{"entity": "researcher", "timestamp": "2026-08-22T08:30:41.650Z", "family": "Svenungsson", "given": "Elisabet", "initials": "E", "orcid": "0000-0003-3396-3244", "affiliations": ["Rheumatology Unit, Department of Medicine , Karolinska Institutet and Karolinska University Hospital , 171 76 Stockholm , Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c44ebd4f33e46a1862877bce94be05b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c44ebd4f33e46a1862877bce94be05b"}}, "publications": [{"entity": "publication", "iuid": "7fdaf83387f347b4beea8fc27c202ef7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7fdaf83387f347b4beea8fc27c202ef7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7fdaf83387f347b4beea8fc27c202ef7"}}, "title": "Quick Systemic Lupus Activity Questionnaire (Q-SLAQ): a simplified version of SLAQ for patient-reported disease activity.", "authors": [{"family": "Svenungsson", "given": "Elisabet", "initials": "E", "orcid": "0000-0003-3396-3244", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c44ebd4f33e46a1862877bce94be05b.json"}}, {"family": "Gunnarsson", "given": "Iva", "initials": "I", "orcid": "0000-0002-4514-7706", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fad22fbcc212423b9bc9539482d723e8.json"}}, {"family": "Illescas-B\u00e4ckelin", "given": "Vera", "initials": "V"}, {"family": "Trysberg", "given": "Estelle", "initials": "E"}, {"family": "J\u00f6nsen", "given": "Andreas", "initials": "A", "orcid": "0000-0002-4418-5786", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1bb7503e46d04e648d95e03e58a4b465.json"}}, {"family": "Leonard", "given": "Dag", "initials": "D"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C", "orcid": "0000-0003-0900-2048", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9fcc24622ec440bac6996072cceea0e.json"}}, {"family": "Pettersson", "given": "Susanne", "initials": "S", "orcid": "0000-0001-7432-2756", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49b93682e1a4420ba9249f467e35b729.json"}}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Lupus Sci Med", "issn": "2053-8790", "volume": "8", "issue": "1", "issn-l": null}, "abstract": "Most indices of disease activity in SLE combine physicians' assessments and laboratory tests. However, there is also a need to capture patients' perspectives of disease activity. Consequently, we need new, preferably quick and easy instruments to collect this information, which can be very useful for online consultations and registry purposes. We compared patients' assessments of SLE disease impact/activity, as reported by a shorter version of the Quick Systemic Lupus Activity Questionnaire (Q-SLAQ), with physicians' assessments using SLE Activity Measure (SLAM) and SLE Disease Activity Index (SLEDAI-2K) and with the original Systemic Lupus Activity Questionnaire (SLAQ).\n\nPatients with SLE (n=115), with a disease duration of 15 years (IQR 17), completed the Q-SLAQ prior to physicians' assessments by SLAM and SLEDAI-2K. A second set of patients (n=85) with similar characteristics filled out Q-SLAQ and SLAQ. Spearman's \u03c1 correlations were explored between patients' total Q-SLAQ and subscales (Symptom Score, Patient's Global Disease Activity) and physicians' SLAM and SLEDAI-2K, with and without laboratory items (SLAM-nolab and SLEDAI-2K-nolab) and SLAQ. Corresponding items in Q-SLAQ and SLAM were compared.\n\nCorrelations between patients' and physicians' assessments were higher for SLAM-nolab (total Q-SLAQ, \u03c1=0.71; Symptom Score, \u03c1=0.67; and Patient's Global Disease Activity, \u03c1=0.68) than for the original SLAM (total Q-SLAQ, \u03c1=0.53; Symptom Score, \u03c1=0.50; and Patient's Global Disease Activity, \u03c1=0.53). Regarding specific symptoms, fatigue (\u03c1=0.72) and alopecia (\u03c1=0.71) correlated best, while pulmonary/respiratory symptoms correlated least (\u03c1=0.19, p=0.039). Physicians assessment with SLEDAI-2K-nolab correlated weakly with patients' assessments (total Q-SLAQ, \u03c1=0.30; Symptom Score, \u03c1=0.30; and Patient's Global Disease Activity, \u03c1=0.36). Bivariate correlations between Q-SLAQ and SLAQ were good (\u03c1=0.82-0.96).\n\nQ-SLAQ and the original SLAQ performed equally well, demonstrating that the shorter Q-SLAQ can safely be used to monitor patients' perception of disease impact/activity. We also noted an intriguing discrepancy between physicians' and patients' evaluations of pulmonary/respiratory symptoms, which requires further investigations.", "doi": "10.1136/lupus-2020-000471", "pmid": "33972457", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8112425"}, {"db": "pii", "key": "8/1/e000471"}], "notes": [], "created": "2026-08-21T12:27:33.947Z", "modified": "2026-08-21T12:27:34.175Z"}, {"entity": "publication", "iuid": "6538516184c34387bbd73b670be1f443", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6538516184c34387bbd73b670be1f443.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6538516184c34387bbd73b670be1f443"}}, "title": "NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus.", "authors": [{"family": "Linge", "given": "Petrus", "initials": "P", "orcid": "0000-0001-8906-2715", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c83a8ed6a2ac4711b0465b6dfbcabcc9.json"}}, {"family": "Arve", "given": "Sabine", "initials": "S", "orcid": "0000-0002-3347-5550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d063b42c4af42efbba4afb26b9a9fd3.json"}}, {"family": "Olsson", "given": "Lina M", "initials": "LM"}, {"family": "Leonard", "given": "Dag", "initials": "D"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C", "orcid": "0000-0003-0900-2048", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9fcc24622ec440bac6996072cceea0e.json"}}, {"family": "Frodlund", "given": "Martina", "initials": "M"}, {"family": "Gunnarsson", "given": "Iva", "initials": "I"}, {"family": "Svenungsson", "given": "Elisabet", "initials": "E", "orcid": "0000-0003-3396-3244", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c44ebd4f33e46a1862877bce94be05b.json"}}, {"family": "Tyd\u00e9n", "given": "Helena", "initials": "H"}, {"family": "J\u00f6nsen", "given": "Andreas", "initials": "A"}, {"family": "Kahn", "given": "Robin", "initials": "R", "orcid": "0000-0002-3167-1179", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/17ecdb4f26a648ba9ee080bb72a86c82.json"}}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L"}, {"family": "Holmdahl", "given": "Rikard", "initials": "R", "orcid": "0000-0002-4969-2576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aef6264212044f46a28c24d5fc147438.json"}}, {"family": "Bengtsson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Ann. Rheum. Dis.", "issn": "1468-2060", "volume": "79", "issue": "2", "pages": "254-261", "issn-l": "0003-4967"}, "abstract": "\u200bOBJECTIVES: A single nucleotide polymorphism in the NCF1 gene (NCF1-339, rs201802880), encoding NADPH oxidase type II subunit NCF1/p47phox, reducing production of reactive oxygen species (ROS) is strongly associated with the development of systemic lupus erythematosus (SLE). This study aimed at characterising NCF1-339 effects on neutrophil extracellular trap (NET) formation, type I interferon activity and antibody profile in patients with SLE. \u200bMETHODS: Neutrophil NET-release pathways (n=31), serum interferon (n=141) and finally antibody profiles (n=305) were investigated in SLE subjects from Lund, genotyped for NCF1-339. Then, 1087 SLE subjects from the rheumatology departments of four Swedish SLE centres, genotyped for NCF1-339, were clinically characterised to validate these findings. \u200bRESULTS: Compared with patients with normal-ROS NCF1-339 genotypes, neutrophils from patients with SLE with low-ROS NCF1-339 genotypes displayed impaired NET formation (p<0.01) and increased dependence on mitochondrial ROS (p<0.05). Low-ROS patients also had increased frequency of high serum interferon activity (80% vs 21.4%, p<0.05) and positivity for anti-\u03b22 glycoprotein I (p<0.01) and anticardiolipin antibodies (p<0.05) but were not associated with other antibodies. We confirmed an over-representation of having any antiphospholipid antibody, OR 1.40 (95% CI 1.01 to 1.95), anti-\u03b22 glycoprotein I, OR 1.82 (95% CI 1.02 to 3.24) and the antiphospholipid syndrome (APS), OR 1.74 (95% CI 1.19 to 2.55) in all four cohorts (n=1087). \u200bCONCLUSIONS: The NCF1-339 SNP mediated decreased NADPH oxidase function, is associated with high interferon activity and impaired formation of NETs in SLE, allowing dependence on mitochondrial ROS. Unexpectedly, we revealed a striking connection between the ROS deficient NCF1-339 genotypes and the presence of phospholipid antibodies and APS.", "doi": "10.1136/annrheumdis-2019-215820", "pmid": "31704719", "labels": [], "xrefs": [{"db": "pii", "key": "S0003-4967(24)01509-7"}], "notes": [], "created": "2026-08-21T12:25:45.018Z", "modified": "2026-08-21T12:25:45.336Z"}, {"entity": "publication", "iuid": "fb1602db4fbf41c9b181f6abc7abad49", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fb1602db4fbf41c9b181f6abc7abad49.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fb1602db4fbf41c9b181f6abc7abad49"}}, "title": "Cytokine Profiles in Autoantibody Defined Subgroups of Systemic Lupus Erythematosus.", "authors": [{"family": "Torell", "given": "Frida", "initials": "F", "orcid": "0000-0002-6294-7844", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ce003340e0c248238c5b9a0c9cf41b8b.json"}}, {"family": "Eketj\u00e4ll", "given": "Susanna", "initials": "S", "orcid": "0000-0003-2165-1251", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c50650bf035b4100bebe9fadb166cbc7.json"}}, {"family": "Idborg", "given": "Helena", "initials": "H"}, {"family": "Jakobsson", "given": "Per-Johan", "initials": "PJ"}, {"family": "Gunnarsson", "given": "Iva", "initials": "I"}, {"family": "Svenungsson", "given": "Elisabet", "initials": "E", "orcid": "0000-0003-3396-3244", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c44ebd4f33e46a1862877bce94be05b.json"}}, {"family": "Trygg", "given": "Johan", "initials": "J", "orcid": "0000-0003-3799-6094", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e227e1e1bb84083b9534f4124830f6d.json"}}], "type": "journal article", "published": "2019-03-01", "journal": {"title": "J. Proteome Res.", "issn": "1535-3907", "volume": "18", "issue": "3", "pages": "1208-1217", "issn-l": "1535-3893"}, "abstract": "The aim of this study was to evaluate how the cytokine profiles differed between autoantibody based subgroups of systemic lupus erythematosus (SLE). SLE is a systemic autoimmune disease, characterized by periods of flares (active disease) and remission (inactive disease). The disease can affect many organ systems, e.g., skin, joints, kidneys, heart, and the central nervous system (CNS). SLE patients often have an overproduction of cytokines, e.g., interferons, chemokines, and interleukins. The high cytokine levels are part of the systemic inflammation, which can lead to tissue injury. In the present study, SLE patients were divided into five groups based on their autoantibody profiles. We thus defined these five groups: ANA negative, antiphospholipid (aPL) positive, anti-Sm/anti-RNP positive, Sj\u00f6gren's syndrome (SS) antigen A and B positive, and patients positive for more than one type of autoantibodies (other SLE). Cytokines were measured using Mesoscale Discovery (MSD) multiplex analysis. On the basis of the cytokine data, ANA negative patients were the most deviating subgroup, with lower levels of interferon (IFN)-\u03b3, tumor necrosis factor (TNF)-\u03b1, interleukin (IL)-12/IL-23p40, and interferon gamma-induced protein (IP)-10. Despite low cytokine levels in the ANA negative group, autoantibody profiles did not discriminate between different cytokine patterns.", "doi": "10.1021/acs.jproteome.8b00811", "pmid": "30742448", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T08:12:17.016Z", "modified": "2026-08-20T08:12:17.205Z"}]}