indicate that RA patients may develop robust and persistent COVID-19-specific T/B cell responses; \u03b3\u03b4 T cells and B cells may play a key role in the management of COVID-19 in RA, and the infection may lead to a profound reshaping of immune cell receptor specificities.", "doi": "10.1111/sji.13151", "pmid": "35212005", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9115348"}], "notes": [], "created": "2026-08-21T12:21:41.863Z", "modified": "2026-08-21T12:21:41.977Z"}]}