{"entity": "researcher", "timestamp": "2026-08-20T21:15:17.355Z", "family": "Schaap", "given": "N P M", "initials": "NPM", "orcid": "0000-0001-7696-4752", "affiliations": ["Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e6c952987b149e1b97baab1b815b600.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e6c952987b149e1b97baab1b815b600"}}, "publications": [{"entity": "publication", "iuid": "6087ac4b304c4b82a815ab2e05edcc5b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6087ac4b304c4b82a815ab2e05edcc5b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6087ac4b304c4b82a815ab2e05edcc5b"}}, "title": "Correction to: IL\u201115 superagonist N\u2011803 improves IFN\u03b3 production and killing of leukemia and ovarian cancer cells by CD34+ progenitor\u2011derived NK cells.", "authors": [{"family": "Van der Meer", "given": "J M R", "initials": "JMR", "orcid": "0000-0001-9288-1500", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec374420f13d480ba3e342acba183a7c.json"}}, {"family": "Maas", "given": "R J A", "initials": "RJA", "orcid": "0000-0002-3185-5226", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4de8f2b519342279c7578490873c4a6.json"}}, {"family": "Guldevall", "given": "K", "initials": "K", "orcid": "0000-0003-1016-2460", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24a750602b1a47d48d92974f972f1c72.json"}}, {"family": "Klarenaar", "given": "K", "initials": "K"}, {"family": "De Jonge", "given": "P K J D", "initials": "PKJD"}, {"family": "Hoogstad-van Evert", "given": "J S", "initials": "JS", "orcid": "0000-0001-9838-0977", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c4e67260bf64a2d963820d64cd4b162.json"}}, {"family": "van der Waart", "given": "A B", "initials": "AB", "orcid": "0000-0001-5986-3060", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a4ab943bebb4a518668d1f1e9dd7363.json"}}, {"family": "Cany", "given": "J", "initials": "J", "orcid": "0000-0002-5214-639X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a526e4e6cde24c6c8807b27101e35ea3.json"}}, {"family": "Safrit", "given": "J T", "initials": "JT", "orcid": "0000-0001-7441-4423", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb8265befd554a1aba34b695852a1016.json"}}, {"family": "Lee", "given": "J H", "initials": "JH"}, {"family": "Wagena", "given": "E", "initials": "E"}, {"family": "Friedl", "given": "P", "initials": "P", "orcid": "0000-0002-0119-4041", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d4fb98a43c1442f9cd904e323dc2769.json"}}, {"family": "\u00d6nfelt", "given": "B", "initials": "B", "orcid": "0000-0001-5178-7593", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b4b8fcbedb54e2ba38633687f417ae8.json"}}, {"family": "Massuger", "given": "L F", "initials": "LF", "orcid": "0000-0002-1539-8985", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd1dab07b61e43b29f9bcdda0383ed00.json"}}, {"family": "Schaap", "given": "N P M", "initials": "NPM", "orcid": "0000-0001-7696-4752", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e6c952987b149e1b97baab1b815b600.json"}}, {"family": "Jansen", "given": "J H", "initials": "JH", "orcid": "0000-0001-9459-568X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4dda0ce64c04555834f61ba0d31278d.json"}}, {"family": "Hobo", "given": "W", "initials": "W", "orcid": "0000-0002-8206-8185", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d9d1653bbb04e1cb8ec62f49217057d.json"}}, {"family": "Dolstra", "given": "H", "initials": "H", "orcid": "0000-0002-3998-687X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a45d0970dc374c218087801fef1baa2a.json"}}], "type": "published erratum", "published": "2021-11-00", "journal": {"title": "Cancer Immunol. Immunother.", "issn": "1432-0851", "volume": "70", "issue": "11", "pages": "3367", "issn-l": "0340-7004"}, "abstract": null, "doi": "10.1007/s00262-021-03049-5", "pmid": "34524494", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8505330"}, {"db": "pii", "key": "10.1007/s00262-021-03049-5"}], "notes": [], "created": "2026-08-20T06:39:30.255Z", "modified": "2026-08-20T06:39:30.394Z"}, {"entity": "publication", "iuid": "960e80f94c714e4d9469b1e3e2d8d29d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/960e80f94c714e4d9469b1e3e2d8d29d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/960e80f94c714e4d9469b1e3e2d8d29d"}}, "title": "IL-15 superagonist N-803 improves IFN\u03b3 production and killing of leukemia and ovarian cancer cells by CD34+ progenitor-derived NK cells.", "authors": [{"family": "Van der Meer", "given": "J M R", "initials": "JMR", "orcid": "0000-0001-9288-1500", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec374420f13d480ba3e342acba183a7c.json"}}, {"family": "Maas", "given": "R J A", "initials": "RJA", "orcid": "0000-0002-3185-5226", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4de8f2b519342279c7578490873c4a6.json"}}, {"family": "Guldevall", "given": "K", "initials": "K", "orcid": "0000-0003-1016-2460", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24a750602b1a47d48d92974f972f1c72.json"}}, {"family": "Klarenaar", "given": "K", "initials": "K"}, {"family": "de Jonge", "given": "P K J D", "initials": "PKJD"}, {"family": "Evert", "given": "J S Hoogstad-van", "initials": "JSH", "orcid": "0000-0001-9838-0977", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c4e67260bf64a2d963820d64cd4b162.json"}}, {"family": "van der Waart", "given": "A B", "initials": "AB", "orcid": "0000-0001-5986-3060", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a4ab943bebb4a518668d1f1e9dd7363.json"}}, {"family": "Cany", "given": "J", "initials": "J", "orcid": "0000-0002-5214-639X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a526e4e6cde24c6c8807b27101e35ea3.json"}}, {"family": "Safrit", "given": "J T", "initials": "JT", "orcid": "0000-0001-7441-4423", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb8265befd554a1aba34b695852a1016.json"}}, {"family": "Lee", "given": "J H", "initials": "JH"}, {"family": "Wagena", "given": "E", "initials": "E"}, {"family": "Friedl", "given": "P", "initials": "P", "orcid": "0000-0002-0119-4041", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d4fb98a43c1442f9cd904e323dc2769.json"}}, {"family": "\u00d6nfelt", "given": "B", "initials": "B", "orcid": "0000-0001-5178-7593", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b4b8fcbedb54e2ba38633687f417ae8.json"}}, {"family": "Massuger", "given": "L F", "initials": "LF", "orcid": "0000-0002-1539-8985", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd1dab07b61e43b29f9bcdda0383ed00.json"}}, {"family": "Schaap", "given": "N P M", "initials": "NPM", "orcid": "0000-0001-7696-4752", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e6c952987b149e1b97baab1b815b600.json"}}, {"family": "Jansen", "given": "J H", "initials": "JH", "orcid": "0000-0001-9459-568X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4dda0ce64c04555834f61ba0d31278d.json"}}, {"family": "Hobo", "given": "W", "initials": "W", "orcid": "0000-0002-8206-8185", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d9d1653bbb04e1cb8ec62f49217057d.json"}}, {"family": "Dolstra", "given": "H", "initials": "H", "orcid": "0000-0002-3998-687X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a45d0970dc374c218087801fef1baa2a.json"}}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Cancer Immunol. Immunother.", "issn": "1432-0851", "volume": "70", "issue": "5", "pages": "1305-1321", "issn-l": "0340-7004"}, "abstract": "Allogeneic natural killer (NK) cell transfer is a potential immunotherapy to eliminate and control cancer. A promising source are CD34 + hematopoietic progenitor cells (HPCs), since large numbers of cytotoxic NK cells can be generated. Effective boosting of NK cell function can be achieved by interleukin (IL)-15. However, its in vivo half-life is short and potent trans-presentation by IL-15 receptor \u03b1 (IL-15R\u03b1) is absent. Therefore, ImmunityBio developed IL-15 superagonist N-803, which combines IL-15 with an activating mutation, an IL-15R\u03b1 sushi domain for trans-presentation, and IgG1-Fc for increased half-life. Here, we investigated whether and how N-803 improves HPC-NK cell functionality in leukemia and ovarian cancer (OC) models in vitro and in vivo in OC-bearing immunodeficient mice. We used flow cytometry-based assays, enzyme-linked immunosorbent assay, microscopy-based serial killing assays, and bioluminescence imaging, for in vitro and in vivo experiments. N-803 increased HPC-NK cell proliferation and interferon (IFN)\u03b3 production. On leukemia cells, co-culture with HPC-NK cells and N-803 increased ICAM-1 expression. Furthermore, N-803 improved HPC-NK cell-mediated (serial) leukemia killing. Treating OC spheroids with HPC-NK cells and N-803 increased IFN\u03b3-induced CXCL10 secretion, and target killing after prolonged exposure. In immunodeficient mice bearing human OC, N-803 supported HPC-NK cell persistence in combination with total human immunoglobulins to prevent Fc-mediated HPC-NK cell depletion. Moreover, this combination treatment decreased tumor growth. In conclusion, N-803 is a promising IL-15-based compound that boosts HPC-NK cell expansion and functionality in vitro and in vivo. Adding N-803 to HPC-NK cell therapy could improve cancer immunotherapy.", "doi": "10.1007/s00262-020-02749-8", "pmid": "33140189", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8053152"}, {"db": "pii", "key": "10.1007/s00262-020-02749-8"}], "notes": [], "created": "2026-08-20T06:39:27.597Z", "modified": "2026-08-20T06:39:28.213Z"}]}