{"entity": "researcher", "timestamp": "2026-08-20T21:23:54.327Z", "family": "Lim", "given": "Fabian", "initials": "F", "orcid": "0000-0001-5628-7707", "affiliations": ["Department of Medicine and Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a685edf15c04126a390e0768b04f0ec.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a685edf15c04126a390e0768b04f0ec"}}, "publications": [{"entity": "publication", "iuid": "b6189b5801bb417783640d54af89c9ae", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b6189b5801bb417783640d54af89c9ae.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b6189b5801bb417783640d54af89c9ae"}}, "title": "3D genomics across the tree of life reveals condensin II as a determinant of architecture type.", "authors": [{"family": "Hoencamp", "given": "Claire", "initials": "C", "orcid": "0000-0003-2047-4724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ff4cc8a913fd439cbcfea504ae71e822.json"}}, {"family": "Dudchenko", "given": "Olga", "initials": "O", "orcid": "0000-0001-9163-9544", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c12b3709d6cc4af8a9c4506848943bd0.json"}}, {"family": "Elbatsh", "given": "Ahmed M O", "initials": "AMO", "orcid": "0000-0001-8012-3999", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dde9f1af0d4945efa77c256d672c9b6f.json"}}, {"family": "Brahmachari", "given": "Sumitabha", "initials": "S", "orcid": "0000-0002-9091-6180", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7862f2f8599c43fea407c56ae0d66b85.json"}}, {"family": "Raaijmakers", "given": "Jonne A", "initials": "JA", "orcid": "0000-0003-1759-8347", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7e940082de2409785aff54503b38189.json"}}, {"family": "van Schaik", "given": "Tom", "initials": "T", "orcid": "0000-0001-7850-5074", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ad8a1152ecd4c25bfbb9694b88099bd.json"}}, {"family": "Sede\u00f1o Cacciatore", "given": "\u00c1ngela", "initials": "\u00c1", "orcid": "0000-0002-2751-0428", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf0c09b05ef04917831af6aa2152bae3.json"}}, {"family": "Contessoto", "given": "Vin\u00edcius G", "initials": "VG", "orcid": "0000-0002-1891-9563", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/270a9ee6499e4db0908e4758e9966915.json"}}, {"family": "van Heesbeen", "given": "Roy G H P", "initials": "RGHP"}, {"family": "van den Broek", "given": "Bram", "initials": "B", "orcid": "0000-0003-1037-907X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3926c94fb2474fc5bf081666984bec34.json"}}, {"family": "Mhaskar", "given": "Aditya N", "initials": "AN", "orcid": "0000-0002-9323-437X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb8d0f9f99ef4a71a3236f0bb5ef7569.json"}}, {"family": "Teunissen", "given": "Hans", "initials": "H"}, {"family": "St Hilaire", "given": "Brian Glenn", "initials": "BG"}, {"family": "Weisz", "given": "David", "initials": "D", "orcid": "0000-0001-5868-6672", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef24de771af5441798794f89a3e920e5.json"}}, {"family": "Omer", "given": "Arina D", "initials": "AD", "orcid": "0000-0003-1336-2505", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/16fc1b515f684af082a4c53c94d920d7.json"}}, {"family": "Pham", "given": "Melanie", "initials": "M", "orcid": "0000-0002-6083-271X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/faf097d179af4409acfc27ee6f3015d1.json"}}, {"family": "Colaric", "given": "Zane", "initials": "Z"}, {"family": "Yang", "given": "Zhenzhen", "initials": "Z"}, {"family": "Rao", "given": "Suhas S P", "initials": "SSP"}, {"family": "Mitra", "given": "Namita", "initials": "N"}, {"family": "Lui", "given": "Christopher", "initials": "C", "orcid": "0000-0002-2904-6745", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ea66d3ccd5c477ba0d5fb4842b368d8.json"}}, {"family": "Yao", "given": "Weijie", "initials": "W"}, {"family": "Khan", "given": "Ruqayya", "initials": "R", "orcid": "0000-0001-7549-8761", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/00a597c034434b5da09ae760777481d3.json"}}, {"family": "Moroz", "given": "Leonid L", "initials": "LL", "orcid": "0000-0002-1333-3176", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a41687e1a70c40e98f6e6a5fc6f73df8.json"}}, {"family": "Kohn", "given": "Andrea", "initials": "A"}, {"family": "St Leger", "given": "Judy", "initials": "J", "orcid": "0000-0002-6213-3429", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7193f40c4ac042e9ab40b8ff7db705f6.json"}}, {"family": "Mena", "given": "Alexandria", "initials": "A"}, {"family": "Holcroft", "given": "Karen", "initials": "K"}, {"family": "Gambetta", "given": "Maria Cristina", "initials": "MC", "orcid": "0000-0002-9450-3551", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24eb943c1b194971bfef9364e5c2953d.json"}}, {"family": "Lim", "given": "Fabian", "initials": "F", "orcid": "0000-0001-5628-7707", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a685edf15c04126a390e0768b04f0ec.json"}}, {"family": "Farley", "given": "Emma", "initials": "E", "orcid": "0000-0002-9241-247X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e594fe164596421dbee2d84d929fe890.json"}}, {"family": "Stein", "given": "Nils", "initials": "N", "orcid": "0000-0003-3011-8731", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/34154a7ee2744d11b3682b1d6ca03d31.json"}}, {"family": "Haddad", "given": "Alexander", "initials": "A"}, {"family": "Chauss", "given": "Daniel", "initials": "D"}, {"family": "Mutlu", "given": "Ayse Sena", "initials": "AS", "orcid": "0000-0002-2849-7210", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5131118db11942a3a045d0bf7ce952bc.json"}}, {"family": "Wang", "given": "Meng C", "initials": "MC", "orcid": "0000-0002-5898-6007", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b105f1b2b86b489c89de4a2e4d67b799.json"}}, {"family": "Young", "given": "Neil D", "initials": "ND", "orcid": "0000-0001-8756-229X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3685d7c7c7b44424a538026a3afed21e.json"}}, {"family": "Hildebrandt", "given": "Evin", "initials": "E", "orcid": "0000-0002-2149-3970", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0c39cd32ad1f48ad9b894ece29fdde6a.json"}}, {"family": "Cheng", "given": "Hans H", "initials": "HH", "orcid": "0000-0003-2071-4644", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6bdbc0e86a31410a9d1b0742104e35ae.json"}}, {"family": "Knight", "given": "Christopher J", "initials": "CJ", "orcid": "0000-0002-7522-4127", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8274179edf24c4b818a1213ff914376.json"}}, {"family": "Burnham", "given": "Theresa L U", "initials": "TLU", "orcid": "0000-0002-5641-737X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/002f8d6a697645d5bea30df53fbbc69a.json"}}, {"family": "Hovel", "given": "Kevin A", "initials": "KA", "orcid": "0000-0002-1643-1847", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc84af7609aa49c992392a1e190c64dd.json"}}, {"family": "Beel", "given": "Andrew J", "initials": "AJ", "orcid": "0000-0002-3044-0651", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b726126a488e420e8ec0269bcce25caa.json"}}, {"family": "Mattei", "given": "Pierre-Jean", "initials": "PJ"}, {"family": "Kornberg", "given": "Roger D", "initials": "RD", "orcid": "0000-0002-2425-7519", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b9a045be6fae46b180431160ed394bff.json"}}, {"family": "Warren", "given": "Wesley C", "initials": "WC", "orcid": "0000-0003-2255-2730", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f417018db424302bb3296b58cc3d33b.json"}}, {"family": "Cary", "given": "Gregory", "initials": "G", "orcid": "0000-0003-3573-5229", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a067f0ebd33d4eabac6f94b860821a20.json"}}, {"family": "G\u00f3mez-Skarmeta", "given": "Jos\u00e9 Luis", "initials": "JL"}, {"family": "Hinman", "given": "Veronica", "initials": "V", "orcid": "0000-0003-3414-1357", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a1625f5203b48f780735996c09a9ad8.json"}}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/612a779b69494f1ca9b6c5f1d84fd711.json"}}, {"family": "Di Palma", "given": "Federica", "initials": "F"}, {"family": "Maeshima", "given": "Kazuhiro", "initials": "K", "orcid": "0000-0003-3909-0341", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c612d926d9754bf0b3e4b454d0111d53.json"}}, {"family": "Multani", "given": "Asha S", "initials": "AS", "orcid": "0000-0002-6989-8627", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b43fe3ad4bdd4627941c3c093b86c82b.json"}}, {"family": "Pathak", "given": "Sen", "initials": "S", "orcid": "0000-0002-2458-6048", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f92ed61662349f9820c15c180c8984c.json"}}, {"family": "Nel-Themaat", "given": "Liesl", "initials": "L"}, {"family": "Behringer", "given": "Richard R", "initials": "RR"}, {"family": "Kaur", "given": "Parwinder", "initials": "P", "orcid": "0000-0003-0201-0766", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b238dcbbacde4a09aac2d02747b25e81.json"}}, {"family": "Medema", "given": "Ren\u00e9 H", "initials": "RH"}, {"family": "van Steensel", "given": "Bas", "initials": "B", "orcid": "0000-0002-0284-0404", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e68726cff15040be923aeb6ff0740d20.json"}}, {"family": "de Wit", "given": "Elzo", "initials": "E", "orcid": "0000-0003-2883-1415", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/800bcbd5f60849f6b796c359f23ae844.json"}}, {"family": "Onuchic", "given": "Jos\u00e9 N", "initials": "JN", "orcid": "0000-0002-9448-0388", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b9592fa9f1b54a29b87e4c89c420ed53.json"}}, {"family": "Di Pierro", "given": "Michele", "initials": "M", "orcid": "0000-0002-2889-2632", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9859e3415cc408c86b7705912044bfd.json"}}, {"family": "Lieberman Aiden", "given": "Erez", "initials": "E", "orcid": "0000-0003-0634-6486", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4b90000755b4e5587ca5115331c1207.json"}}, {"family": "Rowland", "given": "Benjamin D", "initials": "BD", "orcid": "0000-0002-0694-8463", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67f8361527604d88b1491cbadacab26e.json"}}], "type": "journal article", "published": "2021-05-28", "journal": {"title": "Science (New York, N.Y.)", "issn": "1095-9203", "volume": "372", "issue": "6545", "pages": "984-989", "issn-l": "0036-8075"}, "abstract": "We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional (3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedly during eukaryotic evolution. The type of genome architecture that an organism exhibits correlates with the absence of condensin II subunits. Moreover, condensin II depletion converts the architecture of the human genome to a state resembling that seen in organisms such as fungi or mosquitoes. In this state, centromeres cluster together at nucleoli, and heterochromatin domains merge. We propose a physical model in which lengthwise compaction of chromosomes by condensin II during mitosis determines chromosome-scale genome architecture, with effects that are retained during the subsequent interphase. This mechanism likely has been conserved since the last common ancestor of all eukaryotes.", "doi": "10.1126/science.abe2218", "pmid": "34045355", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1704706"}, {"db": "pmc", "key": "PMC8172041"}, {"db": "pii", "key": "372/6545/984"}], "notes": [], "created": "2026-08-20T11:59:25.344Z", "modified": "2026-08-20T11:59:27.055Z"}]}