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"orcid": "0000-0003-1422-2993", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/462fd4169f41418887a5a979e0808d87.json"}}, {"family": "Khaw", "given": "Kay-Tee", "initials": "KT"}, {"family": "Sun", "given": "Yan V", "initials": "YV", "orcid": "0000-0002-2838-1824", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60b03d484f0c4acb93802ce6e6048a10.json"}}, {"family": "Wilson", "given": "Peter W F", "initials": "PWF", "orcid": "0000-0002-5653-7056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e2fa5a1fb3634b88b3a50c4d31bd3a33.json"}}, {"family": "Cho", "given": "Kelly", "initials": "K"}, {"family": "Visscher", "given": "Peter M", "initials": "PM", "orcid": "0000-0002-2143-8760", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9232be0ea244fb7ab43593e04265c2e.json"}}, {"family": "Denny", "given": "Joshua C", "initials": "JC", "orcid": "0000-0002-3049-7332", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee3b66f9be524dfdb2d95834abad0cbf.json"}}, {"family": "Million Veteran Program", "given": "", "initials": ""}, {"family": "Lifelines Cohort Study", "given": "", "initials": ""}, {"family": "CHARGE consortium", "given": "", "initials": ""}, {"family": "ICBP Consortium", "given": "", "initials": ""}, {"family": "Levy", "given": "Daniel", "initials": "D"}, {"family": "Edwards", "given": "Todd L", "initials": "TL", "orcid": "0000-0003-4318-6119", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8c555d3f6704b69821f39dcac8984d5.json"}}, {"family": "Munroe", "given": "Patricia B", "initials": "PB", "orcid": "0000-0002-4176-2947", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e956b6f17a64fb4b478dbc59950a790.json"}}, {"family": "Snieder", "given": "Harold", "initials": "H", "orcid": "0000-0003-1949-2298", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb5a2135b774429596606e980c9268ec.json"}}, {"family": "Warren", "given": "Helen R", "initials": "HR", "orcid": "0000-0003-0511-1386", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d44ccb685e4b4a4894b8cba8c74333ff.json"}}], "type": "journal article", "published": "2024-05-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "56", "issue": "5", "pages": "778-791", "issn-l": "1061-4036"}, "abstract": "Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 \u00d7 10-8) from the largest single-stage blood pressure (BP) genome-wide association study to date (n = 1,028,980 European individuals). These associations explain more than 60% of single nucleotide polymorphism-based BP heritability. Comparing top versus bottom deciles of polygenic risk scores (PRSs) reveals clinically meaningful differences in BP (16.9 mmHg systolic BP, 95% CI, 15.5-18.2 mmHg, P = 2.22 \u00d7 10-126) and more than a sevenfold higher odds of hypertension risk (odds ratio, 7.33; 95% CI, 5.54-9.70; P = 4.13 \u00d7 10-44) in an independent dataset. Adding PRS into hypertension-prediction models increased the area under the receiver operating characteristic curve (AUROC) from 0.791 (95% CI, 0.781-0.801) to 0.826 (95% CI, 0.817-0.836, \u2206AUROC, 0.035, P = 1.98 \u00d7 10-34). We compare the 2,103 loci results in non-European ancestries and show significant PRS associations in a large African-American sample. Secondary analyses implicate 500 genes previously unreported for BP. Our study highlights the role of increasingly large genomic studies for precision health research.", "doi": "10.1038/s41588-024-01714-w", "pmid": "38689001", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11096100"}, {"db": "pii", "key": "10.1038/s41588-024-01714-w"}], "notes": [], "created": "2026-08-20T09:00:02.525Z", "modified": "2026-08-20T09:00:03.969Z"}, {"entity": "publication", "iuid": "8c24e28fd0c2402fbe791fd55046057b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8c24e28fd0c2402fbe791fd55046057b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8c24e28fd0c2402fbe791fd55046057b"}}, "title": "Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.", "authors": [{"family": "Shrine", "given": "Nick", "initials": "N", "orcid": "0000-0003-3641-4371", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e5ea1864e344b0d9afa411230b30063.json"}}, {"family": "Guyatt", "given": "Anna L", "initials": "AL", "orcid": "0000-0003-1860-6337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/699fd6195c4743778182f19e60528f9f.json"}}, {"family": "Erzurumluoglu", "given": "A Mesut", "initials": "AM"}, {"family": "Jackson", "given": "Victoria E", "initials": "VE"}, {"family": "Hobbs", "given": "Brian D", "initials": "BD", "orcid": "0000-0001-9564-0745", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8a9e4dfd9044e2b9916206b979349cd.json"}}, {"family": "Melbourne", "given": "Carl A", "initials": "CA"}, {"family": "Batini", "given": "Chiara", "initials": "C"}, {"family": "Fawcett", "given": "Katherine A", "initials": "KA"}, {"family": "Song", "given": "Kijoung", "initials": "K"}, {"family": "Sakornsakolpat", "given": "Phuwanat", "initials": "P", "orcid": "0000-0002-4308-0974", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77168c1ef56d456e88a5327a437b7f52.json"}}, {"family": "Li", "given": "Xingnan", "initials": "X"}, {"family": "Boxall", "given": "Ruth", "initials": "R"}, {"family": "Reeve", "given": "Nicola F", "initials": "NF"}, {"family": "Obeidat", "given": "Ma'en", "initials": "M", "orcid": "0000-0002-5443-2752", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/422fc72fc8e54948af2939fb8ff12d1e.json"}}, {"family": "Zhao", "given": "Jing Hua", "initials": "JH"}, {"family": "Wielscher", "given": "Matthias", "initials": "M"}, {"family": "Understanding Society Scientific Group", "given": "", "initials": ""}, {"family": "Weiss", "given": "Stefan", "initials": "S", "orcid": "0000-0002-3553-4315", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ebf58f688caa49ab9e0a3e56349b1031.json"}}, {"family": "Kentistou", "given": "Katherine A", "initials": "KA", "orcid": "0000-0002-5816-664X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/772af07e040c4a24a9076e9a8a36723b.json"}}, {"family": "Cook", "given": "James P", "initials": "JP"}, {"family": "Sun", "given": "Benjamin B", "initials": "BB", "orcid": "0000-0001-6347-2281", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/da2eef8768f245dda8ef8f0f81d13715.json"}}, {"family": "Zhou", "given": "Jian", "initials": "J"}, {"family": "Hui", "given": "Jennie", "initials": "J"}, {"family": "Karrasch", "given": "Stefan", "initials": "S"}, {"family": "Imboden", "given": "Medea", "initials": "M"}, {"family": "Harris", "given": "Sarah E", "initials": "SE"}, {"family": "Marten", "given": "Jonathan", "initials": "J"}, {"family": "Enroth", "given": "Stefan", "initials": "S", "orcid": "0000-0002-5056-9137", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae9be8ef3b1145239a4e0231e2a148cd.json"}}, {"family": "Kerr", "given": "Shona M", "initials": "SM"}, {"family": "Surakka", "given": "Ida", "initials": "I"}, {"family": "Vitart", "given": "Veronique", "initials": "V", "orcid": "0000-0002-4991-3797", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3270297f0f1b4de4bb181d7be8e1f447.json"}}, {"family": "Lehtim\u00e4ki", "given": "Terho", "initials": "T"}, {"family": "Allen", "given": "Richard J", "initials": "RJ", "orcid": "0000-0002-8450-3056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b366f94bf4e4409cb74c0853177419e0.json"}}, {"family": "Bakke", "given": "Per S", "initials": "PS"}, {"family": "Beaty", "given": "Terri H", "initials": "TH", "orcid": "0000-0002-7644-1705", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/948c6692dd4748c5aafb9962c9cfebf0.json"}}, {"family": "Bleecker", "given": "Eugene R", "initials": "ER"}, {"family": "Boss\u00e9", "given": "Yohan", "initials": "Y", "orcid": 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"Peter K", "initials": "PK", "orcid": "0000-0002-6361-5059", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67a2c02915a5435d8ff7e148eeab9cc8.json"}}, {"family": "Joubert", "given": "Philippe", "initials": "P"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Li", "given": "Xuan", "initials": "X"}, {"family": "Li", "given": "Liming", "initials": "L"}, {"family": "Lin", "given": "Kuang", "initials": "K"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Locantore", "given": "Nicholas", "initials": "N"}, {"family": "Luan", "given": "Jian'an", "initials": "J"}, {"family": "Mahajan", "given": "Anubha", "initials": "A", "orcid": "0000-0001-5585-3420", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41b3d44662484e0289f07fa25d045cf4.json"}}, {"family": "Maranville", "given": "Joseph C", "initials": "JC"}, {"family": "Murray", "given": "Alison", "initials": "A", "orcid": 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{"family": "Whittaker", "given": "John C", "initials": "JC"}, {"family": "Woodruff", "given": "Prescott G", "initials": "PG"}, {"family": "Yerges-Armstrong", "given": "Laura M", "initials": "LM"}, {"family": "Troyanskaya", "given": "Olga G", "initials": "OG", "orcid": "0000-0002-5676-5737", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ba3b2d1051324a64aa5d71411135b960.json"}}, {"family": "Raitakari", "given": "Olli T", "initials": "OT"}, {"family": "K\u00e4h\u00f6nen", "given": "Mika", "initials": "M"}, {"family": "Pola\u0161ek", "given": "Ozren", "initials": "O"}, {"family": "Gyllensten", "given": "Ulf", "initials": "U"}, {"family": "Rudan", "given": "Igor", "initials": "I", "orcid": "0000-0001-6993-6884", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c9e99f2bcc74658ae0bcffca0a0abee.json"}}, {"family": "Deary", "given": "Ian J", "initials": "IJ"}, {"family": "Probst-Hensch", "given": "Nicole M", "initials": "NM"}, {"family": "Schulz", "given": "Holger", "initials": "H"}, {"family": "James", "given": "Alan L", "initials": "AL"}, {"family": "Wilson", "given": "James F", "initials": "JF", "orcid": "0000-0001-5751-9178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513b6983cc9d478ab9d81c2f21579961.json"}}, {"family": "Stubbe", "given": "Beate", "initials": "B"}, {"family": "Zeggini", "given": "Eleftheria", "initials": "E", "orcid": "0000-0003-4238-659X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/94df27518bb34428a8b1f8f2b278d778.json"}}, {"family": "Jarvelin", "given": "Marjo-Riitta", "initials": "MR"}, {"family": "Wareham", "given": "Nick", "initials": "N"}, {"family": "Silverman", "given": "Edwin K", "initials": "EK"}, {"family": "Hayward", "given": "Caroline", "initials": "C", "orcid": "0000-0002-9405-9550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/542b00d650124ce4a3776ae95571e2c1.json"}}, {"family": "Morris", "given": "Andrew P", "initials": "AP", "orcid": "0000-0002-6805-6014", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aaff6a0afcdf464a8de49c2ece7399e2.json"}}, {"family": "Butterworth", "given": "Adam S", "initials": "AS", "orcid": "0000-0002-6915-9015", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88842023860148bb8d155b5c18db72a8.json"}}, {"family": "Scott", "given": "Robert A", "initials": "RA"}, {"family": "Walters", "given": "Robin G", "initials": "RG", "orcid": "0000-0002-9179-0321", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4c4c1c5209be401c91b60553e49c282c.json"}}, {"family": "Meyers", "given": "Deborah A", "initials": "DA"}, {"family": "Cho", "given": "Michael H", "initials": "MH", "orcid": "0000-0002-4907-1657", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a80666dedf27482ba21cd3861ca1328d.json"}}, {"family": "Strachan", "given": "David P", "initials": "DP", "orcid": "0000-0001-7854-1366", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d43385a350914b0a843fb49008d108b0.json"}}, {"family": "Hall", "given": "Ian P", "initials": "IP"}, {"family": "Tobin", "given": "Martin D", "initials": "MD", "orcid": "0000-0002-3596-7874", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ba839a0d60d412f84088e9320dc1ae5.json"}}, {"family": "Wain", "given": "Louise V", "initials": "LV", "orcid": "0000-0003-4951-1867", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/20f57de56b794e269d73d41b939a7de3.json"}}], "type": "published erratum", "published": "2019-06-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "51", "issue": "6", "pages": "1067", "issn-l": "1061-4036"}, "abstract": "An amendment to this paper has been published and can be accessed via a link at the top of the paper.", "doi": "10.1038/s41588-019-0438-3", "pmid": "31110354", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41588-019-0438-3"}], "notes": [], "created": "2026-08-20T08:59:46.693Z", "modified": "2026-08-20T08:59:47.335Z"}, {"entity": "publication", "iuid": "6204c3f54d9b4ebbb3f82cad0e300582", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6204c3f54d9b4ebbb3f82cad0e300582.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6204c3f54d9b4ebbb3f82cad0e300582"}}, "title": "Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.", "authors": [{"family": "Sakornsakolpat", "given": "Phuwanat", "initials": "P", "orcid": "0000-0002-4308-0974", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77168c1ef56d456e88a5327a437b7f52.json"}}, {"family": "Prokopenko", "given": "Dmitry", "initials": "D", "orcid": "0000-0002-1844-5652", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1617bde48996454daac7127439705862.json"}}, {"family": "Lamontagne", "given": "Maxime", "initials": "M"}, {"family": "Reeve", "given": "Nicola F", "initials": "NF"}, {"family": "Guyatt", "given": "Anna L", "initials": "AL", "orcid": "0000-0003-1860-6337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/699fd6195c4743778182f19e60528f9f.json"}}, {"family": "Jackson", "given": "Victoria E", "initials": "VE"}, {"family": "Shrine", "given": "Nick", "initials": "N", "orcid": "0000-0003-3641-4371", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e5ea1864e344b0d9afa411230b30063.json"}}, {"family": "Qiao", "given": "Dandi", "initials": "D"}, {"family": "Bartz", "given": "Traci M", "initials": "TM"}, {"family": "Kim", "given": "Deog Kyeom", "initials": "DK"}, {"family": "Lee", "given": "Mi Kyeong", "initials": "MK"}, {"family": "Latourelle", "given": "Jeanne C", "initials": "JC"}, {"family": "Li", "given": "Xingnan", "initials": "X"}, {"family": "Morrow", "given": "Jarrett D", "initials": "JD"}, {"family": "Obeidat", "given": "Ma'en", "initials": "M", "orcid": "0000-0002-5443-2752", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/422fc72fc8e54948af2939fb8ff12d1e.json"}}, {"family": "Wyss", "given": "Annah B", "initials": "AB"}, {"family": "Bakke", "given": "Per", "initials": "P"}, {"family": "Barr", "given": "R Graham", "initials": "RG"}, {"family": "Beaty", "given": "Terri H", "initials": "TH", "orcid": "0000-0002-7644-1705", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/948c6692dd4748c5aafb9962c9cfebf0.json"}}, {"family": "Belinsky", "given": 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"0000-0002-3596-7874", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ba839a0d60d412f84088e9320dc1ae5.json"}}, {"family": "Hobbs", "given": "Brian D", "initials": "BD", "orcid": "0000-0001-9564-0745", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8a9e4dfd9044e2b9916206b979349cd.json"}}, {"family": "Cho", "given": "Michael H", "initials": "MH", "orcid": "0000-0002-4907-1657", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a80666dedf27482ba21cd3861ca1328d.json"}}, {"family": "SpiroMeta Consortium", "given": "", "initials": ""}, {"family": "International COPD Genetics Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2019-03-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "51", "issue": "3", "pages": "494-505", "issn-l": "1061-4036"}, "abstract": "Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from the UK Biobank and additional studies from the International COPD Genetics Consortium. We identified 82 loci associated with P < 5 \u00d7 10-8; 47 of these were previously described in association with either COPD or population-based measures of lung function. Of the remaining 35 new loci, 13 were associated with lung function in 79,055 individuals from the SpiroMeta consortium. Using gene expression and regulation data, we identified functional enrichment of COPD risk loci in lung tissue, smooth muscle, and several lung cell types. We found 14 COPD loci shared with either asthma or pulmonary fibrosis. COPD genetic risk loci clustered into groups based on associations with quantitative imaging features and comorbidities. Our analyses provide further support for the genetic susceptibility and heterogeneity of COPD.", "doi": "10.1038/s41588-018-0342-2", "pmid": "30804561", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1517255"}, {"db": "pmc", "key": "PMC6546635"}, {"db": "pii", "key": "10.1038/s41588-018-0342-2"}], "notes": [], "created": "2026-08-20T08:59:44.321Z", "modified": "2026-08-20T08:59:44.832Z"}, {"entity": "publication", "iuid": "851b3f27657c453ca71099b8c0219ced", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/851b3f27657c453ca71099b8c0219ced.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/851b3f27657c453ca71099b8c0219ced"}}, "title": "Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.", "authors": [{"family": "Evangelou", "given": "Evangelos", "initials": "E", "orcid": "0000-0002-5488-2999", "researcher": {"href": 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