{"entity": "researcher", "timestamp": "2026-09-06T14:37:54.624Z", "family": "Rinaldi-Ramos", "given": "Carlos M", "initials": "CM", "orcid": "0000-0001-8886-5612", "affiliations": ["Department of Chemical Engineering and J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611-6005, United States."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/2eb3a842a75142b3aa59ccd88c939017.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/2eb3a842a75142b3aa59ccd88c939017"}}, "publications": [{"entity": "publication", "iuid": "47077ceb46b741478e2c89dca34d3270", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/47077ceb46b741478e2c89dca34d3270.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/47077ceb46b741478e2c89dca34d3270"}}, "title": "Flame-Made Doped Iron Oxide Nanoparticles as Tracers for Magnetic Particle Imaging.", "authors": [{"family": "Ansari", "given": "Shaquib Rahman", "initials": "SR", "orcid": "0000-0003-3710-405X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d50cab7c722144d185a212d83600d80b.json"}}, {"family": "Imhoff", "given": "Eric Daniel", "initials": "ED"}, {"family": "Su\u00e1rez-L\u00f3pez", "given": "Yael Del Carmen", "initials": "YDC"}, {"family": "Melnyk", "given": "Andrii", "initials": "A", "orcid": "0000-0001-5823-5791", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0d15893ae2e44183af0fa46426896ea9.json"}}, {"family": "Rinaldi-Ramos", "given": "Carlos M", "initials": "CM", "orcid": "0000-0001-8886-5612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2eb3a842a75142b3aa59ccd88c939017.json"}}, {"family": "Teleki", "given": "Alexandra", "initials": "A", "orcid": "0000-0001-6514-8960", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fe98cb60a304a5aa33e24401fcd8af6.json"}}], "type": "journal article", "published": "2025-06-10", "journal": {"title": "Chem Mater", "issn": "0897-4756", "volume": "37", "issue": "11", "pages": "4071-4084", "issn-l": null}, "abstract": "Magnetic particle imaging (MPI) is an emerging imaging modality that shows potential in tumor imaging, cell tracking, and angiography. It uses the signal generated from superparamagnetic iron oxide nanoparticles (SPIONs) with zero attenuation in tissue, showing excellent sensitivity and contrast. MPI resolution and sensitivity are dependent on the nonlinear dynamic magnetization of the SPION tracer and can be improved by tuning their magnetic properties. Doping SPIONs with manganese or zinc is an effective and biocompatible route to modify the magnetic properties of SPIONs. This study developed SPIONs doped with manganese or zinc as MPI tracers using flame spray pyrolysis (FSP), a highly scalable synthesis technique. The MPI performance was evaluated with a MOMENTUM imager. Postsynthesis citrate coating and filtration significantly enhanced the MPI resolution of SPIONs. The Zn-doped SPIONs exhibited the best resolution, while Mn-doped SPIONs showed the highest sensitivity. The overall MPI performance of all tracers was closely linked to their magnetic diameter and susceptibility, but deviated noticeably from the predictions of the Langevin model. Zn-doped SPIONs were encapsulated in a water-dispersible nanocarrier using flash nanoprecipitation (FNP), circumventing the need for citrate coating while preserving MPI performance. These findings show that the hydrodynamic size, size distribution, and composition of the SPIONs are critical to MPI performance and highlight the potential of combining FSP and FNP for large-scale production of the MPI tracers.", "doi": "10.1021/acs.chemmater.5c00331", "pmid": "40520624", "labels": {"Alexandra Teleki": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC12159977"}], "notes": [], "created": "2025-11-27T18:51:56.823Z", "modified": "2025-11-27T18:51:56.875Z"}, {"entity": "publication", "iuid": "c3a0bbcce9fb43ac8fafed5624285280", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c3a0bbcce9fb43ac8fafed5624285280.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c3a0bbcce9fb43ac8fafed5624285280"}}, "title": "Pharmaceutical Quality by Design Approach to Develop High-Performance Nanoparticles for Magnetic Hyperthermia.", "authors": [{"family": "Ansari", "given": "Shaquib Rahman", "initials": "SR", "orcid": "0000-0003-3710-405X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d50cab7c722144d185a212d83600d80b.json"}}, {"family": "Su\u00e1rez-L\u00f3pez", "given": "Yael Del Carmen", "initials": "YDC"}, {"family": "Thersleff", "given": "Thomas", "initials": "T"}, {"family": "H\u00e4ggstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Ericsson", "given": "Tore", "initials": "T"}, {"family": "Katsaros", "given": "Ioannis", "initials": "I"}, {"family": "\u00c5hl\u00e9n", "given": "Michelle", "initials": "M"}, {"family": "Karlgren", "given": "Maria", "initials": "M"}, {"family": "Svedlindh", "given": "Peter", "initials": "P", "orcid": "0000-0002-3049-6831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b0341fe5a8e2404f89e556908fdeca81.json"}}, {"family": "Rinaldi-Ramos", "given": "Carlos M", "initials": "CM", "orcid": "0000-0001-8886-5612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2eb3a842a75142b3aa59ccd88c939017.json"}}, {"family": "Teleki", "given": "Alexandra", "initials": "A", "orcid": "0000-0001-6514-8960", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fe98cb60a304a5aa33e24401fcd8af6.json"}}], "type": "journal article", "published": "2024-06-11", "journal": {"title": "ACS Nano", "issn": "1936-086X", "volume": "18", "issue": "23", "pages": "15284-15302", "issn-l": "1936-0851"}, "abstract": "Magnetic hyperthermia holds significant therapeutic potential, yet its clinical adoption faces challenges. One obstacle is the large-scale synthesis of high-quality superparamagnetic iron oxide nanoparticles (SPIONs) required for inducing hyperthermia. Robust and scalable manufacturing would ensure control over the key quality attributes of SPIONs, and facilitate clinical translation and regulatory approval. Therefore, we implemented a risk-based pharmaceutical quality by design (QbD) approach for SPION production using flame spray pyrolysis (FSP), a scalable technique with excellent batch-to-batch consistency. A design of experiments method enabled precise size control during manufacturing. Subsequent modeling linked the SPION size (6-30 nm) and composition to intrinsic loss power (ILP), a measure of hyperthermia performance. FSP successfully fine-tuned the SPION composition with dopants (Zn, Mn, Mg), at various concentrations. Hyperthermia performance showed a strong nonlinear relationship with SPION size and composition. Moreover, the ILP demonstrated a stronger correlation to coercivity and remanence than to the saturation magnetization of SPIONs. The optimal operating space identified the midsized (15-18 nm) Mn0.25Fe2.75O4 as the most promising nanoparticle for hyperthermia. The production of these nanoparticles on a pilot scale showed the feasibility of large-scale manufacturing, and cytotoxicity investigations in multiple cell lines confirmed their biocompatibility. In vitro hyperthermia studies with Caco-2 cells revealed that Mn0.25Fe2.75O4 nanoparticles induced 80% greater cell death than undoped SPIONs. The systematic QbD approach developed here incorporates process robustness, scalability, and predictability, thus, supporting the clinical translation of high-performance SPIONs for magnetic hyperthermia.", "doi": "10.1021/acsnano.4c04685", "pmid": "38814737", "labels": {"Alexandra Teleki": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC11171760"}], "notes": [], "created": "2024-11-28T11:25:50.019Z", "modified": "2024-11-28T11:25:50.077Z"}]}