{"entity": "researcher", "timestamp": "2026-08-20T20:58:56.893Z", "family": "Zhang", "given": "Pei", "initials": "P", "orcid": "0000-0003-2054-928X", "affiliations": ["Gunma University Initiative for Advanced Research (GIAR), Gunma University, Maebashi, Gunma 371-8511, Japan.", "Division of Physiological Chemistry 2, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE-171 77, Sweden.", "Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, P. R. China."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e4af492258b4256992af0279c823400.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e4af492258b4256992af0279c823400"}}, "publications": [{"entity": "publication", "iuid": "f1336fd3bdbe4d0fab56982fc188721c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f1336fd3bdbe4d0fab56982fc188721c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f1336fd3bdbe4d0fab56982fc188721c"}}, "title": "Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective.", "authors": [{"family": "Zhang", "given": "Pei", "initials": "P", "orcid": "0000-0003-2054-928X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e4af492258b4256992af0279c823400.json"}}, {"family": "Carlsten", "given": "Christopher", "initials": "C"}, {"family": "Chaleckis", "given": "Romanas", "initials": "R", "orcid": "0000-0001-8042-1005", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/012934b6c4a64891b76722fbda1e0f28.json"}}, {"family": "Hanhineva", "given": "Kati", "initials": "K", "orcid": "0000-0001-6834-7375", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b66883342d1b45938f17d75e73479d50.json"}}, {"family": "Huang", "given": "Mengna", "initials": "M", "orcid": "0000-0002-4626-4816", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/baf43d2b06f746078bd69385c9e6cf93.json"}}, {"family": "Isobe", "given": "Tomohiko", "initials": "T", "orcid": "0000-0001-9235-1227", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67986b3e12c1468c9b7cea2709e233a1.json"}}, {"family": "Koistinen", "given": "Ville M", "initials": "VM"}, {"family": "Meister", "given": "Isabel", "initials": "I"}, {"family": "Papazian", "given": "Stefano", "initials": "S"}, {"family": "Sdougkou", "given": "Kalliroi", "initials": "K"}, {"family": "Xie", "given": "Hongyu", "initials": "H"}, {"family": "Martin", "given": "Jonathan W", "initials": "JW", "orcid": "0000-0001-6265-4294", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02199c0d99674e2ea5e96e6589c07a00.json"}}, {"family": "Rappaport", "given": "Stephen M", "initials": "SM", "orcid": "0000-0002-3806-0848", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/da3132c271b34cc8a758560a68fe241b.json"}}, {"family": "Tsugawa", "given": "Hiroshi", "initials": "H", "orcid": "0000-0002-2015-3958", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1703a87b2e3444d8ba917253d25d5556.json"}}, {"family": "Walker", "given": "Douglas I", "initials": "DI", "orcid": "0000-0003-2912-398X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4712c06efd674e4b96f494e33ab9084f.json"}}, {"family": "Woodruff", "given": "Tracey J", "initials": "TJ", "orcid": "0000-0003-3622-1297", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ad211bff7564b65ad1a4d6468e0e6b7.json"}}, {"family": "Wright", "given": "Robert O", "initials": "RO"}, {"family": "Wheelock", "given": "Craig E", "initials": "CE", "orcid": "0000-0002-8113-0653", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d98abddc2b14a35ade5cb6d6d2f540d.json"}}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "Environ Sci Technol Lett", "issn": "2328-8930", "volume": "8", "issue": "10", "pages": "839-852", "issn-l": null}, "abstract": "The concept of the exposome was introduced over 15 years ago to reflect the important role that the environment exerts on health and disease. While originally viewed as a call-to-arms to develop more comprehensive exposure assessment methods applicable at the individual level and throughout the life course, the scope of the exposome has now expanded to include the associated biological response. In order to explore these concepts, a workshop was hosted by the Gunma University Initiative for Advanced Research (GIAR, Japan) to discuss the scope of exposomics from an international and multidisciplinary perspective. This Global Perspective is a summary of the discussions with emphasis on (1) top-down, bottom-up, and functional approaches to exposomics, (2) the need for integration and standardization of LC- and GC-based high-resolution mass spectrometry methods for untargeted exposome analyses, (3) the design of an exposomics study, (4) the requirement for open science workflows including mass spectral libraries and public databases, (5) the necessity for large investments in mass spectrometry infrastructure in order to sequence the exposome, and (6) the role of the exposome in precision medicine and nutrition to create personalized environmental exposure profiles. Recommendations are made on key issues to encourage continued advancement and cooperation in exposomics.", "doi": "10.1021/acs.estlett.1c00648", "pmid": "34660833", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8515788"}], "notes": [], "created": "2026-08-20T08:10:04.602Z", "modified": "2026-08-20T08:10:05.065Z"}]}